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PubMed Journals Articles About "Correlation Of Eicosanoid And Proresolving Lipid Mediator Temporal Profiles And Resolution Of Pain After Thoracic Surgery" RSS

19:04 EST 21st January 2019 | BioPortfolio

Correlation Of Eicosanoid And Proresolving Lipid Mediator Temporal Profiles And Resolution Of Pain After Thoracic Surgery PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Correlation Of Eicosanoid And Proresolving Lipid Mediator Temporal Profiles And Resolution Of Pain After Thoracic Surgery articles that have been published worldwide.

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Showing "Correlation Eicosanoid Proresolving Lipid Mediator Temporal Profiles Resolution" PubMed Articles 1–25 of 16,000+

House dust mite drives pro-inflammatory eicosanoid reprogramming and macrophage effector functions.

Eicosanoid lipid mediators play key roles in type 2 immune responses, e.g. in allergy and asthma. Macrophages represent major producers of eicosanoids and they are key effector cells of type 2 immunity. We aimed to comprehensively track eicosanoid profiles during type 2 immune responses to house dust mite (HDM) or helminth infection and to identify mechanisms and functions of eicosanoid reprogramming in human macrophages.


Lipid Mediators, M2 Macrophages, and Pathological Neovascularization.

Sasaki and colleagues [1] (JCI Insight 2018;3,e96902) identified the leukocyte inflammatory lipid mediator leukotriene B4 (LTB4)/LTB4 receptor 1 receptor-signaling axis in M2 macrophages as a causal pathway for the vascular endothelial growth factor-dependent pathological neovascularization in a mouse model that mimics wet age-related macular degeneration. This observation provides a novel mechanism by which an eicosanoid lipid mediator drives retinal vascular pathology and suggests a novel therapeutic targ...

Comprehensive high-resolution multiple-reaction monitoring mass spectrometry for targeted eicosanoid assays.

Eicosanoids comprise a class of bioactive lipids derived from a unique group of essential fatty acids that mediate a variety of important physiological functions. Owing to the structural diversity of these lipids, their analysis in biological samples is often a major challenge. Advancements in mass spectrometric have been helpful for the characterization and quantification of these molecular lipid species in complex matrices. However, there are technical limitations to this approach, including low-abundant ...


Bioactive lipid species and metabolic pathways in progression and resolution of Non-Alcoholic Steatohepatitis.

The prevalence of non-alcoholic steatohepatitis (NASH) is increasing worldwide, yet there are no effective treatments. A decade has passed since initial lipidomic analyses of liver tissues from patients with non-alcoholic fatty liver disease. We have learned that liver cells from patients with NASH have an abnormal lipid composition, and the accumulation of lipids leads to organelle dysfunction, cell injury and death, and chronic inflammation, called liptoxicity. We review the lipid species and metabolic pa...

Gamma-tocotrienol attenuates the aberrant lipid mediator production in NLRP3 inflammasome-stimulated macrophages.

The activation of NLRP3 inflammasome in innate immune cells is associated with enhanced production of pro-inflammatory lipid mediator eicosanoids that play a crucial role in propagating inflammation. Gamma-tocotrienol (γT3) is an unsaturated vitamin E that has been demonstrated to attenuate NLRP3-inflammasome. However, the role of γT3 in regulating eicosanoid formation is unknown. We hypothesized that γT3 abolishes the eicosanoid production by modulating the macrophage lipidome. LPS-primed bone marrow-de...

Omega-3 PUFA attenuate mice myocardial infarction injury by emerging a protective eicosanoid pattern.

Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation is a recommended preventive approach against cardiovascular diseases, but its mechanism of protection against myocardial infarction (MI) injury is not fully understood. Eicosanoid metabolomics demonstrated an abnormal eicosanoid profile was in the plasma of mice receiving MI surgery. 19,20-EDP, 17,18-EEQ, 14,15-EET and 9,10-EpOME were decreased, and PGE was increased by the surgery. N-3 PUFA-rich diets feeding or transgene of Fat-1 shifted the ei...

Sparsity-based super-resolution microscopy from correlation information.

For more than a century, the wavelength of light was considered to be a fundamental limit on the spatial resolution of optical imaging. Particularly in light microscopy, this limit, known as Abbe's diffraction limit, places a fundamental constraint on the ability to image sub-cellular organelles with high resolution. However, modern microscopy techniques such as STED, PALM, and STORM, manage to recover sub-wavelength information, by relying on fluorescence imaging. Specifically, PALM/STORM acquire large seq...

Retraction: Effects of hypoxia on monocyte inflammatory mediator production: Dissociation between changes in cyclooxygenase-2 expression and eicosanoid synthesis.

Quantification of Temporal Resolution Improvement Factor in SMART-RECON Based Time-Resolved C-arm Cone Beam CT Angiography (TR-CBCTA).

In a recently published paper by Li \etal \cite{LiPMB2018}, reconstruction parameters were optimized for the so-called Synchronized MultiArtifact Reduction with Tomographic reconstruction (SMART-RECON) method to enable time-resolved cone beam CT angiography (TR-CBCTA) from a single short-scan CBCT data set. However, the paper did not quantitatively address how much temporal resolution can be improved by using the SMART-RECON algorithm in TR-CBCTA. The purpose of this note was to present a method to quantify...

Dietary omega-3 fatty acids alter the lipid mediator profile and alleviate allergic conjunctivitis without modulating T2 immune responses.

Allergic conjunctivitis (AC) is one of the most common ocular surface diseases in the world. In AC, T helper type 2 (T2) immune responses play central roles in orchestrating inflammatory responses. However, the roles of lipid mediators in the onset and progression of AC remain to be fully explored. Although previous reports have shown the beneficial effects of supplementation of ω-3 fatty acids in asthma or atopic dermatitis, the underlying molecular mechanisms are poorly understood. In this study, a diet ...

Characterization of the thickness of the tear film lipid layer using high resolution microscopy.

Interferometry is an optical technique that have been used to quantify the lipid layer of the precorneal tear film, and to investigate the relationship between lipid layer thickness and tear film evaporation. However, the relationship between lipid layer thickness and the rate of evaporation is far from consistent. One possible reason is the inherent limit of contemporary interferometric systems, which employ objectives with relatively long depth of focus (DOF) (>15 μm or more), which tend to collect exc...

Temporal-spatial analysis of crop residue burning in China and its impact on aerosol pollution.

China has performed crop residue burning (CRB) for a long time and has suffered from resultant environmental pollution. High temporal resolution has not been fully discussed in attempts to address the temporal and spatial impact of CRB in China on air quality. Our study used the MOD14A1 product of the MODerate resolution Imaging Spectrometer (MODIS) to extract the daily CRB for China during the period from 2014 to 2016, and the daily aerosol optical depth (AOD) provided by MODIS Collection 6 was obtained to...

Lipid profiles in Himasthla elongata and their intermediate hosts, Littorina littorea and Mytilus edulis.

In this research, the lipid profiles in rediae and free-living larvae (cercariae) of the trematodes Himasthla elongata were studied. It was shown that the lipid profiles of cercariae and rediae reflect the selective accumulation of membrane phospholipids and polyunsaturated fatty acids. In addition, infected tissues' lipid compositions in the intermediate hosts Littorina littorea (whole organism) and Mytilus edulis (foot) were studied. Modifications in the molluscs' lipid compositions were mainly caused by ...

Lipid profiling of C. elegans strains administered pro-longevity drugs and drug combinations.

We report the effect of four lifespan modifying drugs and of synergistic combinations of these drugs on lipid profile in Caenorhabditis elegans. We employ ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) to compare the abundance of lipid species in treated and control animals. Adult nematodes were treated with rapamycin, rifampicin, psora-4 and allantoin and combinations of these compounds and the resulting change in lipid profiles, specifically in those of triacylglycerol (TAG), ph...

Present and future temporal profiles and their relationship to health intentions and behaviors: A test on a Norwegian general population sample.

We investigated the temporal profiles of a Norwegian general population sample and their relation to health behaviors and intentions. The profiles were based on variables from the present and future dimensions of the Zimbardo Time Perspective Inventory (ZTPI), the Consideration of Future Consequences Scale (CFCS), and the combination of both scales. The analysis revealed that there were only two stable clusters that corresponded to the present and the future profiles. Generally, CFCS-based present and futur...

Software-aided quality control of parallel reaction monitoring based quantitation of lipid mediators.

We characterized the performance of a micro-flow LC-ESI-MS approach to analyze lipid mediators (LMs) and polyunsaturated fatty acids (PUFA) that was optimized for SPE free lipid extraction. Tandem mass spectrometry was exclusively performed in parallel reaction monitoring (PRM) mode using TOF and Orbitrap analyzers. This acquisition strategy allowed in addition to quantitation by specific quantifier ions to perform spectrum comparisons using full MS spectra information of the analyte. Consequently, we devel...

Influence of dietary vegetable oil blend on serum lipid profiles in large yellow croaker (Larimichthys crocea).

Serum lipid metabolic responses are associated with certain metabolic disorders induced by dietary habit in mammals. However, such associations have not been reported in fish. Lipidomic analyses were performed to investigate fish lipid metabolic responses for dietary vegetable oil (VO) blend, and to elucidate the mechanism of how dietary VO blend affects serum lipid profiles. Results showed that dietary VO blend strongly affects serum lipid profiles, especially ratio of triglyceride:phosphatidylcholine (TAG...

Spatio-temporal image correlation (STIC) in evaluation of advanced neuroendocrine tumors.

4D Ultrasound technology merging Power Doppler option called High Definition Flow (HDF) with Spatio-Temporal Image Correlation (STIC) is used in gynecology and obstetrics. It seems to be a promising tool in assessing tissue vascularization.

Temporal Multivariate Pattern Analysis (tMVPA): a single trial approach exploring the temporal dynamics of the BOLD signal.

fMRI provides spatial resolution that is unmatched by non-invasive neuroimaging techniques. Its temporal dynamics however are typically neglected due to the sluggishness of the hemodynamic signal.

Visual Analysis of Spatio-temporal Relations of Pairwise Attributes in Unsteady Flow.

Despite significant advances in the analysis and visualization of unsteady flow, the interpretation of it's behavior still remains a challenge. In this work, we focus on the linear correlation and non-linear dependency of different physical attributes of unsteady flows to aid their study from a new perspective. Specifically, we extend the existing spatial correlation quantification, i.e. the Local Correlation Coefficient (LCC), to the spatio-temporal domain to study the correlation of attribute-pairs from b...

The effects of prednisolone treatment on serological responses and lipid profiles in Ethiopian leprosy patients with Erythema Nodosum Leprosum reactions.

Erythema nodosum leprosum (ENL) is a systemic inflammatory complication occurring mainly in patients with lepromatous leprosy (LL) and borderline lepromatous leprosy (BL). Prednisolone is widely used for treatment of ENL reactions. However, it has been reported that prolonged treatment with prednisolone increases the risk for prednisolone-induced complications such as osteoporosis, diabetes, cataract and arteriosclerosis. It has been speculated that perhaps these complications result from lipid profile alte...

Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high fat diet-fed mice.

Melatonin has been shown to improve lipid metabolism and gut microbiota communities in animals and humans; however, it remains to know whether melatonin prevents obesity through gut microbiota. Here, we found that high fat diet promoted the lipid accumulation and intestinal microbiota dysbiosis in mice, while oral melatonin supplementation alleviated the lipid accumulation, and reversed gut microbiota dysbiosis, including the diversity of intestinal microbiota, relative abundances of Bacteroides and Alistip...

High Spatial-temporal Resolution Reconstruction of Plane-wave Ultrasound Images with a Multichannel Multiscale Convolutional Neural Network.

In recent years, plane-wave imaging (PWI) has attracted considerable attention because of its high temporal resolution. However, the low spatial resolution of PWI limits its clinical applications, which has inspired various studies on the high spatial resolution reconstruction of plane-wave (PW) ultrasound images. Although compounding methods and traditional high spatial resolution reconstruction approaches can improve the image quality, these techniques decrease the temporal resolution. Since learning meth...

Fatty Acid Composition and Eicosanoid Levels (LTE and PGE) of Human Milk from Normal Weight and Overweight Mothers.

Maternal obesity is known to affect human milk composition. Long-chain polyunsaturated fatty acids (LCPUFA) are vital nutrients to the nervous system development and precursors of eicosanoids related to obesity (prostaglandin E-PGE-and leukotriene E-LTE). The aim of the present research was to study the lipid profiles, with particular emphasis to LCPUFAs, and the concentrations of eicosanoids PGE and LTE, involved in adipose tissue development, in human milk from overweight mothers compared with normal weig...

Total Synthesis of the Antidiabetic (Type 2) Lipid Mediator Protectin DX/PDX.

The first total synthesis of a lipid mediator derived from natural ω-3-fatty acid docosahexaenoic acid (DHA), 10 S,17 S-diHDHA (also referred to as protectin DX/PDX), was achieved in a convergent route (29 steps). The two chiral hydroxyl groups at C-10 and C-17 were derived from readily available ( S)-1,2,4-butanetriol and ( R)-glycidol, respectively. The two stereodefined E-double bonds were generated by a Takai olefination, and the skipped diene side chain was introduced with a stereocontrolled Wittig ol...


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