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PubMed Journals Articles About "Electron Microscopy Project Could Revolutionize Search Drugs∨derfield=score∨derval=DESC" RSS

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Electron Microscopy Project Could Revolutionize Search Drugs∨derfield=score∨derval=DESC PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Electron Microscopy Project Could Revolutionize Search Drugs∨derfield=score∨derval=DESC articles that have been published worldwide.

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Showing "Electron Microscopy Project Could Revolutionize Search Drugs derfield" PubMed Articles 1–25 of 14,000+

Extraocular and Intraocular Infections Following Strabismus Surgery: A Review.

An extensive literature review of various types of infections following strabismus surgery was facilitated by using the search engines PubMed and Google Scholar. In both search engines, the phrases "infection following strabismus surgery," "infection strabismus surgery," "complications of strabismus surgery," "endophthalmitis strabismus surgery," and "strabismus scleral perforation" were used for the review. The type of infection, surface involved, and site of the infection determined the type of therapy. I...


Mucosal gene expression changes induced by anti-TNF treatment in inflammatory bowel disease patients.

In the last two decades anti-tumor necrosis factor (anti-TNF) therapy for inflammatory bowel disease (IBD) has been widely used to induce and maintain clinical and endoscopical remission, completely changing management of the disease. In this study, we aimed to identify gene expression changes in inflamed mucosa from Crohn's disease and ulcerative colitis patients treated with 5-aminosalicylic acid (5-ASA) (N = 25) or anti-TNF agents (N = 12) compared to drug-free IBD patients (N = 12) and non-IBD control s...

CAGI SickKids challenges: Assessment of phenotype and variant predictions derived from clinical and genomic data of children with undiagnosed diseases.

Whole genome sequencing (WGS) holds great potential as a diagnostic test. However, the majority of patients currently undergoing WGS lack a molecular diagnosis, largely due to the vast number of undiscovered disease genes and our inability to assess the pathogenicity of most genomic variants. The CAGI SickKids challenges attempted to address this knowledge gap by assessing state-of-the-art methods for clinical phenotype prediction from genomes. CAGI4 and CAGI5 participants were provided with WGS data and cl...


Electron Transfer to Decorated Graphene Oxide Particles.

Graphene oxides (GOs) are popular catalyst supports for precious metals in nanoparticle form. The hydrogen oxidation reaction (HOR) and the hydrogen evolution reaction (HER) on individual GO platelets decorated with Pd nanoparticles (Pd/GOs) were investigated and suggest that the catalytic activity is confined to zone physically close to the point of electrical contact between platelet and electrode with just a fraction of the platelet active.

Triplet Fullerenes as Prospective Spin Labels for Nanoscale Distance Measurements by Pulsed Dipolar EPR.

Precise nanoscale distance measurements by pulsed Electron Paramagnetic Resonance (EPR) play crucial role in structural studies of biomolecules and their complexes. The properties of spin labels used in this approach are of paramount importance, since they determine the sensitivity limits, attainable distances and proximity to biological conditions, including physiological temperatures. Herewith, we propose and validate the use of photoexcited fullerenes as spin labels for pulsed dipolar (PD) EPR distance m...

Photoinduced energy- and electron-transfer processes in a side-to-face RuII-porphyrin/perylene-bisimide array.

A side-to-face array DPy-gPBI[Ru(4-tBuTPP)(CO)]2, based on a "green" perylene bisimide chromophore sandwiched between two RuII-porphyrins, has been prepared by self-assembly. Its photophysical properties have been characterized in detail by a combination of steady-state and time-resolved techniques upon selective excitation of the two different components. Different photoinduced processes are observed as a function of the excitation wavelength. Electron transfer quenching is attained upon "red light" excita...

Emerging roles of exosomal miRNAs in breast cancer drug resistance.

Breast cancer (BC), as a heterogeneous disease, is considered as one of the most common malignancies in women worldwide. The resistance of BC cells to therapeutic agents has remained a big challenge in the treatment of BC patients. Some factors such as cytokines, exosomes, and soluble receptors were recognized as crucial agents involved in the development of drug resistance. However, the exact mechanisms underlying the drug resistance is still unknown. There is growing evidence to support the emerging roles...

A Time-Programmed Release of Dual Drugs from an Implantable Trilayer Structured Fiber Device for Synergistic Treatment of Breast Cancer.

Combination chemotherapy with time-programmed administration of multiple drugs is a promising method for cancer treatment. However, realizing time-programmed release of combined drugs from a single carrier is still a great challenge in enhanced cancer therapy. Here, an implantable trilayer structured fiber device is developed to achieve time-programmed release of combined drugs for synergistic treatment of breast cancer. The fiber device is prepared by a modified microfluidic-electrospinning technique. The ...

Revealing the elemental distribution within latent fingermarks using synchrotron sourced x-ray fluorescence microscopy.

Fingermarks are an important form of crime-scene trace evidence; however, their usefulness may be hampered by a variation in response or a lack of robustness in detection methods. Understanding the chemical composition and distribution within fingermarks may help explain variation in latent fingermark detection with existing methods and identify new strategies to increase detection capabilities.The majority of research in the literature describes investigation of organic components of fingermark residue, le...

Gα and the Phospholipase Cβ3 X-Y Linker Regulate Adsorption and Activity on Compressed Lipid Monolayers.

Phospholipase Cβ (PLCβ) enzymes are peripheral membrane proteins required for normal cardiovascular function. PLCβ hydrolyzes phosphatidylinositiol-4,5-bisphosphate (PIP), producing second messengers that increase intracellular Ca and activate protein kinase C (PKC). Under basal conditions, PLCβ is autoinhibited by its C-terminal domains and by the X-Y linker, which contains a stretch of conserved acidic residues required for interfacial activation. Following stimulation of G protein coupled receptors, ...

In Situ Doping of Black Phosphorus by High-Pressure Synthesis.

Black phosphorus is a two-dimensional semiconductor with promising properties for catalysis, energy storage, and conversion as well as electronic device applications, and control of its electronic structure is critical for such applications. Substitutional doping of phosphorus by electron donating (e.g., sulfur) or electron accepting elements (e.g., germanium) can significantly change its properties, especially charge carrier concentration. Here, we report the in situ doping of black phosphorus by its direc...

Clustering of Giant Unilamellar Vesicles (GUVs) Promoted by Covalent and Non-Covalent Bonding of Functional Groups at Membrane-Embedded Peptides.

Access to clusters of cell-sized globular objects such as giant unilamellar vesicles (GUVs) is of increasing interest due to their potential applications in prototissue and cell-cell adhesion studies. Aggregations of GUVs by four different approaches were observed via covalent as well as non-covalent bond participa-tions of functional groups at membrane embedded cholesterylpeptides using optical microscopy. Passive air oxidation of GUV-surface thiols into trans-GUV disulfide bonds promoted multi-vesicle agg...

The Structural Evolution and Dynamics of an In2O3 Catalyst for CO2 Hydrogenation to Methanol: an Operando XAS-XRD and in situ TEM Study.

We report an operando examination of a model nanocrystalline In2O3 catalyst for methanol synthesis via CO2 hydrogenation (300 oC, 20 bar) by combing X-ray absorption spectroscopy (XAS), X-ray powder diffraction (XRD) and in situ TEM. Three distinct catalytic regimes are identified during CO2 hydrogenation: activation, stable performance, and deactivation. The structural evolution of In2O3 nanoparticles (NPs) with time on stream (TOS) followed by XANES-EXAFS-XRD associates the activation stage with a minor...

Organophotoredox-catalyzed intermolecular oxa-4+2 cycloaddition reactions.

An intermolecular oxa-[4+2] cycloaddition reaction promoted by a thioxanthylium organophotoredox catalyst under irradiation with green light has been developed. The reaction of ortho-quinone methides with styrenes smoothly affords the desired cycloadducts. Especially styrenes bearing electron-donating groups are efficiently transformed in this reaction. This method represents a sustainable way to carry out oxa-[4+2] cycloaddition reactions using only a catalytic amount of a photocatalyst and visible light.

Proton Transfer Reactions Between Methanol and Formic Acid Deposited on Free Ar Nanoparticles.

We have sequentially picked up two astrochemicaly relevant Brønsted acids (methanol and formic acid) on the surface of argon nanoparticles acting as a cold support. Photoionization and electron ionization yield (HCOOH)H, (CHOH)H as well as mixed protonated clusters. Experiments with perdeuterated methanol CDOD demonstrate notable proton transfer to formic acid acting as a proton acceptor in addition to the proton transfer from formic acid which is, perhaps, a more intuitive one. We, therefore, for the firs...

Complexes of Diiodine with Heteroaromatic N-oxides:Effects of Halogen-Bond Acceptors in Halogen Bonding.

Halogen bonding (XB) in complexes of diiodine with heteroaromatic N-oxides was examined via a combination of UV-Vis spectral and X-ray structural measurements, as well as computational analysis. While all these associates were formed by analogous I∙∙∙O bonds, they showed considerable variations of formation constants (5 - 1500 M) and intermolecular I∙∙∙O bond length (2.3 - 3.2 Å). In the solid state, both atoms of I molecules were involved in XB, and the I∙∙∙O separations were determined ...

High-Resolution Liquid Chromatography-Mass Spectrometry-Based Metabolomic Discrimination of -Type Crude Drugs and Comparison with Nuclear Magnetic Resonance Spectroscopy-Based Metabolomics.

Five -type crude drugs (40 samples) were classified using liquid chromatography-mass spectrometry (LC-MS)-based metabolomics. The following six flavonoid derivatives were identified as contributors from the loading plots of multivariate analysis: naringin (), neohesperidin (), neoeriocitrin (), narirutin (), hesperidin (), and 3,5,6,7,8,3',4'-heptamethoxyflavone (). Three coumarin derivatives, namely, meranzin (), meranzin hydrate (), and meranzin glucoside (), were also identified as contributors. Furtherm...

Direct Imaging of Tunable Crystal Surface Structures of MOF MIL-101 Using High-Resolution Electron Microscopy.

Metal-organic frameworks (MOFs) are often synthesized using various additives to modulate the crystallization. Here, we report the direct imaging of the crystal surface of MOF MIL-101 synthesized with different additives, using low-dose high-resolution transmission electron microscopy (HRTEM), and identify three distinct surface structures, at subunit cell resolution. We find that the mesoporous cages at the outermost surface of MIL-101 can be opened up by vacuum heating treatment at different temperatures,...

Evolution of the Solid-Electrolyte Interphase on Carbonaceous Anodes Visualized by Atomic-Resolution Cryogenic-Electron Microscopy.

The stability of modern lithium-ion batteries depends critically on an effective solid-electrolyte interphase (SEI), a passivation layer that forms on the carbonaceous negative electrode as a result of electrolyte reduction. However, a nanoscopic understanding of how the SEI evolves with battery aging remains limited due to the difficulty in characterizing the structural and chemical properties of this sensitive interphase. In this work, we image the SEI on carbon black negative electrodes using cryogenic t...

In situ Electrochemical Mapping of Lithium-Sulfur Battery Interfaces using AFM-SECM.

While lithium-sulfur (Li-S) batteries are explored extensively, many aspects of the lithium polysulfide (LiPS) redox mechanism at the electrode/electrolyte interface still remains unclear. Though various in situ and ex situ characterization techniques have been deployed in recent years, many spatial aspects related to local electrochemical phenomena of the electrode are not elucidated. Herein, we introduce the atomic force microscopy-based scanning electrochemical microscopy (AFM-SECM) technique to study th...

Probing Far-Infrared Surface Phonon Polaritons in Semiconductor Nanostructures at Nanoscale.

Phonon polaritons hold potential prospects of nanophotonic applications at the mid- and far-infrared wavelengths. However, their experimental investigation in the far-infrared range has long been a technical challenge due to the lack of suitable light sources and detectors. To obviate these difficulties, here we use an electron probe with sub-10 meV energy resolution and subnanometer spatial resolution to study far-infrared surface phonon polaritons (~50-70 meV) in ZnO nanostructures. We observe ultra-slow ...

Nursing Knowledge of Alcohol and Other Drugs (AOD) in a Regional Health District: An Exploratory Study.

Nurses remain at the forefront of direct patient care due to the nature of their role; they are in a position to provide assessment, response and referral of individuals in healthcare settings with problematic alcohol and other drug (AOD) use. We aim to determine the AOD knowledge of nurses in a regional health district in Australia and the awareness of an AOD service operating in the clinical environment. We employed a cross-sectional online survey, with descriptive and correlational analysis performed to ...

Uncovering the lived experiences of Filipino drug recoverees towards occupational participation and justice through an interpretative phenomenological analysis.

The drug using crisis entails participation and justice issues making it a pressing health and social concern in the Philippines today. This study explored the lived experiences of Filipinos recovering from drug addiction and sought to understand the occupational justice determinants of drug addiction to better develop substance addiction rehabilitation programs in the Philippines. Using a qualitative approach, we conducted in-depth interviews guided by the Occupational Justice Health Questionnaire to 24 ...

Differences in protein profiles between strains obtained from healthy and infected dogs.

causes infections of the skin and mucous membranes, especially in individuals with metabolic, hormonal, and immunological disorders. The search for properties that differentiate isolates from healthy and infected animals may result in the identification of typically commensal and potentially pathogenic strains within the entire species. We aimed to determine and compare protein profiles of strains isolated from 30 dogs with clinical symptoms of otitis externa and 34 dogs without symptoms of any disease. T...

Standardizing Febrile Neutropenia Management: Antimicrobial Stewardship in the Hematologic Malignancy Population.

Patients with febrile neutropenia (FN) often are subject to antibiotic and diagnostic test overuse. We sought to improve appropriate use of antimicrobials and diagnostic tests for patients with FN. We used a blended quality approach with Lean Six Sigma tools and iterative improvement of a clinical decision aid to guide providers through empirical antimicrobial selection and diagnostic evaluation of patients with FN during a yearlong period. We evaluated the incidence of nonadherence to best practice before,...


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