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PubMed Journals Articles About "CytRx Corporation Product Pipeline Review 2015" RSS

00:07 EST 13th November 2018 | BioPortfolio

CytRx Corporation Product Pipeline Review 2015 PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest CytRx Corporation Product Pipeline Review 2015 articles that have been published worldwide.

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Showing "CytRx Corporation Product Pipeline Review 2015" PubMed Articles 1–25 of 22,000+

Inner-product NMR spectroscopy: A variant of covariance NMR spectroscopy.

We propose a variant of covariance NMR spectroscopy, namely, inner-product NMR spectroscopy, originally suggested in Takeda (2015). The mathematical operation of inner-product NMR is the same as that of covariance NMR, except that subtraction of the average value of the variable is intentionally omitted, so that the correspondence of the spectrum with that of conventional two-dimensional Fourier-transformation is established without having to request the average to become vanishingly small. We demonstrate i...


Thrombogenicity assessment of Pipeline Flex, Pipeline Shield, and FRED flow diverters in an in vitro human blood physiological flow loop model.

Endovascular treatment of intracranial aneurysms with endoluminal flow diverters (single or multiple) has proven to be clinically safe and effective, but is associated with a risk of thromboembolic complications. Recently, a novel biomimetic surface modification with covalently bound phosphorylcholine (Shield Technology™) has shown to reduce the material thrombogenicity of the Pipeline flow diverter. Thrombogenicity of Pipeline Flex, Pipeline Shield, and Flow Redirection Endoluminal Device (FRED) in the p...

Natural Product Dietary Supplement Use by Individuals with Rheumatoid Arthritis: A Scoping Review.

Natural-product dietary supplements (NDS), defined as non-mineral, non-vitamin, ingested natural product-derived substances, are the most frequently used CAM modality in the United States, with musculoskeletal disease being the most frequent reason for their use. Because NDS usage is frequently unreported and individuals with RA may be at higher risk for NDS-related side effects due the underlying nature of the disease and frequent use of complex pharmaceutical regimens, a scoping review of the literature w...


Continuous Manufacturing in Pharmaceutical Process Development and Manufacturing.

The pharmaceutical industry has found new applications for the use of continuous processing for the manufacture of new therapies currently in development. The transformation has been encouraged by regulatory bodies as well as driven by cost reduction, decreased development cycles, access to new chemistries not practical in batch, improved safety, flexible manufacturing platforms, and improved product quality assurance. The transformation from batch to continuous manufacturing processing is the focus of this...

The antimalarial pipeline.

Over the past decade, new high-throughput phenotypic assays with malaria parasites have been developed, and these were used to screen millions of compounds. This effort, as well as improving older chemical scaffolds and optimising compounds against both known and new drug targets has resulted in the discovery of exciting new pipeline drug candidates that are now being evaluated in a number of clinical trials. In addition, the pitfalls and opportunities from this experience has led to a better definition of ...

Tobacco product initiation is correlated with cross-product changes in tobacco harm perception and susceptibility: Longitudinal analysis of the Population Assessment of Tobacco and Health youth cohort.

Youth initiation with one tobacco product is associated with risk of using additional tobacco types. How use of one product potentially encourages use of others could result from changing tobacco-related perceptions. This study aimed to evaluate how tobacco product initiation correlates with changes in susceptibility (curiosity and willingness) and perceived harm of other tobacco products. For each of cigarettes, e-cigarettes, hookah, and smokeless tobacco, youth (ages 12-16; N = 8005) rated perceived h...

MitoFish and MiFish pipeline: a mitochondrial genome database of fish with an analysis pipeline for environmental DNA metabarcoding.

Fish mitochondrial genome (mitogenome) data form a fundamental basis for revealing vertebrate evolution and hydrosphere ecology. Here, we report recent functional updates of MitoFish, which is a database of fish mitogenomes with a precise annotation pipeline MitoAnnotator. Most importantly, we describe implementation of MiFish pipeline for metabarcoding analysis of fish mitochondrial environmental DNA (eDNA), which is a fast-emerging and powerful technology in fish studies. MitoFish, MitoAnnotator, and MiFi...

VCPA: genomic Variant Calling pipeline and data management tool for Alzheimer's Disease Sequencing Project.

We report VCPA, our SNP/Indel Variant Calling Pipeline and data management tool used for analysis of whole genome and exome sequencing (WGS/WES) for the Alzheimer's Disease Sequencing Project. VCPA consists of two independent but linkable components: pipeline and tracking database. The pipeline, implemented using the Workflow Description Language and fully optimized for the Amazon elastic compute cloud environment, includes steps from aligning raw sequence reads, to variant calling using GATK. The tracking ...

Use of Pipeline™ embolization device for the treatment of traumatic intracranial pseudoaneurysms: Case series and review of cases from literature.

Intracranial traumatic pseudoaneurysms (PSA) are a rare but dangerous subtype of cerebral aneurysm. Reports documenting use of flow-diverting stents to treat traumatic intracranial PSAs are few and lack long-term follow-up. To our knowledge, this is the largest case-series to date demonstrating use of Pipeline Endovascular Device (PED) for traumatic intracranial PSAs.

In Cancer Care, Can We Afford To Hope?

At last count, the pharmaceutical industry's new product pipeline included more than 7,000 products in late-stage development, roughly half of which are deemed "specialty." The reality is, our health care system is poorly equipped to address this issue head-on.

Review article A translational view of cells' secretome analysis - from untargeted proteomic to potential circulating biomarkers.

The identification of circulating biomarkers capable of being used as routine for diagnosis, prognosis, risk stratification and therapeutic monitoring is still the major aim at clinical proteomics. However, the direct search in blood samples or other clinical relevant biofluids is frequently associated with technical limitations that makes the biomarker discovery process extremely difficult when using these types of samples. In this sense, the use of different approaches, such as the analysis of cells' secr...

Identifying design guidelines to meet the circular economy principles: A case study on electric and electronic equipment.

This study presents a methodology that allows the analysis of how an existing product design meets the design guidelines required from the circular economy perspective, and which are the design guidelines that would need to be incorporated into its design to become a better circular design product. For that, as a starting point, the design guidelines required for the circular product design have been identified from an extensive literature review. Then, criteria have been defined to measure the margin of im...

Novel Therapeutics in Psoriatic Arthritis. What Is in the Pipeline?

To highlight the recently approved therapeutic agents in psoriatic arthritis (PsA), drugs in the pipeline, as well as to discuss efficacy with regard to different clinical domains of PsA.

Appendicular fracture epidemiology of children and adolescents: a 10-year case review in Western Australia (2005 to 2015).

Fracture incidence data of Australian children and adolescents have not been reported in the literature. A 10-year case review of fracture presentations in Western Australia is provided. Between 2005 and 2015, fracture incidence increased relative to population growth. This is concerning, and interventions are required to reverse this trend.

Understanding mode of action can drive the translational pipeline towards more reliable health benefits for probiotics.

The different levels of knowledge described in a translational pipeline (the connection of molecular mechanisms with pre-clinical physiological and human health effects) are not complete for many probiotics. At present, we are not in a position to fully understand the mechanistic basis of many well established probiotic health benefits which, in turn, limits our ability to use mechanisms to predict which probiotics are likely to be effective in any given population. Here we suggest that this concept of a tr...

Pipeline Embolization Device Flow Diversion for a Dissecting Ruptured Posterior Cerebral Artery Aneurysm in a Pediatric Patient.

Intracranial aneurysms(IAs) are rare in the pediatric population and are usually considered difficult to treat with traditional microsurgery due to their complex morphology. Endovascular techniques have become the standard option for treating IAs in adults. More recently, flow diverters such as the Pipeline Embolization Device(PED) are being widely adopted for unruptured IAs with safety and efficacy in adults, yet their use in the pediatric population is not well defined. In this paper we present a pediatri...

Consumer and product-specific characteristics influencing the effect of nutrition, health and risk reduction claims on preferences and purchase behavior - A systematic review.

The research on nutrition, health, and risk reduction claims (NHR claims) shows a lack of consensus as to whether these claims have a positive or negative effect on consumer's preferences and purchase behavior. This issue has been highlighted by many authors. Therefore, a comprehensive literature review was performed to find reasons for contradictory results. First, a theoretical framework was developed which divided the determinants of the effects of NHR claims on consumers' preferences and purchase behavi...

Pipeline validation for connectivity-based cortex parcellation.

Structural connectivity plays a dominant role in brain function and arguably lies at the core of understanding the structure-function relationship in the cerebral cortex. Connectivity-based cortex parcellation (CCP), in the context of this article a framework to process structural connectivity information gained from diffusion MRI and diffusion tractography, identifies cortical subunits that furnish functional inference. The underlying pipeline of algorithms interprets similarity in structural connectivity ...

Evaluation of Natural Language Processing (NLP) Systems to Annotate Drug Product Labeling with MedDRA Terminology.

The FDA Adverse Event Reporting System (FAERS) is a primary data source for identifying unlabeled adverse events (AEs) in a drug or biologic drug product's postmarketing phase. Many AE reports must be reviewed by drug safety experts to identify unlabeled AEs, even if the reported AEs are previously identified, labeled AEs. Integrating the labeling status of drug product AEs into FAERS could increase report triage and review efficiency. Medical Dictionary for Regulatory Activities (MedDRA) is the standard fo...

Regenerating Eye Tissues to Preserve and Restore Vision.

Ocular regenerative therapies are on track to revolutionize treatment of numerous blinding disorders, including corneal disease, cataract, glaucoma, retinitis pigmentosa, and age-related macular degeneration. A variety of transplantable products, delivered as cell suspensions or as preformed 3D structures combining cells and natural or artificial substrates, are in the pipeline. Here we review the status of clinical and preclinical studies for stem cell-based repair, covering key eye tissues from front to b...

Morphological Feature Elongation Can Predict Occlusion Status Following Pipeline Embolization of Intracranial Aneurysms.

To explore whether computed morphological features can be used as independent predictors of incomplete occlusion of aneurysms treated with pipeline embolization device.

Future Trends and the Economic Burden of Dementia in Manitoba: Comparison with the Rest of Canada and the World.

Dementia is a growing public health concern in Canada. This epidemic is linked to huge human and economic costs. The number of Manitobans (65+) with dementia in 2045 (47,021), representing 2.58% of the Manitoban population, will be 2.3 times that of the year 2015 (20,235). The number of cases of dementia in Manitoba grew by 20.7% from 2015 to 2025, 68.16% from 2015 to 2035 and at an alarming rate of 125% from 2015 to 2045. Importantly, the total economic burden of dementia in Manitoba is close to one billio...

Metagenomic binning reconstruction coupled with automatic pipeline annotation and giant viruses: a potential source of mistake in annotations.

Metagenomic binning reconstructions represent an emergent powerful tool to discover novel microbial genomes and explore the diversity in microbial communities. This method is sometimes coupled with automatic pipeline to perform automatic annotations. Nevertheless, we found a publish Alphaproteobacteria in public database that containing 20 contigs identified as a bacterium that were actually a novel giant viruses close to Aureococcus anophagefferens virus. This virus was completely misidentified by automati...

Patterns of E-Cigarette Use Among Youth and Young Adults: Review of the Impact of E-Cigarettes on Cigarette Smoking.

The present article provides a review of the impact of e-cigarette use on subsequent cigarette smoking among youth and YAs. Studies presented here suggest that e-cigarette use among non-smokers is associated with subsequent cigarette smoking, but study designs are subject to numerous limitations. Future research should focus on addressing the characteristics that put youth and YAs at risk of using either product and how appeal and accessibility of these products are related to product use in order to inform...

Optimising neonatal fMRI data analysis: Design and validation of an extended dHCP preprocessing pipeline to characterise noxious-evoked brain activity in infants.

The infant brain is unlike the adult brain, with considerable differences in morphological, neurodynamic, and haemodynamic features. As the majority of current MRI analysis tools were designed for use in adults, a primary objective of the Developing Human Connectome Project (dHCP) is to develop optimised methodological pipelines for the analysis of neonatal structural, resting state, and diffusion MRI data. Here, in an independent neonatal dataset we have extended and optimised the dHCP fMRI preprocessing p...


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