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Showing "Daiichi Sankyo takes option diabetes stem cell start" PubMed Articles 1–25 of 31,000+

Who Will Win: Induced Pluripotent Stem Cells Versus Embryonic Stem Cells for β Cell Replacement and Diabetes Disease Modeling?

Ever since the reprogramming of human fibroblasts to induced pluripotent stem cells (hiPSCs), scientists have been trying to determine if hiPSCs can give rise to progeny akin to native terminally differentiated cells as human embryonic stem cells (hESCs) do. Many different somatic cell types have been successfully reprogrammed via a variety of methods. In this review, we will discuss recent studies comparing hiPSCs and hESCs and their ability to differentiate to desired cell types as well as explore diabete...

Towards Standardized Stem Cell Therapy in Type 2 Diabetes Mellitus: A Systematic Review.

Setting our AdipoSIGHTS on Stem Cells in Pharmacogenomics.

In a recent study published in Cell Stem Cell, Hu et al. (2019) used human adipose stem cell-derived adipocytes to demonstrate that genetic variation predicts anti-diabetic response to thiazolidinediones (TZDs) by modulating PPARγ binding.

Competition for Food Drives Stem Cell Fate in Facultative Niches.

Mechanisms regulating maintenance of the stem cell pool in facultative niches of the mammalian testis are poorly understood. In this issue of Cell Stem Cell, Kitadate et al. (2019) propose a minimal model in which stem cells compete for limited resources of fibroblast growth factors, which predicts their density during homeostasis and regenerative conditions.

Impact of conditioning intensity on outcomes of haploidentical stem cell transplantation for patients with acute myeloid leukemia over 45 years of age.

T cell-replete haploidentical stem cell transplantation (haplo-SCT) is a valid therapeutic option for adult patients with high-risk acute myeloid leukemia (AML) lacking an HLA-matched sibling or unrelated donor.

Spatiotemporal Resolution of SCF Supply in Early Hematopoiesis.

Evidence suggests that hematopoietic progenitor cells self-replenish in situ over prolonged time frames, centering the question on the identity and source of growth factors maintaining HPC fidelity. In this issue of Cell Stem Cell, Comazzetto et al. (2019) suggest that normal stem and progenitor function relies on stem cell factor provided by distinct cellular sources.

Stem Cell Aging? Blame It on the Niche.

The molecular basis for the neural stem cell quiescence-to-activation transition has become an important focus in the study of adult neurogenesis. Recently in Cell, Kalamakis et al. (2019) show that aged neural stem cells face greater barriers to exiting quiescence, imposed by the niche through inflammation and altered Wnt signaling.

Women in Stem Cell Science: Part I.

Female scientists play important leadership roles in the field and with the International Society for Stem Cell Research. We asked a number of these top researchers to share their personal stories and reflect on their career paths. Part II of this series will run in the October 2018 issue of Stem Cell Reports.

Systemic delivery of mesenchymal stem cells condition media in repeated doses acts as magic bullets in restoring IFN-γ/IL-4 balance in asthmatic rats.

With respect to recent advantage in stem cell application, given the concern reported previously after stem cell transplantation, mesenchymal stem cell-derived conditioned media (MSC-CM) could be a potential approach to guarantee more safety and efficient outcomes than the current stem cell-based regenerative therapies.

Peritoneal Dialysis as an Option for Unplanned Dialysis Initiation in Patients with End-Stage Renal Disease and Diabetes Mellitus.

This study aimed to compare the short-term complications and long-term prognosis between urgent-start peritoneal dialysis (PD) and hemodialysis (HD), and explore the safety and feasibility of PD in end-stage renal disease (ESRD) patients with diabetes.

An Unexpected Calm: Mfge8 Controls Stem Cell Quiescence and Maintenance.

Radial glia-like neural stem cells (RGLs) in the mouse hippocampus generate neurons throughout life, but RGL maintenance mechanisms remain unclear. In this issue of Cell Stem Cell, Zhou et al. (2018) identified Mfge8, a well-known mediator of the "eat-me" signal, as a factor that reinforces quiescence and protects the RGL niche from depletion.

Human Skeletal Stem Cells: The Markers Provide Some Clues in the Hunt for Hidden Treasure.

Little is known about skeletal stem cell populations in vivo. Recently in Cell, Chan et al. (2018) identified a human skeletal stem cell population that can be isolated from multiple human bone locations and is capable of self-renewal and differentiation into bone, cartilage, and stroma, but not fat.

Influence of pH on Skin Stem Cells and Their Differentiation.

Intracellular pH influences proliferation and differentiation in a range of stem-like and progenitor cells, including embryonic stem cells, induced pluripotent stem cells, mesenchymal stem cells, and cancer stem cells. Sodium hydrogen exchanger (NHE1), a glycoprotein that plays a major role in regulating intracellular pH, has a major role in the proliferation and cell differentiation in multiple cell types. We review observations collected on the influence of pH on multiple stem-like cell populations. Alter...

The Making of a Leukemic Stem Cell: A Novel Role for IKZF2 in AML Stemness and Differentiation.

Identification of key stemness regulators is critical for developing more effective therapies against acute myeloid leukemia stem cells (LSCs). In this issue of Cell Stem Cell, Park et al. (2019) report that IKZF2, a member of the Ikaros family of transcription factors, drives self-renewal and suppresses differentiation in LSCs through modulation of chromatin accessibility.

20 Years of Human Pluripotent Stem Cell Research: It All Started with Five Lines.

November 2018 marks the 20 anniversary of the seminal human embryonic stem cell (hESC) publication, which reported the initial hESC derivations and launched the field of human pluripotent stem cell research. To commemorate this significant milestone, we reflect on the scientific, economic, and clinically relevant impact of this groundbreaking achievement.

Efficacy and Safety of Autologous Bone Marrow Mesenchymal Stem Cell Transplantation in Patients with Diabetic Retinopathy.

The treatment options for diabetic retinopathy (DR) are limited. Mesenchymal stem cells (MSCs) are a promising treatment option for diabetes and its complications. In this pilot clinical trial, we evaluated the safety and efficacy of intravenous autologous bone marrow MSCs (ABMSC) for the treatment of DR.

Close Quarters Can Be a Good Fit for Stem Cells to Become T Cells.

Human pluripotent stem cells (PSCs) could potentially provide a potentially unlimited supply of T cells. In this issue of Cell Stem Cell, Montel-Hagen et al. (2019) take advantage of a three-dimensional mouse stromal cell-based system that combines mesoderm specification with organoid-induced hematopoietic differentiation to enable commitment, selection, and maturation of conventional human T cells.

Adipose-derived Human Perivascular Stem Cells May Improve Achilles Tendon Healing in Rats.

Achilles tendon rupture is a common injury and the best treatment option remains uncertain between surgical and nonoperative methods. Biologic approaches using multipotent stem cells such as perivascular stem cells pose a possible treatment option, although there is currently a paucity of evidence regarding their clinical therapeutic use.

Corrigendum to "Establishment of TUSMi007-A, an induced pluripotent stem cell (iPSC) line from an 83-year old Chinese Han patient with Alzheimer's disease (AD)" Stem Cell Research 33(2018) 265-268.

Corrigendum to Establishment of TUSMi005-A, an induced pluripotent stem cell (iPSC) line from a 32-year old Chinese Han patient with Bipolar Disorder (BD). Stem Cell Research 33(2018) 65-68.

Hematopoietic Stem Cells Rock Around The Clock: Circadian Fate Control via TNF/ROS Signals.

Hematopoietic stem cell function is closely tied to circadian rhythms. In this issue of Cell Stem Cell, Golan et al. (2018) identify crosstalk between circadian hormone signals, the inflammatory cytokine TNF, and bone marrow macrophages as a key regulator of HSC proliferation, differentiation, and self-renewal in the bone marrow.

The Harmful Consequences of Increased Fitness in Hematopoietic Stem Cells.

Clonal hematopoiesis of indeterminate potential (CHIP) describes clonal selection of a hematopoietic stem cell with a somatic mutation that confers increased fitness, influenced by a selective environment such as aging, inflammation, or therapeutic exposure. In this issue of Cell Stem Cell, Hsu et al. (2018) explore the role of cytotoxic therapy in disease-relevant CHIP.

Early Start Peritoneal Dialysis: Technique Survival in Long-Term Follow-Up.

Peritoneal dialysis (PD) has gained interest over the last decade as a viable option for early start dialysis. It is still unknown if shorter break-in periods and less time for proper patient evaluation and training could influence technique survival in comparison to planned-start PD.

Development and organization of the zebrafish intestinal epithelial stem cell niche.

Development of the vertebrate intestinal epithelial stem cell niche begins during embryogenesis but maturation occurs post-embryonic. The intestinal mammalian crypt contains stem cells interspersed by secretory cells that play a role in regulation of proliferation. Epithelial cells are specified as either secretory or enterocytes as they migrate up the villi in mammals or fold in zebrafish. Zebrafish forms a functional intestine by the end of embryogenesis but takes another four weeks to develop the adult p...

Stem cells in the treatment of diabetes mellitus - focus on mesenchymal stem cells.

Diabetes mellitus type 1 and type 2 have become a global epidemic with dramatically increasing incidences. Poorly controlled diabetes is associated with severe life-threatening complications. Beside traditional treatment with insulin and oral anti-diabetic drugs, clinicians try to improve patient's care by cell therapies using embryonic stem cells (ESC), induced pluripotent stem cells (iPSC) and adult mesenchymal stem cells (MSC). ESC display a virtually unlimited plasticity, including the differentiation i...

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