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The majority of U.S. teens admit to handheld cellphone use while driving, an increasingly common cause of crashes. Attitudes towards novel cellphone applications and settings that block use while driving are poorly understood, potentially limiting uptake. We examined teens' willingness to reduce cellphone use while driving and perceptions of potential strategies to limit this behavior.
Chronic kidney disease-mineral and bone disorder (CKD-MBD) play a critical role in the pathogenesis of cardiovascular complications in patients with chronic kidney disease (CKD). Zuogui pill as a traditional Chinese herbal drug has been used for nourish kidney essence improve bone malnutrition of renal bone disease by regulating the metabolism of calcium and phosphorus and participating in osteoblast metabolism. In the present study, 5/6 nephrectomy rat model was used to reveal the mechanism of zuogui pill ...
The pulmonary embolism rule out criteria (PERC) reliably predicts a low probability of PE in adults. We examine the diagnostic accuracy of the objective components of the PERC rule in children previously tested for PE.
Numerous studies have explored the neural mechanisms related to task switching or rule shifting, but few have revealed the neural substrates related to rule shifting at different hierarchical levels. The purpose of this study is to explore the different event-related potentials (ERPs) elicited by higher and lower hierarchical levels of rule shifting in a cue-target task. In the task, participants were presented with Arabic digits (1-9, excluding 5), and performed a parity or magnitude judgment according to ...
The "HERDOO2 rule" is a prospectively validated clinical decision rule used to identify low-risk women who can safely discontinue anticoagulants after completing 5-12 months of anticoagulant treatment for unprovoked venous thromboembolism. The VIDASd-Dimer (DD) assay, a component of the rule, was used in the derivation and validation of the rule at half the usual diagnostic cut-point for exclusion of venous thrombosis. It is unknown if other commercial DD assays used at a corresponding cut-point will cate...
On August 12, 2016, VA published in the Federal Register the proposed rule for Schedule for Rating Disabilities: Skin. VA received multiple responses during the 60-day comment period. This final rule implements the Secretary’s proposed rule with limited revisions.
The Rule of 7s for Lyme Meningitis is a validated clinical prediction rule to distinguish Lyme meningitis from aseptic meningitis.
Morning fatigue is a distinct symptom experienced during chemotherapy that demonstrates significant interindividual variability.
Humans demonstrate a circadian rhythm of melatonin production that closely tracks the daily light/dark cycle, with profound increases in circulating levels during the night-time and nearly nonexistent levels during daylight hours. Although melatonin is known to play a role in preparing the brain and body for sleep, its effects on cognition and brain function are not well understood. We hypothesized that declines in morning melatonin would be associated with increased functional activation within cortical re...
Expectations shape human behavior. Initial drug use might be associated with information-based expectations. In this study, we presumed that changes in affect and perceived physical wellbeing will be stronger after receiving an active placebo (Tic Tac mint; n = 40), than a pure placebo (inert pill; n = 40) given as a mood-enhancing "super pill." After baseline measures, participants completed a treatment-expectancy scale, ingested the mint/super pill, and attended to the effects over 3-minutes. Subsequently...
Thirty years ago, Parr and Yang postulated that favorable chemical processes are associated with large changes in the electronic chemical potential or, equivalently, the electronegativity. They called this the "|Δμ| big is good" rule and noted that, if the rule could be justified, it "would constitute a validation of frontier theory from first principles." In this letter we provide a simple and insightful justification for the "|Δμ| big is good" rule, with special emphasis on electron-transfer reactions...
The present study investigated whether increasing morning rectal temperatures (T) to evening levels, or increasing morning and evening Tto an "optimal" level (38.5°C), resulting in increased muscle temperatures (T), would offset diurnal variation in repeated sprint (RS) performance in a causal manner. Twelve trained males underwent five sessions [age (mean ± SD) 21.0 ± 2.3 years, maximal oxygen consumption (V̇Omax) 60.0 ± 4.4 mL.kg min, height 1.79 ± 0.06 m, body mass 78.2 ± 11.8 kg]. Th...
Since November 2017, the digital pill, which makes it possible to know whether a patient has achieved compliance or not with the treatment has become a reality. This drug can benefit the patients by helping them to better follow their treatment and avoid misuse. However, even though the use of this device requests patient consent, major questions arise regarding the respect for privacy and freedom of action. Evidently, the correct use of drugs is both a public health and economic issue, but through this dig...
Sharp foreign bodies such as toothpicks or chicken bones can lead to intestinal perforation. Small intestinal perforation secondary to foreign body ingestion is usually manifested as an acute abdomen without a history of trauma. Here we describe the diagnosis and treatment of a case of small bowel perforation caused by an ingested pill and its outer packing.
A database analysis was conducted to assess the effectiveness of sucroferric oxyhydroxide (SO) on lowering serum phosphorus and phosphate binder (PB) pill burden among adult peritoneal dialysis (PD) patients prescribed SO as part of routine care.
Adverse cardiovascular events such as myocardial infarction and sudden cardiac death occur more frequently in the morning. Prior studies have shown that vascular endothelial function (VEF), a marker of cardiovascular disease, is attenuated during physical inactivity, and declines across the night. We sought to determine whether a morning attenuation in VEF is a result of prior sleep or the inactivity that inevitably accompanies sleep.
Medication adherence after myocardial infarction remains low. Pharmacy claims have typically been used to measure medication adherence, but electronic pill bottles may offer additional information.
Infants' ability to learn complex linguistic regularities from early on has been revealed by electrophysiological studies indicating that 3-month-olds, but not adults, can automatically detect non-adjacent dependencies between syllables. While different ERP responses in adults and infants suggest that both linguistic rule learning and its link to basic auditory processing undergo developmental changes, systematic investigations of the developmental trajectories are scarce. In the present study, we assessed ...
In patients consulting in the Emergency Department for chest pain, a HEART score ≤ 3 has been shown to rule out an acute coronary syndrome (ACS) with a low risk of major adverse cardiac event (MACE) occurrence. A negative CARE rule (≤ 1) that stands for the first four elements of the HEART score may have similar rule-out reliability without troponin assay requirement. We aim to prospectively assess the performance of the CARE rule and of the HEART score to predict MACE in a chest pain population. ...
Accumulating evidence suggests that trends in salivary cortisol after awakening may be reliable biological predictors of morbidity and mortality. In a sample of elite military men, our lab recently established summary parameters of morning cortisol as well as their stability across 2 d of repeated sampling.
After discrimination learning between two stimuli that lie on a continuum, animals typically exhibit generalization on the basis of similarity to the physical features of the stimuli, often producing a peak-shifted gradient. However, post-discrimination generalization in humans usually resembles a monotonically increasing (e.g., linear) gradient that is better characterized as following a relational rule describing the difference between the stimuli. The current study tested whether rule-based generalizatio...
Dahuang zhechong pill (DHZCP) is a famous traditional Chinese medicinal prescription from the "Synopsis of Prescriptions of the Golden Chamber (Jin Kui Yao Lue)", an ancient Chinese medical classic. DHZCP is commonly used for clinical treatment of liver cancer by promoting blood circulation to dissolve blood stasis and by removing pathogenic vegetations. DHZCP-based treatment has been derived from Traditional Chinese Medicine (TCM) and is officially recorded in the Chinese Pharmacopoeia.
Globally, the prevalence of uncontrolled hypertension is high, particularly in low- and middle-income countries. There is a critical need for strategies to improve hypertension control. The early use of a fixed low-dose combination of three antihypertensive drugs (triple pill) has the potential to significantly improve hypertension control. The ple Pill vs. sual care anagement for atients with mild-to- moderate ypertension (TRIUMPH) randomised controlled trial (RCT) is designed to test the effects of t...
Case-control study; clinical prediction rule.
Among weeds, morning glories comprise a very important group of climbing plants that infest sugarcane crops. The objective of this study was to evaluate the shoot and root interference of Merremia cissoides on the initial growth of sugarcane cultivar RB 966928. The experiment consisted of five treatment groups: (i) sugarcane monocropping, (ii) morning glory monocropping, (iii) sugarcane intertwined with morning glory but inseparate boxes, (iv) sugarcane intertwined with morning glory in attached boxes and (...