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PubMed Journals Articles About "Correlation Of Eicosanoid And Proresolving Lipid Mediator Temporal Profiles And Resolution Of Pain After Thoracic Surgery" RSS

02:30 EDT 24th May 2018 | BioPortfolio

Correlation Of Eicosanoid And Proresolving Lipid Mediator Temporal Profiles And Resolution Of Pain After Thoracic Surgery PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Correlation Of Eicosanoid And Proresolving Lipid Mediator Temporal Profiles And Resolution Of Pain After Thoracic Surgery articles that have been published worldwide.

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Showing "Correlation Eicosanoid Proresolving Lipid Mediator Temporal Profiles Resolution" PubMed Articles 1–25 of 15,000+

Metabololipidomic profiling of functional immunoresolvent clusters and eicosanoids in mammalian tissues.

Metabolomics enables a systems approach to interrogate the bioactive mediators, their pathways and further metabolites involved in the physiology and pathophysiology of human and animal tissues. New metabololipidomic approaches with mass spectrometry presented in this brief review can now be utilized for the identification and profiling of lipid mediator networks that control inflammation-resolution in human blood and healthy and diseased solid tissues. Coagulation of blood is a protective response that pre...


Antenna-Enhanced Fluorescence Correlation Spectroscopy Resolves Calcium-Mediated Lipid-Lipid-Interactions.

Fluorescence correlation spectroscopy (FCS) has provided a wealth of information on the composition, structure, and dynamics of cell membranes. However, it has proved challenging to reach the spatial resolution required to resolve biophysical interactions at the nm-scale relevant to many crucial membrane processes. In this work, we form artificial cell membranes on dimeric, nanoplasmonic antennas, which shrink the FCS probe volume down to the ~20 nm length-scale. By analysing the autocorrelation functions (...

Unified nexus of macrophages and maresins in cardiac reparative mechanisms.

Macrophages are immune-sensing "big eater" phagocytic cells responsible for an innate, adaptive, and regenerative response. After myocardial infarction, macrophages predominantly clear the deceased cardiomyocyte apoptotic or necrotic neutrophils to develop a regenerative and reparative program with the activation of the lipoxygenase-mediated maresin (MaR) metabolome at the site of ischemic injury. The specialized proresolving molecule and macrophage mediator in resolving inflammation, MaR-1, produced by hum...


Oral ibuprofen differentially affects plasma and sweat lipid mediator profiles in healthy adult males.

Sweat contains a variety of lipid mediators, but whether they originate from the plasma filtrate or from the cutaneous sweat glandular tissues themselves is unknown. To explore this knowledge gap, we collected plasma and sweat from healthy men (n = 9) immediately before and 0.5, 2 and 4 h after oral administration of 400 mg ibuprofen. Of the over 100 lipid mediators assayed by liquid chromatography-tandem mass spectrometry, ~45 were detected in both plasma and sweat, and 36 were common to both matri...

Resolution of fatty liver and weight loss: Independent associations with changes in serum lipids and apolipoproteins.

It is uncertain whether resolution of fatty liver can improve cardiovascular disease risk factors, independently of changes in body mass index (BMI). Our aim was to test whether resolution of fatty liver is associated with improvements in components of the lipid profile, independently of changes in BMI, and to quantify and compare the magnitude of benefit of resolution of liver fat, and decreases in BMI on the lipid profile.

Association between lipid profiles and osteoporosis in postmenopausal women: a meta-analysis.

To investigate the relationship between blood lipid profiles and osteoporosis in postmenopausal women.

Dexamethasone induces ω3-derived immunoresolvents driving resolution of allergic airway inflammation.

Dexamethasone induces the production of DHA-derived specialized proresolving lipids and the resolution of allergic airway inflammation. This adds glucocorticosteroids to the short list of drugs that are known to possess direct pro-resolving functions.

Effects of Growth Hormone Treatment on Lipid Profiles.

To assess the effects of growth hormone (GH) on lipid profiles in children and whether the effect is pharmacological.

New maresin conjugates in tissue regeneration pathway counters leukotriene D-stimulated vascular responses.

Resolution of acute inflammation is governed, in part, by lipid mediator class switching from proinflammatory eicosanoids to specialized proresolving mediators, including a recently identified new pathway of mediators, termed maresin conjugates in tissue regeneration (MCTR), which includes MCTR1, MCTR2, and MCTR3. Here, we addressed whether each MCTR can impact the known vascular actions of cysteinyl leukotrienes. Leukotriene D(LTD; 1.5 nmol/mouse) initiated vascular leakage in mouse cremaster vessels, whic...

Optical Antenna-Based Fluorescence Correlation Spectroscopy to Probe the Nanoscale Dynamics of Biological Membranes.

The plasma membrane of living cells is compartmentalized at multiple spatial scales ranging from the nano- to the meso-scale. This non-random organization is crucial for a large number of cellular functions. At the nanoscale, cell membranes organize into dynamic nano-assemblies enriched by cholesterol, sphingolipids and certain types of proteins. Investigating these nano-assemblies known as lipid rafts is of paramount interest in fundamental cell biology. However, this goal requires simultaneous nanometer s...

Does Chicago Classification address Symptom Correlation with High-resolution Esophageal Manometry?

To assess the correlation of symptoms with findings on esophageal high-resolution manometry (HRM) in Indian patients.

Learning Effects in Psychophysical Tests of Spectral and Temporal Resolution.

Psychophysical tests of spectral and temporal resolution, such as the spectral-ripple discrimination task and the temporal modulation detection test, are valuable tools for the evaluation of cochlear implant performance. Both tests correlate with speech intelligibility and are reported to show no instantaneous learning effect. However, some of our previous trials have suggested that there is a learning effect over time. The aim of this study was to investigate the test-retest reliability of the two tests wh...

Resolvin D1 blocks H2O2-mediated inhibitory crosstalk between SHP2 and PP2A and suppresses endothelial-monocyte interactions.

In recent years, various studies have demonstrated a role for endogenously derived specialized proresolving mediators such as resolvins in the resolution of inflammation. In exploring the signaling mechanisms, in the present study we show that Resolvin D1 (RvD1) reduces LPS-induced endothelial cell (EC)-monocyte interactions via blocking H2O2-mediated PP2A inactivation, NFκB activation and ICAM1 and VCAM1 expression. In addition, we found that H2O2-mediated SHP2 inhibition leads to tyrosine phosphorylation...

Towards targeting resolution pathways of airway inflammation in asthma.

Asthma is a chronic disorder characterized by persistent inflammation of the airways with mucosal infiltration of eosinophils, T lymphocytes, and mast cells, and release of proinflammatory cytokines and lipid mediators. The natural resolution of airway inflammation is now recognized as an active host response, with highly coordinated cellular events under the control of endogenous pro-resolving mediators that enable the restoration of tissue homeostasis. Lead members of proresolving mediators are enzymatica...

Trends in the management levels of metabolic risk factors in middle-aged and elderly patients with type 2 diabetes mellitus: The Korean National Health and Nutrition Examination Survey 1998-2014.

The present study examined the temporal trends in the management of blood pressure, glucose, and lipid levels among middle-aged and elderly patients with type 2 diabetes using data from the Korean National Health and Nutrition Examination Survey (1998-2014). A total of 3,689 patients with diabetes were included and divided into middle-aged (30-64 years old) and elderly (≥65 years old) groups. Demographic and lifestyle data were obtained using a self-reported questionnaire, and trained medical staff obtain...

Super-temporal resolved microscopy reveals multistep desorption kinetics of α-lactalbumin from nylon.

Insight into the mechanisms driving protein-polymer interactions is constantly improving due to advances in experimental and computational methods. In this work, we used super-temporal resolved microscopy (STReM) to study the interfacial kinetics of a globular protein, α-lactalbumin (α-LA), adsorbing at the water-nylon 6,6 interface. The improved temporal resolution of STReM revealed that residence time distributions involve an additional step in the desorption process. Increasing the ionic strength in th...

Clinical correlation of biopsy results in patients with temporal arteritis.

Temporal arteritis is systemic vasculitis of medium and large sized vessels. The lowest incidence rates were reported in Turkey, Japan and Israel. We aimed to investigate the results of patients with biopsy-proven temporal arteritis and those classified according to the American College of Rheumatology criteria from a low-incidence region for temporal arteritis. The results of our study are noteworthy, since there is limited data on pathologic diagnosis of temporal arteritis in Turkey.

Damage of the temporal lobe and APOE status determine neural compensation in mild cognitive impairment.

In mild cognitive impairment (MCI), the APOE4 genotype is associated with accelerated memory decline, likely due to the impact of neuropathology on main cerebral networks required for successful memory retrieval and/or to decreased capacity for recruiting secondary networks that might compensate for that brain damage. Here, we tested this hypothesis in twenty-six healthy older adults and thirty-four MCI patients, of which sixteen were APOE4 carriers. Compared to controls, MCI showed hippocampal volume reduc...

Bias-Exchange Metadynamics Simulation of Membrane Permeation of 20 Amino Acids.

Thermodynamics of the permeation of amino acids from water to lipid bilayers is an important first step for understanding the mechanism of cell-permeating peptides and the thermodynamics of membrane protein structure and stability. In this work, we employed bias-exchange metadynamics simulations to simulate the membrane permeation of all 20 amino acids from water to the center of a dipalmitoylphosphatidylcholine (DPPC) membrane (consists of 256 lipids) by using both directional and torsion angles for confor...

Hypersensitivity as Extraordinary High Temporal Processing in Individuals with Autism-Spectrum Disorders.

Most individuals with autism-spectrum disorders have hypersensitivity/hyposensitivity to various types of sensory stimuli. Although several hypotheses such as higher sensitivity to stimuli, alterations in brain structure and function, and dysfunction of inhibitory systems at the molecular level have been suggested, there is no convincing evidence. We found that individuals with high temporal resolution tended to have strong hypersensitivity to sensory stimuli and vice versa. In addition, we focused on a cas...

Membrane Lipid Oscillation: An Emerging System of Molecular Dynamics in the Plant Membrane.

Biological rhythm represents a major biological process of living organisms. However, rhythmic oscillation of membrane lipid content is poorly described in plants. The development of lipidomic technology has led to the illustration of precise molecular profiles of membrane lipids under various growth conditions. Compared to conventional lipid signaling, which produces unpredictable lipid changes in response to ever-changing environmental conditions, lipid oscillation generates a fairly predictable lipid pro...

Anatomical variations of the human cochlea determined from micro-CT and high-resolution CT imaging and reconstruction.

Understanding the anatomical variations in the human cochlea are important for cochlear implants. This study examined these variations using a reconstructed fusion model of the skull and temporal bone. The 3D digital model of the temporal bone was reconstructed from multiple axial micro-CT scans of temporal bone and high resolution CT (HRCT) of the skull from 15 cadavers. A skull model was reconstructed and merged with the reconstructed temporal bone. The 3D relationship between the cochlea and the skull's ...

Pesticide Risks in Small Streams - How to Get as Close as Possible to the Stress Imposed on Aquatic Organisms.

The risks associated with pesticides in small streams remain poorly characterized. The challenges reside in understanding the complexities of (1) the highly dynamic concentration profiles of (2) several hundred active substances with (3) differing seasonality. The present study addressed these three challenges simultaneously. Five small streams in catchments under intensive agricultural land use were sampled using half-day composite samples from March to August 2015. Of 213 active substances quantified usin...

A regulatory insertion-deletion polymorphism in the FADS gene cluster influences PUFA and lipid profiles among Chinese adults: a population-based study.

Arachidonic acid (AA) is the major polyunsaturated fatty acid (PUFA) substrate for potent eicosanoid signaling to modulate inflammation and thrombosis and is controlled in part by tissue abundance. Fatty acid desaturase 1 (FADS1) catalyzes synthesis of omega-6 (n-3) AA and n-3 eicosapentaenoic acid (EPA). The rs66698963 polymorphism, a 22-base pair (bp) insertion-deletion 137 bp downstream of a sterol regulatory element in FADS2 intron 1, mediates expression of FADS1 in vitro, as well as exerting positive s...

Modeling emissions for three-dimensional atmospheric chemistry transport models.

Poor air quality is still a threat for human health in many parts of the world. In order to assess measures for emission reductions and improved air quality, three-dimensional atmospheric chemistry transport modeling systems are used in numerous research institutions and public authorities. These models need accurate emission data in appropriate spatial and temporal resolution as input. This paper reviews the most widely used emission inventories on global and regional scale and looks into the methods used ...


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