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PubMed Journals Articles About "Ectogenesis Artificial Placentas Could Premature Babies Upend Entrenched" RSS

18:26 EST 28th January 2020 | BioPortfolio

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Showing "Ectogenesis artificial placentas could premature babies upend entrenched" PubMed Articles 1–25 of 2,400+

In response to: Surfactant therapy in premature babies: SurE or InSurE.


The increased expression of glucose transporters in human full-term placentas from assisted reproductive technology without changes of mTOR signaling.

In the mouse model, manipulations of assisted reproductive technology (ART) can lead to enlarged placentas and influence the expression of glucose transporters (GLUTs) in placentas during mid-to late-gestation. Expression of imprinted genes which plays a vital role in placental growth and function, is also vulnerable to be affected by ART. However, it is uncertain whether those abnormal changes presented in ART mouse placentas also occur in human ART placentas.

Infantile haemangioma: topical timolol gel may be safer in premature babies.


Plasmodium falciparum infection dysregulates placental autophagy.

Plasmodium (P.) falciparum malaria during pregnancy has been frequently associated with severe consequences such as maternal anemia, abortion, premature birth, and reduced birth weight. Placental damage promotes disruption of the local homeostasis; though, the mechanisms underlying these events are still to be elucidated. Autophagy is a fundamental homeostatic mechanism in the natural course of pregnancy by which cells self-recycle in order to survive in stressful environments. Placentas from non-infected a...

Early postnatal hypoferremia in low birthweight and preterm babies: A prospective cohort study in hospital-delivered Gambian neonates.

Neonates, particularly those born preterm (PTB) and with low birthweight (LBW), are especially susceptible to bacterial and fungal infections that cause an estimated 225,000 deaths annually. Iron is a vital nutrient for the most common organisms causing septicaemia. Full-term babies elicit an immediate postnatal hypoferremia assumed to have evolved as an innate defence. We tested whether PTB and LBW babies are capable of the same response.

Parental anxiety regarding premature infants and factors affecting parental concern.

Premature births have a great impact on the parents. The purpose of this study was to investigate the anxieties of parents of premature infants regarding infantile diseases and to help medical staff better communicate with parents of premature infants.

Perinatal care provided for babies born at 23 and 24 weeks of gestation.

In recent years, significant improvements in survival and survival-free of major morbidity in babies born at 23 to 24  weeks of gestation have led to a more pro-active approach to resuscitation at these peri-viable gestations. Antenatal counselling and interventions, intrapartum care and postnatal advice should be part of the package of care provided to optimise outcomes for these babies and their families. This observational study assesses the perinatal care provided to mothers and their babies who were b...

Role of elevated sflt-1 on the regulation of placental transporters in women with pre-eclampsia.

Pre-eclampsia (PE) is an obstetric complication associated with elevated levels of sFlt-1 and dysregulated trophoblast differentiation. However, limited information exists on the expression and regulation of placental drug transporters in PE. Transporter mRNA and protein expression was analyzed in human placentas diagnosed with PE (n=34) and gestational age-matched controls (n=24) while placental BeWo cells were treated with angiogenic factors in vitro. Significant downregulation of BCRP and several other t...

Final outcome of a second trimester low-positioned placenta: A systematic review and meta-analysis.

Low-positioned placentas which are located in the lower uterine segment (LUS), either a low-lying placenta or a placenta previa, are associated with increased obstetric risks. However, most second trimester low-positioned placentas resolve during pregnancy and have a higher position in the third trimester, without posing any risks. We performed a systematic review and meta-analysis to evaluate the proportion of second trimester low-positioned placentas that have a position towards the fundus in the third tr...

An analysis of MRI derived cortical complexity in premature-born adults: Regional patterns, risk factors, and potential significance.

Premature birth bears an increased risk for aberrant brain development concerning its structure and function. Cortical complexity (CC) expresses the fractal dimension of the brain surface and changes during neurodevelopment. We hypothesized that CC is altered after premature birth and associated with long-term cognitive development. One-hundred-and-one very premature-born adults (gestational age

Quality of Kangaroo Mother Care services in Ethiopia: Implications for policy and practice.

Providing high-quality kangaroo mother care (KMC) is a strategy proven to improve outcomes in premature babies. However, whether KMC is consistently and appropriately provided in Ethiopia is unclear. This study assesses the quality of KMC services in Ethiopia and the factors associated with its appropriate initiation among low birth weight neonates.

Referral rates for newborn hearing screening based on the test time.

To suggest the optimal timing for newborn hearing screening to obtain an ideal and stable referral rate in well babies and in babies in neonatal intensive care units (NICU).

Artificial Womb Technology and the Choice to Gestate Ex Utero: is Partial Ectogenesis the Business of the Criminal Law?

It is frequently claimed that artificial wombs (AWs) could alleviate the burdens placed exclusively on women in reproduction. In this article, I demonstrate how AWs used for the partial gestation of preterm neonates could introduce new choices for women by changing perceptions of tolerable risks in gestation. In light of advancing medical technology, it is necessary to consider whether the current legal framework in England and Wales would support increased choice for women about alternative forms of gestat...

Modification of endothelial nitric oxide synthase by 4-oxo-2(E)-nonenal(ONE) in preeclamptic placentas.

Preeclampsia (PE) is a leading cause of pregnancy complications, affecting 3-7% of pregnant women worldwide. The pathophysiology of preeclampsia involves a redox imbalance, oxidative stress and a reduced nitric oxide (NO) bioavailability. The molecular and cellular mechanisms leading to the dysfunction of the placental endothelial NO synthase (eNOS) are not clarified. This study was designed to investigate whether aldehydes generated by lipid peroxidation products (LPP), may contribute to placental eNOS dys...

ADHERENCE TO THE HELPING BABIES BREATHE STRATEGY AT DELIVERY ROOM OF AN INSTITUTION LEVEL II OF CALI (COLOMBIA), YEAR 2017: CROSS SECTIONAL STUDY.

To determine adherence, overall and by components, to the Helping Babies Breathe strategy by physicians caring for neonates in an intermediate complexity institution.

Complement activation in the plasma and placentas of women with different subsets of antiphospholipid syndrome.

As antiphospholipid antibody-positive women with adverse pregnancy outcomes have higher plasma complement activation product levels and the placentas of women with antiphospholipid syndrome (APS) exhibit C4d complement component deposition, complement activation involvement has been hypothesized in APS pregnancy complications.

Ultraviolet Radiation May Cause Premature Fading of Colored Tattoos.

Colored tattoos are common among young adults worldwide. However, ultraviolet radiation (UVR) may affect tattoos by causing abnormal healing, premature fading, scabbing, dryness, and scarring. Although tattoo artists provide sun safety information to their clients along with aftercare instructions to prevent premature tattoo fading, there is insufficient evidence to support these findings. We present a case of a white male with premature fading of his colored tattoo due to excessive UVR exposure. This artic...

An Injury to Justice: Workers' Comp Disputes Could Tilt in Insurers' Favor.

Medicine is working to upend a recent appeals court decision that threatens to give health plans an overwhelming advantage in fee disputes in workers compensation cases.

Artificial womb technology and clinical translation: Innovative treatment or medical research?

In 2017 and 2019, two research teams claimed 'proof of principle' for artificial womb technology (AWT). AWT has long been a subject of speculation in bioethical literature, with broad consensus that it is a welcome development. Despite this, little attention is afforded to more immediate ethical problems in the development of AWT, particularly as an alternative to neonatal intensive care. To start this conversation, I consider whether experimental AWT is innovative treatment or medical research. The researc...

Efficient delipidation of a recombinant lung surfactant lipopeptide analogue by liquid-gel chromatography.

Pulmonary surfactant preparations extracted from natural sources have been used to treat millions of newborn babies with respiratory distress syndrome (RDS) and can possibly also be used to treat other lung diseases. Due to costly production and limited supply of animal-derived surfactants, synthetic alternatives are attractive. The water insolubility and aggregation-prone nature of the proteins present in animal-derived surfactant preparations have complicated development of artificial surfactant. A non-ag...

Randomised oral stimulation and exclusive breastfeeding duration in healthy premature infants.

Although exclusive breastfeeding is recommended for all newborn in the first six months of life, only 13% of Danish premature infants complies with this. This trial aimed to examine if oral stimulation prolonged exclusive breastfeeding in premature infants.

Idiopathic SIADH in the premature newborn, a case report.

Hyponatremia is a common laboratory finding in premature and ill neonates. When the degree of hyponatremia is more severe, the likelihood of a pathologic entity increases. In this case report we describe a premature neonate with severe hyponatremia due to the idiopathic syndrome of inappropriate antidiuretic hormone secretion (SIADH).

Bone spoons for prehistoric babies: Detection of human teeth marks on the Neolithic artefacts from the site Grad-Starčevo (Serbia).

Around 8000 years ago, throughout the Neolithic world a new type of artefact appeared, small spoons masterly made from cattle bone, usually interpreted as tools, due to their intensive traces of use. Contrary to those interpretations, the small dimensions of spoons and presence of intensive traces of use led us to the assumption that they were used for feeding babies. In order to test that assumption we compared 2230 marks on three spoons from the Neolithic site of Grad-Starčevo in Serbia (5800-5450 cal BC...

Is testosterone replacement an effective treatment of secondary premature ejaculation?

There are very few studies that have evaluated premature ejaculation characteristics in regard to subtypes. Additionally, to our knowledge, there are no studies which have explored testosterone replacement therapy in secondary premature ejaculation patients with testosterone deficiency. Therefore, our aims were as follows: (a) to determine the characteristics of patients with premature ejaculation in regard to the four subtypes of premature ejaculation and (b) to determine the efficacy of testosterone repla...

Consequences of Chronic Frequent Premature Atrial Contractions: Association with Cardiac Arrhythmias and Cardiac Structural Changes.

Frequent premature ventricular contractions (PVCs) can cause cardiomyopathy (CM). Post-extrasystolic potentiation and irregularity have been in implicated as triggers of PVC-CM. Since both phenomena can also be found in premature atrial contractions (PACs), it is speculated that frequent PACs have similar consequences.


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