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PubMed Journals Articles About "Determination Of Pre-Absorptive Dissociation Of Zinc From A Zinc Amino Acid Complex In Healthy Men" RSS

13:36 EST 20th February 2020 | BioPortfolio

Determination Of Pre-Absorptive Dissociation Of Zinc From A Zinc Amino Acid Complex In Healthy Men PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Determination Of Pre-Absorptive Dissociation Of Zinc From A Zinc Amino Acid Complex In Healthy Men articles that have been published worldwide.

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Showing "Determination Absorptive Dissociation Zinc From Zinc Amino Acid" PubMed Articles 1–25 of 13,000+

Separation of C and N-Isotopologues of Amino Acids with a Primary Amine without Mass Resolution by means of O-Phthalaldehyde Derivatization and Collision Induced Dissociation.

Computational and experimental advances of recent years have culminated in establishing C-Metabolic Flux Analysis (C-MFA) as a routine methodology to unravel the fluxome. As the acronym suggests, C-MFA has relied on the relative abundance of C-isotopes in metabolites for flux inference, most commonly measured by mass spectrometry. In this manuscript we expand the scope of labeling measurements to the case of simultaneous C and N labeling of amino acids. Analytically, the separation of isotopologues of this ...


Asymmetric Synthesis of α-Amino Phosphonic Acids Using Stable Imino Phosphonate as a Universal Precursor.

A practical method for synthesizing chiral α-amino phosphonic acid derivatives was developed. Readily available and stable N-o-nitrophenylsulfenyl (Nps) imino phosphonate was utilized as a substrate for a highly enantioselective Friedel-Crafts-type addition of indole or pyrrole nucleophiles catalyzed by chiral phosphoric acid. The resulting adduct was easily converted to N-9-fluorenylmethyloxycarbonyl (Fmoc) amino phosphonic acid, which is useful for synthesizing peptides containing an amino phosphonic aci...

Immunosuppressive properties of amino acid and peptide derivatives of mycophenolic acid.

Mycophenolic acid (MPA) was coupled with amino acids and biologically active peptides including derivatives of tuftsin to modify its immunosuppressive properties. Both amino acid unit in the case of simple MPA amides and modifications within peptide moiety of MPA - tuftsin conjugates influenced the observed activity. Antiproliferative potential of the obtained conjugates was investigated in vitro and MPA amides with threonine methyl ester and conjugate of MPA with retro-tuftisin occurred to be more selecti...


Synthesis of Chiral β-Fluoroalkyl β-Amino Acid Derivatives via Palladium-catalyzed Hydrogenation.

An enantioselective palladium-catalyzed hydrogenation of β-fluoroalkyl-β-amino acrylic acid derivatives has been successfully developed, providing the corresponding chiral β-fluoroalky β-amino acid derivatives in good yields with excellent enantioselectivities. In addition, chiral γ-fluoroalkyl-γ-amino alcohol could be synthesized by simple reduction of the corresponding hydrogenated product. The mechanism of the reaction was explored by deuterium labeling experiments.

Peptide-Driven Shape Control of Low-Dimensional DNA Nanostructures.

We report the rational design and fabrication of unusual low-dimensional DNA nanostructures through programmable and sequence-specific peptide interactions. Dual-bioactive block copolymers composed of DNA and amino acid-based polymers (DNA--poly(amino acid)) were synthesized by coupling oligonucleotides to phenylalanine (Phe)-based polymers. Unlike prototypical DNA block copolymers, which typically form simple spherical micelles, DNA--poly(amino acid) assemble into various low-dimensional structures such as...

The synergistic effects of Cu clusters and InO on ethanol synthesis from acetic acid hydrogenation.

The development of high efficiency catalysts for acetic acid hydrogenation to ethanol could ameliorate the petroleum crisis and acetic acid overproduction. Cu and In2O3 catalysts both show catalytic activity for acetic acid hydrogenation. However, monometallic Cu catalysts are less active in the dissociative adsorption of acetic acid through C-O bond breaking, while the H2 adsorption and dissociation ability of In2O3 is weak. In this work, Cu4/In2O3 is designed to enhance the dissociation of both acetic aci...

Molecular Cloning of an Amino Acid Permease Gene and Structural Characterization of the Protein in Common Bean (Phaseolus vulgaris L.).

Plants synthesize amino acids by collateral metabolic pathways using primary elements carbon and oxygen from air, hydrogen from water in soil and nitrogen from soil. Following synthesis, amino acids are immediately used for metabolism, transient storage or transported to the phloem. Different families of transporters have been identified for import of amino acids into plant cells. The first identified amino acid transporter, amino acid permease 1 (AAP1) in Arabidopsis belongs to a family of eight members an...

Skeletal muscle proteome of piglets is affected in a muscle-dependent manner by a limiting total sulfur amino acid supply.

A total sulfur amino acid (TSAA) deficient diet can affect the amino acid composition of skeletal muscles. However, it is unknown how the different muscle proteins are affected by the TSAA deficiency.

Reduced Na K -ATPase activity may reduce amino acid uptake in IUGR fetal sheep muscle despite unchanged ex vivo amino acid transporter activity.

Fetuses with intrauterine growth restriction (IUGR) have reduced muscle mass that persists postnatally, which may contribute to their increased risk for adult onset metabolic diseases, such as diabetes and obesity. Amino acid transporter mediated histidine uptake and system L amino acid transporter activity were similar in sarcolemmal membranes isolated from control and IUGR hindlimb skeletal muscle. Activity of Na K -ATPase, which is responsible for establishing the sodium gradient necessary for system A a...

How dissociation of carboxylic acid groups in a weak polyelectrolyte brush depend on their distance from the substrate.

A weak polyelectrolyte brush is composed of a layer of polyacids or polybases grafted by one end of their chains to a substrate surface. For such brush layers immersed in an aqueous solution, the dissociation behavior of the acidic or basic groups and the structural and physical properties of the brush layer will thus be strongly dependent on the environmental conditions. For a polyacid brush layer consisting of, e.g., poly(acrylic acid), this means that the chains in the brush layer will be charged at high...

Enzymatic Conversions of Glutamate and γ-Aminobutyric Acid as Indicators of Plant Stress Response.

Glutamate plays a central role in amino acid metabolism, in particular, in aminotransferase reactions leading to formation of many other proteinogenic and nonproteinogenic amino acids. In stress conditions, glutamate can be either metabolized to γ-aminobutyric acid (GABA) by glutamate decarboxylase which initiates a GABA shunt bypassing several reactions of the tricarboxylic acid cycle or converted to 2-oxoglutarate by glutamate dehydrogenase. Both reactions direct protein carbon to respiration but also li...

A Comparative Synthetic Strategy Perspective on α-Amino Acids (α-AA) and Non-Amino Acid Derived Synthons towards Total Syntheses of Selected Natural Macrolides.

Macrocyclic alkaloids and cyclopeptides have immense applications in drug discovery research because of their natural abundance with potential biological and physicochemical properties. Presently, more than 100 approved drugs or clinical drug candidates contain macrocyclic scaffolds as the biologically active component. The review provides an interesting perspective about the use of amino acid derived chiral pools versus other methods derived from miscellaneous synthons towards total synthesis of non-peptid...

Rapid Access to Hindered α-Amino Acid Derivatives and Benzodiazepin-3-ones from Aza-Oxyallyl Cations.

Catalyst-free and mild synthetic methods for the construction of hindered α-amino acid derivatives are presented herein. A wide range of hindered amino acid amides can be readily obtained from the reaction of α-halohydroxamates with a variety of amines, including anilines, primary amines, and secondary amines. Moreover, the aza/aza-[4+3] cycloaddition of in situ-generated aza-oxyallyl cations with 2-aminophenyl α,β-unsaturated carbonyls to furnish seven-membered benzodiazepin-3-ones is reported for the ...

Determination of four omega-3 polyunsaturated fatty acids by UPLC-MS/MS in plasma of hyperlipidemic and normolipidemic subjects.

Omega-3 polyunsaturated fatty acids (PUFAs), including alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA), play critical roles in numerous biochemical reactions. Our aim is to develop a rapid and sensitive method for simultaneous determination of ALA, EPA, DHA and DPA in the plasma of hyperlipidemic and normolipidemic subjects.

Extraprostatic Uptake of F-Fluciclovine: Differentiation of Nonprostatic Neoplasms From Metastatic Prostate Cancer.

Fluciclovine is a synthetic radiolabeled amino acid analog used for imaging of biochemical recurrent prostate cancer. Uptake of fluciclovine is mediated by several amino acid transporters, including alanine-serine-cysteine transporter 2 and large neutral amino acid transporters, which are known to be overexpressed in other malignancies. Knowledge of the common patterns of prostate cancer recurrence, in addition to what other neoplasms can show uptake, is critical for accurate study interpretation.

Determination of scoring functions for protein damage susceptibility.

Protein damage (partly followed by protein aggregation) plays a significant role in ageing, cancer and in neurodegenerative and other diseases. It is known that the proteinogenic amino acids differ in their susceptibility to non-enzymatic modification, such as hydroxylation, peroxidation, chlorination etc. In a novel bioinformatics approach, we introduce measures to quantify the susceptibility of the 20 standard proteinogenic amino acids to such modification. Based on these amino acid scores, we calculated ...

Modelling of amino acid turnover in the horse during training and racing: A basis for developing a novel supplementation strategy.

Horses in heavy training in preparation for racing and competition have increased metabolic demands to support the more intensive levels of exercise and recovery. However, little is known at the metabolic level about amino acid turnover and the specific alterations of demand caused by high intensity exercise. During exercise, certain amino acids are required in greater quantities due to disproportionate losses via excretory systems and usage in biosynthetic pathways. This investigation has built a theoretic...

Neuronal processing of amino acids in Drosophila: from taste sensing to behavioural regulation.

Finding and feeding on appropriate food are crucial for all animals. Carbohydrates and amino acids are both essential nutrients, albeit with distinct roles: the former are the main energy source whereas the latter are the building blocks of proteins and are used as neurotransmitters. Despite their crucial role, neither the sensing nor the neuronal processing of amino acids is well understood. Studies in Drosophila melanogaster have only recently gained momentum in shedding new light on the molecular and neu...

Deactivation and mislocalization of Toxoplasma gondii rhoptry protein 18 induced by a single amino acid mutation on the proton transport catalytic aspartic acid.

Rhoptry protein 18 (ROP18) is a major determinant of strain-specific virulence in Toxoplasma gondii. The kinase activity of ROP18 is required for acute virulence, while the aspartate in the catalytic loop of ROP18 is considered essential for phosphoryl transfer. We showed that a single amino acid mutation at the catalytic aspartate residue (D409A mutation) significantly altered ROP18 kinase activity in vitro, and abolished ROP18-mediated ATF6β degradation. Furthermore, the investigated single amino acid mu...

Amino Acid Sensing: Architecture of mTORC1 on the Lysosome Surface.

Amino acid signaling through the Rag GTPases promotes mTORC1 lysosomal localization and subsequent activation. Two new cryo-EM structures examine the architecture of the Rag GTPase heterodimers complexed with mTORC1.

Amino acid polymorphism in Succinate dehydrogenase subunit C involved in biological fitness of Botrytis cinerea.

Succinate dehydrogenase (SDH) is an important respiratory enzyme which participates in tricarboxylic acid cycle (TCA) and oxidative phosphorylation. Previous study about the baseline sensitivity of Botrytis cinerea against succinate dehydrogenase inhibitors (SDHIs) showed that intrinsic sensitivity of the small population against the SDHIs exhibited significantly difference. In the sequencing assay, we found five kinds of amino acid polymorphism in SDHC of B. cinerea isolates which were never exposed to the...

Ultrafine FeC nanoparticles embedded in N-doped graphitic carbon sheets for simultaneous determination of ascorbic acid, dopamine, uric acid and xanthine.

A pyrolytic method is described for preparation of ultrafine FeC nanoparticles incorporated into N-doped graphitic carbon nanosheets (FeC@NGCSs). Iron phthalocyanine and graphitic carbon nitride (g-CN) are used as starting materials. The hybrid nanocomposite was placed on a glassy carbon electrode (GCE) and then applied to simultaneous determination of ascorbic acid (AA), dopamine (DA), uric acid (UA) and xanthine (XA). Figures of merits are as follows: for AA, the linear response range covers the 54.0-5491...

Calculating Resin Functionalization in Solid-Phase Peptide Synthesis Using a Standardized Method based on Fmoc Determination.

Solid-phase synthesis is the method of choice for peptide preparation in both research and industrial settings. The whole synthetic process is governed by the initial functionalization of the resin. Although the literature provides several methods to determine such functionalization, the addition of an Fmoc-amino acid and the posterior spectrophotometric measurement based on the Beer-Lambert law of the dibenzofulvene adduct formed after Fmoc removal is the most widely used for this purpose. However, a range...

In silico study of colchicine resistance molecular mechanisms caused by tubulin structural polymorphism.

Starting from 1972, colchicine is known as the most useful drug for prevention of familial Mediterranean fever attacks. However, some patients do not respond to colchicine treatment, even taken in high doses. Despite the fact, that different hypotheses have been proposed, the molecular mechanisms of colchicine resistance are not completely clear. It is generally known, that colchicine binds β-tubulin and inhibits microtubules polymerization. The β-tubulin gene has SNPs, which lead to amino acid substituti...

Investigation of tryptophan-related yellowing in parenteral amino acid solution: Development of a stability-indicating method and assessment of degradation products in pharmaceutical formulations.

Parenteral amino acid solutions containing tryptophan tend to develop a yellow colouration upon storage. Hence, the aim of the present study was to find out whether tryptophan degradation products are the reason for the yellowing. The degree of discolouration and tryptophan degradation was examined by visual examination and UV/Vis measurements with respect to oxygen presence, pH value, and duration of steam sterilization. LC-UV analyses of autoclaved tryptophan solutions indicated eight degradation products...


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