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PubMed Journals Articles About "CytRx Corporation Product Pipeline Review 2015" RSS

16:39 EST 20th January 2019 | BioPortfolio

CytRx Corporation Product Pipeline Review 2015 PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest CytRx Corporation Product Pipeline Review 2015 articles that have been published worldwide.

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Showing "CytRx Corporation Product Pipeline Review 2015" PubMed Articles 1–25 of 22,000+

Inner-product NMR spectroscopy: A variant of covariance NMR spectroscopy.

We propose a variant of covariance NMR spectroscopy, namely, inner-product NMR spectroscopy, originally suggested in Takeda (2015). The mathematical operation of inner-product NMR is the same as that of covariance NMR, except that subtraction of the average value of the variable is intentionally omitted, so that the correspondence of the spectrum with that of conventional two-dimensional Fourier-transformation is established without having to request the average to become vanishingly small. We demonstrate i...


Thrombogenicity assessment of Pipeline Flex, Pipeline Shield, and FRED flow diverters in an in vitro human blood physiological flow loop model.

Endovascular treatment of intracranial aneurysms with endoluminal flow diverters (single or multiple) has proven to be clinically safe and effective, but is associated with a risk of thromboembolic complications. Recently, a novel biomimetic surface modification with covalently bound phosphorylcholine (Shield Technology™) has shown to reduce the material thrombogenicity of the Pipeline flow diverter. Thrombogenicity of Pipeline Flex, Pipeline Shield, and Flow Redirection Endoluminal Device (FRED) in the p...

Pipeline for Integrated Microarray Expression Normalization Tool Kit (PIMENTo) for Tumor Microarray Profiling Experiments.

We have developed a Pipeline for Integrated Microarray Expression & Normalization Tool kit (PIMENTo) with the aim of streamlining the processes necessary for gene expression analysis in tumor tissue using DNA microarrays. Built with the R programming language and leveraging several open-source packages available through CRAN and Bioconductor, PIMENTo enables researchers to perform complex tasks with a minimal number of operations. Here, we describe the pipeline, review necessary data inputs, examine data ou...


Natural Product Dietary Supplement Use by Individuals with Rheumatoid Arthritis: A Scoping Review.

Natural-product dietary supplements (NDS), defined as non-mineral, non-vitamin, ingested natural product-derived substances, are the most frequently used CAM modality in the United States, with musculoskeletal disease being the most frequent reason for their use. Because NDS usage is frequently unreported and individuals with RA may be at higher risk for NDS-related side effects due the underlying nature of the disease and frequent use of complex pharmaceutical regimens, a scoping review of the literature w...

Tobacco product initiation is correlated with cross-product changes in tobacco harm perception and susceptibility: Longitudinal analysis of the Population Assessment of Tobacco and Health youth cohort.

Youth initiation with one tobacco product is associated with risk of using additional tobacco types. How use of one product potentially encourages use of others could result from changing tobacco-related perceptions. This study aimed to evaluate how tobacco product initiation correlates with changes in susceptibility (curiosity and willingness) and perceived harm of other tobacco products. For each of cigarettes, e-cigarettes, hookah, and smokeless tobacco, youth (ages 12-16; N = 8005) rated perceived h...

Chemical ecology of the marine plankton.

Covering: January 2015 through December 2017This review focuses on recent studies on the chemical ecology of planktonic marine ecosystems, with the objective of presenting a comprehensive overview of new findings in the field in the time period covered. In order to highlight the role of chemically mediated interactions in the marine plankton this review has been organized by ecological concepts starting with intraspecific communication, followed by interspecific interactions (including facilitation and mutu...

Nurturing a talent pipeline.

Vet nurse , who is a joint venture partner with Vets4Pets, has created a talent pipeline to develop her practices' staff and help with long-term recruitment.

VCPA: genomic Variant Calling pipeline and data management tool for Alzheimer's Disease Sequencing Project.

We report VCPA, our SNP/Indel Variant Calling Pipeline and data management tool used for analysis of whole genome and exome sequencing (WGS/WES) for the Alzheimer's Disease Sequencing Project. VCPA consists of two independent but linkable components: pipeline and tracking database. The pipeline, implemented using the Workflow Description Language and fully optimized for the Amazon elastic compute cloud environment, includes steps from aligning raw sequence reads, to variant calling using GATK. The tracking ...

Identifying design guidelines to meet the circular economy principles: A case study on electric and electronic equipment.

This study presents a methodology that allows the analysis of how an existing product design meets the design guidelines required from the circular economy perspective, and which are the design guidelines that would need to be incorporated into its design to become a better circular design product. For that, as a starting point, the design guidelines required for the circular product design have been identified from an extensive literature review. Then, criteria have been defined to measure the margin of im...

Pharmaceutical cocrystals: from serendipity to design to application.

The field of pharmaceutical cocrystals has reached a tipping point, particularly because cocrystals can improve the physicochemical properties of drugs without compromising their therapeutic benefit. Accounts of cocrystal investigations in the literature started in earnest in 2003 and patent applications soon followed. The frequency of both has steadily accelerated, demonstrating an enhanced understanding of the design, characterisation, and manufacture of cocrystals and heightened interest from industry. I...

Understanding mode of action can drive the translational pipeline towards more reliable health benefits for probiotics.

The different levels of knowledge described in a translational pipeline (the connection of molecular mechanisms with pre-clinical physiological and human health effects) are not complete for many probiotics. At present, we are not in a position to fully understand the mechanistic basis of many well established probiotic health benefits which, in turn, limits our ability to use mechanisms to predict which probiotics are likely to be effective in any given population. Here we suggest that this concept of a tr...

Value of RNA oxidation product 8-oxo-Gsn in evaluating renal function in patients with chronic kidney disease.

To investigate the relationship of DNA oxidative product 8-oxo-dGsn and RNA oxidative product 8-oxo-Gsn with chronic kidney disease (CKD). Between January 2015 and December 2016, 146 cases of CKD (30, 30, 31, 30 and 25 cases of CKD stage 1-5, respectively) were collected in the Department of Nephrology in Beijing Hospital. Among them, 70 cases were male, accounting for 47.95%. The age distribution ranged from 21 to 88 years, with an average age of (56.43±16.79) years. Their fasting blood and morning urine...

Pipeline Embolization Device Flow Diversion for a Dissecting Ruptured Posterior Cerebral Artery Aneurysm in a Pediatric Patient.

Intracranial aneurysms(IAs) are rare in the pediatric population and are usually considered difficult to treat with traditional microsurgery due to their complex morphology. Endovascular techniques have become the standard option for treating IAs in adults. More recently, flow diverters such as the Pipeline Embolization Device(PED) are being widely adopted for unruptured IAs with safety and efficacy in adults, yet their use in the pediatric population is not well defined. In this paper we present a pediatri...

Pipeline validation for connectivity-based cortex parcellation.

Structural connectivity plays a dominant role in brain function and arguably lies at the core of understanding the structure-function relationship in the cerebral cortex. Connectivity-based cortex parcellation (CCP), in the context of this article a framework to process structural connectivity information gained from diffusion MRI and diffusion tractography, identifies cortical subunits that furnish functional inference. The underlying pipeline of algorithms interprets similarity in structural connectivity ...

Future Trends and the Economic Burden of Dementia in Manitoba: Comparison with the Rest of Canada and the World.

Dementia is a growing public health concern in Canada. This epidemic is linked to huge human and economic costs. The number of Manitobans (65+) with dementia in 2045 (47,021), representing 2.58% of the Manitoban population, will be 2.3 times that of the year 2015 (20,235). The number of cases of dementia in Manitoba grew by 20.7% from 2015 to 2025, 68.16% from 2015 to 2035 and at an alarming rate of 125% from 2015 to 2045. Importantly, the total economic burden of dementia in Manitoba is close to one billio...

Morphological Feature Elongation Can Predict Occlusion Status Following Pipeline Embolization of Intracranial Aneurysms.

To explore whether computed morphological features can be used as independent predictors of incomplete occlusion of aneurysms treated with pipeline embolization device.

Metagenomic binning reconstruction coupled with automatic pipeline annotation and giant viruses: a potential source of mistake in annotations.

Metagenomic binning reconstructions represent an emergent powerful tool to discover novel microbial genomes and explore the diversity in microbial communities. This method is sometimes coupled with automatic pipeline to perform automatic annotations. Nevertheless, we found a publish Alphaproteobacteria in public database that containing 20 contigs identified as a bacterium that were actually a novel giant viruses close to Aureococcus anophagefferens virus. This virus was completely misidentified by automati...

Optimising neonatal fMRI data analysis: Design and validation of an extended dHCP preprocessing pipeline to characterise noxious-evoked brain activity in infants.

The infant brain is unlike the adult brain, with considerable differences in morphological, neurodynamic, and haemodynamic features. As the majority of current MRI analysis tools were designed for use in adults, a primary objective of the Developing Human Connectome Project (dHCP) is to develop optimised methodological pipelines for the analysis of neonatal structural, resting state, and diffusion MRI data. Here, in an independent neonatal dataset we have extended and optimised the dHCP fMRI preprocessing p...

Pipeline Embolization of Vertebrobasilar Aneurysms - a Multicenter Case Series.

and purpose: The Pipeline Embolization Device (PED) is being increasingly utilized for treatment of posterior circulation aneurysms. The purpose of this study was to examine the clinical and angiographic outcomes of patients with vertebrobasilar aneurysms treated with the PED.

Review of Natural Product Biosynthesis: Chemical Logic and Enzymatic Machinery Natural Product Biosynthesis: Chemical Logic and Enzymatic Machinery . By Christopher T. Walsh and Yi Tang. Royal Society of Chemistry Publishing . 2017 . xx + 765 pp. £89.00 (∼$119). ISBN 978-1-78801-076-4 .

Rotating Catalysts Are Superior - Suppressing Product Inhibition by Anchimeric Assistance in Four-Component Catalytic Machinery.

Three distinct four-component supramolecular nanorotors, prepared by varying the rotator's structure and keeping all other components constant, exhibit rotational frequencies that differ by almost two orders of magnitude. When the rotors were used as catalyst for two click reactions, the product yield correlated with the speed of the machine, e.g. 20% at 0.50 kHz, 44% at 20 kHz and 62% at 42 kHz. The kinetic effect on the product yield is attributed to the ability of the rotating catalysts to displace the p...

Histopathological demonstration of subacute endothelialization following aneurysm re-treatment with the Pipeline embolization device.

Endothelial cell coverage along the Pipeline embolization device (PED) is one of two primary proposed mechanisms of action of the device, along with induction of intra-aneurysmal thrombosis. The temporal course of endothelialization following device deployment is poorly understood in human patients.

RepeatCraft: a meta-pipeline for repetitive element de-fragmentation and annotation.

Repetitive elements comprise large proportion of many genomes. They have impact on both genome evolution and regulation. Their classification and the study of evolutionary history is a major emerging field. Various software exist to-date to classify and map repeats across genomes. The major unresolved drawback, however, is the fragmented nature of many identified repeat loci. This ultimately makes the classification of novel repeats and their evolutionary analyses difficult. To improve on this, we developed...

Current and future treatment of hidradenitis suppurativa.

This scholarly review on the current and future treatment of hidradenitis suppurativa (HS) focuses on medical and surgical treatment options, while novel pipeline drugs are also discussed. Treatment goals are to limit the incidence and duration of flares, reducing inflammation and suppuration, achieving local cure after surgery and, most importantly, to improve the quality of life of patients with HS. The type of medication and/or surgery should be chosen based on the stage of the disease and the degree of ...

Pyridoxal phosphate-dependent reactions in the biosynthesis of natural products.

Covering: up to mid-2018Pyridoxal 5'-phosphate (PLP) is a versatile organic cofactor used to catalyze diverse reactions on amino acid, oxoacid, and amine substrates. Here we review the reactions catalyzed by PLP-dependent enzymes, highlighting enzymes reported in the natural product biosynthetic literature. We describe enzymes that catalyze transaminations, Claisen-like condensations, and β- and γ-eliminations and substitutions, along with epimerizations, decarboxylations, and transaldolations. Finally, w...


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