PubMed Journals Articles About "Coagulation Analyzers Strategic Profiles Leading Suppliers Report Updated" RSS

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Veterinarians specializing in nondomestic species are faced with unique challenges regarding research and diagnostic capabilities given the wild and frequently dangerous nature of their patients. Standard diagnostic techniques used in small or large animal practice are not always possible due to anatomical constraints, size, tractability, or the inherent risk of anesthesia in highly valued, rare species. Diagnostic modalities that utilize simple, relatively noninvasive techniques show promise in evaluating ...

Lowering Low-Density Lipoprotein Particles in Plasma Using Dextran Sulphate Co-Precipitates Procoagulant Extracellular Vesicles.

Plasma extracellular vesicles (EVs) are lipid membrane vesicles involved in several biological processes including coagulation. Both coagulation and lipid metabolism are strongly associated with cardiovascular events. Lowering very-low- and low-density lipoprotein ((V)LDL) particles via dextran sulphate LDL apheresis also removes coagulation proteins. It remains unknown, however, how coagulation proteins are removed in apheresis. We hypothesize that plasma EVs that contain high levels of coagulation protein...

In vitro assessment of the effect of acidemia on coagulation in dogs.

Minimal data are available assessing the effect of acidemia on coagulation in dogs. The objective of this study was to assess the effect of in vitro acidification of canine blood on coagulation as measured via thromboelastography (TEG) and traditional tests of coagulation. We hypothesized that worsening acidemia would lead to progressive impairment on coagulation.

Role of the blood coagulation cascade in hepatic fibrosis.

Liver is the primary source of numerous proteins critical for normal function of the blood coagulation cascade. Because of this, diseases of the liver, particularly when affiliated with severe complications like cirrhosis, are associated with abnormalities of blood clotting. Although conventional interpretation has inferred cirrhosis as a disorder of uniform bleeding risk, it is now increasingly appreciated as a disease wherein the coagulation cascade is precariously rebalanced. Moreover, prothrombotic risk...

Circulating Microparticles and Coagulation Profiles in Patients with Advanced Stage Solid Tumors.

Fatal Sepsis Associated with Bacterial Contamination of Platelets - Utah and California, August 2017.

During August 2017, two separate clusters of platelet transfusion-associated bacterial sepsis were reported in Utah and California. In Utah, two patients died after platelet transfusions from the same donation. Clostridium perfringens isolates from one patient's blood, the other patient's platelet bag, and donor skin swabs were highly related by whole genome sequencing (WGS). In California, one patient died after platelet transfusion; Klebsiella pneumoniae isolates from the patient's blood and platelet bag ...

Neural mechanisms mediating degrees of strategic uncertainty.

In social interactions, strategic uncertainty arises when the outcome of one's choice depends on the choices of others. An important question is whether strategic uncertainty can be resolved by assessing subjective probabilities to the counterparts' behavior, as if playing against nature, and thus transforming the strategic interaction into a risky (individual) situation. By means of fMRI with human participants we tested the hypothesis that choices under strategic uncertainty are supported by the neural ci...

A diet defined by its content of bovine milk exosomes and their RNA cargos has moderate effects on gene expression, amino acid profiles and grip strength in skeletal muscle in C57BL/6 mice.

Exosomes are nanoparticles that transfer cargos from donor cells to recipient cells where they elicit changes in gene expression and metabolism. Evidence suggests that exosomes and their cargos are also absorbed from dietary sources such as bovine milk, and bovine exosomes promote the growth of myofibers in murine C2C12 myotube cell cultures. The aim of the current study was to determine whether the dietary intake of bovine milk exosomes alters strength, gene expression and amino acid profiles in murine ske...

Effects of Acute Stress on Thrombosis.

Stress, the nonspecific response to any demand for change, is an adaptive response of the human body to various stimulants. As such, stress-induced hypercoagulation may represent an adaptive response to bleeding. Numerous epidemiological studies have revealed that a correlation exists between stress and thrombotic risk and biochemically, links of the relationship between psychological stress and coagulation pathways have been made. The stress reaction is coupled with neurohormonal changes mediated mainly by...

Incidence and clinical significance of hyperfibrinolysis during living donor liver transplantation.

: We evaluated the incidence and clinical significance of hyperfibrinolysis during living donor liver transplantation (LDLT) using viscoelastic coagulation tests. We retrospectively reviewed adult LDLT recipients from February 2010 to February 2015. Hyperfibrinolysis was defined when clot lysis index [LY60 = (MA - A60)/MA × 100, %] was less than 85, where A60 is the clot amplitude at 60 min after maximum amplitude (MA) occurred. Viscoelastic coagulation tests were performed six times (T1: imm...

A novel suction/coagulation integrated probe for achieving better hemostasis: development and clinical use.

Modern electrosurgical tools have a specific coagulation mode called "soft coagulation". However, soft coagulation has not been widely accepted for surgical operations. To optimize the soft coagulation environment, we developed a novel suction device integrated with an electrosurgical probe, called the "Suction ball coagulator" (SBC). In this study, we aimed to optimize the SBC design with a prototyping process involving a bench test and preclinical study; then, we aimed to demonstrate the feasibility, safe...

Calvian Endo-pen: New Coagulation Forceps for Endoscopic Endonasal Transsphenoidal Surgery.

 Over the past few years bipolar electrocoagulation techniques in neurosurgery have been continually improving. However, limited access during endoscopic endonasal transsphenoidal surgery (EETS) for central skull base pathologies and the requirement of very precise coagulation in that dedicated anatomical area requires further refinement of bipolar coagulation instruments. We describe our experience (effectiveness of coagulation, intraoperative handling, and the use as a dissecting tool) with a new type o...

3DCONS-DB: A Database of Position-Specific Scoring Matrices in Protein Structures.

Many studies have used position-specific scoring matrices (PSSM) profiles to characterize residues in protein structures and to predict a broad range of protein features. Moreover, PSSM profiles of Protein Data Bank (PDB) entries have been recalculated in many works for different purposes. Although the computational cost of calculating a single PSSM profile is affordable, many statistical studies or machine learning-based methods used thousands of profiles to achieve their goals, thereby leading to a substa...

Slitted leading edge profiles for the reduction of turbulence-aerofoil interaction noise.

Aerofoils operating in a turbulent flow are an efficient source of noise radiation by scattering vorticity into sound at the leading edge (LE). Much work has now been undertaken demonstrating the effectiveness of serrations, or undulations, introduced onto the LE can substantially reduce broadband LE interaction noise. However, all of this work is focused on sinusoidal LE serration profiles. In this paper, an alternative profile is proposed that is capable of providing significantly greater noise reductions...

Thromboelastometry profile in critically ill patients: A single-center, retrospective, observational study.

Transfusion therapy is associated with increased morbidity, mortality and costs. Conventional coagulation tests (CCT) are weak bleeding predictors, poorly reflecting coagulation in vivo. Thromboelastometry (ROTEM) provides early identification of coagulation disorders and can guide transfusion therapy by goals, reducing blood components transfusion.

Coagulation behavior of humic acid in aqueous solutions containing Cs, Srand Eu: DLS, EEM and MD simulations.

The coagulation behaviors of humic acid (HA) with Cs(10-500 mM), Sr(0.8-10.0 mM) and Eu(0.01-1.0 mM) at different pH values (2.8, 7.1 and 10.0) were acquired through a dynamic light scattering (DLS) technique combined with spectroscopic analysis and molecular dynamic (MD) simulations. The coagulation rate and the average hydrodynamic diameter () increased significantly as the concentration of nuclides increased. could be scaled to time t as ∝ tat higher Srconcentrations, which shows that HA coagula...

An updated assessment of morbidity and mortality following skull base surgical approaches.

Updated multi-institutional database studies assessing perioperative risk factors on 30-day morbidity and mortality after skull base surgeries are limited. We aim to identify perioperative risk factors and report the incidence of 30-day morbidity and mortality in adult patients after skull base surgery.

Life on the other side: moving from clinical nursing to strategic management.

Alan Nobbs reflects on his decision to move into a more strategic nursing role rather than stay by the bedside, and the feelings of apprehension that followed.

Coagulopathy in Severe Sepsis: Interconnectivity of Coagulation and the Immune System.

Disseminated intravascular coagulation (DIC) remains a challenging complication of infection with inadequate treatment and significant morbidity and mortality rates.

Rare cause of isolated severe coagulation failure in cirrhosis: traditional healing with fenugreek.

Patients with cirrhosis develop decompensation events during the natural history of the disease that encompass ascites, variceal bleeding, hepatic encephalopathy and jaundice. Coagulation failure, defined using the international normalised ratio, even though not a decompensation event, is important in patients with stratifying cirrhosis into those who require liver transplantation for long-term survival. Isolated coagulation failure in cirrhosis is rare and usually occurs with use of anticoagulants in the s...

On the Cusp of a Healthcare Revolution: BME Technologies Have the Potential to ?Transform Our World?

Of the key technologies listed as "ready to propel industries and transform our world" in the 2017 report Top 50 Emerging Technologies: Growth Opportunities of Strategic Imperative, most fall under the scope of biomedical engineering (BME). Issued by the major market research and analysis company Frost and Sullivan [1], the report's findings are no surprise to the researchers, clinicians, and others who are heavily invested in this field.

Cognitive Bridging: Using Strategic Communication To Connect Abstract Goals With The Means To Achieve Them.

Three studies test several mechanisms of cognitive bridging, or how a strategic communication message functions to connect the abstract goal of an individual with the specific means to achieve the goal. Across all of the experiments (n = 276, n = 209, n = 145), it was demonstrated that participants who received an induced bridging mechanism were more likely to produce cognitive bridging outputs and report more abstract responses than participants who did not receive a bridging technique. We do not fin...

Coagulation Defects in the Cirrhotic Patient Undergoing Liver Transplantation.

Patients with cirrhosis undergoing liver transplantation have unique challenges with regard to the prevention and management of thrombosis and hemorrhage. Patients with cirrhosis have an unstable balance of the coagulation system due to defects in both prothrombotic and antithrombotic components. These changes make laboratory monitoring challenging, prophylaxis against bleeding and thrombosis controversial, and therapy for the same uncertain. When cirrhotic patients undergo liver transplantation they freque...

Apoptotic vesicles: deathly players in cancer-associated coagulation.

Although cancer is associated with coagulation disorders, it is still unclear how the combination of tumour cell and host factors enhance the hypercoagulable state of cancer patients. Emerging evidence points to a central role for tumour endosomal and plasma-membrane derived vesicular components in the pathogenesis of cancer-related thrombosis. In particular, tumour cell membranes and extracellular vesicles (EV) harbour lipids and proteinaceous coagulation factors able to initiate multiple points within the...

Use of viscoelastic methods in surgery.

Major liver resections are associated with high morbidity and mortality. The main causes of this fact include a significant blood loss which may be associated with this surgical procedure. Hemocoagulation disorder, diagnosed by standard laboratory tests, is very frequent in the postoperative period and often requires the administration of blood derivatives. Several recent studies, however, have questioned the presence of such coagulopathy when viscoelastic methods are used to assess the coagulation process....

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