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12:44 EDT 17th July 2019 | BioPortfolio

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Showing "Drugmakers over rule requiring prices" PubMed Articles 1–25 of 1,600+

Why drug prices will continue to roil the waters-and why Scott Gottlieb, MD, will be in the center of the action.

We'll see what happens to the administration's Part B proposal. Congress is not likely to take bold action, partly because drugmakers are a strong influence on both parties. That leaves the FDA and Administrator Scott Gottlieb, MD, as major players in efforts to rein in drug prices.

Hospital Prices Grew Substantially Faster Than Physician Prices For Hospital-Based Care In 2007-14.

Evidence suggests that growth in providers' prices drives growth in health care spending on the privately insured. However, existing work has not systematically differentiated between the growth rate of hospital prices and that of physician prices. We analyzed growth in both types of prices for inpatient and hospital-based outpatient services using actual negotiated prices paid by insurers. We found that in the period 2007-14 hospital prices grew substantially faster than physician prices. For inpatient car...

Asymmetric impact of oil prices on stock returns in Shanghai stock exchange: Evidence from asymmetric ARDL model.

This study scrutinized the asymmetric impact of oil prices on stock returns in Shanghai stock exchange with data (January 2000 to December 2018) by using asymmetric ARDL model. The examined results of asymmetric autoregressive distributed lag model indicate that cointegration exists between the oil prices and the stock returns. Results of asymmetric autoregressive distributed lag model confirm that both in the long run and the short run increase in oil prices have a negative impact on the stock returns of S...

Evolution of Average European Medicine Prices: Implications for the Methodology of External Price Referencing.

There are indications of staggered market entry of medicines in the national markets, with medicines being marketed first in countries with high prices. This study aimed to analyse the availability and evolution of medicine prices in the European Union (EU).

Beyond asking: Exploring the use of automatic price evaluations to implicitly estimate consumers' willingness-to-pay.

Explicit consumers responses are often adverse for the validity of procedures used to estimate consumers' willingness-to-pay (WTP). This paper investigates if price evaluations occur automatically and to what extent these automatic processes can be used to implicitly estimate consumers' WTP. An adapted version of the task-rule congruency (TRC) paradigm was used in two studies. Results of the first study provided evidence for the notion that prices are automatically evaluated. However, the used procedure had...

It's Still The Prices, Stupid: Why The US Spends So Much On Health Care, And A Tribute To Uwe Reinhardt.

A 2003 article titled "It's the Prices, Stupid," and coauthored by the three of us and the recently deceased Uwe Reinhardt found that the sizable differences in health spending between the US and other countries were explained mainly by health care prices. As a tribute to him, we used Organization for Economic Cooperation and Development (OECD) Health Statistics to update these analyses and review critiques of the original article. The conclusion that prices are the primary reason why the US spends more on ...

The drug price iceberg: more than meets the eye.

When it comes to the political iceberg of drug prices, there is more below the surface. Policies that reduce prices but do not lower consumers' out-of-pocket costs will not address the main challenge facing most Americans.

Gasoline prices and economic policy uncertainty: what causes what, and why does it matter? Evidence from 18 selected countries.

In this paper, we examine asymmetric causal relationships between gasoline prices and economic policy uncertainty in a panel of 18 countries over the period 1998-2017, using the recently introduced panel causality approach of Hatemi et al (Appl Econ, 48:2301-2308, 2016) that accounts for asymmetric dynamics and is robust to both cross-sectional dependence and slope heterogeneity. Empirical findings reveal asymmetric causal relationships between gasoline prices and economic policy uncertainty in the sampled ...

Forecasting stock prices with a feature fusion LSTM-CNN model using different representations of the same data.

Forecasting stock prices plays an important role in setting a trading strategy or determining the appropriate timing for buying or selling a stock. We propose a model, called the feature fusion long short-term memory-convolutional neural network (LSTM-CNN) model, that combines features learned from different representations of the same data, namely, stock time series and stock chart images, to predict stock prices. The proposed model is composed of LSTM and a CNN, which are utilized for extracting temporal ...

Kasha's rule: a reappraisal.

This work revises some anomalous cases reported in the literature, which seemingly violate Kasha's rule. To the contrary, apart from azulene, the remaining molecules fulfill Kasha's rule. Kasha's rule must be stated just as in the seminal paper (M. Kasha, Discuss. Faraday Soc., 1950, 9, 14-19): "The emitting electronic level of a given multiplicity is the lowest excited level of that multiplicity". Therefore, Kasha's rule focuses on the emission (photophysics) for complex molecules, in condensed phase, for ...

Calculated Decisions: Ottawa Subarachnoid Hemorrhage Rule

The Ottawa subarachnoid hemorrhage rule is used to rule out subarachnoid hemorrhage in patients with headache.


Bougies dilation is considered an effective technique for the treatment of simple benign esophageal strictures. The "rule of three" has been advocated to prevent reported adverse events such as bleeding and perforation. However, adherence to this rule has increased the cost and duration of treatment.

Fuzzy Knowledge-Based Prediction Through Weighted Rule Interpolation.

Fuzzy rule interpolation (FRI) facilitates approximate reasoning in fuzzy rule-based systems only with sparse knowledge available, remedying the limitation of conventional compositional rule of inference working with a dense rule base. Most of the existing FRI work assumes equal significance of the conditional attributes in the rules while performing interpolation. Recently, interesting techniques have been reported for achieving weighted interpolative reasoning. However, they are either particularly tailor...

The impact of pharmaceutical tendering on prices and market concentration in South Africa over a 14-year period.

We investigated the South African tendering system for medicines to (a) evaluate its impact on prices and market concentration over a 14-year period and (b) analyze the accuracy of government forecasts of drug demand.

A Survey Of Americans With High-Deductible Health Plans Identifies Opportunities To Enhance Consumer Behaviors.

Most high-deductible health plan (HDHP) enrollees do not engage in consumer behaviors such as price shopping. Why not? We surveyed 1,637 Americans in HDHPs-which can be linked to health savings accounts (HSAs) but usually are not-about factors that may predict, facilitate, or impede HDHP enrollees' engagement in consumer behaviors. We found that having an HSA was associated with saving for future care, high financial literacy was associated with comparing prices and quality, and high confidence in talking w...

The Rule of 57: Orthopaedic Trigonometry Made Easy.

The Rule of 57 is an easy method for planning osteotomies and calculating translations when correcting spine and limb deformities.

The Dead Donor Rule as Policy Indoctrination.

Since the 1960s, organ procurement policies have relied on the boundary of death-advertised as though it were a factual, value-free, and unobjectionable event-to foster organ donation while minimizing controversy. Death determination, however, involves both discoveries of facts and events and decisions about their meaning (whether the facts and events are relevant to establish a vital status), the latter being subjected to legitimate disagreements requiring deliberation. By revisiting the historical origin ...

When Is The Price Of A Drug Unjust? The Average Lifetime Earnings Standard.

The majority of Americans believe that lowering drug prices should be the top health care priority for the federal government. Yet drug costs as a proportion of the country's medical expenditures have increased substantially in recent years. Because drugs are basic necessities, and because how much society should contribute toward providing basic necessities is a question of justice, policies regarding drug prices must fulfill principles of justice, not just economic efficiency. In this article I define a s...

Oil price shocks, economic policy uncertainty and industrial economic growth in China.

This paper combines a Granger causality test and a VAR model to investigate the relationships among oil price shocks, global economic policy uncertainty (GEPU), and China's industrial economic growth. Based on monthly data from 2000 to 2017, we reveal that GEPU and world oil prices jointly Granger cause China's industrial economic growth; world oil prices have a positive effect on China's industrial economic growth, while GEPU has a negative effect. Further analyses investigate the asymmetry effect of oil p...

Neural Correlates of Enhanced Memory for Meaningful Associations with Age.

Evidence suggests that age differences in associative memory are attenuated for associations that are consistent with prior knowledge. Such knowledge structures have traditionally been associated with the default network (DN), which also shows reduced modulation with age. In the present study, we investigated whether DN activity and connectivity patterns could account for this age-related effect. Younger and older adults underwent functional magnetic resonance imaging as they learned realistic and unrealist...

Calibration and evaluation of Quigley's hybrid housing price model in Microsoft Excel.

Quigley derived his hybrid price model to improve the precision of predicted prices of sold homes by statistically merging data of resold homes in a repeat sales model with that of once-sold homes in a single sales hedonic price model. The literature has few applications of the hybrid model aside from those by Quigley and his collaborators. Two reasons for this underuse may be its computational intensiveness and its marginal empirical improvement in comparison with two other models. This paper first demysti...

Changes to the littered cigarette pack environment in New York City between 2011 and 2015.

Imposing policies that increase tobacco prices is a key strategy for reducing smoking prevalence, although it may result in more cigarette trafficking. In 2013, New York City (NYC) passed the Sensible Tobacco Enforcement (STE) law requiring cigarettes be sold for a minimum price of $10.50 per pack. To evaluate whether cigarette price increases changed patterns of behaviour related to cigarette tax evasion, we examined littered pack study data from 2011 and 2015.

Using External Reference Pricing In Medicare Part D To Reduce Drug Price Differentials With Other Countries.

Many countries use external reference pricing to help determine drug prices. However, external reference pricing has received little attention in the US-perhaps because the US is often the first adopter of drugs. External reference pricing could be used to set prices for drugs that were already established in the market. We compared the price differentials between the US and the UK, Japan, and Ontario (Canada) for single-source brand-name drugs that had been on the market for at least three years. We found ...

Functional (Psychogenic) Neurological Disorders: Assessment and Acute Management in the Emergency Department.

Functional neurological disorders (FND) are complex and prevalent neuropsychiatric conditions. Importantly, some patients with FND develop acute onset symptoms requiring emergency department (ED) evaluations. Historically, FND was a "rule-out" diagnosis, making assessment and management in the ED difficult. While the rapid triage of potential neurological emergencies remains the initial task, advancements have altered the approach to FND. FND is now a "rule-in" diagnosis based on validated neurological exam...

Elimination of the Donor Service Area (DSA) from Lung Allocation; No Turning Back.

Following the issuance of the Final Rule governing the Organ Procurement and Transplantation Network (OPTN) in 1998, the then Chair of the OPTN Thoracic Transplantation Committee (hereafter referred to as the Committee) cited and supported the American Society of Transplant Surgeons (ASTS) testimony before congress stating "giving priority to the sickest patients first over broad geographic areas would be wasteful and dangerous, resulting in fewer patients transplanted, increased death rates, increased re-t...

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