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PubMed Journals Articles About "Correlation Of Eicosanoid And Proresolving Lipid Mediator Temporal Profiles And Resolution Of Pain After Thoracic Surgery" RSS

23:31 EDT 21st October 2018 | BioPortfolio

Correlation Of Eicosanoid And Proresolving Lipid Mediator Temporal Profiles And Resolution Of Pain After Thoracic Surgery PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Correlation Of Eicosanoid And Proresolving Lipid Mediator Temporal Profiles And Resolution Of Pain After Thoracic Surgery articles that have been published worldwide.

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Showing "Correlation Eicosanoid Proresolving Lipid Mediator Temporal Profiles Resolution" PubMed Articles 1–25 of 16,000+

Comprehensive high-resolution multiple-reaction monitoring mass spectrometry for targeted eicosanoid assays.

Eicosanoids comprise a class of bioactive lipids derived from a unique group of essential fatty acids that mediate a variety of important physiological functions. Owing to the structural diversity of these lipids, their analysis in biological samples is often a major challenge. Advancements in mass spectrometric have been helpful for the characterization and quantification of these molecular lipid species in complex matrices. However, there are technical limitations to this approach, including low-abundant ...


Gamma-tocotrienol attenuates the aberrant lipid mediator production in NLRP3 inflammasome-stimulated macrophages.

The activation of NLRP3 inflammasome in innate immune cells is associated with enhanced production of pro-inflammatory lipid mediator eicosanoids that play a crucial role in propagating inflammation. Gamma-tocotrienol (γT3) is an unsaturated vitamin E that has been demonstrated to attenuate NLRP3-inflammasome. However, the role of γT3 in regulating eicosanoid formation is unknown. We hypothesized that γT3 abolishes the eicosanoid production by modulating the macrophage lipidome. LPS-primed bone marrow-de...

Bioactive lipid species and metabolic pathways in progression and resolution of Non-Alcoholic Steatohepatitis.

The prevalence of non-alcoholic steatohepatitis (NASH) is increasing worldwide, yet there are no effective treatments. A decade has passed since initial lipidomic analyses of liver tissues from patients with non-alcoholic fatty liver disease. We have learned that liver cells from patients with NASH have an abnormal lipid composition, and the accumulation of lipids leads to organelle dysfunction, cell injury and death, and chronic inflammation, called liptoxicity. We review the lipid species and metabolic pa...


Omega-3 PUFA attenuate mice myocardial infarction injury by emerging a protective eicosanoid pattern.

Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation is a recommended preventive approach against cardiovascular diseases, but its mechanism of protection against myocardial infarction (MI) injury is not fully understood. Eicosanoid metabolomics demonstrated an abnormal eicosanoid profile was in the plasma of mice receiving MI surgery. 19,20-EDP, 17,18-EEQ, 14,15-EET and 9,10-EpOME were decreased, and PGE was increased by the surgery. N-3 PUFA-rich diets feeding or transgene of Fat-1 shifted the ei...

Unified nexus of macrophages and maresins in cardiac reparative mechanisms.

Macrophages are immune-sensing "big eater" phagocytic cells responsible for an innate, adaptive, and regenerative response. After myocardial infarction, macrophages predominantly clear the deceased cardiomyocyte apoptotic or necrotic neutrophils to develop a regenerative and reparative program with the activation of the lipoxygenase-mediated maresin (MaR) metabolome at the site of ischemic injury. The specialized proresolving molecule and macrophage mediator in resolving inflammation, MaR-1, produced by hum...

Sparsity-based super-resolution microscopy from correlation information.

For more than a century, the wavelength of light was considered to be a fundamental limit on the spatial resolution of optical imaging. Particularly in light microscopy, this limit, known as Abbe's diffraction limit, places a fundamental constraint on the ability to image sub-cellular organelles with high resolution. However, modern microscopy techniques such as STED, PALM, and STORM, manage to recover sub-wavelength information, by relying on fluorescence imaging. Specifically, PALM/STORM acquire large seq...

Oral ibuprofen differentially affects plasma and sweat lipid mediator profiles in healthy adult males.

Sweat contains a variety of lipid mediators, but whether they originate from the plasma filtrate or from the cutaneous sweat glandular tissues themselves is unknown. To explore this knowledge gap, we collected plasma and sweat from healthy men (n = 9) immediately before and 0.5, 2 and 4 h after oral administration of 400 mg ibuprofen. Of the over 100 lipid mediators assayed by liquid chromatography-tandem mass spectrometry, ~45 were detected in both plasma and sweat, and 36 were common to both matri...

Eicosanoid signaling in carcinogenesis of colorectal cancer.

Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related death in the USA. It is of practical importance to identify novel therapeutic targets of CRC to develop new anti-cancer drugs and to discover novel biomarkers of CRC to develop new detection methods. Eicosanoids, which are metabolites of polyunsaturated fatty acids produced by cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP) enzymes, are important lipid-signaling molecules involved in th...

Quantification of Temporal Resolution Improvement Factor in SMART-RECON Based Time-Resolved C-arm Cone Beam CT Angiography (TR-CBCTA).

In a recently published paper by Li \etal \cite{LiPMB2018}, reconstruction parameters were optimized for the so-called Synchronized MultiArtifact Reduction with Tomographic reconstruction (SMART-RECON) method to enable time-resolved cone beam CT angiography (TR-CBCTA) from a single short-scan CBCT data set. However, the paper did not quantitatively address how much temporal resolution can be improved by using the SMART-RECON algorithm in TR-CBCTA. The purpose of this note was to present a method to quantify...

Resolution of fatty liver and weight loss: Independent associations with changes in serum lipids and apolipoproteins.

It is uncertain whether resolution of fatty liver can improve cardiovascular disease risk factors, independently of changes in body mass index (BMI). Our aim was to test whether resolution of fatty liver is associated with improvements in components of the lipid profile, independently of changes in BMI, and to quantify and compare the magnitude of benefit of resolution of liver fat, and decreases in BMI on the lipid profile.

Lipid profiles in Himasthla elongata and their intermediate hosts, Littorina littorea and Mytilus edulis.

In this research, the lipid profiles in rediae and free-living larvae (cercariae) of the trematodes Himasthla elongata were studied. It was shown that the lipid profiles of cercariae and rediae reflect the selective accumulation of membrane phospholipids and polyunsaturated fatty acids. In addition, infected tissues' lipid compositions in the intermediate hosts Littorina littorea (whole organism) and Mytilus edulis (foot) were studied. Modifications in the molluscs' lipid compositions were mainly caused by ...

Dexamethasone induces ω3-derived immunoresolvents driving resolution of allergic airway inflammation.

Dexamethasone induces the production of DHA-derived specialized proresolving lipids and the resolution of allergic airway inflammation. This adds glucocorticosteroids to the short list of drugs that are known to possess direct pro-resolving functions.

Software-aided quality control of parallel reaction monitoring based quantitation of lipid mediators.

We characterized the performance of a micro-flow LC-ESI-MS approach to analyze lipid mediators (LMs) and polyunsaturated fatty acids (PUFA) that was optimized for SPE free lipid extraction. Tandem mass spectrometry was exclusively performed in parallel reaction monitoring (PRM) mode using TOF and Orbitrap analyzers. This acquisition strategy allowed in addition to quantitation by specific quantifier ions to perform spectrum comparisons using full MS spectra information of the analyte. Consequently, we devel...

Influence of dietary vegetable oil blend on serum lipid profiles in large yellow croaker (Larimichthys crocea).

Serum lipid metabolic responses are associated with certain metabolic disorders induced by dietary habit in mammals. However, such associations have not been reported in fish. Lipidomic analyses were performed to investigate fish lipid metabolic responses for dietary vegetable oil (VO) blend, and to elucidate the mechanism of how dietary VO blend affects serum lipid profiles. Results showed that dietary VO blend strongly affects serum lipid profiles, especially ratio of triglyceride:phosphatidylcholine (TAG...

Serum Lipid Concentrations and FADS Genetic Variants in Young Mexican College Students: The UP-AMIGOS Cohort Study.

Recent genome-wide association studies in the Mexican population have identified several genetic loci associated with blood lipid levels in adults. However, studies focusing on the fatty acid desaturase (FADS) gene cluster have been understudied in this population, even though it seems associated with lipid profiles in other ethnicities. The aim of this study was to test associations between single nucleotide polymorphisms (SNPs) in the FADS cluster (rs174546, rs1535, rs174548, rs174550, rs174450, and rs174...

Temporal Multivariate Pattern Analysis (tMVPA): a single trial approach exploring the temporal dynamics of the BOLD signal.

fMRI provides spatial resolution that is unmatched by non-invasive neuroimaging techniques. Its temporal dynamics however are typically neglected due to the sluggishness of the hemodynamic signal.

Visual Analysis of Spatio-temporal Relations of Pairwise Attributes in Unsteady Flow.

Despite significant advances in the analysis and visualization of unsteady flow, the interpretation of it's behavior still remains a challenge. In this work, we focus on the linear correlation and non-linear dependency of different physical attributes of unsteady flows to aid their study from a new perspective. Specifically, we extend the existing spatial correlation quantification, i.e. the Local Correlation Coefficient (LCC), to the spatio-temporal domain to study the correlation of attribute-pairs from b...

High Spatial-temporal Resolution Reconstruction of Plane-wave Ultrasound Images with a Multichannel Multiscale Convolutional Neural Network.

In recent years, plane-wave imaging (PWI) has attracted considerable attention because of its high temporal resolution. However, the low spatial resolution of PWI limits its clinical applications, which has inspired various studies on the high spatial resolution reconstruction of plane-wave (PW) ultrasound images. Although compounding methods and traditional high spatial resolution reconstruction approaches can improve the image quality, these techniques decrease the temporal resolution. Since learning meth...

Super-temporal resolved microscopy reveals multistep desorption kinetics of α-lactalbumin from nylon.

Insight into the mechanisms driving protein-polymer interactions is constantly improving due to advances in experimental and computational methods. In this work, we used super-temporal resolved microscopy (STReM) to study the interfacial kinetics of a globular protein, α-lactalbumin (α-LA), adsorbing at the water-nylon 6,6 interface. The improved temporal resolution of STReM revealed that residence time distributions involve an additional step in the desorption process. Increasing the ionic strength in th...

Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high fat diet-fed mice.

Melatonin has been shown to improve lipid metabolism and gut microbiota communities in animals and humans; however, it remains to know whether melatonin prevents obesity through gut microbiota. Here, we found that high fat diet promoted the lipid accumulation and intestinal microbiota dysbiosis in mice, while oral melatonin supplementation alleviated the lipid accumulation, and reversed gut microbiota dysbiosis, including the diversity of intestinal microbiota, relative abundances of Bacteroides and Alistip...

Relationship between serum lipid concentrations and posttraumatic stress symptoms in the bereaved after the Sewol ferry disaster: A prospective cohort study.

The objective of this study was to investigate the relationship between serum lipid concentrations and PTSD symptoms in the bereaved after a traumatic familial loss. Eighteen months after the Sewol ferry disaster, 107 subjects who experienced traumatic losses as a result of the accident completed a mental and medical survey as well as laboratory tests for lipid profiles. At 30 months after the trauma, a total of 64 individuals completed a follow-up psychometric survey and biochemical measurements. We perfor...

Age- and sex-related difference of lipid profile in patients with ischemic stroke in China.

Age- and sex-related differences of lipid profiles were not well understood among ischemic stroke patients in China. Our study aimed to investigate the relationship between lipid abnormalities and ischemic stroke in China. A retrospective analysis was performed involving 2074 patients with ischemic stroke who admitted to Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University between January 1, 2014 and March 1, 2017. Our study indicated that there were signific...

Increased brain docosahexaenoic acid has no effect on the resolution of neuroinflammation following intracerebroventricular lipopolysaccharide injection.

Resolution of inflammation in the periphery was once thought to be a passive process, but new research now suggests it is an active process mediated by specialized pro-resolving lipid mediators (SPM) derived from omega-3 polyunsaturated fatty acids (n-3 PUFA). However, this has yet to be illustrated in neuroinflammation. The purpose of this study was to measure resolution of neuroinflammation and to test whether increasing brain docosahexaenoic acid (DHA) affects the resolution of neuroinflammation. C57Bl/6...

Fatty Acid Composition and Eicosanoid Levels (LTE and PGE) of Human Milk from Normal Weight and Overweight Mothers.

Maternal obesity is known to affect human milk composition. Long-chain polyunsaturated fatty acids (LCPUFA) are vital nutrients to the nervous system development and precursors of eicosanoids related to obesity (prostaglandin E-PGE-and leukotriene E-LTE). The aim of the present research was to study the lipid profiles, with particular emphasis to LCPUFAs, and the concentrations of eicosanoids PGE and LTE, involved in adipose tissue development, in human milk from overweight mothers compared with normal weig...

Bias-Exchange Metadynamics Simulation of Membrane Permeation of 20 Amino Acids.

Thermodynamics of the permeation of amino acids from water to lipid bilayers is an important first step for understanding the mechanism of cell-permeating peptides and the thermodynamics of membrane protein structure and stability. In this work, we employed bias-exchange metadynamics simulations to simulate the membrane permeation of all 20 amino acids from water to the center of a dipalmitoylphosphatidylcholine (DPPC) membrane (consists of 256 lipids) by using both directional and torsion angles for confor...


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