Advertisement

Topics

PubMed Journals Articles About "Eka Chemicals AB" RSS

18:30 EST 11th December 2018 | BioPortfolio

Eka Chemicals AB PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Eka Chemicals AB articles that have been published worldwide.

More Information about "Eka Chemicals AB" on BioPortfolio

We have published hundreds of Eka Chemicals AB news stories on BioPortfolio along with dozens of Eka Chemicals AB Clinical Trials and PubMed Articles about Eka Chemicals AB for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Eka Chemicals AB Companies in our database. You can also find out about relevant Eka Chemicals AB Drugs and Medications on this site too.

Showing "Chemicals" PubMed Articles 1–25 of 919

DEVELOPMENT OF A CURATED HERSHBERGER DATABASE.

A systematic literature review was conducted to identify Hershberger bioassays for ~3200 chemicals including those used to validate the OECD/US EPA guideline assay, US EPA's chemicals screened for endocrine activity, and the library of chemicals run in US EPA 's ToxCast in vitro assays. For 134 chemicals that met pre-defined criteria, experimental results were extracted into a database used to characterize uncertainty in results and evaluate the concordance of the Hershberger assay with other in vivo rodent...


Screening tools for the bioconcentration potential of monovalent organic ions in fish.

Currently the bioaccumulation potential of organic chemicals is assessed in a first tier approach via their octanol-water partition coefficient. This approach has been developed for neutral chemicals and cannot work for ionizable and ionic chemicals because the latter have different sorption-mechanisms and -preferences. Thus, suitable screening tools for the bioconcentration potential of ionic and ionizable chemicals need to be developed because it cannot be expected that these chemicals are non-bioaccumula...

Endpoint sensitivity in Amphibian Metamorphosis Assay.

The Amphibian Metamorphosis Assay (AMA) is a screening test for detecting chemicals with thyroid activity. There is little experience in data interpretation and in using AMA data for screening, testing and identifying endocrine disruptors. To investigate the sensitivity of different endpoints of the AMA, the publically available data for 57 thyroid active and inactive chemicals were compiled and analyzed. Endpoints body weight and length appeared as sensitive as apical thyroid responsive endpoints hind limb...


Serum polyfluoroalkyl chemicals are associated with risk of cardiovascular diseases in national US population.

Perfluoroalkyl chemicals (PFCs) as possible cardiovascular disrupters are universally detected in humans. However, evidence from epidemiological studies appears insufficient and ambiguous.

The roles of radio-functional natural chemicals for the development of cancer radiation therapy.

Ionizing radiation (IR) targeted at killing cancer cells also damages normal human cells and tissues through oxidative stress. Thus, the practical treatment of cancer using radiation therapy (RT) is sometimes limited because of the acute side effects in individual patients. In addition, some radioresistant cancers are difficult to treat with limited doses of IR, which leads to treatment failure. Natural chemicals that have unique physiological functions and low toxicity offer significant advantages for the ...

Chemical use in the semiconductor manufacturing industry.

The semiconductor industry is known to use a number of chemicals, but little is known about the exact chemicals used due to the ingredients being kept as a trade secret.

Variability of urinary concentrations of non-persistent chemicals in pregnant women and school-aged children.

Exposome studies are challenged by exposure misclassification for non-persistent chemicals, whose temporal variability contributes to bias in dose-response functions.

Concentrations of endocrine disrupting chemicals in newborn blood spots and infant outcomes in the upstate KIDS study.

Novel methodologies to quantify infant exposures to endocrine disrupting chemicals (EDCs) for population-based studies are needed.

A model for risk-based screening and prioritization of human exposure to chemicals from near-field sources.

Exposure and risk-based assessments for chemicals used indoors or applied to humans (i.e., in near-field environments) necessitate an aggregate exposure pathway framework that aligns chemical exposure information from use sources to internal dose and eventually to their potential for health effects. Such a source-to-effect continuum is advocated to balance the complexity of human exposure and the insufficiency of relevant data for thousands of existing and emerging chemicals. Here, we introduce the Risk Ass...

A framework for the identification of promising bio-based chemicals.

Recent progress in metabolic engineering and synthetic biology enables the use of microorganisms for the production of chemicals ("bio-based chemicals"). However, it is still unclear which chemicals have the highest economic prospect. To this end, we develop a framework for the identification of such promising ones. Specifically, we first develop a genome-scale constraint-based metabolic modeling approach, which is used to identify a candidate pool of 209 chemicals (together with the estimated yield, produc...

Human health risks due to exposure to inorganic and organic chemicals from textiles: A review.

It is well known that a number of substances used in the textile industry can mean not only environmental, but also health problems. The scientific literature regarding potential adverse health effects of chemical substances in that industry is mainly related with human exposure during textile production. However, information about exposure of consumers is much more limited. Although most research on the health effects of chemicals in textiles concern allergic skin reactions, contact allergy is not the only...

Infer the in vivo point of departure with ToxCast in vitro assay data using a robust learning approach.

The development and application of high throughput in vitro assays is an important development for risk assessment in the twenty-first century. However, there are still significant challenges to incorporate in vitro assays into routine toxicity testing practices. In this paper, a robust learning approach was developed to infer the in vivo point of departure (POD) with in vitro assay data from ToxCast and Tox21 projects. Assay data from ToxCast and Tox21 projects were utilized to derive the in vitro PODs for...

Evaluation of androgen assay results using a curated Hershberger database.

A set of 39 reference chemicals with reproducible androgen pathway effects in vivo, identified in the companion manuscript [1], were used to interrogate the performance of the ToxCast/Tox 21 androgen receptor (AR) model based on 11 high throughput assays. Cytotoxicity data and specificity confirmation assays were used to distinguish assay loss-of-function from true antagonistic signaling suppression. Overall agreement was 66% (19/29), with ten additional inconclusive chemicals. Most discrepancies were expla...

Current EU research activities on combined exposure to multiple chemicals.

Humans and wildlife are exposed to an intractably large number of different combinations of chemicals via food, water, air, consumer products, and other media and sources. This raises concerns about their impact on public and environmental health. The risk assessment of chemicals for regulatory purposes mainly relies on the assessment of individual chemicals. If exposure to multiple chemicals is considered in a legislative framework, it is usually limited to chemicals falling within this framework and co-ex...

A Murine Pancreatic Islet Cell-based Screening for Diabetogenic Environmental Chemicals.

Exposure to certain environmental chemicals in human and animals has been found to cause cellular damage of the pancreatic β cells which will lead to the development of type 2 diabetes mellitus (T2DM). Although the mechanisms for the chemical-induced β cell damage were unclear and likely to be complex, one recurring finding is that these chemicals induce oxidative stress leading to the generation of excessive reactive oxygen species (ROS) which induce damage to the β cell. To identify potential diabetoge...

(Q)SARs as Adaptations to REACH Information Requirements.

REACH is a regulation of the European Union adopted to improve the safe use of chemicals with regard to human health and the environment. The safe use of chemicals can be achieved only if the hazard and the exposure of the substances are well characterized. Testing on animals has been traditionally the main tool for hazard assessment. For ethical and economic reasons, alternative ways of testing that do not use laboratory animals have been developed by different parties (regulatory agencies, researchers, in...

Growing practices and the use of potentially harmful chemical additives among a sample of small-scale cannabis growers in three countries.

With the growth of legal cannabis markets there has been recognition of the adverse impacts of certain cannabis growing practices, notably, use of harmful chemicals. A major concern has been the use of Plant Growth Regulators (PGRs) which limit plant size and stimulate bud production. These chemicals, many of which have been banned from food crops, have been found unlisted in cannabis growing nutrients sold online or in hydroponic stores. This study describes the cannabis growing practices used by small-sca...

Numerical-ecotoxicological approach to assess potential risk associated with oilfield production chemicals discharged into the sea.

Several different chemical products are used on oil platforms to aid oil-water separation during the production process. These chemicals may enter into the sea by means of production water (PW), the main discharge derived from oil and gas offshore platforms. Consequently, toxic effects may occur in the marine environment, causing reductions in wildlife numbers, degrading ecosystem functions and threatening human health. For most of these chemicals, environmental toxicity and safety thresholds in marine ecos...

Reduced Transcriptomic Approach for Screening and Prediction of Chemical Toxicity.

The reduced transcriptomic approach allows full dose range testing of hundreds of chemicals or mixtures using human cells or zebrafish embryos. Points of departure of genes and pathways can be used for potency ranking and to classify chemicals by disrupted biological pathways.

Endocrine-disrupting chemicals: Effects on neuroendocrine systems and the neurobiology of social behavior.

A contribution to SBN/ICN special issue. Endocrine-disrupting chemicals (EDCs) are pervasive in the environment. They are found in plastics and plasticizers (bisphenol A (BPA) and phthalates), in industrial chemicals such as polychlorinated biphenyls (PCBs), and include some pesticides and fungicides such as vinclozolin. These chemicals act on hormone receptors and their downstream signaling pathways, and can interfere with hormone synthesis, metabolism, and actions. Because the developing brain is particul...

Impact of European chemicals regulation on the industrial use of plasticizers and patterns of substitution in Scandinavia.

REACH aims at promoting the safe use of chemicals in Europe, inter alia by identification and regulation of substances of very high concern (SVHCs). Once identified, SVHCs need to be substituted by safer alternatives. However, substitutes are frequently not safer than the substances that they replace but rather show similar hazard profiles, resulting in regrettable substitution. This paper investigates the impact of chemicals regulation on substitution of chemicals by analyzing time trends in the industrial...

Skin Sensitization Induction Potential From Daily Exposure to Fragrances in Personal Care Products.

Many chemicals used for fragrance purposes in a diversity of products have allergenic potential. Based on such concerns, industry groups developed concentration limits for use of fragrance chemicals in personal care and cosmetic products.

Evaluating the Risk Assessment Approach of the REACH Legislation: A Case Study.

Risk assessments based on occupational exposure to chemicals have increased since REACH (European regulation on Registration, Evaluation, Authorization, and restriction of Chemicals) came into force. The European Chemicals Agency (ECHA) recommends that chemical exposure could be calculated using exposure models and that parameters used to calculate the exposure scenario (ES) should be communicated in extended safety data sheets (e-SDS) as workplace instructions which downstream users are obligated to follow...

A framework for application of quantitative property-property relationships (QPPRs) in physiologically based pharmacokinetic (PBPK) models for high-throughput prediction of internal dose of inhaled organic chemicals.

New generation of toxicological tests and assessment strategies require validated toxicokinetic data or models that are lacking for most chemicals. This study aimed at developing a quantitative property-property relationship (QPPR)-based human physiologically based pharmacokinetic (PBPK) modeling framework for high-throughput predictions of inhalation toxicokinetics of organic chemicals. A PBPK model was parameterized with QPPR-derived values for hepatic clearance (CL) and partition coefficients (P) [blood:...

Salinity-gradient energy driven microbial electrosynthesis of value-added chemicals from CO reduction.

Biological conversion of CO to value-added chemicals and biofuels has emerged as an attractive strategy to address the energy and environmental concerns caused by the over-reliance on fossil fuels. In this study, an innovative microbial reverse-electrodialysis electrolysis cell (MREC), which combines the strengths of reverse electrodialysis (RED) and microbial electrosynthesis technology platforms, was developed to achieve efficient CO-to-value chemicals bioconversion by using the salinity gradient energy a...


Advertisement
Quick Search
Advertisement
Advertisement