PubMed Journals Articles About "Calixar Partners With Regeneron Antibody Research" RSS

07:47 EDT 20th September 2019 | BioPortfolio

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Showing "Calixar partners with Regeneron antibody research" PubMed Articles 1–25 of 26,000+

Subcutaneous immunotherapy in patients with eosinophilic esophagitis.

Dr. Dellon is a consultant for Adare, Alivio, Allakos, Banner, Calypso, Enumeral, EsoCap, GSK, Gossamer Bio, Receptos/Celegene, Regeneron, Robarts, and Shire, receives research funding from Allakos, Adare, GSK, Meritage, Miraca, Nutricia, Receptos/Celgene, Regeneron, and Shire, and has received an educational grant from Allakos, Banner, and Holoclara. None of the other authors report and potential conflicts of interest with this study.

The Future Of Omics For Clinical Practice.

Dr. Kari Nadeau: Dr. Nadeau receives grant support from NIAID, Food Allergy Research & Education (FARE), End Allergies Together, Allergenis, Ukko; personal Fees from Regeneron, AstraZeneca, ImmuneWorks, Cour; sponsored research from Novartis, Sanofi, Astellas, Nestle; Sponsored research for clinical trials from Genentech, Aimmune Therapeutics, DBV Technologies, AnaptysBio, Stallergenes-Greer, Regeneron, and Adare Pharmaceuticals; Data and Safety Monitoring Board member at Novartis and NHLBI; co-founded Befo...

Advance in research on recycling antibody.

Monoclonal antibodies have become the main type of antibody drug because of their high specificity and strong affinity to antigen. However, with the intensive study of the natural monoclonal antibody, many defects have faced, such as the limit times of binding to antigen, the unanticipated antibody clearance and antigen accumulation. Therefore, studies are no longer limited to the natural antibody screening, but rather to improve the efficiency of antibody drugs by engineering. In recent years, the bottlene...

Production of polyclonal antibody against human Neuritin and its application of immunodetection.

To date, a commercial antibody to human Neuritin for immunoprecipitation is still limited. In this study, we aimed to develop a specific antibody for further research on the potential function of Neuritin.

'Man in the driving seat': a grounded theory study of the psychosocial experiences of Black African and Black Caribbean men treated for prostate cancer and their partners.

Evidence suggests that treatment side-effects of prostate cancer (CaP) substantially affect the psychosocial well-being of affected men and their partners. However, this phenomenon is poorly understood among high risk (1 in 4) Black African (BA)/Black Caribbean (BC) men and their partners as they are currently under-represented in global research on CaP survivorship. This study explored the psychosocial experiences of BA/BC men with CaP and their partners in the United Kingdom as they lived through the side...

Adolescents' Contraceptive Use with School-Discordant Partners: Exploring Individual- and Relationship-Level Characteristics.

Heterosexual adolescents are less likely to use contraceptives when their partners are of different backgrounds or social circles. It is unclear why risky behaviors are more common within these relationships, and characteristics associated with school-discordant partners-that is, partners who do not attend the adolescent's school-are particularly understudied.

Controlling the viscosities of antibody solutions through control of their binding sites.

For biotechnological drugs, it is desirable to formulate antibody solutions with low viscosities. We go beyond previous colloid theories in treating protein-protein self-association of molecules that are antibody-shaped and flexible and have spatially specific binding sites. We consider interactions either through fragment antigen (Fab-Fab) or fragment crystalizable (Fab-Fc) binding. Wertheim's theory is adapted to compute the cluster-size distributions, viscosities, second virial coefficients, and Huggins ...

NIH-Funded CBPR: Self-Reported Community Partner and Investigator Perspectives.

The community-based participatory research (CBPR) approach across health contexts has matured greatly over the last 20 years. Though contributions to the literature on the development and effectiveness of CBPR interventions have grown, the number of publications on the function and evaluation of actual community-research partnerships has not kept pace. To help address that gap, we searched National Institutes of Health archival data and identified a set of 489 CBPR projects including collaboration-building...

ICER Can Do Better for Patients.

No outside funding supported the writing of this article. Mendez is president and CEO of the Asthma and Allergy Foundation of America, which receives greater than 25% of its funding to produce educational materials and for patient research through grants from pharmaceutical companies, including AstraZeneca, Genentech, GSK, Sanofi/Regeneron, and Teva.

Leveraging Patient/Community Partnerships to Disseminate Patient Centered Outcomes Research in Geriatrics.

With the growth of patient-centered outcomes research (PCOR), partnerships between researchers and patients have presented novel opportunities for disseminating results. A large gap exists in disseminating patient-centered research results to older adult patient end-users. We sought to examine the experiences of patient/community partners in disseminating PCOR results and characterize lessons learned that may facilitate future researcher-patient/community dissemination partnerships. Patient/community partn...

Identity, Couple and Intergroup Dynamics in Intercultural Families: Implications on Life Satisfaction of Partners.

The current study analyzed how identity, couple, and intergroup dynamics are related to life satisfaction among 210 intercultural partners living in Italy. Three levels of analysis were considered: a micro level, taking into account the identity aspect of each partner in terms of self- or hetero-ethnic identification; a meso level, examining the passion, commitment, and intimacy of the couple sphere of the partners; a macro level investigating the discrimination that partners can perceive by the community a...

Psychological interventions targeting partners of cancer patients: A systematic review.

Cancer patients' intimate partners often experience levels of psychological burden that are comparable to or even exceed that of the patients, making it imperative that they too be provided with appropriate psychological support. This review aimed to present the content and the effects of interventions delivered to caregiving partners of cancer patients on both partners and patients. Furthermore, we provide information about the acceptability of the interventions and study quality.

A Scoping Review of the Involvement of Children's Communication Partners in Aided Augmentative and Alternative Communication Modeling Interventions.

Purpose The purpose of this study was to inform practice and research by identifying and synthesizing research on interventions in which natural communication partners implemented aided augmentative and alternative communication (AAC) modeling strategies. Method A scoping review yielded 29 studies. Data were charted related to participant characteristics, intervention characteristics, partner instruction and assessment, and partner perspectives of social validity. Results More than 157 peer and 100 adult co...

Interethnic Bias in Willingness to Engage in Casual Sex Versus Committed Relationships.

Interethnic romantic relationships are widely seen as a strong indicator of a well-integrated society. However, racial bias may still be evident in the tendency to engage in casual sex versus committed relationships. Using a large, age-diverse sample of 3,453 White British participants, this study found a general preference for White partners over racial minority partners. Furthermore, in line with social structural theory, participants reported a relative preference for marriage (versus casual sex) with Wh...

Assessment of the information sources and interest in research collaboration among individuals with Vascular Ehlers-Danlos Syndrome.

Patient centered research requires active engagement of patients. The Vascular Ehlers-Danlos Syndrome (vEDS) research collaborative was established to ascertain patient-centered vEDS research priorities and to engage affected individuals as research partners. Evaluation of access to information and interest in research among individuals with vEDS was the first step undertaken as part of this work.

Relationship Satisfaction of Intimate Partners of Persons Living With Urinary Incontinence.

The purpose of this study was to examine effects of urinary incontinence (UI) on midlife women's relationships with their intimate partners, from the perspective of both women and their partners.

Taking active steps: Changes made by partners of people with multiple sclerosis who undertake lifestyle modification.

Multiple sclerosis (MS), a demyelinating condition of the central nervous system with an unpredictable course, has a major impact on the lives of people with MS. Partners of people with MS may be significantly affected by the diagnosis, management and uncertainty around disease progression and may provide substantial support and care. Modification of lifestyle risk factors in conjunction with standard medical management has been associated with improved physical and mental quality of life. Adopting major li...

Immunophenotyping Using Dried and Lyophilized Reagents.

Antibody reagents that are used for flow cytometry immunophenotyping have traditionally been prepared by combining individual liquid antibody conjugates into mixtures. These cocktails have limited shelf-life, and their preparation is time-consuming and prone to laboratory error. Manufacturers of these reagents, in collaboration with several clinical and research centers, have made advances in constructing dried antibody cocktails which have addressed many of the problems inherent in preparing the liquid coc...

Applying Relational Turbulence Theory to Adult Caregiving Relationships.

Although the quality of the relationship between caregivers and care recipients predicts the well-being of both people, gaps exist in understanding the interpersonal dynamics of adult caregiving. We introduce relational turbulence theory as a conceptual framework for understanding how caregivers and care recipients relate to each other. We searched for research on relational turbulence theory as well as research on the relationships of adult care partners. Then, we integrated the two bodies of work. Our rev...

HIV Disclosure: HIV-positive status disclosure to sexual partners among individuals receiving HIV care in Addis Ababa, Ethiopia.

Disclosure of HIV status to sexual partners can help HIV prevention efforts and enable HIV positive people to receive social support, as well as increasing access and adherence to treatment. This study was conducted to determine the rate, processes, outcomes, and correlates of HIV status disclosure to sexual partners among HIV positive individuals.

Vamorolone, a dissociative steroidal compound, reduces collagen antibody-induced joint damage and inflammation when administered after disease onset.

The objective of this study was to assess the effect of vamorolone, a first-in-class dissociative steroidal compound, to inhibit inflammation when administered after disease onset in the murine collagen antibody-induced arthritis model of arthritis.

How Workplace Bullying Relates to Facades of Conformity and Work-Family Conflict: The Mediating Role of Psychological Strain.

This study examined the effects of workplace bullying on facades of conformity in the work domain and on work-family conflict in the family domain. In this research, workplace bullying is seen as a reality in organizations, and this study considers individuals' judgments concerning various features of their workplace situations. Employees' experiences of workplace bullying influence their creation of facades of conformity and crosses over to influence their partners' family life through psychological strain...

A rapid and quantitative technique for assessing IgG monomeric purity, calibrated with the NISTmAb reference material.

The fraction of intact monomer in a sample (moles/moles), the monomeric purity, is measured as a quality control in therapeutic monoclonal antibodies but is often unknown in research samples and remains a major source of variation in quantitative antibody-based techniques such as immunoassay development. Here, we describe a novel multiplex technique for estimating the monomeric purity and antigen affinity of research grade antibody samples. Light scattering was used to simultaneously observe the mass of ant...

Alteration of Physicochemical Properties for Antibody Drug Conjugates and Their Impact on Stability.

Antibody conjugates, in particular antibody drug conjugates (ADC), are a fast-growing area in research and in the pharmaceutical industry. The covalent attachment of an antibody to a chemical moiety can be an effective measure for drug targeting or can also positively impact pharmacokinetics of small molecular compounds by serum half-life extension. Stability, physicochemical properties and degradation pathways of biotherapeutics or small molecule therapeutics are often not totally known and understood. How...

Role of the partner/spouse in melanoma discovery and related health behaviors and practices.

Spouses and partners play a key role in early melanoma detection. We surveyed newly-diagnosed patients with primary invasive cutaneous melanoma and their spouses/partners regarding melanoma-related health behaviors to investigate the partners' role in earlier detection. This article is protected by copyright. All rights reserved.

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