PubMed Journals Articles About "DiFusion Announces Data ZFUZE Immuno Stealth Surgical Polymer" RSS

07:50 EDT 20th September 2019 | BioPortfolio

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Showing "DiFusion Announces Data ZFUZE Immuno Stealth Surgical Polymer" PubMed Articles 1–25 of 31,000+

Architectural Modification of Conformal PEG-Bottlebrush Coatings Minimizes Anti-PEG Antigenicity While Preserving Stealth Properties.

Poly(ethylene glycol) (PEG), a linear polymer known for its "stealth" properties, is commonly used to passivate the surface of biomedical implants and devices, and it is conjugated to biologic drugs to improve their pharmacokinetics. However, its antigenicity is a growing concern. Here, the antigenicity of PEG is investigated when assembled in a poly(oligoethylene glycol) methacrylate (POEGMA) "bottlebrush" configuration on a planar surface. Using ethylene glycol (EG) repeat lengths of the POEGMA sidechains...

First-line Immuno-Oncology Combination Therapies in Metastatic Renal-cell Carcinoma: Results from the International Metastatic Renal-cell Carcinoma Database Consortium.

In metastatic renal-cell carcinoma (mRCC), recent data have shown efficacy of first-line ipilimumab and nivolumab (ipi-nivo) as well as immuno-oncology (IO)/vascular endothelial growth factor (VEGF) inhibitor combinations. Comparative data between these strategies are limited.

Evidence for integration of palliative care into surgical oncology practice and education.

High-quality data support multiple clinical benefits of integrating palliative care into routine oncology care. Though these data come largely from the medical oncology literature, data from surgical oncology populations support similar associations between palliative care integration and improved clinical outcomes, all without compromise in survival. This paper will review data supporting palliative care integration into oncology care, with a focus on surgical populations and recommendations for incorporat...

Surgical Data Recording Technology: A Solution to Address Medical Errors?

: Reducing preventable medical errors remains a universal goal, yet implementing effective solutions remains a challenge. The development of surgical data recording technology shows promise to generate robust qualitative and quantitative data in the surgical theater. These data can allow physicians and their teams to capture specific sources of error and implement corrective interventions. Surgical data recording technology encompasses rudimentary data tabulation on notecards, to integrated audio-video syst...

The tumor microenvironment is immuno-tolerogenic and a principal determinant of patient outcome in EBV positive Diffuse Large B Cell Lymphoma.

Epstein-Barr virus positive Diffuse Large B-Cell Lymphoma (EBV DLBCL) is a recently identified entity. Data regarding outcome to frontline immuno-chemotherapy is conflicting. Although the prognostic impact of the tumor microenvironment (TME) in EBV DLBCL is well-established, it remains untested whether the TME influences survival in EBV DLBCL. There is no data with new digital gene expression technologies that simultaneously interrogate the virus, B-cells and the tumor microenvironment (TME).

Design and characteristics of an agar additive polymer gel dosimeter.

Herein, we investigate the use of agar and gelatin in a polymer gel dosimeter. The polymer gel is enclosed in a vinyl film to obtain a dosimeter of arbitrary shape and maintain the shape at room temperature. The resulting polymer gel dosimeter could preserve its shape across a wide temperature range. Excluding the surface region, the obtained dose distribution was within 3% of that determined in an ionization chamber.

Immunotherapy and the Interventional Oncologist: Challenges and Opportunities-A Society of Interventional Oncology White Paper.

Interventional oncology is a subspecialty field of interventional radiology that addresses the diagnosis and treatment of cancer and cancer-related problems by using targeted minimally invasive procedures performed with image guidance. Immuno-oncology is an innovative area of cancer research and practice that seeks to help the patient's own immune system fight cancer. Both interventional oncology and immuno-oncology can potentially play a pivotal role in cancer management plans when used alongside medical, ...

Triple-Labelling of Polymer-Coated Quantum Dots and Adsorbed Proteins for Tracing their Fate in Cell Cultures.

Colloidal CdSe/ZnS quantum dots were water-solubilized by overcoating with an amphiphilic polymer. Human serum albumin (HSA) as model protein was either adsorbed or chemically linked to the surface of the polymer coated quantum dots. As the quantum dots are intrinsically fluorescent, and as the polymer coating and the HSA were fluorescent labelled, the final nanoparticle had three differently fluorescent components: the quantum dot core, the polymer shell, and the human serum albumin corona. Cells were incu...

Complication Rates for Pediatric Hepatectomy and Nephrectomy: A Comparison of NSQIP-P, PHIS, and KID.

Three large national data sets are commonly used to assess operative outcomes in pediatric surgery; National Surgical Quality Improvement Program Pediatric (NSQIP-P), Pediatric Health Information System (PHIS), and Kids' Inpatient Data set (KID). Hepatectomy and nephrectomy are rare pediatric surgical procedures, which may benefit from large administrative data sets for the assessment of short-term complications.

Nigerian surgical outcomes - A report of 7-DAY prospective cohort study and external validation of the African surgical outcomes study surgical risk calculator.

Surgical outcomes study for individual nations remains important because of international differences in patterns of surgical disease. We aimed to contribute to data on post-operative complications, critical care admissions and mortality following elective surgery in Nigeria and also validate the African Surgical Outcomes Study (ASOS) surgical risk calculator in our adult patient cohort.

The utility and benefit of a newly established postgraduate training course in surgical exposures for orthopedic and trauma surgery.

Limited data exist on specialty surgical cadaver courses for graduates, their skill gain, and whether the course contents are transferable to other surgical disciplines.

Gender Equity in Humanitarian Surgical Outreach: A Decade of Volunteer Surgeons.

Workforce trends in surgery demonstrate persistent gender inequity. Humanitarian surgical outreach opportunities exist for surgeons; however, it is unclear as to whether gender disparities exist in this arena. This pilot study examines gender equity among volunteer surgeons using a decade of compiled data from a surgical nongovernmental organization (NGO) that hosts multinational surgical outreach. We aim to evaluate gender proportions among surgical volunteers, compare the gender profiles of NGO surgeons w...

A comparison of the da Vinci Xi vs. the da Vinci Si Surgical System for Roux-En-Y gastric bypass.

The da Vinci Surgical System family remains the most widely used surgical robotic system for laparoscopy. Data about gastric bypass surgery with the Xi Surgical System are not available yet. We compared Roux-en-Y gastric bypass surgery performed at our institution with the da Vinci Xi and the da Vinci Si Surgical System.

Tightly-Bound PMMA on Silica Has Reduced Heat Capacities.

The heat capacities of very small adsorbed amounts of poly(methyl methacrylate) on high surface-area silica (Cab-O-Sil) were measured using temperature-modulated differential scanning calorimetry (TMDSC) using a quasi-isothermal method and interpreted via different models. The composition-dependent heat capacities of the adsorbed samples were measurably less than those predicted with a simple mixture model. A two-state model, comprised of tightly- and loosely-bound polymer, fit the data better with heat cap...

Improving the Adhesion, Flexibility, and Hemostatic Efficacy of a Sprayable Polymer Blend Surgical Sealant by Incorporating Silica Particles.

Commercially available surgical sealants for internal use either lack sufficient adhesion or produce cytotoxicity. This work describes a surgical sealant based on a polymer blend of poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) that increases wet tissue adherence by incorporation of nano-to-microscale silica particles, without significantly affecting cell viability, biodegradation rate, or local inflammation. In functional studies, PLGA/PEG/silica composite sealants produce intestinal...

Estimating Lifetime Benefits Associated with Immuno-Oncology Therapies: Challenges and Approaches for Overall Survival Extrapolations.

Standard parametric survival models are commonly used to estimate long-term survival in oncology health technology assessments; however, they can inadequately represent the complex pattern of hazard functions or underlying mechanism of action (MoA) of immuno-oncology (IO) treatments.

Comparing Five New Polymer Barriers for the Prevention of Intra-abdominal Adhesions in a Rat Model.

Intra-abdominal adhesions affect up to 93% of the patients after abdominal surgery, causing small-bowel obstruction, infertility, chronic abdominal pain, and iatrogenic bowel injury at reoperation. The efficacy of five new polymer antiadhesive barriers to avoid adhesion formation is evaluated in an ischemic button model in rats.

Comparative Safety of Systemic Immuno-modulatory Medications in Adults with Atopic Dermatitis.

Severe atopic dermatitis (AD) is increasingly treated with systemic immuno-modulatory drugs yet their safety is unclear.

The American Association for Bronchology and Interventional Pulmonology Announces the First Certificate of Added Qualification in Advanced Diagnostic Bronchoscopy.

Video-based surgical skill assessment using 3D convolutional neural networks.

A profound education of novice surgeons is crucial to ensure that surgical interventions are effective and safe. One important aspect is the teaching of technical skills for minimally invasive or robot-assisted procedures. This includes the objective and preferably automatic assessment of surgical skill. Recent studies presented good results for automatic, objective skill evaluation by collecting and analyzing motion data such as trajectories of surgical instruments. However, obtaining the motion data gener...

The first cohort of prospective Fontan surgical planning patients with follow-up data: How accurate is surgical planning?

Fontan surgical planning is an image-based, collaborative effort, which is hypothesized to result in improved patient outcomes. A common motivation for Fontan surgical planning is the progression (or concern for progression) of pulmonary arteriovenous malformations. The purpose of this study was to evaluate the accuracy of surgical planning predictions, specifically hepatic flow distribution (HFD), a known factor in pulmonary arteriovenous malformation progression, and identify methodological improvements n...

ADAR1: A New Target for Immuno-oncology Therapy.

Three recent studies by Ishizuka et al. (2019), Liu et al. (2019), and Gannon et al. (2018) show that deleting RNA editing enzyme ADAR1 could induce higher cell lethality and render tumor cells more vulnerable to immunotherapy, pinpointing ADAR1 as a new immuno-oncology target.

Technical factors affecting cardiac surgical mortality in Australia.

Examination of potentially avoidable issues in surgical deaths can provide a basis for quality improvement. Perioperative technical factors in cardiac surgery may lead or contribute to patient mortality. Using data from a well-established and comprehensive national surgical mortality audit, we aimed to identify and describe clinical management issues leading to mortality in Australian cardiac surgical patients.

Universal Route to Impart Orthogonality to Polymer Semiconductors for Sub-Micrometer Tandem Electronics.

A universal method that enables utilization of conventional photolithography for processing a variety of polymer semiconductors is developed. The method relies on imparting chemical and physical orthogonality to a polymer film via formation of a semi-interpenetrating diphasic polymer network with a bridged polysilsesquioxane structure, which is termed an orthogonal polymer semiconductor gel. The synthesized gel films remain tolerant to various chemical and physical etching processes involved in photolithogr...

The adverse health effects of bisphenol A and related toxicity mechanisms.

Bisphenol A (BPA) is an industrial component commonly used in synthesis of polycarbonate plastics, epoxy resin and other polymer materials. Due to its mass productions and widespread applications, the presence of BPA is ubiquitous in the environment. BPA can enter the body via different ways such as digestive tract, respiratory tract and dermal tract. As an endocrine disruptor, BPA has estrogen-like and anti-androgen effects causing damages to different tissues and organs, including reproductive system, imm...

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