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PubMed Journals Articles About "Chemists Electricity Drug Manufacturing" RSS

15:46 EST 20th November 2017 | BioPortfolio

Chemists Electricity Drug Manufacturing PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Chemists Electricity Drug Manufacturing articles that have been published worldwide.

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Showing "Chemists Electricity Drug Manufacturing" PubMed Articles 1–25 of 9,500+

CO2 Emissions Embodied in Interprovincial Electricity Transmissions in China.

Existing studies on the evaluation of CO2 emissions due to electricity consumption in China are inaccurate and incomplete. This study uses a network approach to calculate CO2 emissions of purchased electricity in Chinese provinces. The CO2 emission factors of purchased electricity range from 265 g/kWh in Sichuan to 947 g/kWh in Inner Mongolia. We find that emission factors of purchased electricity in many provinces are quite different from the emission factors of electricity generation. This indicates the i...


Evaluation of electricity generation from lignin residue and biogas in cellulosic ethanol production.

This study takes the first insight on the rigorous evaluation of electricity generation based on the experimentally measured higher heating value (HHV) of lignin residue, as well as the chemical oxygen demand (COD) and biological oxygen demand (BOD5) of wastewater. For producing one metric ton of ethanol fuel from five typical lignocellulose substrates, including corn stover, wheat straw, rice straw, sugarcane bagasse and poplar sawdust, 1.26-1.85tons of dry lignin residue is generated from biorefining proc...

Dropwise Additive Manufacturing of Pharmaceutical Products for Amorphous and Self Emulsifying Drug Delivery Systems.

The improvements in healthcare systems and the advent of the precision medicine initiative have created the need to develop more innovative manufacturing methods for the delivery and production of individualized dosing and personalized treatments. In accordance with the changes observed in healthcare systems towards more innovative therapies, this paper presents dropwise additive manufacturing of pharmaceutical products (DAMPP) for small scale, distributed manufacturing of individualized dosing as an altern...


Recent advances in gossypol derivatives and analogs: a chemistry and biology view.

Gossypol as a natural occurring polyphenol has been studied in a wide range of therapeutic contexts for a long time. The chemical modifications on gossypol were limited due to the unique chemical properties of polyphenols. The design and synthesis of gossypol derivatives and the exploration of their biological activities are the interest of the synthetic chemists, medicinal chemists and pharmacologists. Thus, the progress of diverse gossypol derivatives and analogs' synthesis, biological activities, mechani...

In silico absorption, distribution, metabolism, excretion and pharmacokinetics (ADME-PK): utility and best practices - An industry perspective from the International Consortium for Innovation through Quality in Pharmaceutical Development.

In silico tools to investigate absorption, distribution, metabolism, excretion and pharmacokinetics (ADME-PK) properties of new chemical entities are an integral part of the current industrial drug discovery paradigm. While many companies are active in the field, scientists engaged in this area don't necessarily share the same background and have limited resources when seeking guidance on how to initiate and maintain an in silico ADME-PK infrastructure in an industrial setting. This work summarizes the view...

Engineered Particles Demonstrate Improved Flow Properties at Elevated Drug Loadings for Direct Compression Manufacturing.

Optimizing powder flow and compaction properties is critical for ensuring a robust tablet manufacturing process. The impact of flow and compaction properties of the active pharmaceutical ingredient (API) becomes progressively significant for higher drug load formulations, and for scaling up manufacturing processes. This study demonstrated that flow properties of a powder blend can be improved through API particle engineering, without critically impacting blend tabletability at elevated drug loadings. In stu...

Heat-Related Mortality in Japan after the 2011 Fukushima Disaster: An Analysis of Potential Influence of Reduced Electricity Consumption.

In March 2011, the Great East Japan Earthquake devastated several power stations and caused severe electricity shortages. This accident was followed by the implementation of policies to reduce summer electricity consumption in the affected areas, for example, by limiting air-conditioning (AC) use. This provided a natural experimental scenario to investigate if these policies were associated with an increase in heat-related mortality.

Robust network data envelopment analysis approach to evaluate the efficiency of regional electricity power networks under uncertainty.

In this paper, new Network Data Envelopment Analysis (NDEA) models are developed to evaluate the efficiency of regional electricity power networks. The primary objective of this paper is to consider perturbation in data and develop new NDEA models based on the adaptation of robust optimization methodology. Furthermore, in this paper, the efficiency of the entire networks of electricity power, involving generation, transmission and distribution stages is measured. While DEA has been widely used to evaluate t...

Application of the Pentafluorosulfanyl Group as a Bioisosteric Replacement.

The success of fluorinated molecules in drug design has led medicinal chemists to search for new fluorine-containing substituents. A major recently developed group is the pentafluorosulfanyl group. This group is stable under physiological conditions and displays unique physical and chemical properties. Currently, few synthetic methods exist that install the SF5 group, yet efforts to integrate this group into lead optimization continue unabated. Typically, the SF5 group has been used as a replacement for a t...

Opportunities and Challenges of Real-Time Release Testing in Biopharmaceutical Manufacturing.

Real-time release testing (RTRT) is defined as "the ability to evaluate and ensure the quality of in-process and/or final drug product based on process data, which typically includes a valid combination of measured material attributes and process controls" (ICH Q8(R2)). This article discusses sensors (process analytical technology, PAT) and control strategies that enable RTRT for the spectrum of critical quality attributes (CQAs) in biopharmaceutical manufacturing. Case studies from the small-molecule and b...

Sponging off Nature for New Drug Leads.

Marine sponges have consistently been the richest source of new marine natural products with unprecedented chemical scaffolds and potent biological activities that have been reported in the chemical literature since the early 1970s. During the last 40 years, chemists in the Andersen laboratory at UBC, in collaboration with biologists, have discovered many novel bioactive sponge natural products. Four experimental drug candidates for treatment of inflammation and cancer, that were inspired by members of this...

Quality Standards for Herbal Drugs and Herbal Drug Preparations - Appropriate or Improvements Necessary?

Standards for quality control as defined in the European Pharmacopoeia contribute significantly to a consistent and high quality of herbal drugs, herbal drug preparations, and herbal medicinal products. The minimum content of single plant constituents is considered of high relevance. Therefore, nearly all monographs on herbal drugs or herbal drug preparations contain an obligatory assay.However, a critical evaluation of the data published for such assayed constituents reveals that in most cases these consti...

Opportunity and challenges of nasal powders: Drug formulation and delivery.

In the field of nasal drug delivery, among the preparations defined by the European Pharmacopoeia, nasal powders facilitate the formulation of poorly water-soluble active compounds. They often display a simple composition in excipients (if any), allowing for the administration of larger drug doses and enhance drug diffusion and absorption across the mucosa, improving bioavailability compared to nasal liquids. Despite the positive features, however, nasal products in this form still struggle to enter the mar...

Life cycle assessment of a printed circuit board manufacturing plant in Turkey.

The objective of this study is to investigate the environmental impacts of a printed circuit board (PCB) manufacturing plant through streamlined life cycle assessment approach. As a result, the most effective recommendations on minimizing the environmental impacts for the mentioned sector are revealed and first steps towards establishing a country specific database are taken. The whole PCB production consists of two consecutive stages: namely board fabrication followed by the manufacturing of PCB. Manufactu...

Unveiling the target promiscuity of pharmacologically active compounds in silico.

Drug discovery is governed by the desire to find ligands with defined modes of action. It has been realized that even designated selective drugs may have more macromolecular targets than is commonly thought. Consequently, it will be mandatory to consider multi-target activity for the design of future medicines. Computational models assist medicinal chemists in this effort by helping to eliminate unsuitable lead structures and spot undesired drug effects early in the discovery process. Here, we present a str...

Unusual Undergraduate Training in Medicinal Chemistry in Collaboration between Academia and Industry.

Globalization has driven new paradigms for drug discovery and development. Activities previously carried out predominantly in the United States, Europe, and Japan are now carried out globally. This has caused considerable change in large pharma including how medicinal chemists are trained. Described here is the training of chemistry undergraduates in medicinal chemistry (as practiced in industry) in two modules developed in collaboration between the University of Nottingham (UoN) and GlaxoSmithKline (GSK). ...

A new strategy to sustained release of ocular drugs by one-step drug-loaded microcapsule manufacturing in hydrogel punctal plugs.

To design an injectable hyaluronate (HA)-based hydrogel system that contains drug-loaded microcapsules as resorbable plugs to deliver ocular drugs.

Metabolomic analysis reveals the composition differences in 13 Chinese tea cultivars of different manufacturing suitabilities.

Green tea and black tea are manufactured using appropriate tea cultivars in China. However, the metabolite differences relating to the manufacturing suitability of tea cultivars are unclear. In this study, we performed a non-targeted metabolomic analysis on 13 Chinese tea cultivars using ultra-high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF/MS) to investigate comprehensively the metabolite differences between cultivars suitable for manufacturing g...

Energy demand analysis via small scale hydroponic systems in suburban areas - An integrated energy-food nexus solution.

The study is a qualitative approach and looks into new ways for the effective energy management of a wind farm (WF) operation in a suburban or near-urban environment in order the generated electricity to be utilised for hydroponic farming purposes as well. Since soilless hydroponic indoor systems gain more and more attention one basic goal, among others, is to take advantage of this not typical electricity demand and by managing it, offering to the grid a less fluctuating electricity generation signal. In t...

The Forty-Sixth Euro Congress on Drug Synthesis and Analysis: Snapshot (†).

The 46th EuroCongress on Drug Synthesis and Analysis (ECDSA-2017) was arranged within the celebration of the 65th Anniversary of the Faculty of Pharmacy at Comenius University in Bratislava, Slovakia from 5-8 September 2017 to get together specialists in medicinal chemistry, organic synthesis, pharmaceutical analysis, screening of bioactive compounds, pharmacology and drug formulations; promote the exchange of scientific results, methods and ideas; and encourage cooperation between researchers from all over...

Ownership reform and the changing manufacturing landscape in Chinese cities: The case of Wuxi.

Since the economic transition, manufacturing in China has undergone profound changes not only in number of enterprises, but also in ownership structure and intra-urban spatial distribution. Investigating the changing manufacturing landscape from the perspective of ownership structure is critical to a deep understanding of the changing role of market and government in re-shaping manufacturing location behavior. Through a case study of Wuxi, a city experiencing comprehensive ownership reform, this paper prese...

Remediation of PAH polluted soils using a soil microbial fuel cell: Influence of electrode interval and role of microbial community.

The soil microbial fuel cells (SMFCs) were constructed to remediate soils contaminated by polycyclic aromatic hydrocarbons (PAHs). With a maximum power density of 12.1mWm(-2) and an internal resistance of 470Ω, a closed SMFC showed electricity generation comparable to that by an open SMFC after 175days of operation and meanwhile increased the removal rates of anthracene, phenanthrene, and pyrene to 54.2±2.7%, 42.6±1.9% and 27.0±2.1% from 20.8±1.1%, 17.3±1.2% and 11.7±0.9%, respectively, by the open S...

On the Sourcing of Steam and Electricity for Carbon Capture Retrofits.

This paper compares different steam and electricity sources for carbon capture and sequestration (CCS) retrofits of pulverized coal (PC) and natural gas combined cycle (NGCC) power plants. Analytical expressions for the thermal efficiency of these power plants are derived under 16 different CCS retrofit scenarios for the purpose of illustrating their environmental and economic characteristics. The scenarios emerge from combinations of steam and electricity sources, fuel used in each source, steam generation...

Melt extrusion with poorly soluble drugs - An integrated review.

Over the last few decades, hot melt extrusion (HME) has emerged as a successful technology for a broad spectrum of applications in the pharmaceutical industry. As indicated by multiple publications and patents, HME is mainly used for the enhancement of solubility and bioavailability of poorly soluble drugs. This review is focused on the recent reports on the solubility enhancement via HME and provides an update for the manufacturing/scaling up aspects of melt extrusion. In addition, drug characterization me...

Biosimilars in psoriasis: the future or not?

As patents for the biologic agents reach their expiration dates, dermatologists must prepare for the coming of biosimilars. These agents have been deemed "highly similar" to their reference products in a process outlined by the US Food and Drug Administration (FDA). In 2016, the FDA approved 3 biosimilars for various indications including plaque psoriasis and psoriatic arthritis. However, biosimilars are not the same as small-molecule generics because they have a complex manufacturing process that makes it ...


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