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PubMed Journals Articles About "Catalent Present Drug Delivery Formulation Patient Focused Drug" RSS

08:46 EDT 25th September 2018 | BioPortfolio

Catalent Present Drug Delivery Formulation Patient Focused Drug PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Catalent Present Drug Delivery Formulation Patient Focused Drug articles that have been published worldwide.

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Showing "Catalent Present Drug Delivery Formulation Patient Focused Drug" PubMed Articles 1–25 of 42,000+

Basics of Compounding--Nonsterile: Compounding Self-emulsifying Drug Delivery Systems and Other Self-emulsifying Lipid Formulations, Part 2.

Self-emulsifying Drug Delivery Systems are being introduced and are increasing in popularity for improving the solubility of lipophilic drugs. They are isotropic mixtures of drug, oil, surfactant and/or cosurfactant, and sometimes cosolvents. There is some overlap of this discussion in the March-April 2018 issue of the International Journal of Pharmaceutical Compounding in an article on the discussion of microemulsions. Self-emulsifying Drug Delivery Systems can be orally administered in hard-gelatin capsul...


Basics of Compounding-Nonsterile: Compounding Self-emulsifying Drug Delivery Systems and Other Self-emulsifying Lipid Formulations, Part 1.

Self-emulsifying Drug Delivery Systems are being introduced and are increasing in popularity for improving the solubility of lipophilic drugs. They are isotropic mixtures of drug, oil, surfactant and/or cosurfactant, and sometimes cosolvents. There is some overlap of this discussion in the March-April 2018 issue of the International Journal of Pharmaceutical Compounding in an article on the discussion of microemulsions. Self-emulsifying Drug Delivery Systems can be orally administered in hard-gelatin capsul...

Formulation Design and Optimization of Novel Soft Glycerosomes for Enhanced Topical Delivery of Celecoxib and Cupferron by Box-Behnken Statistical Design.

The present study describes glycerosomes (vesicles composed of phospholipids, glycerol and water) as a novel drug delivery system for topical application of celecoxib (CLX) and cupferron (CUP) compound.


Protein-Polymer Delivery: Chemistry from the Cold Chain to the Clinic.

Drug delivery is commonly thought of as the performance of a drug in vivo. Rather, the process of drug delivery can comprise of the journey of the drug from manufacturer to clinic, clinic to patient, patient to disease. Each step of the journey includes hurdles that must be overcome for the therapeutic to be successful. Recent developments in proteinaceous therapeutics have made the success-ful completion of this journey even more important because of the relatively fragile nature of proteins in a drug deli...

3D printed drug delivery and testing systems - a passing fad or the future?

The US Food and Drug Administration approval of the first 3D printed tablet in 2015 has ignited growing interest in 3D printing, or additive manufacturing (AM), for drug delivery and testing systems. Beyond just a novel method for rapid prototyping, AM provides key advantages over traditional manufacturing of drug delivery and testing systems. These includes the ability to fabricate complex geometries to achieve variable drug release kinetics; ease of personalising pharmacotherapy for patient and lowering t...

The role of formulation and follicular pathway in voriconazole cutaneous delivery from liposomes and nanostructured lipid carriers.

In general, colloids provide increased cutaneous permeation of drugs. Still, skin interaction and main pathways for drug diffusion may vary depending on system and formulation characteristics. The knowledge of how different colloidal systems interact with biological membranes and the formulation impact on delivery is especially relevant for drugs that can be encapsulated in multiple nanosystems, as voriconazole (VOR). In here, we compared VOR release and permeation profile from liposomes (LP) and nanostruct...

Patient centric drug product design in modern drug delivery as an opportunity to increase safety and effectiveness.

The advances in drug delivery technologies have enabled pharmaceutical scientists to deliver a drug through various administration routes and optimize the drug release and absorption. The wide range of drug delivery systems and dosage forms represent a toolbox of technology for the development of pharmaceutical drug products but might also be a source of medication errors and nonadherence. Patient centric drug product development is being suggested as an important factor to increase therapeutic outcomes. Ar...

Supersaturation Potential of Ordered Mesoporous Silica Delivery Systems. Part 1: Dissolution Performance and Drug Membrane Transport Rates.

Ordered mesoporous silica materials have shown great potential as oral drug delivery systems for poorly soluble drugs. However, the ability of these delivery systems to generate drug supersaturation has not been widely investigated, and the recently noted phenomenon of incomplete drug release is not well understood. Therefore, the aim of this study was to comprehensively evaluate the release of hydrophobic drug molecules into solution from ordered mesoporous silica, focusing on the extent and duration of dr...

Recent advance of nanoparticle-based topical drug delivery to the posterior segment of the eye.

Considering that the number of patients afflicted by posterior eye diseases is increasing, effective drug delivery to the posterior segment is currently in high clinical demand. Topical administration has been identified as the preferred option, while suffering from multiple drainage and biological barriers. The development of nanoparticle-based drug delivery system provides an option to overcome the limitation of conventional strategies, which would enhance the drug permeability across the barriers and ach...

Synthesis of an oleic acid based pH-responsive lipid and its application in nanodelivery of vancomycin.

Stimuli-responsive nano-drug delivery systems can optimize antibiotic delivery to infection sites. Identifying novel lipids for pH responsive delivery to acidic conditions of infection sites will enhance the performance of nano-drug delivery systems. The aim of the present investigation was to synthesize and characterize a biosafe novel pH-responsive lipid for vancomycin delivery to acidic conditions of infection sites. A pH-responsive solid lipid, N-(2-morpholinoethyl) oleamide (NMEO) was synthesized and u...

EGF receptor targeted methotrexate and siRNA co-delivery.

Developing new drug delivery carriers addressing chemoresistance is still full of challenges and opportunities. As the rapid development of small interfering RNA (siRNA) provides promising therapeutic perspectives, nanocarriers for drug and siRNA co-delivery present new alternatives for cancer therapy.

Development of pH-Dependent Nanospheres for Nebulisation- In vitro Diffusion, Aerodynamic and Cytotoxicity Studies.

The aim of this work was to evaluate the in vitro performance of nebulized nanosuspension formulation when nebulized using ultrasonic nebulizer. The present investigation deals with successful formulation of Beclomethasone dipropionate loaded HPMCP nanospheres prepared by solvent evaporation technique using PEG 400 as a stabilizer. Beclomethasone dipropionate is a water insoluble drug molecule was encapsulated in HPMCP nanospheres to have pH dependent solubility at basic pH for targeted drug delivery in lun...

An overview of polymeric dosage forms in buccal drug delivery: State of art, design of formulations and their in vivo performance evaluation.

Owing to the ease of the administration, the oral cavity is an attractive site for the delivery of drugs. The main difficulty for administration via the buccal route is an effective physiological removal mechanism of the oral cavity that takes way the formulation from the buccal site and decreases the bioavailability of drugs. The use of mucoadhesive polymers in buccal drug delivery shows assessing buccal drug permeation and absorption, however some studies bring an in vivo performance. This review points t...

How to measure release from nanosized carriers?

Novel drug delivery systems exhibit great potential in the formulation of poorly soluble compounds but also reduce the side effects of highly active drug molecules. Despite all efforts, there are only few technologies available to investigate the in vitro release of next-generation nanotherapeutics. In the following, different approaches for application of drug release testing from nanoparticles in the fields of formulation development and quality control are discussed. A variety of methods is available, st...

Preparation and Optimization of Rivaroxaban by Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Enhanced Oral Bioavailability and No Food Effect.

In this paper, a novel self-nanoemulsifying drug delivery system (SNEDDS) was used to improve the oral bioavailability in fasted state and diminish the food effect for rivaroxaban. Oil, surfactant, and co-surfactant were selected by saturated solubility study. IPM, Tween80, and 1,2-propanediol were finally selected as oil, surfactant, and co-surfactant, respectively. The pseudo-ternary-phase diagram was utilized to optimize the preliminary composition of SNEDDS formulation. The optimized rivaroxaban-SNEDDS ...

Investigating structure-dependent diffusion in hydrogels using spatially resolved NMR spectroscopy.

Incorporation of the drug-loaded surfactant micelles into polymer hydrogels is a common method used to achieve controlled drug delivery. The characterization of the diffusion processes in drug delivery systems is critical in order to tune the drug loading and release.

Nanocrystal-Silica-Lipid Hybrid Particles for the Improved Oral Delivery of Ziprasidone in vitro.

The synergistic effect of nanosizing and lipid-based drug delivery systems (LBDDS) was explored to enhance formulation drug loading levels and improve drug solubilisation in the gastrointestinal environment. A novel formulation combining drug nanocrystals and silica-lipid hybrid (SLH) microparticles as a solid-state LBDDS was developed for the challenging poorly water-soluble drug, ziprasidone. A ziprasidone nanosuspension was fabricated via high-pressure homogenisation, achieving a mean particle size of 28...

Formulation and evaluation of curcumin microsponges for oral and topical drug delivery.

The aim of the present study was to improve the release rate of curcumin by microsponges prepared through quasi-emulsion solvent diffusion technique using ethylcellulose and PVA as carriers. The microsponges were characterized by FTIR, DSC, XRD and SEM studies followed by determination of total drug content and entrapment efficiency. The prepared microsponges were further filled in hard gelatin capsule shell and then loaded in carbopol gel to evaluate its potential in oral and topical drug delivery. Further...

Lipid based nanocarriers: A Translational Perspective.

Over the recent couple of decades, pharmaceutical field has embarked most phenomenal noteworthy achievements in the field of medications as well as drug delivery. The rise of Nanotechnology in this field has reformed the existing drug delivery for targeting, diagnostic, remedial applications and patient monitoring. The convincing usage of nanotechnology in the conveyance of medications that prompts an extension of novel lipid-based nanocarriers and non-liposomal systems has been discussed. Present review de...

Computational modelling of drug delivery to solid tumour: Understanding the interplay between chemotherapeutics and biological system for optimised delivery system.

Drug delivery to solid tumour involves multiple physiological, biochemical and biophysical processes taking place across a wide range of length and time scales. The therapeutic efficacy of anticancer drugs is influenced by the complex interplays among the intrinsic properties of tumours, biophysical aspects of drug transport and cellular uptake. Mathematical and computational modelling allows for a well-controlled study on the individual and combined effects of a wide range of parameters on drug transport a...

Multi-Drug Delivery System Based on Lipid Membrane Mimetic Coated Nano-hydroxyapatite Formulations.

Local delivery systems from an osteoconductive biomaterial are suggested as a promising strategy to avoid simultaneously peri-implant traumas and to induce tissue regeneration. In this work, it is detailed the design and construction of a multi-drug delivery formulation based on lipid membrane mimetic coated nano-hydroxyapatite, LMm / nano-HA, as a bone-specific drug delivery approach. The optimal LMm / nano-HA formulation was selected after analysing the lipid/ nano-HA interaction by dynamic light scatteri...

Ligand conjugation: An emerging platform for enhanced brain drug delivery.

The drug delivery across the brain has always been problematic due to the tight junction present namely the blood brain barrier (BBB). BBB only allows selected pharmaceutical drugs to get across it and reach the brain via lipid free diffusion process and exert their therapeutic effect. This leads to the decrease in drug accessibility to brain. More recently, various approaches were employed to allow larger molecules to cross BBB by reengineering them and conjugating them with ligands which could facilitate ...

Temozolomide loaded nano lipid based chitosan hydrogel for nose to brain delivery: Characterization, nasal absorption, histopathology and cell line study.

The present study was designed to develop and optimize Temozolomide nano lipid chitosan gel delivery (TMZNLCHG) to target the brain through nasal route. The formulation was developed using chitosan as a gelling agent and Vit E: gelucire 44/14 blend as lipid. The formulations were evaluated for particle size, drug loading, morphology, drug release, nasal diffusion, cell line study, and histopathology study. The average particle size, PDI, %EE, loading, drug release, and % permeation were found to be 134 nm...

Carboxymethylcellulose capsulated Cu-based metal-organic framework-drug nanohybrid as a pH-sensitive nanocomposite for ibuprofen oral delivery.

Due to non-invasive nature of oral delivery and the fact that avoids patient pain and discomfort, so the oral method is one of the most commonly used. By consideration this aim, Cu-based metal-organic framework encapsulated ibuprofen (IBU) drug nanohybrid (Cu-MOF@Drug) protected with pH-sensitive biopolymeric carboxymethylcellulose (CMC) as a novel nanocomposite for oral delivery system was synthesized. The prepared hydrogel bead characterized using FT-IR, BET, XRD, UV-Vis spectroscopy and SEM analysis. The...

Personalized medicine in nasal delivery: the use of patient-specific administration parameters to improve nasal drug targeting using 3D printed nasal replica casts.

Effective targeting of nasal spray deposition could improve local, systemic, and CNS drug delivery, however, this has proven to be difficult due anatomical features of the nasal cavity including the nasal valve and turbinate structures. Furthermore, nasal cavity geometries and dimensions vary between individuals based on differences in their age, gender and ethnicity. The effect of patient-specific administration parameters was evaluated for their ability to overcome the barriers to targeted nasal drug deli...


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