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PubMed Journals Articles About "Building Pipeline∨derfield=score∨derval=DESC" RSS

14:42 EDT 19th July 2019 | BioPortfolio

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Showing "Building Pipeline derfield score derval DESC" PubMed Articles 1–25 of 4,200+

Gestational age-related reference values for Apgar score and umbilical cord arterial and venous pH in preterm and term newborns.

Despite much literature on reference values of acid-base status in umbilical cord blood at birth, there are yet no studies performed to determine gestational age-dependent references in cord venous blood and no studies on preterm acid-base standards. Similarly, the normal reference range of Apgar score for term and preterm infants has not yet been determined.


Consecutive transperineal prostatic template biopsies employing cognitive and systematic approach: a single center study.

The role of transperineal template biopsy for prostate cancer diagnosis is well established. Pre-biopsy multiparametric magnetic resonance imaging (MRI) is used in most centers for planning of prostate biopsies and staging. Cognitive and software fusion techniques are increasingly getting popular. We retrospectively reviewed patients who underwent transperineal template biopsies from January 2016 till December 2018. This included patients on active surveillance, previous negative transrectal ultrasonograph...

Evidence that Tenecteplase Is Noninferior to Alteplase for Acute Ischemic Stroke.

Background and Purpose- TNK (tenecteplase), a newer fibrinolytic agent, has practical delivery advantages over ALT (alteplase) that would make it a useful agent if noninferior in acute ischemic stroke treatment outcome. Accordingly, the most recent US American Heart Association/American Stroke Association acute ischemic stroke guideline recognized TNK as an alternative to ALT, but only based on informal consideration, rather than formal meta-analysis, of completed randomized control trials. Methods- Systema...


Blood Pressure and Outcome After Mechanical Thrombectomy With Successful Revascularization.

Background and Purpose- Successful reperfusion can be achieved in more than two-thirds of patients treated with mechanical thrombectomy. Therefore, it is important to understand the effect of blood pressure (BP) on clinical outcomes after successful reperfusion. In this study, we investigated the relationship between BP on admission and during the first 24 hours after successful reperfusion with clinical outcomes. Methods- This was a multicenter study from 10 comprehensive stroke centers. To ensure homogene...

Association of Psychache and Alexithymia With Suicide in Patients With Schizophrenia.

Suicide is a leading cause of death in patients with schizophrenia. Previous studies have mostly investigated the association between suicide and sociodemographics, positive and negative symptoms, and depressive symptoms. This study evaluated psychache and alexithymia in patients with schizophrenia, which have both been associated with suicide attempts and thoughts in patients with other psychiatric disorders. Positive and Negative Syndrome Scale (PANSS), Psychache Scale (PAS), Beck Scale for Suicidal Ideat...

Minimal Clinically Important Difference of Shoulder Outcome Measures and Diagnoses: A Systematic Review.

Patient-reported outcome scales determine response to treatment. The minimal clinically important difference of these scales is a measure of responsiveness: the smallest change in a score associated with a clinically important change to the patient. This study sought to summarize the literature on minimal clinically important difference for the most commonly reported shoulder outcome scales.

One Year Mortality in Geriatric Trauma Patients: Improving Upon the Geriatric Trauma Outcomes Score Utilizing the Social Security Death Index.

GTOS predicts in-patient mortality in geriatric trauma patients and has been validated in a prospective multicenter trial and expanded to predict adverse discharge (GTOS II). We hypothesized that these formulations actually underestimate the downstream sequelae of injury and sought to predict longer-term mortality in geriatric trauma patients.

The Significance of Visceral Protection in Preventing Enteroatmospheric Fistulae During Open Abdomen Treatment in Patients With Secondary Peritonitis: A Propensity Score-matched Case-control Analysis.

To evaluate the influence of a visceral protective layer (VPL) on the formation of enteroatmospheric fistulae (EAF) in open abdomen treatment (OAT) for peritonitis.

An Aging-Related Single-Nucleotide Polymorphism is Associated with Altered Clinical Outcomes and Distinct Inflammatory Profiles in Aged Blunt Trauma Patients.

The contribution of individual genetic determinants of aging to the adverse clinical outcomes and altered inflammation mediator networks characteristic of aged trauma patients is unknown. The AA genotype of the aging-related single-nucleotide polymorphism (SNP) rs2075650 in TOMM40 has been associated with longevity, while the AG and GG genotypes are associated with an increased risk of Alzheimer's disease. Here, we studied the effect of rs2075650 on clinical outcomes and dynamic biomarker patterns after tra...

Assembling a plug-and-play production line for combinatorial biosynthesis of aromatic polyketides in Escherichia coli.

Polyketides are a class of specialised metabolites synthesised by both eukaryotes and prokaryotes. These chemically and structurally diverse molecules are heavily used in the clinic and include frontline antimicrobial and anticancer drugs such as erythromycin and doxorubicin. To replenish the clinicians' diminishing arsenal of bioactive molecules, a promising strategy aims at transferring polyketide biosynthetic pathways from their native producers into the biotechnologically desirable host Escherichia coli...

Awareness of residents about kala-azar and its related practices in two endemic areas of Bangladesh.

Kala-azar, a worldwide disease, is caused by the parasitic protozoan species of genus Leishmania and transmitted by species of sandflies. Awareness of the population about the disease is essential to run a successful control-strategies program. This cross-sectional study was conducted to assess the awareness of residents about it and related practices in two highly-endemic areas of Bangladesh. In total, 511 household respondents were selected conveniently from two unions (Kushmail and Kanihari) under two su...

Evaluation of the Pint of Science festival in Thailand.

The Pint of Science festival is the biggest annual international science festival. In May 2017, we coordinated the first Pint of Science festival in Thailand and reported our initial reflections. Building on this work, we set out to evaluate more systematically events conducted in 2018.

Long survival of patients with metastatic clear cell renal cell carcinoma. Results of real life study of 344 patients.

The treatment landscape in metastatic renal cell carcinoma has changed fundamentally over the last decade by the development of anti-angiogenic agents, mTOR inhibitors, and immunotherapy. Outside of the context of a clinical trial the treatments are used sequentially. We describe results under real life conditions of a sequential treatment strategy, before the era of immunotherapy. All patients were treated according to their prognostic score (either MSKCC or IMDC) for advanced renal cell carcinoma. A treat...

Interest of plasma microvesicles to monitor pancreatic islet graft dysfunction: beta cell- and leukocyte-derived microvesicles as specific features in a pilot longitudinal study.

Markers of early pancreatic islet graft dysfunction and its causes are lacking. We monitored 19 T1D islet-transplanted patients for up to 36 months following last islet injection. Patients were categorized as Partial (PS) or complete (S) Success, or Graft Failure (F), using the β-score as an indicator of graft function. F was the subset reference of maximum worsened graft outcome. To identify the immune, pancreatic, and liver contribution to the graft dysfunction, the cell origin and concentration of circu...

Early ALT response to corticosteroid treatment distinguishes idiosyncratic Drug-induced Liver Injury from Autoimmune Hepatitis.

Drug-induced liver injury (DILI) and idiopathic autoimmune hepatitis (AIH) are competing diagnoses in patients with acute liver injury and drug intake. In absence of unequivocal markers, scores like RUCAM and the AIH score are used to distinguish both entities. However, in some cases the diagnosis remains ambiguous. Our aim was to identify a simple parameter to discriminate DILI and AIH shortly after starting corticosteroid treatment.

Hydroxamate titanium-organic frameworks and the effect of siderophore-type linkers over their photocatalytic activity.

The chemistry of Metal-Organic Frameworks (MOFs) relies on the controlled linking of organic molecules and inorganic secondary building units to assemble an unlimited number of reticular frameworks. However, the design of porous solids with chemical stability remains still limited to carboxylate or azolate groups. There is a timely opportunity to develop new synthetic platforms that make use of unexplored metal binding groups to produce metal-linker joints with hydrolytical stability. Living organisms use s...

5S multifunctional intelligent coating with super-durable, superhydrophobic, self-monitoring, self-heating, and self-healing properties for existing construction application.

There is a constant drive to develop ultrahigh performance multifunctional coatings for existing construction used in modern engineering technologies. For these materials to be used in unsound infrastructure protections, they are required to present enhanced robustness while bearing functionalities to meet multiple uses. Single-function coating is not smart enough to provide satisfactory protection, and the preparation process of multifunctional materials is complex, costly, and provides poor durability. Th...

Chronic Cannabis Use and Circulating Biomarkers of Neural Health, Stress, and Inflammation in Physically Active Individuals.

Previous research has associated cannabis use with altered circulating neurotrophins and biomarkers of immune health, but these relationships have yet to be fully explored in physically active individuals. The specific aim of this study was to explore the relationships between biomarkers of neural health: nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), immune health: interleukin 6 (IL-6), c-reactive protein (CRP), and cortisol, as well as the presence of depression, in physically act...

Lifestyle and occupational factors associated with participation in colorectal cancer screening among men and women in Australia.

This study explores the associations between lifestyle and occupational factors and participation in colorectal cancer (CRC) screening among men and women aged 50 and over and living in Australia. We used weighted data from the Australian National Health Survey 2014-15 to produce population estimates. Lifestyle variables investigated were smoking, physical activity, alcohol consumption, fruit and vegetable consumption, and body mass index, while the occupational variables were labour force status, occupatio...

Using Deep Siamese Neural Networks for Detection of Brain Asymmetries Associated with Alzheimer's Disease and Mild Cognitive Impairment.

In recent studies, neuroanatomical volume and shape asymmetries have been seen during the course of Alzheimer's Disease (AD) and could potentially be used as preclinical imaging biomarkers for the prediction of Mild Cognitive Impairment (MCI) and AD dementia. In this study, a deep learning framework utilizing Siamese neural networks trained on paired lateral inter-hemispheric regions is used to harness the discriminative power of whole-brain volumetric asymmetry. The method uses the MRICloud pipeline to yie...

Genomic characterization of mumps viruses from a large-scale mumps outbreak in Arkansas, 2016.

In 2016, a year-long large-scale mumps outbreak occurred in Arkansas among a highly-vaccinated population. A total of 2954 mumps cases were identified during this outbreak. The majority of cases (1676 (57%)) were school-aged children (5-17 years), 1536 (92%) of these children had completed the mumps vaccination schedule. To weigh the possibility that the mumps virus evaded vaccine-induced immunity in the affected Arkansas population, we established a pipeline for genomic characterization of the outbreak s...

Promoting green infrastructure in Mexico's northern border: The Border Environment Cooperation Commission's experience and lessons learned.

This paper describes the application of a comprehensive strategic approach for integrating Green Infrastructure (GI) in urban planning in Mexican communities along the U.S-Mexico border as a means to mitigate the environmental, economic, and social impacts of inadequate stormwater management. Population growth and extended urban footprints in the region's cities have decreased rainfall infiltration and significantly increased runoff, carrying sediments and other pollutants into binational watersheds thus co...

Albumin-to-alkaline phosphatase ratio as a novel prognostic indicator for patients undergoing minimally invasive lung cancer surgery: A prospective propensity score matching study.

To evaluate prognostic significance of albumin-to-alkaline phosphatase ratio (AAPR) for patients undergoing video-assisted thoracoscopic surgery (VATS) lobectomy for non-small-cell lung cancer (NSCLC) by a propensity score-matching (PSM) analysis.

Effects of antibiotic-free pig rearing on ammonia emissions from five pairs of swine rooms in a wean-to-finish experiment.

Antibiotic use and ammonia (NH) emissions during animal production are two environmental issues of worldwide concern. However, the role of antibiotics on NH emissions is still unknown. This study evaluated the effects of rearing pigs without antibiotics on NH emissions from a swine experimental building starting with 657 piglets during a wean-to-finish production cycle of 154 days. Pigs were reared in two groups of 10 rooms that were divided into five 2-room pairs (P1-P5) and fed in nine dietary phases. E...

Big data in nephrology: are we ready for the change?

Chronic kidney disease (CKD) is a major public health issue worldwide. However, the status of kidney health care needs to be strengthened globally and research evidence in nephrology is relatively limited. The unmet needs in nephrology leave ample space for imagination regarding leveraging big data and artificial intelligence (AI). Big data has potential to drive medical innovation, reduce medical costs and improve health care quality. Compared with other specialties such as cardiology, the scopes of utiliz...


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