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PubMed Journals Articles About "Chiral Technologies, Inc" RSS

21:10 EST 22nd January 2019 | BioPortfolio

Chiral Technologies, Inc PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Chiral Technologies, Inc articles that have been published worldwide.

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Showing "Chiral Technologies" PubMed Articles 1–25 of 2,400+

Chiral pharmaceuticals: Environment sources, potential human health impacts, remediation technologies and future perspective.

Chiral pharmaceuticals (CPs), including non-steroid anti-inflammatory drugs (NSAIDs), β-blockers and some herbicide and pesticides, are widely used in aquaculture, clinical treatment and many other fields. However, people are increasingly concerned about such ubiquitous pollutants, which can frequently be detected in contaminated soil and water. In large part, the significant sources of chiral pharmaceuticals stem from industrial processes, such as the direct discharge of untreated or incompletely treated ...


Potential Induced Fine-tuning the Enantioaffinity of Chiral Metal Phases.

Concepts leading to single enantiomers of chiral molecules are of crucial importance for many applications, including pharmacology and biotechnology. Recently, mesoporous metal phases encoded with chiral information have been developed. We propose here to fine-tune the enantioaffinity of such structures by imposing an electric potential, which can influence the electrostatic interactions between the chiral metal and the target enantiomer. This allows increasing the binding affinity and thus the discriminati...

Synthesis of Chiral Cyclic Alcohols from Chiral Epoxides by H or N Substitution with Frontside Displacement.

Diverse examples are provided of enantioselective sequences for the transformation of cycloalkenes to either chiral trans-β-substituted cycloalkanols or chiral α-amino ketones.


Planar-Chiral Ferrocene-based NHC Ligands.

In the last few decades, N-heterocyclic carbene (NHC) ligands characterized by attractive features have increased their presence in transition metal catalysis. However, chiral NHC ligands still require further design enhancement to realize far more exciting synthetic applications. This review documents advances in chiral NHC ligands, focusing on planar-chiral ferrocene-based NHCs. As the basic shape of most classes of NHC rings is planar, it seems rational to employ a planar-chiral element in the design of ...

Liquid chromatographic enantiomer separations applying chiral ion-exchangers based on Cinchona alkaloids.

As the understanding of the various biological actions of compounds with different stereochemistry has grown, the necessity to develop methods for the analytical qualification and quantification of chiral products has become particularly important. The last quarter of the century has seen a vast growth of diverse chiral technologies, including stereocontrolled synthesis and enantioselective separation and analysis concepts. By the introduction of covalently bonded silica-based chiral stationary phases (CSPs...

A Continuously Regenerable Chiral Ammonia Borane for Asymmetric Transfer Hydrogenations.

A novel chiral ammonia borane was designed and developed via the dehydrogenation of ammonia borane with chiral phosphoric acid, which was highly effective for the asymmetric transfer hydrogenation of imines and β-enamino esters to afford high levels of reactivities and enantioselectivies. Significantly, this chiral ammonia borane can be continuously regenerated during the transfer hydrogenation with the assistance of water and ammonia borane, which allowed as low as 0.1 mol % of chiral phosphoric acid to g...

Proline-Based Boronic Acid Receptors for Chiral Recognition of Glucose.

Chiral recognition remains a major challenge in the area of molecular receptor design. With this research we set out to explore the use of proline based receptors for chiral recognition. Importantly, the proline structure allows for the in-troduction of at least two different binding groups due to the availability of both an amine and carboxylic acid group. Here we report a proof-of-concept exploration into the chiral recognition of D-/L-glucose, as model chiral species which prefers to bind to at least two...

Comments on "Chiral pharmaceuticals: Environment sources, potential human health impacts, remediation technologies and future perspective".

Stereoselective bioaccumulation and elimination of chiral PCBs 95 and 149 in earthworm Eisenia fetida.

The chiral signatures and environmental behaviors of chiral polychlorinated biphenyls (PCBs) have been extensively studied. However, information regarding chiral PCBs in invertebrates, especially earthworms, is limited. This study aimed to investigate the stereoselective bioaccumulation, elimination, and biotransformation of chiral PCBs 95 and 149 in an earthworm-soil system. Preferential enrichment of (+)-atropisomers and elimination of (-)-atropisomers were observed, for both PCBs 95 and 149, during the u...

Optically active inverse opal photonic crystals.

Chiral photonic crystals have been a widely investigated topic in chemistry, physics and biology. Till now, the researches about chiral photonic crystals are conducted on the objects of helical structures, while the chiral photonic crystals made of periodic chiral media remain unexplored experimentally. In this work, we have successfully constructed three-dimensional chiral polymer inverse opal photonic crystals (3D CPIOPCs) by a template-based method. Impressively, the 3D CPIOPCs exhibit emerging circular ...

Asymmetric Robinson Annulation of 3-Indolinone-2-carboxylates with Cyclohexenone: Access to Chiral Bridged Tricyclic Hydrocarbazoles.

A chiral bifuntional thiourea catalyzed diastereo- and enantioselective Michael addition followed by an intramolecular Aldol reaction of 3-indolinone-2-carboxylates with cyclohexenone has been accomplished using a chiral thiourea catalyst. It is a novel strategy for the construction of chiral bridged tricyclic hydrocarbazole derivatives bearing four contiguous stereocenters with excellent diastereo- and enantioselectivity.

Three-Dimensional Enantiomeric Recognition of Optically Trapped Single Chiral Nanoparticles.

We optically trap freestanding single metallic chiral nanoparticles using a standing-wave optical tweezer. We also incorporate within the trap a polarimetric setup that allows us to perform in situ chiral recognition of single enantiomers. This is done by measuring the S_{3} component of the Stokes vector of a light beam scattered off the trapped nanoparticle in the forward direction. This unique combination of optical trapping and chiral recognition, all implemented within a single setup, opens new perspe...

Chiral bambusurils for enantioselective recognition of carboxylate anion guests.

Synthesis of the first enantiomerically pure chiral bambusurils is reported. The bambusurils were prepared on the gram scale without using any chromatography techniques. The bambusurils formed supramolecular complexes with all tested chiral carboxylates including amino acids and drug molecules with the enantioselectivity ranging from 1.1 to 3.2.

The On-Off chiral mesoporous silica nanoparticles for delivering achiral drug in chiral environment.

In the current stage, the On-Off mechanism of chiral mesoporous silica nanoparticles (CMSN) for delivering achiral drug in chiral environment has rarely been reported. Herein, On-Off chiral mesoporous silica nanoparticles (On-Off-D-CMSN and On-Off-L-CMSN) were successfully synthesized and its particular contribution in delivering achiral drug indometacin (IMC) in chiral environment was mainly studied. The as-synthesized On-Off-D-CMSN and On-Off-L-CMSN were verified by fourier transform infrared spectrometer...

Asymmetric Synthesis of Axially Chiral Benzocarbazole Derivatives Based on Catalytic Enantioselective Hydroarylation of Alkynes.

A new synthetic approach to novel axially chiral benzocarbazole derivatives based on the highly enantioselective intramolecular hydroarylation (94-96% ee) of linked alkyne-indole systems by using the prevalent chiral base catalyst, cinchonidine or cinchonine, under unprecedented transition-metal-free conditions is described. The process is considered to involve chiral base catalysis for enantioselective transformation of the alkyne part to a reaction intermediate with an axially chiral vinylidene o-quinone ...

Chiral metamaterials via Moiré stacking.

Chiral metamaterials have attracted strong interest due to their versatile capabilities in spin-dependent light manipulation. Benefiting from advancements in nanofabrication and mechanistic understanding of chiroptical effects, chiral metamaterials have shown potential in a variety of applications including circular polarizers, chiral sensors, and chiroptical detectors. Recently, chiral metamaterials made by moiré stacking, superimposing two or more periodic patterns with different lattice constants or rel...

Chiral aldehyde catalysis for the catalytic asymmetric activation of glycine esters.

Chiral aldehyde catalysis is uniquely suitable for the direct asymmetric α-functionalization of N-unprotected amino acids, because aldehydes can reversibly form imines. However, there have been few successful reports of these transformations. In fact, only chiral aldehyde catalyzed aldol reactions of amino acids and alkylation of 2-amino malonates have been reported with good chiral induction. Here, we report a novel type of chiral aldehyde catalyst based on face control of the enolate intermediates. The r...

Multiple Chiral Majorana Fermion Modes and Quantum Transport.

The chiral Majorana fermion is a massless self-conjugate fermionic particle that could arise as the quasiparticle edge state of a two-dimensonal topological state of matter. Here we propose a new platform for a chiral topological superconductor (TSC) in two dimensions with multiple N chiral Majorana fermions from a quantized anomalous Hall insulator in proximity to an s-wave superconductor with nontrivial band topology. A concrete example is that a N=3 chiral TSC is realized by coupling a magnetic topologic...

Assembling a Hybrid Pd-Catalyst from Chiral Anionic Co(III)-Complex and Ligand for Asymmetric C(sp3)-H Functionalization.

An unusual hybrid palladium catalyst containing an anionic chiral Co(III) complex and a chiral phosphoramidite ligand shows high capacity of catalyzing the asymmetric thioamide-directed C(sp3)-H arylation and delivers excellent levels of yield and enantioselectivity (up to 99% yield, 99% ee). A significant synergy of chiral ligand and anion in the stereochemical control has been observed. Mechanistic investigations have revealed both the nature of the C-H activation and the origin of the enantioselectivity.

Synthesis and Characterization of Self-Assembled Chiral FeII2L3 Cages.

We present here the synthesis of chiral BINOL derived bisamine and bispyridine-aldehyde building blocks that can be used for the self-assembly of novel chiral FeII2L3 cages when mixed with an Fe(II) precursor. The properties of a series of chiral cages were studied by NMR, CSI-MS and CD spectroscopy and molecular modelling. Upon formation of the M2L3 cages the iron corners can adopt various isomeric forms: mer, fac-Δ or fac-Λ. We found that the coordination geometry around the metal centers in R-Cage 1 an...

Enantioselective Synthesis of Tetrahydroquinolines from 2-Aminochalcones via a Consecutive One-pot Reaction Catalyzed by Chiral Phosphoric Acid.

A new asymmetric protocol for the synthesis of chiral tetrahydroquinolines from 2-aminochalcones via a two-step one-pot consecutive process (cyclization/asymmetric reduction) has been developed using chiral phosphoric acid as the sole catalyst. 2-Aminochalcones were converted into the corresponding quinolines through chiral phosphoric acid-catalyzed dehydrative cyclization, and the resultant quinolines were subsequently reduced to the chiral tetrahydroquinolines via chiral phosphoric acid-cataylzed asymmetr...

Chiral separation and modeling of quinolones on teicoplanin macrocyclic glycopeptide antibiotics CSP.

New chiral high-performance liquid chromatography (HPLC) method for the enantiomeric resolution of quinolones is developed and described. The column used was Chirobiotic T (150 × 4.6 mm, 5.0 μm). Three mobile phases used were MeOH:ACN:Water:TEA (70:10:20:0.1%), (60:30:10:0.1%), and (50:30:20:0.1%). The flow rate of the mobile phases was 1.0 mL/min with UV detection at different wavelengths. The values of retention, resolution, and separation factors ranged from 1.5 to 6.0, 1.80 to 2.25, and 2.86 to 6...

Cu/Chiral Phosphoric Acid-Catalyzed Asymmetric Three-Component Radical-Initiated 1,2-Dicarbofunctionalization of Alkenes.

An asymmetric intermolecular, three-component radical-initiated dicarbofunctionalization of 1,1-diarylalkenes with diverse carbon-centered radical precursors and electron-rich heteroaromatics by a copper(I) and chiral phosphoric acid cooperative catalysis strategy has been developed, providing straightforward access to chiral triarylmethanes bearing quaternary all-carbon stereocenters with high efficiency as well as excellent chemo- and enantioselectivity. The key to success is not only the introduction of ...

Synthesis of Chiral Tryptamines via a Regioselective Indole Alkylation.

A practical synthesis of chiral tryptamines from simple, unprotected indoles has been developed. Indole nucleophiles prepared with MeMgCl in the presence of CuCl reacted with chiral cyclic sulfamidates almost exclusively at the C-position of indole to form a variety of α- and/or β-substituted chiral tryptamines in good yield with excellent regioselectivity. The utility of this simple alkylation process has been demonstrated with the practical synthesis of two biologically active targets, cipargamin and TI...

Synthesis of enantiopure planar chiral bis-(para)-pseudo-meta-type 2.2paracyclophanes.

A new type of planar chiral (R )- and (S )-4,7,12,15-tetrasubstituted [2.2]paracyclophanes was prepared from racemic 4,7,12,15-tetrabromo[2.2]paracyclophane as the starting substrate. Regioselective lithiation and transformations afforded racemic bis-(para)-pseudo-meta-type [2.2]paracyclophane (4,15-dibromo-7,12-dihydroxy[2.2]paracyclophane). Its optical resolution was performed by the diastereomer method using a chiral camphanoyl group as the chiral auxiliary. The diastereoisomers were readily isolated by ...


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