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Showing "Edge Therapeutics Present Cowen Company 37th Annual Healthcare" PubMed Articles 1–25 of 25,000+

Abstracts and Highlight Papers of the 37th Annual European Society of Regional Anesthesia & Pain Therapy (ESRA) Congress 2018: Invited Speakers.

Lean Methodology in Healthcare.

To improve the delivery of patient care, governments and healthcare institutions adopted quality improvement methods that had been developed decades earlier in manufacturing industries. Many healthcare practitioners are either unaware or are inexperienced about what these practices entail and whether they are successful in healthcare. This article reviews Lean, an improvement philosophy made famous by the Toyota Motor Company. Lean uses a set of instruments and incorporates a long-term vision aiming for con...

One-stop shop: Simultaneous direct mitral annuloplasty and percutaneous mitral edge-to-edge repair in a patient with severe mitral regurgitation.

Percutaneous edge-to-edge repair of severe mitral regurgitation has been established as an alternative treatment option for patients at high risk for cardiac surgery. More recently, the introduction of the Cardioband system enabled percutaneous direct annuloplasty. Here, we present a case of simultaneous percutaneous direct annuloplasty with edge-to-edge repair. Moreover, annuloplasty did facilitate clip implantation bei approximating the anterior and posterior mitral leaflet. In conclusion, the combination...

Estimates of Edge Detection Filters in Human Vision.

Edge detection is widely believed to be an important early stage in human visual processing. However, there have been relatively few attempts to map human edge detection filters. In this study, observers had to locate a randomly placed step edge in brown noise (the integral of white noise) with a 1/f power spectrum. Their responses were modelled by assuming the probability the observer chose an edge location depended on the response of their own edge detection filter to that location. The observer's edge de...

Edge transport at the boundary between topologically equivalent lattices.

Edge currents of paramagnetic colloidal particles propagate at the edge between two topologically equivalent magnetic lattices of different lattice constant when the system is driven with periodic modulation loops of an external magnetic field. The number of topologically protected particle edge transport modes is not determined by a bulk-boundary correspondence. Instead, we find a rich variety of edge transport modes that depend on the symmetry of both the edge and the modulation loop. The edge transport c...

Building reliable evidence from real-world data: Needs, methods, cautiousness and recommendations.

National healthcare systems of advanced countries, including Italy, widely agree on the approach whereby public healthcare decisions should be driven by available evidence on effectiveness and safety of therapeutics. It is equally accepted that randomized controlled clinical trials (RCTs), although universally recognised as the most robust "evidence generators", are insufficient for guiding the decision-making process since they are intrinsically unsuited to capture the impact of treatments in routine clini...

Evaluating the Use of Nonrandomized Real World Data Analyses for Regulatory Decision Making.

The analysis of longitudinal healthcare data outside of highly-controlled parallel-group randomized trials, termed real-world evidence (RWE), has received increasing attention in the medical literature. In this paper, we discuss the potential role of RWE in drug regulation with a focus on the analysis of healthcare databases. We present several cases where RWE is already used and cases where RWE could potentially support regulatory decision-making. We summarize key issues that investigators and regulators s...

Revisiting the Dependence of Cu K-Edge X-ray Absorption Spectra on Oxidation State and Coordination Environment.

X-ray absorption spectroscopy (XAS) at the Cu K-edge is an important tool for probing the properties of copper centers in transition-metal chemistry and catalysis. However, the interpretation of experimental XAS spectra requires a detailed understanding of the dependence of spectroscopic features on the local geometric and electronic structure, which can be established by theoretical X-ray spectroscopy. Here, we present a systematic computational study of the Cu K-edge XAS spectra of selected Cu complexes b...

Mental health treatment dose and annual healthcare costs in patients with cancer and major depressive disorder.

Depression in patients with cancer has been associated with increased annual health care use and costs relative to nondepressed patients. Little is known of the potential cost savings associated with receipt of mental health treatment. This study evaluated the association between number of mental health visits and annual health care costs in patients with cancer and comorbid major depression.

Subpixel Edge Localization Based on Adaptive Weighting of Gradients.

This paper presents a subpixel edge localization method based on the adaptive weighting of gradients (AWG). The method first finds the optimal power factors to be used by the AWG through an error propagation scheme. Then, with the goal of fast implementation of the method, a process that directly relates the edge width to the optimal powers is proposed. A method that uses the squared weighting of gradients (SWG) is also proposed, which applies a power of 2 to the gradients of an edge profile to calculate th...

Air pollution and healthcare expenditure: Implication for the benefit of air pollution control in China.

Quantitating the health effects of air pollution is important for understanding the benefits of environmental regulations. Using the China Urban Household Survey (UHS) Database, this paper estimated the effect of air pollution exposure on household healthcare expenditure. To address potential endogeneity concerns, we performed household healthcare expenditure regressions using an instrumental variables (IV) strategy based on spatial air pollution spillovers. Our research revealed that a 1% increase in yearl...

Prostate Volume Segmentation in TRUS using Hybrid Edge-Bhattacharyya Active Surfaces.

We present a new hybrid edge and region-based parametric deformable model, or active surface, for prostate volume segmentation in transrectal ultrasound (TRUS) images.

Influence of residual thermal stresses on the edge chipping resistance of PFM and veneered zirconia structures: Experimental and FEA study.

Chipping fractures of the veneering porcelain are frequently reported for veneered all-ceramic crowns. In the present study, the edge chipping test is used to measure the toughness and the edge chipping resistance of veneered zirconia and porcelain-fused-to-metal (PFM). The aim is to describe an edge chipping method developed with the use of a universal testing machine and to verify the accuracy of this method to determine the influence of residual thermal stresses on the chipping fracture resistance of ven...

The Global Landscape of Tuberculosis Therapeutics.

Tuberculosis (TB) is one of the oldest infections afflicting humans yet remains the number one infectious disease killer worldwide. Despite decades of experience treating this disease, TB regimens require months of multidrug therapy, even for latent infections. There have been important recent advances in treatment options across the spectrum of TB, from latent infection to extensively drug-resistant (XDR) TB disease. In addition, new, potent drugs are emerging out of the development pipeline and are being ...

Influence of edge magnetization and electric fields on zigzag silicene, germanene and stanene nanoribbons.

Using a multi-orbital tight-binding model, we have studied the edge states of zigzag silicene, germanene, and stanene nanoribbons (ZSiNRs, ZGeNRs and ZSnNRs, respectively) in the presence of the Coulomb interaction and a vertical electric field. The resulting edge states have non-linear energy dispersions due to multi-orbital effects, and the nanoribbons show induced magnetization at the edges. Owing to this non-linear dispersion, ZSiNRs, ZGeNRs and ZSnNRs may not provide superior performance in field effec...

Near field focusing by edge diffraction.

Spherical microparticles have the ability for nonresonant focusing of light in the near field zone, forming nanojet (NJ) beams. Arbitrary-shaped microstructures, with wavelength-scale dimensions, may offer similar functionality with lower fabrication complexity. The focusing properties are ruled by the edge diffraction phenomenon. The diffraction of light on the edge of a dielectric microstructure forms a tilted focused beam whose deviation angle depends on the index ratio between the structure material and...

Multiple harmonics control of edge pseudomagnetoplasmons in strained grapheme.

Valley-resolved edge plasmons are relevant to nano-optics at subwavelength scales. However, less attention has been paid to their tunable properties in time domain. In this work we investigate edge pseudomagnetoplasmons in a strained graphene modulated by multiple harmonics with frequency in the THz regime. The edge plasmon is described by a set of nonlinear hydrodynamic equations, which are self-consistently solved by the flux-corrected transport method. Without the applied voltage, there exist two unidire...

Percutaneous mitral and tricuspid valve repair using edge-to-edge technique.

Stress Among Healthcare Professionals Calls Out for Attention.

PRACTITIONER APPLICATION: Innovative Leadership Initiatives to Reduce the Cost of Healthcare.

Previous TAVR in patients undergoing percutaneous edge-to-edge mitral valve repair (PMVR) affects improvement of MR.

Patients after transcatheter aortic valve replacement (TAVR) and persistent severe mitral regurgitation (MR) are increasingly treated with percutaneous edge-to-edge mitral valve repair (PMVR). The impact of a former TAVR on PMVR procedures is not clear.

On Detection of Faint Edges in Noisy Images.

A fundamental question for edge detection in noisy images is how faint can an edge be and still be detected. In this paper we offer a formalism to study this question and subsequently introduce computationally efficient multiscale edge detection algorithms designed to detect faint edges in noisy images. In our formalism we view edge detection as a search in a discrete, though potentially large, set of feasible curves. First, we derive approximate expressions for the detection threshold as a function of curv...

Successful Edge-to-Edge Mitral Repair Using the New MitraClip XTR System Following Rupture of Transapical Implanted NeoChord.

Oral and dental healthcare during pregnancy: Evaluating a theory-driven intervention.

The present research aimed to investigate the effect of an educational intervention based on the health belief model in pregnant women visiting the healthcare centers in the west of Tehran in 2016.

Cancer Core Europe: A European cancer research alliance realizing a research infrastructure with critical mass and programmatic approach to cure cancer in the 21st century.

Translational cancer research covers the whole cancer research continuum from basic to preclinical to early clinical, late clinical and outcomes research. Basic-preclinical research is the "engine" for early clinical research bridging the early translational research gap. Cancer Core Europe has been created to construct a sustainable, high level, shared research infrastructure platform with research collaborations and taskforces (data sharing, clinical trials, genomics, immunotherapy, imaging, legal & ethic...

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