PubMed Journals Articles About "Bristol-Myers Squibb Company" RSS

14:30 EDT 23rd March 2019 | BioPortfolio

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Showing "Bristol Myers Squibb Company" PubMed Articles 1–25 of 187

A Fully Automated Method for the Determination of Serum Belatacept and Its Application in a Pharmacokinetic Investigation in Renal Transplant Recipients.

Belatacept (Nulojix; Bristol-Myers Squibb, New York, NY) is a biological immunosuppressive drug used for the prophylaxis of acute rejection after renal transplantation. Few studies have described belatacept pharmacokinetics, and the effect of therapeutic drug monitoring has not been investigated. We have developed a drug-capture assay (using drug target) to measure belatacept in serum and applied this assay in a pharmacokinetic study in renal transplant recipients.

The Fast Real-time Assessment of Combination Therapies in Immuno-ONcology (FRACTION) program: innovative, high-throughput clinical screening of immunotherapies.

The unprecedented success of immuno-oncology (I-O) agents targeting the cytotoxic T lymphocyte-associated antigen 4 and programmed death-1/programmed death-ligand 1 pathways has stimulated the rapid development of other I-O agents against novel immune targets. Bristol-Myers Squibb has designed a novel phase II platform trial, the Fast Real-time Assessment of Combination Therapies in Immuno-ONcology (FRACTION) Program, to efficiently identify promising combinations for patients with specific malignancies. ...

A Man (or a Woman) is Known by the Company He/She Keeps.

Nivolumab for Treating Metastatic or Unresectable Urothelial Cancer: An Evidence Review Group Perspective of a NICE Single Technology Appraisal.

As part of its single technology appraisal (STA) process, the National Institute for Health and Care Excellence (NICE) invited the manufacturer (Bristol-Myers Squibb) of nivolumab (Opdivo) to submit evidence of its clinical and cost effectiveness for metastatic or unresectable urothelial cancer. Kleijnen Systematic Reviews Ltd, in collaboration with Maastricht University Medical Centre+, was commissioned to act as the independent Evidence Review Group (ERG), which produced a detailed review of the evidence ...

After 40+ Years, Company's Focus Remains High-Quality, Reliable Replacement Parts.

Partnering With an Online Program Management Company: Heresy, Innovative Entrepreneurship, or an Evolving Mind-Set?

A qualitative evaluation of the appropriateness, validity, acceptability, feasibility and interpretability of the Bristol Impact of Hypermobility (BIoH) questionnaire.

The Bristol Impact of Hypermobility (BIoH) questionnaire is a condition-specific patient-reported outcome measure developed for adults with Joint Hypermobility Syndrome (JHS). It has previously demonstrated strong concurrent validity with the Short-Form 36 health questionnaire and excellent test-retest reliability.

Notes from the Field: Lead Exposures Among Employees at a Bullet Manufacturing Company - Missouri, 2017.

Copper Toxicity in Bristol Bay Headwaters: Part 1-Acute Mortality and Ambient Water Quality Criteria in Low-Hardness Water.

The world-class Bristol Bay (Alaska) salmon fishery and vast deposits of copper and other metals in the watershed warrant further investigation into the potential toxicity of copper to salmonids under the low water-hardness conditions that occur in the watershed. Therefore, we investigated the acute toxicity of copper to rainbow trout (Oncorhynchus mykiss) and fathead minnows (Pimephales promelas) in low hardness (∼30 mg/L as CaCO ) water formulated in the laboratory and collected from the Bristol Bay w...

Pseudophedrine-Derived Myers Enolates: Structures and Influence of Lithium Chloride on Reactivity and Mechanism.

The structures and reactivities of pseudoephedrine-derived dianionic Myers enolates are examined. A combination of NMR and IR spectroscopic, crystallographic, and computational data reveal that the homoaggregated dianions form octalithiated tetramers displaying S-symmetric LiO cores and overall C symmetry. Computational and isotopic labeling studies reveal strong N-Li contacts in the carboxamide enolate moiety. The method of continuous variations proves deceptive, as octalithiated tetrameric homoaggregates ...

Is a veterinary student's performance on multiple-mini interviews affected by personality preferences?

The objectives of this study were to evaluate the association between a student's Myers-Briggs Type Indicator (MBTI) preference pairs and resulting types and his or her multiple-mini interview (MMI) scores upon admission, and to determine the proportions of types among veterinary classes over five years.

Assessment of Pharmaceutical Company and Device Manufacturer Payments to Gastroenterologists and Their Participation in Clinical Practice Guideline Panels.

Payments from pharmaceutical and device manufacturers to physicians may influence the advice physicians give patients and peers.

Reply to Comment on ' Role of platelet-rich fibrin on intestinal anastomosis wound healing in a rat'.


Developing Two Culture of Health Measurement Tools: Examining Employers' Efforts to Influence Population Health Inside and Outside Company Walls.

To develop tools that quantify employers' investment in building cultures of health (COH) - inside and outside company walls.

Dimensional changes of the carpal tunnel and median nerve during manual mobilization of the carpal bones - Anatomical study.

Cross-sectional study.

Relationship between knee abduction moment with patellofemoral joint reaction force, stress and self-reported pain during stair descent in women with patellofemoral pain.

Integrative modeling of drug therapy and the bone turnover.

Denosumab has been successfully used for the postmenopausal osteoporosis treatment. This research is focused on the computational analysis of the effect of denosumab on bone remodeling.

'Pre-launch' finite element analysis of a short-stem total hip arthroplasty system consisting of two implant types.

We applied a previously established and validated numerical model to a novel short-stemmed implant for a 'pre-launch' investigation.

Influence of loading rate and limb position on patellar tendon mechanical properties in vivo.

The aims of this study were to clarify the changes of patellar tendon length during isometric knee joint extension and the double leg squat position using ultrasonography.

Do we understand voiding dysfunction in women? Current understanding and future perspectives: ICI-RS 2017.

Urinary retention in women is poorly understood, compared to the equivalent condition in men, and was the subject of a dedicated session organized at the International Consultation on Incontinence Research Society (ICI-RS) in Bristol, United Kingdom, 2017.

Effects of personal and task constraints on limb coordination during walking: A systematic review and meta-analysis.

In human behaviour, emergence of movement patterns is shaped by different, interacting constraints and consequently, individuals with motor disorders usually display distinctive lower limb coordination modes.

Knee extensor torque and BMI differently relate to sit-to-stand strategies in obesity.

Obesity alters whole body kinematics during activities of daily living such as sit-to-stand (STS), but the relative contributions of excess body mass and decreased relative strength are unknown.

Abacavir Hypersensitivity Reaction Reporting Rates During a Decade of HLA-B*5701 Screening as a Risk Mitigation Measure.

HLA-B*5701 screening identifies patients at increased risk for abacavir (ABC) hypersensitivity reaction (HSR). Screening was adopted in GlaxoSmithKline and ViiV Healthcare clinical trials in 2007 and HIV treatment guidelines in 2008. Company meta-analyses of trials pre-HLA-B*5701 screening reported HSR rates of 4% to 8%. We analyzed the effectiveness of HLA-B*5701 screening on reducing HSR rates using clinical trial, observational (OPERA) cohort, and spontaneous reporting data.

A tolerability assessment of new respiratory protective devices developed for health care personnel: A randomized simulated clinical study.

U.S. health care personnel (HCP) have reported that some respiratory protective devices (RPD) commonly used in health care have suboptimal tolerability. Between 2012 and 2016, the U.S. National Institute for Occupational Safety and Health, and the Veterans Health Administration collaborated with two respirator manufacturers, Company A and B, to bring new RPD with improved tolerability to the U.S. health care marketplace. The purpose of this study was to compare the tolerability of four new prototype RPD to ...

Diffusion based MR measurements correlates with age-related changes in human intervertebral disks.

Understanding the association between MR parameters and age related deterioration in human intervertebral disks forms an important step in the development of clinical diagnostic protocols for disk disease.

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