PubMed Journals Articles About "CYCling Lynch Patients For Exercise And Prevention: CYCLE-P" RSS

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Showing "CYCling Lynch Patients Exercise Prevention CYCLE" PubMed Articles 1–25 of 41,000+

DNA mismatch repair protein deficient non-neoplastic colonic crypts: a novel indicator of Lynch syndrome.

Lynch syndrome is the most common form of hereditary colorectal carcinoma. However, establishing the diagnosis of Lynch syndrome is challenging, and ancillary studies that distinguish between sporadic DNA mismatch repair (MMR) protein deficiency and Lynch syndrome are needed, particularly when germline mutation studies are inconclusive. The aim of this study was to determine if MMR protein-deficient non-neoplastic intestinal crypts can help distinguish between patients with and without Lynch syndrome. We ev...

Comparative Effectiveness of Low-Volume Time-Efficient Resistance Training Versus Endurance Training in Patients With Heart Failure.

Cardiorespiratory fitness is positively related to heart failure (HF) prognosis, but lack of time and low energy are barriers for adherence to exercise. We, therefore, compared the effect of low-volume time-based resistance exercise training (TRE) with aerobic moderate-intensity cycling (AMC) on maximal and submaximal exercise capacity, health-related quality of life, and vascular function.

Tumor development in Japanese patients with Lynch syndrome.

Lynch syndrome (LS) patients have a high risk of developing various tumors. This study aimed to clarify the characteristics of tumors developing in LS patients.

Effect of Physical Exercise on Platelet Reactivity in Patients with Dual Antiplatelet Therapy.

It is known that physical exercise may increase platelet activity. However, the effect of exercise on platelet reactivity in patients on dual antiplatelet therapy has not been investigated yet. In our study, 21 patients with coronary artery disease on dual antiplatelet therapy and 10 controls were enrolled. We performed an exercise test using a cycle ergometer and determined the adenosine diphosphate-induced platelet reactivity before and immediately after exercise testing. Additionally, we analysed maximal...

Functional Electrical Stimulation-A new therapeutic approach to enhance exercise intensity in Chronic Obstructive Pulmonary Disease patients : a randomised controlled cross-over trial.

To evaluate the effect of quadriceps Functional Electrical Stimulation (FES)-Cycling on exertional VOcompared with Placebo FES-cycling in patients with COPD.

Is Inspiratory Muscle Weakness a Determinant of Endurance Exercise Tolerance During NIV-Supported Exercise in Patients With COPD?

Previous research has reported that inspiratory muscle weakness is critical to decreased exercise tolerance and exercise tolerance improves with 10 cmH2O pressure support ventilation in patients with chronic obstructive pulmonary disease (COPD). The purpose of this study was to evaluate the effects of proportional assist ventilation (PAV) and continuous positive airway pressure (CPAP) compared with sham on exercise tolerance in patients with and without inspiratory muscle weakness.

Effects of submaximal cycling at different exercise intensities on maximal isometric force output of the non-exercised elbow flexor muscles.

The purpose of this study was to examine the effects of submaximal cycling at different exercise intensities on maximal isometric force output of the non-exercised elbow flexor muscles after the cycling. A total of 8 healthy young men performed multiple maximal voluntary contractions by the right elbow flexion before, immediately after, 5 min after, and 10 min after a 6-min submaximal cycling at ventilatory threshold (LI), 70% [Formula: see text] (MI), and 80% [Formula: see text] (HI) with both arms relax...

Promotion of Home-Based Exercise Training as Secondary Prevention of Coronary Heart Disease: A PILOT WEB-BASED INTERVENTION.

Although cardiac rehabilitation (CR) is cost-effective in improving the health of patients with coronary heart disease (CHD), less than half of eligible CHD patients attend a CR program. Innovative web-based technologies might improve CR delivery and utilization. We assessed the feasibility and impact on functional capacity and secondary prevention targets of a long-term web-monitored exercise-based CR maintenance program.

Intact regulation of muscle expression and circulating levels of myokines in response to exercise in patients with type 2 diabetes.

Regular exercise plays an important role in the prevention and treatment of type 2 diabetes (T2D). The synthesis and secretion of myokines in response to contraction may contribute to the beneficial metabolic effects of exercise. However, some exercise-induced responses may be attenuated in T2D. Here, we investigated whether the effect of acute exercise on selected myokines are impaired in T2D. Skeletal muscle biopsies and blood samples were obtained from 13 men with T2D and 14 weight-matched, glucose-toler...

Routine molecular analysis for Lynch syndrome among adenomas or colorectal cancer within a national screening program.

It is important to identify individuals with Lynch syndrome because surveillance programs can reduce their morbidity and mortality from colorectal cancer (CRC). We assessed the diagnostic yield of immunohistochemistry to detect Lynch syndrome in patients with advanced and multiple adenomas within our national CRC screening program.

Impact of a Graded Exercise Program on VO2peak and Survival in Heart Failure Patients.

Although exercise therapy has the potential to improve health outcomes of patients with Chronic Heart Failure (CHF), less than 50% of patients adhere to prescribed physical activity guidelines one year after Cardiac Rehabilitation (CR). We aimed to assess the effects of an extended CR program with 12-months of Graded Exercise Therapy (GET) and resistance exercise training (RT) on exercise capacity and long-term survival in patients with CHF.

Examination of A Multi-Ingredient Pre-Workout Supplement on Total Volume of Resistance Exercise and Subsequent Strength and Power Performance.

This study examined the acute effects of a multi-ingredient pre-workout supplement on: 1) total, lower, and upper body volume of resistance exercise; and 2) the subsequent lower body strength (isokinetic leg extension and flexion), lower (vertical jump [VJ] height), upper body power (bench-throw velocity [BTv]), and cycle ergometry performance (critical power [CP] and anaerobic work capacity [AWC]). Twelve men completed baseline strength and power measures prior to two experimental visits, supplement (SUP) ...

Effects of intradialytic cycling exercise on exercise capacity, quality of life, physical function and cardiovascular measures in adult haemodialysis patients: a systematic review and meta-analysis.

Intradialytic cycling (IDC), delivered during haemodialysis (HD), has the potential to improve many health issues. This systematic review and meta-analysis examine the evidence on the effects of IDC on exercise capacity, quality of life (QoL), physical function and cardiovascular health.

Characterizing the plasma metabolome during and following a maximal exercise cycling test.

While complex in nature, a number of metabolites have been implicated in the onset of exercise-induced fatigue. The purpose of this study was to identify changes in the plasma-metabolome and specifically, identify candidate-metabolites associated with the onset of fatigue during prolonged cycling. Eighteen healthy and recreationally active men (mean{plus minus}SD age: 24.7{plus minus}4.8 years; mass 67.1{plus minus}6.1 kg; BMI: 22.8{plus minus}2.2; VO: 40.9{plus minus}6.1 were recruited to this s...

Cycling injury risk in London: A case-control study exploring the impact of cycle volumes, motor vehicle volumes, and road characteristics including speed limits.

Cycling injury risk is an important topic, but few studies explore cycling risk in relation to exposure. This is largely because of a lack of exposure data, in other words how much cycling is done at different locations. This paper helps to fill this gap. It reports a case-control study of cycling injuries in London in 2013-2014, using modelled cyclist flow data alongside datasets covering some characteristics of the London route network. A multilevel binary logistic regression model is used to investigate ...

The exaggerated blood pressure response to exercise in the sub-acute phase after stroke is not affected by aerobic exercise.

The prevalence of an exaggerated exercise blood pressure (BP) response is unknown in patients with subacute stroke, and it is not known whether an aerobic exercise program modulates this response. The authors randomized 53 patients (27 women) with subacute stroke to 12 weeks of twice-weekly aerobic exercise (n = 29) or to usual care without scheduled physical exercise (n = 24). At baseline, 66% of the patients exhibited an exaggerated exercise BP response (peak systolic BP ≥210 mm Hg in men and ≥...

How Do the Mechanical Demands of Cycling Affect the Information Content of the EMG?

The persistence of phase-related information in EMG signals can be quantified by its entropic half-life, EnHL. It has been proposed that the EnHL would increase with the demands of a movement task, and thus increase as the pedalling power increased during cycling. However, simulation work on the properties of EMG signals suggests that the EnHL depends on burst duration and duty cycle in the EMG that may not be related to task demands. This study aimed to distinguish between these alternate hypotheses.

Molecular subtype classification of urothelial carcinoma in Lynch syndrome.

Lynch syndrome confers an increased risk for urothelial carcinoma (UC). Molecular subtypes may be relevant to prognosis and therapeutic possibilities, but have to date not been defined in Lynch syndrome-associated urothelial cancer. We aimed to provide a molecular description of Lynch syndrome-associated UC. Thus, Lynch syndrome-associated UC of the upper urinary tract and the urinary bladder were identified in the Danish hereditary non-polyposis colorectal cancer (HNPCC) register and were transcriptionally...

Effect of pre-exercise carbohydrate availability on fat oxidation and energy expenditure after a high-intensity exercise.

The aim of this study was to test the hypothesis that reduced pre-exercise carbohydrate (CHO) availability potentiates fat oxidation after an exhaustive high-intensity exercise bout. Eight physically active men underwent a high-intensity exercise (∼95% V̇O2max) until exhaustion under low or high pre-exercise CHO availability. The protocol to manipulate pre-exercise CHO availability consisted of a 90-min cycling bout at ∼70% V̇O2max + 6 × 1-min at 125% V̇O2max with 1-min rest, followed by 48 h under ...

Measurement of postprandial glucose fluxes in response to acute and chronic endurance exercise in healthy humans.

The effect of endurance exercise on enhancing insulin sensitivity and glucose flux has been well established with techniques such as the hyperinsulinemic clamp. Although informative, such techniques do not emulate the physiological postprandial state, and it remains unclear how exercise improves postprandial glycaemia. Accordingly, combining mixed meal tolerance testing and the triple-stable isotope glucose tracer approach, glucose fluxes (rates of meal glucose appearance (Ra), disposal (Rd) and endogenous ...

Feasibility and effects of intra-dialytic low-frequency electrical muscle stimulation and cycle training: A pilot randomized controlled trial.

Exercise capacity is reduced in chronic kidney failure (CKF). Intra-dialytic cycling is beneficial, but comorbidity and fatigue can prevent this type of training. Low-frequency electrical muscle stimulation (LF-EMS) of the quadriceps and hamstrings elicits a cardiovascular training stimulus and may be a suitable alternative. The main objectives of this trial were to assess the feasibility and efficacy of intra-dialytic LF-EMS vs. cycling.

No Difference in Colorectal Cancer Incidence or Stage at Detection by Colonoscopy Among 3 Countries With Different Lynch Syndrome Surveillance Policies.

Patients with Lynch syndrome are at high risk for developing colorectal cancer (CRC). Regular colonoscopic surveillance is recommended, but there is no international consensus on the appropriate interval. We investigated whether shorter intervals are associated with lower CRC incidence and detection at earlier stages by comparing the surveillance policies in Germany, which evaluates patients by colonoscopy annually, in the Netherlands (patients evaluated at 1-2-year intervals), and Finland (patients evaluat...

Influence of Disease Severity and Exercise Limitation on Exercise Training Intensity and Load and Health Benefits From Pulmonary Rehabilitation in Patients with COPD: AN EXPLORATORY STUDY.

Some patients with chronic obstructive pulmonary disease (COPD) fail to achieve health benefits with pulmonary rehabilitation (PR). Exercise intensity and load represent stimulus for adaptation but it is unclear whether inappropriate exercise intensity and/or load are affected by severity of COPD, which may affect health benefits. The purpose was to determine whether COPD severity and/or the severity of pulmonary limitation to exercise (PLE) impacted exercising intensity or load and whether resultant intens...

Acute High-Intensity Interval Cycling Improves Postprandial Lipid Metabolism.

To examine the effects of 2 exercise regimes on physiological and postprandial lipemic responses.

Maintenance of serum ionized calcium during exercise attenuates parathyroid hormone and bone resorption responses.

Exercise can cause a decrease in serum ionized calcium (iCa) and increases in parathyroid hormone (PTH) and bone resorption. We used a novel intravenous iCa clamp technique to determine whether preventing a decline in serum iCa during exercise prevents increases in PTH and carboxy-terminal collagen crosslinks (CTX). Eleven cycling-trained men (aged 18-45 y) underwent two identical 60-minute cycling bouts with infusion of Ca gluconate or saline. Blood sampling for iCa, total calcium (tCa), PTH, CTX, and proc...

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