PubMed Journals Articles About "Eckert Ziegler BEBIG Eckert Ziegler BEBIG First Half" RSS

01:39 EST 20th January 2019 | BioPortfolio

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Showing "Eckert Ziegler BEBIG Eckert Ziegler BEBIG First Half" PubMed Articles 1–25 of 2,000+

The Walrus and the Carpenter: Complex Regulation of Tumor Immunity in Colorectal Cancer.

Immune infiltration has been correlated with survival of patients with colorectal cancer. In this issue, Ziegler et al. reveal complex and unexpected connections between loss of STAT3, mitophagy, and the induction of an adaptive immune response that limits the growth of colorectal carcinoma.

Low coordinated titanium(III) alkyl - molecular and surface - complexes: detailed structure from advanced EPR spectroscopy.

The structure of paramagnetic surface species is notoriously difficult to determine. For Ti(III) centers related to Ziegler-Natta catalysis, we demonstrate here that detailed structural information can be obtained by advanced EPR spectroscopy and DFT computations, benchmarked on molecular analogues. The hyperfine sublevel correlation (HYSCORE) spectra obtained after reaction with 13C-labelled ethylene provides information about the coupling for a proton in the first coordination sphere of Ti(III) as well as...

Secretome analysis of nerve repair mediating Schwann cells reveals Smad-dependent trophism.

Schwann cells promote nerve regeneration by adaptation of a regenerative phenotype referred to as repair mediating Schwann cell. Down-regulation of myelin proteins, myelin clearance, formation of Bungner's bands, and secretion of trophic factors characterize this cell type. We have previously shown that the sphingosine-1-phosphate receptor agonist Fingolimod/FTY720P promotes the generation of this particular Schwann cell phenotype by activation of dedifferentiation markers and concomitant release of trophic...

Evaluating the environmental parameters that determine aerobic biodegradation half-lives of pesticides in soil with a multivariable approach.

Aerobic biodegradation half-lives (half-lives) are key parameters used to evaluate pesticide persistence in soil. However, half-life estimates for individual pesticides often span several orders of magnitude, reflecting the impact that various environmental or experimental parameters have on half-lives in soil. In this work, we collected literature-reported half-lives for eleven pesticides along with associated metadata describing the environmental or experimental conditions under which they were derived. W...

Defect driven spin state transition and the existence of half-metallicity in CoO.

We unveil the native defect induced high spin (HS) to low spin (LS) state transition in $\mathrm{Co^{+3}}$ and half-metallicity in CoO. First principles calculation unravel that, defect density holds a key role in dictating the spin-state transition in $\mathrm{Co^{+3}}$ ion in CoO, and introducing the half-metallicity. Charge transfer in the vicinity of vacancy plane favors the stabilization and coexistence of bivalent $\mathrm{Co^{+2}}$ and trivalent $\mathrm{Co^{+3}}$ ion in CoO. We propose that, defect ...

QSPR modelling of in vitro degradation half-life of acyl glucuronides.

1. Acyl glucuronidation is an important Phase II biotransformation, which is an efficient detoxification mechanism for the metabolism of carboxylic acid group containing drugs. However, the reactivity of acyl glucuronide (AG) metabolites associated with short half-lives may be indication of idiosyncratic drug toxicity. 2. The degradation half-lives of AGs elucidate several important reactions such as hydrolysis, acyl migration, and covalent binding to proteins. Prediction of degradation half-life using comp...

Hypertrichosis cubiti in a girl with precocious puberty: Case report.

Hypertrichosis cubiti is a localized increase in hair density, length and thickness. It is an uncommon and benign entity with very few patients described in the medical literature (more or less than half a hundred). Half of the described patients associate other defects or malformations and the other half are purely aesthetic cases. Early pubarche in girls is defined as the onset of pubic hair before 8 years of age. We present a six-year-old patient with the association not previously described of hypertric...

Half-Dose Versus Full-Dose Alteplase for Treatment of Pulmonary Embolism.

Recent evidence suggests that half-dose thrombolysis for pulmonary embolism may provide similar efficacy with reduced bleeding risk compared with full-dose therapy, but comparative studies are lacking. We aimed to evaluate the effectiveness and safety of half-dose versus full-dose alteplase for treatment of pulmonary embolism.

Inferring Half-Lives at the Effect Site of Oligonucleotide Drugs.

Knowledge of the kinetics of the active drug in biophase, that is, at the effect site, is fundamental to select dose and to reason about safety. Unfortunately, the kinetics is cumbersome to measure in vivo. We describe how dose-response-time (DRT) analysis estimates the biophase and the target-response half-lives from data of the circulating protein of the encoded messenger RNA for seven antisense oligonucleotides (ASOs) and four small interfering RNA (siRNA) drugs. The biophase half-lives were estimated wi...

Presence of Intra-helical Salt-Bridge in Loop E Half-Helix Can Influence the Transport Properties of AQP1 and GlpF Channels: Molecular Dynamics Simulations of In Silico Mutants.

Major intrinsic protein (MIP) superfamily contains water-transporting AQP1 and glycerol-specific GlpF belonging to two major phylogenetic groups, namely aquaporins (AQPs) and aquaglyceroporins (AQGPs). MIP channels have six transmembrane helices (TM1 to TM6) and two half-helices (LB and LE). LE region contributes two residues to the aromatic/arginine (Ar/R) selectivity filter (SF) within the MIP channel. Bioinformatics analyses have shown that all AQGPs have an intra-helical salt-bridge (IHSB) in LE half-he...

Psychiatry in Shetland.

The Shetland Isles are a place of breathtaking landscapes and pristine wildlife. As harsh as the weather can be, so warm and welcoming are the people and their proud half-Scottish, half-Scandinavian culture. Practising psychiatry in this northernmost outpost of the UK involves significant challenges. The authors were the only two psychiatrists based on this remote island group, which is home to 23 000 people.

Fill "half your child's plate with fruits and vegetables": Correlations with food-related practices and the home food environment.

This study examined the prevalence of parental report of children's adherence to USDA's MyPlate guidelines of 'half of plate filled with fruits and vegetables (FV)' and associations with child and parent/guardian report of food-related practices and the home food environment. Data for this study represent the baseline assessment (n = 160 parent-child dyads) of the Healthy Home Offerings via the Mealtime Environment (HOME) Plus study, a randomized controlled trial to prevent excess weight gain among 8-12...

Awareness and Knowledge of Human Papilloma Virus and Cervical Cancer in Women with High Pap Uptake.

This cross-sectional study explored knowledge, awareness, and health practices surrounding cervical cancer prevention and screening. Patients (n = 129) were recruited from three community clinics of underserved populations in Dallas, Texas. Women between ages 18-65 were surveyed using a self-administered questionnaire to evaluate their knowledge, awareness, and attitudes related to pap tests, human papilloma virus (HPV), HPV vaccines, and cervical cancer. Most women reported having a pap test in the pas...

Electrically induced 2D half-metallic antiferromagnets and spin field effect transistors.

Engineering the electronic band structure of material systems enables the unprecedented exploration of new physical properties that are absent in natural or as-synthetic materials. Half metallicity, an intriguing physical property arising from the metallic nature of electrons with singular spin polarization and insulating for oppositely polarized electrons, holds a great potential for a 100% spin-polarized current for high-efficiency spintronics. Conventionally synthesized thin films hardly sustain half met...

Ebstein's Anomaly: "The One and a Half Ventricle Heart".

Ebstein's anomaly remains a relatively ignored disease. Lying in the 'No Man's land' between congenital and valve surgeons, it largely remains inadequately studied. We report our short-term results of treating it as a 'one and a half ventricle heart' and propose that the true tricuspid annulus (TTA) 'Z' score be used as an objective criterion for estimation of 'functional' right ventricle (RV).

Morphological and Functional Changes Immediately After Half-Time Photodynamic Therapy in Patients With Central Serous Chorioretinopathy.

To evaluate early treatment outcomes of half-time photodynamic therapy (PDT) in patients with central serous chorioretinopathy (CSC).

Differences in the Repeated Sprint Performance Between the First and Latter Halves of Trials Under Conditions of Several Thermal States in Exercising Muscles.

Inoue, K, Yamashita, N, Kume, M, and Yoshida, T. Differences in the repeated sprint performance between the first and latter halves of trials under conditions of several thermal states in exercising muscles. J Strength Cond Res XX(X): 000-000, 2018-The purpose of this study was to determine whether the effects of thermal states in exercising muscle on repeated sprint cycling (RSC) performance differ between the first and latter half of trials. Nine male subjects performed 8 × 8 seconds of RSC with a 40-sec...

A practical omni-directional SH wave transducer for structural health monitoring based on two thickness-poled piezoelectric half-rings.

Structural health monitoring (SHM) has become more and more important in modern industries as it can monitor the safety of structures during the full service life and prevent possible losses of life and economics. Shear horizontal wave in plate-like structures is very useful for long distance inspection since its fundamental mode (SH) is totally non-dispersive. However, all the currently available SH wave transducers are not suitable for practical SHM because of their complicated structures. In this work, w...

The half magnetization plateau in Ni3V2O8 studied by electron spin resonance.

Ni<sub>3</sub>V<sub>2</sub>O<sub>8</sub>, regarded as an S = 1 kagome staircase lattice antiferromagnet, possesses a novel magnetic field - temperature phase diagram. Specifically, a half plateau region is observed in the high field magnetization curve for magnetic fields in the range of 11-19 T. This experimental observation is theoretically unexpected for a standard kagome lattice antiferromagnet, and consequently, the underlying magnetic structure is still unclear. Mul...

Effect of ABO blood group on haemostatic parameters in severe haemophilia A patients performing acute moderate-intensity exercise.

: The primary objective was to assess the effect of ABO blood group on von Willebrand factor (VWF) rise induced by four bouts of moderate-intensity physical activity, on pharmacokinetics of a B-domain-deleted recombinant FVIII (BDD-rFVIII), and haemostatic parameters in severe haemophilia A patients with a null mutation. The secondary objective was to compare the response to exercise according to infused product type in a subgroup of patients who previously participated to the same exercise protocol, while ...

Survey to Assess Interest in a Mindfulness Intervention at a Midwifery and Women's Health Clinic.

We conducted a voluntary survey among ethnically and socioeconomically diverse women. About half of the respondents reported experiencing at least one health issue; over half were interested in attending a mindfulness class to reduce stress. Our study suggests interest in participating in a mindfulness intervention, primarily among those with more health issues.

Half-dose Coronary Artery Calcium Scoring: Impact of Iterative Reconstruction.

The purpose of this study was to assess the impact of adaptive statistical iterative reconstruction (ASiR) on half-dose coronary artery calcium scoring (CACS) acquisition protocol.

Choroidal vascularity changes in idiopathic central serous chorioretinopathy after half-fluence photodynamic therapy.

This study evaluated changes in choroidal vascularity after half-fluence photodynamic therapy (HF-PDT) in patients with central serous chorioretinopathy (CSC) using swept-source optical coherence tomography (SS-OCT) en face imaging.

Half-time photodynamic therapy in treatment of chronic central serous chorioretinopathy.

Different modes of photodynamic therapy (PDT) were described for treatment of central serous chorioretinopathy (CSC). The purpose of the current study was to evaluate the outcome of half-time PDT in chronic CSC.

An augmentation study of MSI-195 (S-adenosylmethionine) in Major Depressive Disorder.

We conducted a 6-week double-blind, placebo-controlled, augmentation study comparing the efficacy and safety of MSI-195 800 mg (a proprietary formulation of S-adenosylmethionine) or placebo added to ongoing antidepressant medication (ADT) in acutely depressed subjects with Major Depressive Disorder (MDD) who had experienced an inadequate response to their ongoing ADT (The Horizon Study, NCT01912196). There were 234 eligible subjects randomized to either MSI-195 (n = 118) or placeb...

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