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PubMed Journals Articles About "Eckert Ziegler BEBIG Eckert Ziegler BEBIG First Half" RSS

21:02 EDT 20th June 2018 | BioPortfolio

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Showing "Eckert Ziegler BEBIG Eckert Ziegler BEBIG First Half" PubMed Articles 1–25 of 2,100+

The Effect of Gene Flow on Coalescent-based Species-tree Inference.

Most current methods for inferring species-level phylogenies under the coa-lescent model assume that no gene flow occurs following speciation. Several studies have examined the impact of gene flow (e.g., Eckert and Carstens (2008); Chung and Ané (2011); Leaché et al. (2014); Solís-Lemus et al. (2016)) and of ancestral population structure (DeGeorgio and Rosenberg, 2016) on the performance of species-level phylogenetic inference, and analytic results have been proven for network models of gene flow (e.g.,...


Relevance of Half-life in Drug Design.

Drug half-life has important implications for dosing regimen and peak-to-trough ratio at the steady state. A half-life of 12-48 hours is generally ideal for once daily dosing of oral drugs. If the half-life is too short, it may require more frequent dosing in order to maintain desired exposures and avoid unnecessarily high peak concentrations. This may pose challenges to achieving optimal efficacy, safety and patient compliance. If the half-life it too long, the time over which accumulation and subsequent e...

No better moment to score a goal than just before half time? A soccer myth statistically tested.

We test the soccer myth suggesting that a particularly good moment to score a goal is just before half time. To this end, rich data on 1,179 games played in the UEFA Champions League and UEFA Europa League are analysed. In contrast to the myth, we find that, conditional on the goal difference and other game characteristics at half time, the final goal difference at the advantage of the home team is 0.520 goals lower in case of a goal just before half time by this team. We show that this finding relates to t...


Rare occurrence of eight-and-a-half syndrome as a clinically isolated syndrome.

Eight-and-a-half syndrome is a rare condition that is described as a combination of one-and-a-half syndrome and an ipsilateral facial nucleus lesion. We present a clinical case of occurrence of eight-and-a-half syndrome that was caused by a demyelinating lesion in the dorsal pontine tegmentum. A 44-year-old man presented to the hospital with a subacute onset of horizontal diplopia and left-sided facial weakness. MRI revealed a T2 hyperintense lesion in his dorsal pons, which was consistent with a demyelinat...

The Match Heart-Rate and Running Profile of Elite Under 21 Hurlers During Competitive Match-Play.

The aims of the current study were to examine the physical and physiological demands of elite under-21 male hurling match-play across halves of play and between positions. Global positioning systems (10-Hz) and heart rate (HR) monitors were used to collect data from 95 players during 10 games. Total distance (TD), relative speed, high-speed running (HSR), sprint distance, total sprints and mean length of sprint was 6688 ± 942 m, 112 ± 16 m·min, 661 ± 203 m, 274 ± 111 m, 18 ± 8 and 16 ± 5 m respective...

Similarities and differences among half-marathon runners according to their performance level.

This study aimed to identify the similarities and differences among half-marathon runners in relation to their performance level. Forty-eight male runners were classified into 4 groups according to their performance level in a half-marathon (min): Group 1 (n = 11, < 70 min), Group 2 (n = 13, < 80 min), Group 3 (n = 13, < 90 min), Group 4 (n = 11, < 105 min). In two separate sessions, training-related, anthropometric, physiological, foot strike pattern and spatio-temporal variables were recorded. Significant...

Enhancement of inosine-mediated A2AR signaling through positive allosteric modulation.

Inosine is an endogenous nucleoside that is produced by metabolic deamination of adenosine. Inosine is metabolically more stable (half-life 15h) than adenosine (half-life

Hypoxia-Induced Reporter Genes with Different Half-Lives.

The utility of reporter genes has gained significant momentum over the last three decades. Reporter genes are used to understand the transcriptional activity of a gene both in vitro and in vivo, and in pathway analysis and drug screening for diseases involving protozoan parasites, and in anti-cancer drug developments. Here, using a human prostate cancer xenograft model (PC3), we describe a method to construct and validate hypoxia reporter genes with different half-lives. Using molecular biology and optical ...

Thiol-ene click chemistry towards easy microarraying of half-antibodies.

A UV light-induced thiol-ene coupling reaction (TEC) between half-antibodies (hIgG) and vinyl functionalized glass surfaces was run for biosensing in the microarray format. The accomplished performance improved that obtained with whole antibodies.

In silico approaches for predicting the half-life of natural and modified peptides in blood.

This paper describes a web server developed for designing therapeutic peptides with desired half-life in blood. In this study, we used 163 natural and 98 modified peptides whose half-life has been determined experimentally in mammalian blood, for developing in silico models. Firstly, models have been developed on 261 peptides containing natural and modified residues, using different chemical descriptors. The best model using 43 PaDEL descriptors got a maximum correlation of 0.692 between the predicted and t...

5'-Bromouridine IP Chase (BRIC)-Seq to Determine RNA Half-Lives.

Analysis of RNA stability at genome-wide level is an advanced method in RNA biology that examines the half-life of each transcript. In particular, a pulse-labeling method using uridine analogs enables the determination of half-life of each transcript under physiologically undisturbed conditions. The technique involves pulse labeling of endogenous RNAs in mammalian cells with 5'-bromouridine (BrU), followed by measuring the chronological decrease of BrU-labeled RNAs using deep sequencing (BRIC-seq). Here, we...

Half-lives ofRhandAg.

Using long-term gamma-ray spectroscopy with high resolution germanium detectors and a ratio method, the half-lives ofRhandAghave been determined to be 4.07 ± 0.05 years and 448 ± 27 years, respectively. These results are compared with previously reported values.

Using Isomeric and Metabolic Ratios of DDT to Identify the Sources and Fate of DDT in Chinese Agricultural Topsoil.

The metabolic ratio of (p,p'-DDE + p,p'-DDD)/p,p'-DDT or p,p'-DDE/p,p'-DDT has been used previously to estimate the approximate half-life of p,p'-DDT, with a relatively unclear concept of "old" and "new" sources of p,p'-DDT and without paying attention to the influence by dicofol-type DDT contributed from the more recent usage of dicofol. Based on the isomeric ratio of o,p'-DDT/p,p'-DDT to distinguish the sources of DDT, this study used the corrected metabolic ratio of (p,p'-DDE + p,p'-DDD)/p,p'-DDT to esti...

New Half-Metallic Materials: FeRuCrP and FeRhCrP Quaternary Heusler Compounds.

The electronic structures and magnetic properties of FeRuCrP and FeRhCrP quaternary Heusler compounds with LiMgPbSb-type structures have been investigated via first-principles calculations. The calculational results show that both FeRuCrP and FeRhCrP compounds present perfect half-metallic properties: Showing large half-metallic band gaps of 0.39 eV and 0.38 eV, respectively. The total magnetic moments of FeRuCrP and FeRhCrP are 3 μB and 4 μB per formula unit, respectively. The magnetism of them mainly co...

Facile Synthesis of Porous Pd3 Pt Half-Shells with Rich "Active Sites" as Efficient Catalysts for Formic Acid Oxidation.

Exploring highly efficient electrocatalysts is greatly important for the widespread uptake of the fuel cells. However, many newly generated nanocrystals with attractive nanostructures often have extremely limited surface area or large particle-size, which leads them to display limited electrocatalytic performance. Herein, a novel anode catalyst of hollow and porous Pd3 Pt half-shells with rich "active sites" is synthesized by using urea as a guiding surfactant. It is identified that the formation of Pd3 Pt ...

Effect of adjuvant on pendimethalin and dimethenamid-P behaviour in soil.

Adjuvants are used to improve pesticides' performance. It is expected that adjuvants should increase sorption and persistence, as well as decrease mobility of pesticides in soils. Impact of the "Grounded" brand adjuvant on the behaviour of two herbicides, pendimethalin and dimethenamid-P, was investigated in a Haplic Chernozem. Both herbicides were tested in a laboratory batch sorption experiment with and without adjuvant. The sorption experiment showed that adjuvant negligibly increased dimethenamid-P sorp...

Relationship among aqueous copper half-lives and responses of Pimephales promelas to a series of copper sulfate pentahydrate concentrations.

Copper algaecide exposures in situ are often of shorter duration than exposures for static toxicity experiments because aqueous concentrations in situ dissipate as a function of site-specific fate processes. Consequently, responses of organisms to static copper exposures may overestimate effects following in situ exposures. To understand the role of exposure duration for altering responses, Pimephales promelas survival was compared following static (96 h) and pulse (1.5, 4, 8, and 15 h half-lives) expos...

Raman spectrum of methane in nitrogen, carbon dioxide, hydrogen, ethane, and propane environments.

Using binary CH4 - mixtures with varied concentrations of H2, N2, CO2, C2H6 and C3H8 and a fixed ambient pressure of 25bar, the influence of the environment on spectral characteristics (Raman shift, half-width, peak intensity) of Q-branches of the ν1, ν2, ν3, and 2ν4 methane Raman bands are investigated. It is found that depending on the environment these bands demonstrate different changes in their Raman shifts and half-widths. It is shown that the ratios of peak intensities I(ν2)/I(ν1), I(ν3)/I(ν1...

Wave diffraction by a reflectionless half-plane.

The concept of reflectionless surface is put forth, and its reflection and transmission coefficients are determined by using the scattered geometrical optics fields of transmissive and perfectly electric conducting surfaces. The boundary condition of the surface is introduced. The scattering problem of plane waves by a reflectionless half-screen is studied. The solution is investigated numerically.

The Influence of Obesity on the Pharmacokinetics of Dioxin in Mice: An Assessment Using Classical and PBPK Modeling.

The effects of body fat mass on the elimination of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was examined in mice. When male C57BL/6J mice are fed a high-fat, simple carbohydrate diet (HFD) for 13 weeks, they develop an obese phenotype. In contrast, A/J mice fed a HFD do not become obese. After 13 weeks on a normal diet (ND) or HFD, male C57BL/6J and A/J mice received a single dose by gavage of 0.1 or 5.0 µg of 2,3,7,8-tetrachloro[1,6-3H] dibenzo-p-dioxin ([3H]TCDD) per kg bw. Using classical pharmacokine...

Prediction of Triple Point Fermions in Simple Half-Heusler Topological Insulators.

We predict the existence of triple point fermions in the band structure of several half-Heusler topological insulators by ab initio calculations and the Kane model. We find that many half-Heusler compounds exhibit multiple triple points along four independent C_{3} axes, through which the doubly degenerate conduction bands and the nondegenerate valence band cross each other linearly nearby the Fermi energy. When projected from the bulk to the (111) surface, most of these triple points are located far away ...

Realization of half-metallic state on bilayer WSe2 by doping transition metals (Cr, Mn, Fe, Co, Ni) in its interlayer.

The structural, electronic and magnetic properties of Cr, Mn, Fe, Co and Ni-doped bilayer WSe2 are predicted by using first principles calculations. The doped transition-metal atoms show a covalent-binding with the nearest Se atoms. The calculated electronic structures reveal that the transition metal Cr, Mn, Fe and Co-doped bilayer WSe2 exhibit the half-metallic character with a 100% spin polarization at the Fermi level, and the reason is ascribed to the strong hybridization peak between the transition met...

Toward an accurate determination of half-life of Sm isotope.

The task of an accurate determination of alpha-decay rate of Sm isotope, a topic of importance in both basic and applied science, has been performed in the present research following two different routes. First, a critical review and data analysis of the whole set of half-life values obtained till date yielded an average of 106.3 ± 0.5 Ga. Second, a one-parameter, semi-empirical model for alpha emission from nuclei, developed in the framework of quantum mechanical tunneling mechanism through a Coulomb-...

The half-bridge component Kar1 promotes centrosome separation and duplication during budding yeast meiosis.

The budding yeast centrosome, often called the spindle pole body (SPB), nucleates microtubules for chromosome segregation during cell division. An appendage, called the half bridge, attaches to one side of the SPB and regulates SPB duplication and separation. Like DNA, the SPB is duplicated only once per cell cycle. During meiosis, however, after one round of DNA replication, two rounds of SPB duplication and separation are coupled with homolog segregation in meiosis I and sister-chromatid segregation in me...

Conjugation with eight-arm PEG markedly improves the in vitro activity and prolongs the blood circulation of staphylokinase.

Staphylokinase (SAK) is a profibrinolytic protein and can be used for therapy of acute myocardial infarction and coronary thrombosis. However, SAK suffers from a short serum half-life time (~6 min) that limits its clinical application. PEGylation prolongs the half-life time of SAK, whereas significantly decreases the bioactivity of SAK for the steric shielding effect of PEG. To improve the bioactivity and prolong the half-life time of SAK, 8-arm PEG maleimide (8-arm PEG) was used for conjugation of multiple...


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