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PubMed Journals Articles About "Does Putting Clocks Forward Make More Likely Fail" RSS

11:35 EST 17th December 2018 | BioPortfolio

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Showing "Does putting clocks forward make more likely fail" PubMed Articles 1–25 of 4,200+

Circadian rhythms - daylight saving time, health, and body clocks.

Each year we are reminded of our body clocks with the change in "daylight saving times". At those times we are forcefully reminded of our bodily clocks and need to plan our daily schedules more carefully. In contrast, we like to deny our clocks becoming a 24/7 type, since we are "homo sapiens" (Latin - "wise man") as Carl Linnaeus, also known after his ennoblement as Carl von Linné, described us in his biological classification. This article is protected by copyright. All rights reserved.


Prospects for Circadian Treatment of Mood Disorders.

Disruption of circadian clocks is strongly associated with mood disorders. "Chronotherapies" targeting circadian rhythms have been shown to be very effective treatments of mood disorders, but still are not widely used in clinical practice. The mechanisms by which circadian disruption leads to mood disorders are poorly characterized and therefore may not convince clinicians to apply chronotherapies. Hence, in this review, we describe specific potential mechanisms, in order to make this connection more credib...

Improving counterfactual reasoning with kernelised dynamic mixing models.

Simulation-based approaches to disease progression allow us to make counterfactual predictions about the effects of an untried series of treatment choices. However, building accurate simulators of disease progression is challenging, limiting the utility of these approaches for real world treatment planning. In this work, we present a novel simulation-based reinforcement learning approach that mixes between models and kernel-based approaches to make its forward predictions. On two real world tasks, managing ...


Epigenetic clocks.

Recent research has revealed clock-like patterns of epigenetic change across the life span in humans. Models describing these epigenetic changes have been dubbed "epigenetic clocks," and they can not only predict chronological age but also reveal biological age, which measures physiological homeostasis and deterioration over the life span. Comparative studies of the epigenetic clocks of different primate species are likely to provide insights into the evolution of life history schedules, as well as shed lig...

Interplay of central and peripheral circadian clocks in energy metabolism regulation.

Metabolic health founds on a homeostatic balance which has to integrate the daily changes of rest/activity and feeding/fasting cycles. A network of endogenous 24-hour circadian clocks helps to anticipate daily recurring events and adjust physiology and behavioral functions accordingly. Circadian clocks are self-sustained cellular oscillators based on a set of clock genes/proteins organized in interlocked transcriptional-translational feedback loops. The body's clocks need to be regularly reset and synchroni...

Dependence and independence of the root clock on the shoot clock in Arabidopsis.

Temporal and spatial compartmentalization of biological processes is facilitated by tissue-specific uncoupled circadian clocks in plants. However, interactions among tissue-specific circadian clocks have not been well established. The primary objective of this study was to describe both organ-specific circadian behaviors and centralized actions of the root clock. We analyzed transcript accumulation of circadianly-oscillating genes in roots and shoots. Expression of many clock components was different in roo...

A crossroads in predictive analytics monitoring for clinical medicine.

A new goal for medical informatics is to develop robust tools that integrate clinical data on a patient in order to estimate the risk of imminent adverse events. This new field of predictive analytics monitoring is growing very quickly. Its claims, however, can be vulnerable when clinicians fail to use the best mathematical and statistical tools, when quantitative scientists fail to grasp the nuances of clinical medicine, and when either fails to incorporate knowledge of physiology. Its potential, though is...

Mitigation of Lamplight-Induced Frequency Jumps in Space Rubidium Clocks.

Rubidium clocks are currently the most common atomic clocks for space applications, playing a fundamental role in global navigation satellite systems. Their stability is affected by the light-shift effect, turning lamplight variations into frequency variations, e.g., lamplight intensity jumps into frequency jumps. In our previous work, analyzing data from GPS rubidium clocks, we uncovered the impact of the lamp on the in-orbit clock's performance. Specifically, the rubidium clock's random walk of frequency ...

Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks.

Metabolic diseases are often characterized by circadian misalignment in different tissues, yet how altered coordination and communication among tissue clocks relate to specific pathogenic mechanisms remains largely unknown. Applying an integrated systems biology approach, we performed 24-hr metabolomics profiling of eight mouse tissues simultaneously. We present a temporal and spatial atlas of circadian metabolism in the context of systemic energy balance and under chronic nutrient stress (high-fat diet [HF...

Flies as models for circadian clock adaptation to environmental challenges.

Life on earth is assumed to have developed in tropical regions that are characterized by regular 24 hour cycles in irradiance and temperature that remain the same throughout the seasons. All organisms developed circadian clocks that predict these environmental cycles and prepare the organisms in advance for them. A central question in chronobiology is how endogenous clocks changed in order to anticipate very different cyclical environmental conditions such as extremely short and long photoperiods existing c...

Feed-forward: Paving ways for students' subsequent learning.

Written feedback assists students in refining their future academic work. However, students prefer having feed-forward instead of feedback by their instructors that are the comments provided to them on drafts prior to the actual assignment submission. The current literature describes two common ways to convey feed-forward: the foremost one is on outlines while the second is on drafts. However, no existing literature had been found yet for sufficient guidance on the ideal approach of feed-forward to facilita...

The Clocks within Our Cells.

Intestinal Stem Cells Exhibit Conditional Circadian Clock Function.

The circadian clock is a molecular pacemaker that produces 24-hr physiological cycles known as circadian rhythms. How the clock regulates stem cells is an emerging area of research with many outstanding questions. We tested clock function in vivo at the single cell resolution in the Drosophila intestine, a tissue that is exquisitely sensitive to environmental cues and has circadian rhythms in regeneration. Our results indicate that circadian clocks function in intestinal stem cells and enterocytes but are ...

Increasing adenoma detection rates in the right side of the colon comparing retroflexion or a second forward view: a systematic review.

Right-sided lesions are often missed during standard colonoscopy (SC). A second forward view examination or retroflexion in the right side of the colon, have both been proposed as techniques to improve ADR in the right side of the colon. Comparative data of examining the right side of the colon with a second forward view or retroflexion is not known in a pooled analysis. We performed a systematic review of the literature to assess the yield of a second forward view compared with retroflexion examination for...

Synchronization and maintenance of circadian timing in the mammalian clockwork.

The hypothalamic suprachiasmatic nucleus (SCN) is the principal circadian pacemaker in mammals. Cells in the SCN contain cell-autonomous transcriptional-translational feedback loops, which are synchronised to each other and thereby provide a coherent output to direct synchrony of peripheral clocks located in the brain and body. A major difference between these peripheral clocks and the SCN is the requirement for intercellular coupling mechanisms, which confer robustness, stability and amplitude to the syste...

Session 2 Discussion: Clocks, Hormones and the Environment.

Potential of muscles to accelerate the body during late-stance forward progression in individuals with knee osteoarthritis.

Many individuals with knee osteoarthritis (OA) generate low forward center of mass (COM) acceleration during the late stance phase, consequently making it difficult to walk fast. This study analyzed individual muscle contributions to forward COM acceleration and the muscle potential (i.e., acceleration by unit force) to clarify whether reduced acceleration was related to decreased muscle potential of forward progression by the triceps sure. Twelve individuals with knee OA and 12 healthy age-matched individu...

Feeding time entrains the olfactory bulb circadian clock in anosmic PER2::LUC mice.

Circadian rhythms in many brain regions and peripheral organs can be entrained by daily feeding schedules. The set of feeding related signals that entrain peripheral clocks are tissue specific and include nutrients, metabolic hormones and temperature. Signals that entrain neural circadian clocks to mealtime have yet to be established for any brain region. The olfactory bulb (OB) contains a robust circadian clock that can cycle independently of the suprachiasmatic nucleus (SCN) master pacemaker. We used PER2...

Putting Mucins on the Map.

Functional variability in the flight phase of one metre springboard forward dives.

In springboard diving, low variability in takeoff conditions and in the somersault orientation angle at water entry is to be expected since consistency and accuracy are necessary for a good dive. A diver's adjustment of body configuration during flight may be a deliberate compensation for variations in takeoff conditions, leading to increased joint angle variability and decreased entry angle variability. The aim of this research was to investigate the extent to which a diver pre-plans the aerial phase and t...

Putting guidelines into practice: has the era of perioperative chemotherapy arrived?

Epigenetic clocks galore: a new improved clock predicts age-acceleration in Hutchinson Gilford Progeria Syndrome patients.

Ultrasound-Guided Plantar Fascia Injections: Where Are You Putting the Gas or Steroids?

Stride-time variability is related to sensorimotor cortical activation during forward and backward walking.

Previous research has used functional near-infrared spectroscopy (fNIRS) to show that motor areas of the cortex are activated more while walking backward compared to walking forward. It is also known that head movement creates motion artifacts in fNIRS data. The aim of this study was to investigate cortical activation during forward and backward walking, while also measuring head movement. We hypothesized that greater activation in motor areas while walking backward would be concurrent with increased head m...

A Sub-ps Stability Time Transfer Method Based on Optical Modems.

Coherent optical fiber links recently demonstrate their ability to compare the most advanced optical clocks over a continental scale. The outstanding performances of the optical clocks are stimulating the community to build much more stable time scales, and to develop the means to compare them. Optical fiber link is one solution that needs to be explored. Here, we are investigating a new method to transfer time based on an optical demodulation of a phase step imprint onto the optical carrier. We show the im...


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