PubMed Journals Articles About "Discovery Impact Nanoscale Science" RSS

21:46 EDT 18th March 2019 | BioPortfolio

Discovery Impact Nanoscale Science PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Discovery Impact Nanoscale Science articles that have been published worldwide.

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Showing "Discovery Impact Nanoscale Science" PubMed Articles 1–25 of 22,000+

The impact of perampanel and targeting AMPA transmission on anti-seizure drug discovery.

Synthesis and Biological Activity of Analogs of the Antifungal Antibiotic UK-2A. II. Impact of modifications to the macrocycle benzyl position.

UK-2A is an antifungal antibiotic produced by Streptomyces sp. 517-02. Derivatization of its picolinamide-OH to form the isobutyryl-acetal led to the discovery of fenpicoxamid (InatreqTM active) currently under development as a fungicide by Dow AgroSciences LLC. This paper documents efforts to achieve additional efficacy enhancements through semi-synthetic modification of the benzyl substituent of the UK-2A macrocycle.

Impact of hydrophobic micron ellipsoids on liquid surfaces.

Hydrophobic spheres may exhibit three impact modes after impacting the liquid surface. For the impact of common non-spherical particles in practical processes, particle shape affects the flow of surrounding fluid and forces acting on them, thus the impact behaviors of non-spherical particles may differ from those of spherical particles and remain to be revealed.

The clinical impact of exosomes in cardiovascular disorders: From basic science to clinical application.

Cardiovascular disease (CVD) is the major cause of death globally; therefore, there is a need for the identification of a valid biomarker that accurately predicts the risk of developing CVD, and novel therapeutic approaches for its treatment. Exosomes are very small extracellular vesicles containing protein, lipid, transcription factors, messenger RNAs, noncoding RNA, and nucleic acid contents that are important players in intercellular communication, and that act via long-range signals or cell-to-cell cont...

Tuning adatom mobility and nanoscale segregation by twin formation and polytypism.

Nanoscale variations in the composition of an Al Ga As shell around a GaAs nanowire affect the nanowire functionality and can lead to the formation of localized quantum emitters. These composition fluctuations can be the consequence of variations of crystal phase and/or nanoscale adatom mobility. By applying electron-microscopy-related techniques we correlate the optical, compositional and structural properties at the nanoscale on the same object. The results indicate a clear correlation between the twin d...

Using Science-Driven Analog Research to Investigate Extravehicular Activity Science Operations Concepts and Capabilities for Human Planetary Exploration.

Biologic Analog Science Associated with Lava Terrains (BASALT) is a science-driven exploration program seeking to determine the best tools, techniques, training requirements, and execution strategies for conducting Mars-relevant field science under spaceflight mission conditions. BASALT encompasses Science, Science Operations, and Technology objectives. This article outlines the BASALT Science Operations background, strategic research questions, study design, and a portion of the results from the second fie...

Conversion Reactions of Atomically Precise Semiconductor Clusters.

Clusters are unique molecular species that can be viewed as a bridge between phases of matter and thus between disciplines of chemistry. The structural and compositional complexity observed in cluster chemistry serves as an inspiration to the material science community and motivates our search for new phases of matter. Moreover, the formation of kinetically persistent cluster molecules as intermediates in the nucleation of crystals makes these materials of great interest for determining and controlling mech...

Pre- and Post-analytical Factors in Biomarker Discovery.

The translation of promising biomarkers, which were identified in biomarker discovery experiments, to clinical assays is one of the key challenges in present-day proteomics research. Many so-called "biomarker candidates" fail to progress beyond the discovery phase, and much emphasis is placed on pre- and post-analytical variability in an attempt to provide explanations for this bottleneck in the biomarker development pipeline. With respect to such variability, there is a large number of pre- and post-analyt...

Meeting the discovery challenge of drug-resistant infections: progress and focusing resources.

Following multiple warnings from governments and health organisations, there has been renewed investment, led by the public sector, in the discovery of novel antimicrobials to meet the challenge of rising levels of drug-resistant infection, particularly in the case of resistance to antibiotics. Initiatives have also been announced to support and enable the antibiotic discovery process. In January 2018, the Medicines Discovery Catapult, UK, hosted a symposium: Next Generation Antibiotics Discovery, to consid...

Impact of dosing schedule in animal models on compound progression decisions.

In-situ Nanoscale Redox Mapping Using Tip-enhanced Raman Spectroscopy.

Electrochemical atomic force microscopy tip-enhanced Raman spectroscopy (EC-AFM-TERS) was used for the first time to spatially resolve local heterogeneity in redox behavior on an electrode surface in-situ and at the nanoscale. A structurally well-defined Au(111) nanoplate located on a polycrystalline ITO substrate was studied to examine nanoscale redox contrast across the two electrode materials. By monitoring the TERS intensity of adsorbed Nile Blue (NB) molecules on the electrode surface, TERS maps were a...

Reliable novelty: New should not trump true.

Although a case can be made for rewarding scientists for risky, novel science rather than for incremental, reliable science, novelty without reliability ceases to be science. The currently available evidence suggests that the most prestigious journals are no better at detecting unreliable science than other journals. In fact, some of the most convincing studies show a negative correlation, with the most prestigious journals publishing the least reliable science. With the credibility of science increasingly ...

Polymer spreading on substrates with nanoscale grooves using molecular dynamics.

Understanding how liquid polymer interacts with and spreads on surfaces with nanoscale texture features is crucial for designing complex nanoscale systems. We use molecular dynamics to simulate different types of polymer as they spread on substrates with a single nanoscale groove. We study how groove design affects the potential energy of a substrate and how this governs polymer spreading and orientation. Based on our simulations, we show that groove shape, polymer chemistry, and polymer molecule entangleme...

Pseudoelasticity at Large Strains in Au Nanocrystals.

Pseudoelasticity in metals is typically associated with phase transformations (e.g., shape memory alloys) but has recently been observed in sub-10 nm Ag nanocrystals that rapidly recovered their original shape after deformation to large strains. The discovery of pseudoelasticity in nanoscale metals dramatically changes the current understanding of the properties of solids at the smallest length scales, and the motion of atoms at surfaces. Yet, it remains unclear whether pseudoelasticity exists in different...

Probing spin density at the nanoscale using spin-orbital coupling in light scattering.

We propose a scattering-type nano-polarimeter for probing the local spin density with subwavelength spatial resolution via the spin-orbital interactions at the nanoscale. The nano-polarimeter is simple to operate and can be applied to a variety of asymmetric nanoprobes, allowing direct data retrieval using two point detectors. Moreover, this technique is not limited to the spin-density detection but can also be used for the measurement of any given polarization states of light, no matter whether it is a fre...

FDA plans Office of Drug Evaluation Science.

Religiosity predicts negative attitudes towards science and lower levels of science literacy.

Past research suggests that religion and science may conflict on which is a better tool for explaining the world. This conflict implies that religiosity might negatively impact both attitudes toward science and science knowledge. However, past research has focused mostly on religious affiliation and has not consistently identified such a relation using a general religiosity measure that assesses religious beliefs and religious practice. Using two large, nationally representative datasets as well as two orig...

Time trends in the impact attributable to cold days in Spain: Incidence of local factors.

While numerous studies have shown that the impact of cold waves is decreasing as result of various processes of adaptation, far fewer have analysed the time trend shown by such impact, and still fewer have done so for the different provinces of a single country, moreover using a specific cold waves definition for each. This study thus aimed to analyse the time trend of the impact of cold days on daily mortality in Spain across the period 1983-2003.

Marie Simonin, Agnès Richaume (2015) Impact of engineered nanoparticles on the activity, abundance, and diversity of soil microbial communities: a review. Environmental Science and Pollution Research, 22:13710-13723.

Insights on the nitrate reduction and norfloxacin oxidation over a novel nanoscale zero valent iron particle: Reactivity, products, and mechanism.

Herein, the application of a novel acid mine drainage-based nanoscale zero valent iron (AMD-based nZVI) for the remediation of nitrate and norfloxacin (NOR) was studied. Experimental results indicated that the catalytic reactivity of AMD-based nZVI toward nitrate reduction was superior to that of iron salt-based nanoscale zero valent iron (Iron salt-based nZVI). The presence of ultrasound irradiation could significantly enhance the reactivity toward both the nitrate reduction and NOR oxidation processes. Th...

Progress in Inherited Retinal Disease Drug Discovery and Development: A Foundation's Perspective.

Ophthalmic drug discovery and development has enjoyed a recent renaissance, with a major shift away from reformulating old systemic drugs for ocular use to de novo discovery of drugs for specific ocular disease targets. This shift, coupled with a revolution in molecular biology and genetic sequencing, has uncovered an unprecedented number and variety of novel targets for therapeutic intervention in eye disease. With such a treasure chest of new science to pursue, it also creates a new challenge for translat...

Impact of Dry Eye on Prolonged Reading.

Patients with dry eye frequently report difficulty with reading. However, the impact of dry eye on reading has not been studied in detail. This study shows the unfavorable effect of dry eye on reading speed and offers mechanisms that may be responsible.

The determining role of nanoscale mechanical twinning on cellular functions of nanostructured materials.

Considering that micromotions generated at the bone-implant interface under physiological loading introduce mechanical strain on the tissue and surface of the implant and that strain can be introduced during processing of the biomedical device, we elucidate here the interplay between mechanically-induced nanoscale twinning in austenitic stainless steel on osteoblast functions. Mechanically-induced nanoscale twinning significantly impacted cell attachment, cell-substrate interactions, proliferation, and subs...

Titanium-oxide based nanoscale and embeddable subzero temperature sensor using MIT deformation characteristics.

In this research, we propose a nanoscale and embeddable subzero temperature sensor that is made with a temperature-dependent titanium-oxide based metal-insulator-transition (MIT) device. For a nanoscale two-terminal structured MIT device, the MIT device's characteristics are noticeably changed from abrupt to gradual MIT under zero temperature, which is called MIT deformation. On the basis of the MIT deformation characteristics, subzero temperatures can be detected by reading current levels as temperature ch...

Quantification of cellular associated graphene and induced surface receptor responses.

The use of graphene for biomedical and other applications involving humans is growing and shows practical promise. However, quantifying the graphitic nanomaterials that interact with cells and assessing any corresponding cellular response is extremely challenging. Here, we report an effective approach to quantify graphene interacting with single cells that utilizes combined multimodal-Raman and photoacoustic spectroscopy. This approach correlates the spectroscopic signature of graphene with the measurement ...

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