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PubMed Journals Articles About "Dow AgroSciences LLC And LenioBio" RSS

04:38 EST 21st February 2019 | BioPortfolio

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Showing "AgroSciences LenioBio" PubMed Articles, all 1

Synthesis and Biological Activity of Analogs of the Antifungal Antibiotic UK-2A. II. Impact of modifications to the macrocycle benzyl position.

UK-2A is an antifungal antibiotic produced by Streptomyces sp. 517-02. Derivatization of its picolinamide-OH to form the isobutyryl-acetal led to the discovery of fenpicoxamid (InatreqTM active) currently under development as a fungicide by Dow AgroSciences LLC. This paper documents efforts to achieve additional efficacy enhancements through semi-synthetic modification of the benzyl substituent of the UK-2A macrocycle.



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