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Combinatorial Chemistry PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Combinatorial Chemistry articles that have been published worldwide.
We have published hundreds of Combinatorial Chemistry news stories on BioPortfolio along with dozens of Combinatorial Chemistry Clinical Trials and PubMed Articles about Combinatorial Chemistry for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Combinatorial Chemistry Companies in our database. You can also find out about relevant Combinatorial Chemistry Drugs and Medications on this site too.
Nano-bio interfaces are emerging from the convergence of engineered nanomaterials and biological entities. Despite rapid growth, clinical translation of biomedical nanomaterials is heavily compromised by the lack of comprehensive understanding of biophysicochemical interactions at nano-bio interfaces. In the past decade, a few investigations have adopted a combinatorial approach toward decoding nano-bio interfaces. Combinatorial nano-bio interfaces comprise the design of nanocombinatorial libraries and high...
Dynamic combinatorial chemistry (DCC) has repeatedly proven to be an effective approach to generate directed ligand libraries for macromolecular targets. In the absence of an external stimulus, a dynamic library forms from reversibly reacting building blocks and reaches a stable thermodynamic equilibrium. However, upon addition of a macromolecular host which can bind and stabilize certain components of the library, the equilibrium composition changes and induces an evolution-like selection and enrichment of...
Monosized beads of polar resins were synthesized for combinatorial chemistry and chemical biology by sustainable microchannel flow synthesis. Regular, biocompatible and optically encoded beads could be efficiently prepared on large scale and in high yield. In a preparative flow polymerization instrument, taking advantage of a designed T-connector for droplet formation, quality beads were synthesized with accurate size control using a minimal amount of recirculating silicon oil as suspension medium. Bead-siz...
In this paper, a novel inkjet printing technique, micro impact printing (MI printing), is applied for the first time to combinatorial peptide array synthesis on amine functionalized micro disc arrays through standard Fmoc chemistry. MI printing shows great advantages in combinatorial peptide array synthesis compared with other printing techniques, including 1) a disposable cartridge; 2) a small spot size (80 μm) increases array density; 3) minimal loading volume (0.6 μL) and dead volume (
Staphylococcus aureus is a bacterial pathogen that can cause significant disease burden and mortality by counteracting host defences through producing virulence factors to survive the immune responses evoked by infection. This emerging drug-resistant pathogen has led to a decline in the efficacy of traditional antimicrobial therapy. To combat these threats, precision antimicrobial therapeutics have been created to target key virulence determinants of specific pathogens. Here we review the benefits of, progr...
Chemistry testing is requested for body fluid (BF) specimens despite the lack of assays approved by the US Food and Drug Administration (FDA). The criteria for categorizing fluids as transudate or exudate are not validated across analyzers.
Prize Winners at the 7th EuCheMS Chemistry Congress European Chemistry Gold Medal for Ben L. Feringa/European Sustainable Chemistry Award for Paul J. Dyson/August Wilhelm von Hofmann Memorial Medal for Michael Graetzel.
A new study coupling bioinformatic and experimental investigations highlights the importance of combinatorial microRNA targeting in human EMT, a phenotypic program underlying normal and pathological processes.
In this study, we demonstrate the extensive scalability of the biasing potential replica exchange multisite λ-dynamics (BP-REX MSλD) free energy method by calculating binding affinities for 512 inhibitors to HIV Reverse Transcriptase (HIV-RT). This is the largest exploration of chemical space using free energy methods known to date, requires only a few simulations, and identifies 55 new inhibitor designs against HIV-RT predicted to be at least as potent as a tight binding reference compound (i.e., as pote...
Click chemistry involves reactions that were originally introduced and used in organic chemistry to generate substances by joining small units together with heteroatom linkages (C-X-C). Over the last few decades, click chemistry has been widely used in virus-related research. Using click chemistry, the virus particle as well as viral protein and nucleic acids can be labeled. Subsequently, the labeled virions or molecules can be tracked in real time. Here, we reviewed the recent applications of click reactio...
Bioorthogonal chemistry has developed significant over the past few decades, to the particular benefit of molecular imaging. Bioluminescence imaging (BLI) along with other imaging modalities have significantly benefitted from this chemistry. Here, we review bioorthogonal reactions that have been used to signific antly broaden the application range of BLI.
Current crop protection chemicals span an array of chemistry classes and modes of action. Typically, within each chemistry class there are multiple chemically distinct active ingredients competing with each other for market position. In this competition, the first product to market in a new class or mode of action may or may not have an advantage depending on a number of parameters including relative efficacy against the target pests, pest resistance, regulatory pressures, synthetic complexity, and marketin...
In a recent issue of Nature, Tsunemoto et al. (2018) perform a systematic screening to identify several transcription factor pairs able to generate a variety of different induced neuronal cell populations that share a core neuronal signature, yet differ for specific molecular features.
RETROSPECTIVE ANALYSIS: REPRODUCIBILITY OF INTERBLASTOMERE DIFFERENCES OF mRNA EXPRESSION IN 2-CELL STAGE MOUSE EMBRYOS IS REMARKABLY POOR DUE TO COMBINATORIAL MECHANISMS OF BLASTOMERE DIVERSIFICATION.
What is the prevalence, reproducibility and biological significance of transcriptomic differences between sister blastomeres of the mouse 2-cell embryo?
Development of synthetic systems carrying life-like features is a long-standing challenge in chemistry and material science. Poor understanding of mechanisms ruling the emergence of life-like features in an inanimate matter makes the challenge even more exciting. The growing field of systems chemistry takes the lead in defining life-like dynamic signatures in minimalistic (macro)molecular systems through the development of multicomponent synthetic models using tools from organic and supramolecular chemistry...
This article describes the development and calibration of items from the 1997 to 2006 Tertiary Entrance Exams (TEE) in Chemistry conducted by the Curriculum Council of Western Australia for the purposes of establishing a Chemistry item bank. Only items that met the strict Rasch measurement criterion of ordered thresholds were included. Item Residuals and Chi-square conformity of the items were likewise scrutinized. Further, specialist experts in chemistry were employed to ascertain the qualitative propertie...
Research in origins of life is an intrinsically multi-disciplinary field, aimed at finding answers to the formidably complex problem of understanding the emergence of life from the modern versions of Charles Darwin's celebrated "primordial soup". In the last few years, thanks to the increasing computational power and the development of sophisticated theoretical and numerical methods, several computational chemistry and physics groups have invested this field, providing new microscopic insights on fundamenta...
Ectopic bone formation in mice is the gold standard for evaluation of osteogenic constructs. By regular procedures, usually only 4 constructs can be accommodated per mouse, limiting screening power. Combinatorial cassettes (combi-cassettes) hold up to 19 small, uniform constructs from the time of surgery, through time in vivo, and subsequent evaluation. Two types of bone tissue engineering constructs were tested in the combi-cassettes: i) a cell-scaffold construct containing primary human bone marrow stroma...
Flow chemistry and heterogenous catalysis hold incredible potential from a sustainability point of view and from a green perspective. In fact, if heterogenous catalysts are required by the chemical industry for their efficiency, on the other hand, heterogenous flow catalysis would allow performing greener and more efficient chemistry at an industrial level. In the context of sustainable flow chemistry, in this chapter we report and discuss selected examples recently published in the specialized literature o...