PubMed Journals Articles About "CYCling Lynch Patients For Exercise And Prevention: CYCLE-P" RSS

02:24 EST 14th December 2018 | BioPortfolio

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Showing "CYCling Lynch Patients Exercise Prevention CYCLE" PubMed Articles 1–25 of 41,000+

DNA mismatch repair protein deficient non-neoplastic colonic crypts: a novel indicator of Lynch syndrome.

Lynch syndrome is the most common form of hereditary colorectal carcinoma. However, establishing the diagnosis of Lynch syndrome is challenging, and ancillary studies that distinguish between sporadic DNA mismatch repair (MMR) protein deficiency and Lynch syndrome are needed, particularly when germline mutation studies are inconclusive. The aim of this study was to determine if MMR protein-deficient non-neoplastic intestinal crypts can help distinguish between patients with and without Lynch syndrome. We ev...

Anaerobic capacity estimated by the sum of both oxygen equivalents from the glycolytic and phosphagen pathways is dependent on exercise mode: Running versus cycling.

The purpose of this study was to verify whether the exercise modality (i.e., running and cycling) alters the magnitude of "anaerobic" capacity estimated by a single supramaximal effort (AC[La]+EPOCfast). Fourteen healthy men (age: 26±9 years) underwent a maximum incremental test and a supramaximal effort to exhaustion at 115% of the intensity associated with maximal oxygen uptake to determine the AC[La]+EPOCfast (i.e., the sum of both oxygen equivalents from the glycolytic and phosphagen pathways), perform...

Effect of Physical Exercise on Platelet Reactivity in Patients with Dual Antiplatelet Therapy.

It is known that physical exercise may increase platelet activity. However, the effect of exercise on platelet reactivity in patients on dual antiplatelet therapy has not been investigated yet. In our study, 21 patients with coronary artery disease on dual antiplatelet therapy and 10 controls were enrolled. We performed an exercise test using a cycle ergometer and determined the adenosine diphosphate-induced platelet reactivity before and immediately after exercise testing. Additionally, we analysed maximal...

Pilot randomized controlled trial of functional electrical stimulation cycling exercise in people with multiple sclerosis with mobility disability.

Exercise training has been shown to be beneficial for persons with multiple sclerosis (MS). Adapted exercise modalities are needed to accommodate those with severe mobility impairment (Expanded Disability Status Scale [EDSS] scores 5.5-6.5). Functional electrical stimulation (FES) cycling is one such exercise modality; however, few studies have examined the feasibility and potential benefits of FES cycling for people with MS with severe mobility impairment.

Promotion of Home-Based Exercise Training as Secondary Prevention of Coronary Heart Disease: A PILOT WEB-BASED INTERVENTION.

Although cardiac rehabilitation (CR) is cost-effective in improving the health of patients with coronary heart disease (CHD), less than half of eligible CHD patients attend a CR program. Innovative web-based technologies might improve CR delivery and utilization. We assessed the feasibility and impact on functional capacity and secondary prevention targets of a long-term web-monitored exercise-based CR maintenance program.

Effects of submaximal cycling at different exercise intensities on maximal isometric force output of the non-exercised elbow flexor muscles.

The purpose of this study was to examine the effects of submaximal cycling at different exercise intensities on maximal isometric force output of the non-exercised elbow flexor muscles after the cycling. A total of 8 healthy young men performed multiple maximal voluntary contractions by the right elbow flexion before, immediately after, 5 min after, and 10 min after a 6-min submaximal cycling at ventilatory threshold (LI), 70% [Formula: see text] (MI), and 80% [Formula: see text] (HI) with both arms relax...

Physiological Responses and Prognostic Value of Common Exercise Testing Modalities in Idiopathic Pulmonary Fibrosis.

This pilot study aimed to compare physiological responses between cycle cardiopulmonary exercise tests (CPETs) and 6-min walk tests (6MWTs) and to assess their prognostic value among patients with idiopathic pulmonary fibrosis (IPF).

Intact regulation of muscle expression and circulating levels of myokines in response to exercise in patients with type 2 diabetes.

Regular exercise plays an important role in the prevention and treatment of type 2 diabetes (T2D). The synthesis and secretion of myokines in response to contraction may contribute to the beneficial metabolic effects of exercise. However, some exercise-induced responses may be attenuated in T2D. Here, we investigated whether the effect of acute exercise on selected myokines are impaired in T2D. Skeletal muscle biopsies and blood samples were obtained from 13 men with T2D and 14 weight-matched, glucose-toler...

Vastly Different Exercise Programs Similarly Improve Parkinsonian Symptoms: A Randomized Clinical Trial.

To directly compare the effects of agility exergaming (EXE) and stationary cycling (CYC) exercise training on Parkinson's disease (PD) patients' mobility and clinical symptoms.

Routine molecular analysis for Lynch syndrome among adenomas or colorectal cancer within a national screening program.

It is important to identify individuals with Lynch syndrome because surveillance programs can reduce their morbidity and mortality from colorectal cancer (CRC). We assessed the diagnostic yield of immunohistochemistry to detect Lynch syndrome in patients with advanced and multiple adenomas within our national CRC screening program.

Impact of a Graded Exercise Program on VO2peak and Survival in Heart Failure Patients.

Although exercise therapy has the potential to improve health outcomes of patients with Chronic Heart Failure (CHF), less than 50% of patients adhere to prescribed physical activity guidelines one year after Cardiac Rehabilitation (CR). We aimed to assess the effects of an extended CR program with 12-months of Graded Exercise Therapy (GET) and resistance exercise training (RT) on exercise capacity and long-term survival in patients with CHF.

Injury prevention class exercise: three-pronged list making.

It is difficult to find classroom exercises that have been specifically designed for injury prevention students. The suggested list-making classroom exercise forces students to recognise and devise many policy and programmatic options over and above the ones that normally spring to mind. Most important, it helps give students a better understanding of what is meant by, and the potential usefulness of, the public health approach to injury prevention.

Protein intake in the early recovery period after exhaustive exercise improves performance the following day.

The aim of the present study was to investigate the effect of protein and carbohydrate ingestion during early recovery from exhaustive exercise on performance after 18 h recovery. Eight elite cyclists (VO 74.0±1.6 ml∙kg∙min) completed two exercise and diet interventions in a double-blinded, randomized, crossover design. Participants cycled first at 73% of VO (W73%) followed by one-min intervals at 90% of VO until exhaustion. During the first two hours of recovery, participants ingested either 1.2 g car...

Characterizing the plasma metabolome during and following a maximal exercise cycling test.

While complex in nature, a number of metabolites have been implicated in the onset of exercise-induced fatigue. The purpose of this study was to identify changes in the plasma-metabolome and specifically, identify candidate-metabolites associated with the onset of fatigue during prolonged cycling. Eighteen healthy and recreationally active men (mean{plus minus}SD age: 24.7{plus minus}4.8 years; mass 67.1{plus minus}6.1 kg; BMI: 22.8{plus minus}2.2; VO: 40.9{plus minus}6.1 were recruited to this s...

Home-Based, Moderate-Intensity Exercise Training Using a Metronome Improves the Breathing Pattern and Oxygen Saturation During Exercise in Patients With COPD.

One of the well-known but less-investigated effects of pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD) is the change in breathing pattern toward a more efficient one (higher tidal volume [VT], lower breathing frequency). Evidence suggests this change can be obtained only with supervised, high-intensity exercise training (ExTr). However, some patients either do not have such programs available or are unable to exercise at higher intensity. We evaluated the effects of a ...

The Intra-rater and Inter-rater Reliability of measures derived from Cardiopulmonary Exercise Testing (CPET) in patients with Abdominal Aortic Aneurysms (AAA).

Patients with abdominal aortic aneurysms (AAA) often have low exercise tolerance due to comorbidities and advance age. Cardiopulmonary exercise testing (CPET) is predictive of post-operative morbidity and mortality in patients with AAA. We aimed to assess the intra- and inter-rater reliability of both treadmill and cycle ergometer based CPET variables.

Moderate-Intensity Arm-cranking Exercise May not Improve Arterial Function in Healthy Adult Men.

Endurance exercises, such as cycling or running, are useful for improving arterial function. However, people suffering from partial paralysis or arthritis are unable to perform these kinds of lower-limb exercises. In the present study, we explored the acute effect of upper-arm exercise on arterial stiffness in healthy men. Fourteen healthy adult men performed two experimental trials. The order of experiments was randomized between a 30-min arm-cranking exercise at 50% V̇O (A-trial) and a 30-min leg-cycling...

Clinicopathological features of breast cancer in Japanese female patients with Lynch syndrome.

Lynch syndrome (LS) is a predominantly inherited syndrome caused by a pathological germline mutation in one of the mismatch repair (MMR) genes. Whether breast cancer (BC) is one of the LS-associated tumors is controversial. The aim of this retrospective cohort study was to evaluate the clinical features of BC in Japanese patients with LS.

Molecular subtype classification of urothelial carcinoma in Lynch syndrome.

Lynch syndrome confers an increased risk for urothelial carcinoma (UC). Molecular subtypes may be relevant to prognosis and therapeutic possibilities, but have to date not been defined in Lynch syndrome-associated urothelial cancer. We aimed to provide a molecular description of Lynch syndrome-associated UC. Thus, Lynch syndrome-associated UC of the upper urinary tract and the urinary bladder were identified in the Danish hereditary non-polyposis colorectal cancer (HNPCC) register and were transcriptionally...

How Do the Mechanical Demands of Cycling Affect the Information Content of the EMG?

The persistence of phase-related information in EMG signals can be quantified by its entropic half-life, EnHL. It has been proposed that the EnHL would increase with the demands of a movement task, and thus increase as the pedalling power increased during cycling. However, simulation work on the properties of EMG signals suggests that the EnHL depends on burst duration and duty cycle in the EMG that may not be related to task demands. This study aimed to distinguish between these alternate hypotheses.

Exercise as a diagnostic and therapeutic tool for the prevention of cardiovascular dysfunction in breast cancer patients.

Anthracycline chemotherapy may be associated with decreased cardiac function and functional capacity measured as the peak oxygen uptake during exercise ([Formula: see text] peak). We sought to determine (a) whether a structured exercise training program would attenuate reductions in [Formula: see text] peak and (b) whether exercise cardiac imaging is a more sensitive marker of cardiac injury than the current standard of care resting left ventricular ejection fraction (LVEF).

No Difference in Colorectal Cancer Incidence or Stage at Detection by Colonoscopy Among 3 Countries With Different Lynch Syndrome Surveillance Policies.

Patients with Lynch syndrome are at high risk for developing colorectal cancer (CRC). Regular colonoscopic surveillance is recommended, but there is no international consensus on the appropriate interval. We investigated whether shorter intervals are associated with lower CRC incidence and detection at earlier stages by comparing the surveillance policies in Germany, which evaluates patients by colonoscopy annually, in the Netherlands (patients evaluated at 1-2-year intervals), and Finland (patients evaluat...

Feasibility and effects of intra-dialytic low-frequency electrical muscle stimulation and cycle training: A pilot randomized controlled trial.

Exercise capacity is reduced in chronic kidney failure (CKF). Intra-dialytic cycling is beneficial, but comorbidity and fatigue can prevent this type of training. Low-frequency electrical muscle stimulation (LF-EMS) of the quadriceps and hamstrings elicits a cardiovascular training stimulus and may be a suitable alternative. The main objectives of this trial were to assess the feasibility and efficacy of intra-dialytic LF-EMS vs. cycling.

Menstrual Cycle Phase Does Not Modulate Whole-Body Heat Loss during Exercise in Hot, Dry Conditions.

Menstrual cycle phase has long been thought to modulate thermoregulatory function. However, information pertaining to the effects of menstrual phase on time-dependent changes in whole-body dry and evaporative heat exchange during exercise-induced heat stress and the specific heat load at which menstrual phase modulates whole-body heat loss remained unavailable. We therefore used direct calorimetry to continuously assess whole-body dry and evaporative exchange in twelve habitually active, non-endurance train...

Deception of cycling distance on pacing strategies, perceptual responses, and neural activity.

Pacing during exercise performance is well-established; however, little is known about the neural responses associated with changes in power output and the effect of exercise end-point knowledge. Therefore, the aim of this study was to examine the effect of deception of cycling distance on pacing, cerebral oxy- (OHb) and deoxy-haemoglobin concentrations, and alpha (α) wave activity. Ten well-trained male cyclists (23.7 ± 6.6 years) completed three cycling time trials (TT) on a stationary air-braked c...

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