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PubMed Journals Articles About "Eton Pharmaceuticals Provides Update Program" RSS

13:36 EDT 24th August 2019 | BioPortfolio

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Showing "Eton Pharmaceuticals Provides Update Program" PubMed Articles 1–25 of 3,900+

Why is There Discordance between the Reimbursement of High-Cost 'Life-Extending' Pharmaceuticals and Medical Devices? The Funding of Ventricular Assist Devices in Australia.

New health technologies often yield health benefits, but often at a high cost. In Australia, the processes for public reimbursement of high-cost pharmaceuticals and medical devices are different, potentially resulting in inequity in support for new therapies. We explore how reimbursement is different for medical devices compared with pharmaceuticals, including whether higher cost-effectiveness thresholds are accepted for pharmaceuticals. A literature review identified the challenges of economic evaluations ...


An industry update: the latest developments in therapeutic delivery covering September 2018.

The present industry update covers the period 1-30 September 2018, with information sourced from company press releases, regulatory and patent agencies as well as scientific literature. Various technologies using reformulations of know drugs with nanoparticles, hydrogels, aerosols, etc. emerged in new financing rounds (BioTime; CA, USA, SiSaf; Guildford, UK, Cassion Biotech; TX, USA), intellectual property protection (TFF Pharmaceuticals; TX, USA), repackaging (Leiters; CA, USA) and reformulation (Virpax Ph...

Occurrence and distribution of pharmaceuticals in raw, finished, and drinking water from seven large river basins in China.

The occurrence of pharmaceuticals in the drinking water is a growing concern in China. In this study, we determined the concentration and distribution of 59 selected pharmaceuticals in raw, finished, and tap water samples from 79 drinking water treatment plants (DWTPs) in 15 cities, encompassing seven large river basins in China, using solid-phase extraction pretreatment and ultra-high-performance liquid chromatography-tandem mass spectrometry analysis. Forty-seven pharmaceuticals were detected in raw water...


Insight into the distribution of pharmaceuticals in soil-water-plant systems.

Pharmaceuticals in agricultural soils originating from irrigation with treated wastewater and land-applied biosolids can enter field crops. However, little is known about the role of pore water in plant uptake of pharmaceuticals from soils. In this study, the fate, uptake and distribution of fifteen commonly used pharmaceuticals in soil-water-radish systems were investigated to examine the relationship between the accumulation and their physicochemical processes in soils. The results indicate that the distr...

U.S. Emergency Department Visits Resulting From Nonmedical Use of Pharmaceuticals, 2016.

National data on morbidity from nonmedical use of pharmaceuticals are limited. This study used nationally representative, public health surveillance data to characterize U.S. emergency department visits for acute harms from nonmedical use of pharmaceuticals and to guide prevention efforts.

Telemedicine for Neurotrauma Prevents Unnecessary Transfers: An Update from a Nation-Wide Program of Albania and Analysis of 590 Patients.

Telemedicine program in Albania includes a specialized teleneurotrauma program. There is only one national trauma center with neurosurgery capability in the capital city of Tirana. Patients with isolated head or spine injury that require a consultation with neurosurgeons located at the National Trauma Center undergo telemedicine consultation. The aim of this follow-up study is to evaluate the effectiveness of a nation-wide tele-neurotrauma network in preventing unnecessary transfers for neurotrauma.

Survival disparities among racial/ethnic groups of women with ovarian cancer: An update on data from the Surveillance, Epidemiology and End Results (SEER) registry.

Update information on racial disparities in ovarian cancer survival from the Surveillance, Epidemiology, and End Results (SEER) Program.

Simultaneous aqueous chlorination of amine-containing pharmaceuticals.

Amine-containing pharmaceuticals such as acetaminophen, diclofenac, and sulfamethoxazole are the most often detected pharmaceuticals in wastewater and other aquatic environments. Amine-containing pharmaceuticals can be effectively removed by chlorination. These drugs, however, may coexist in wastewater. Thus, they may compete with each other, and their chlorinated products may react with each other to form new products. In this study, competitive effects of the above three amine-containing pharmaceuticals b...

An Update of Current Cannabis-Based Pharmaceuticals in Pain Medicine.

Cannabis users have long reported therapeutic properties of the plant for a variety of conditions, some of which include nausea, emesis, seizures, cancer, neurogenic diseases and pain control. Research has elucidated many cannabinoid pharmacodynamic and pharmacokinetic properties, expanding the potential use of cannabinoids as a medical therapy. Due to the inconsistent delivery and control of the active components involved with smoking, pharmaceutical companies are investigating and prioritizing routes othe...

Tracking changes in the occurrence and source of pharmaceuticals within the River Thames, UK; from source to sea.

There is a growing interest in the occurrence and sources of pharmaceutical substances in the environment. This paper reports the first detailed transect of pharmaceutical occurrence along the River Thames, UK, from source to sea, undertaken during a period of high flow in 2016. In 37 samples a total of 41 pharmaceuticals and 2 lifestyle compounds (cocaine and sucralose) were detected. Total concentration of pharmaceuticals ranged from 0.0012 μg/l to 10.24 μg/l with a median of 2.6 μg/l. Sucralose ...

Distribution and ecological risk of pharmaceuticals in surface water of the Yeongsan river, Republic of Korea.

This study examined the distribution of pharmaceuticals in Yeongsan River and at point sources (PSs) in the associated water system, and performed a risk assessment based on our findings. The samples included effluents collected from three sewage treatment plants (PS1, PS2, and PS3) and two industrial complexes (PS4 and PS5) as well as surface water collected from seven mainstreams and 11 tributaries of the river. The target pharmaceuticals were acetylsalicylic acid, carbamazepine, clarithromycin, naproxen,...

Single and mixture toxicity of four pharmaceuticals of environmental concern to aquatic organisms, including a behavioral assessment.

Pharmaceuticals are frequently detected in aquatic environments as mixtures and can cause toxic effects to non-target organisms. We aimed to evaluate the single and mixture effects of the pharmaceuticals metformin, bisoprolol, ranitidine and sotalol using Daphnia similis and Danio rerio. In addition, we aimed to test the predictive accuracy of the mathematical models concentration addition and independent action and to evaluate the nature of the possible toxicological interactions among these pharmaceutical...

Oxidation of Pharmaceuticals by Ferrate(VI) in Hydrolyzed Urine: Effects of Major Inorganic Constituents.

Destruction of pharmaceuticals excreted in urine can be an efficient approach to eliminate these environmental pollutants. However, urine contains high concentrations of chloride, ammonium, and bicarbonate, which may hinder treatment processes. This study evaluated the application of ferrate(VI) (FeVIO42-, Fe(VI)) to oxidize pharmaceuticals (carbamazepine (CBZ), naproxen (NAP), trimethoprim (TMP) and sulfonamide antibiotics (SAs)) in synthetic hydrolyzed human urine and uncovered new effects from urine's ma...

A three-arm randomized controlled trial of Lidcombe Program and Westmead Program early stuttering interventions.

To compare two experimental Westmead Program treatments with a control Lidcombe Program treatment for early stuttering.

Individual and mixture toxicity evaluation of three pharmaceuticals to the germination and growth of Lactuca sativa seeds.

This work aims to assess, individually and in mixtures, possible phytotoxic effects of three pharmaceuticals (paracetamol, ibuprofen and amoxicillin) on germination and early growth of Lactuca sativa seeds. Pharmaceuticals are an important group of emerging contaminants, whose presence has been described in several environmental compartments, including soils. However, knowledge on their possible impact in terrestrial organisms is still sparse and even more when mixtures are considered. Germination tests are...

Occurrence, removal and seasonal variation of pharmaceuticals in Brasilian drinking water treatment plants.

The presence of pharmaceuticals in aquatic environments has become a major issue of concern for scientific community, since there is a lack of information about risks and impacts to the environment and public health. In the context of Brazil, many cities do not have Wastewater Treatment Plants (WWTPs) and domestic sewage is dumped directly into the water bodies, aggravating the problem. Thus, the present study aimed to evaluate the presence of 28 prescribed pharmaceuticals from different therapeutic classes...

An Approach for Using In Vitro and In Silico Data to Identify Pharmaceuticals with Potential (Anti-)Estrogenic Activity in Aquatic Vertebrates at Environmentally Relevant Concentrations.

Endocrine-active pharmaceuticals can cause adverse reproductive and developmental effects in non-target organisms. Aquatic vertebrates may be susceptible to the effects of such pharmaceuticals given that the structure of hormone receptors and the physiology of the endocrine system are highly conserved across vertebrates. To aid in the regulatory review of the environmental impact of drugs, we demonstrate an approach to screen and support the prioritization of pharmaceuticals based on their ability to intera...

Effective elimination of fifteen relevant pharmaceuticals in hospital wastewater from Colombia by combination of a biological system with a sonochemical process.

This work presents the treatment of selected emerging concern pharmaceuticals in real hospital wastewater (HWW) from Tumaco-Colombia by combination of a biological system with a sonochemical process. Fifteen compounds, commonly present in HWW, were considered: acetaminophen, diclofenac, carbamazepine, venlafaxine, loratadine, ciprofloxacin, norfloxacin, valsartan, irbesartan, sulfamethoxazole, trimethoprim, clarithromycin, azithromycin, erythromycin and clindamycin. Initially, HWW was characterized in terms...

Equity analysis of resource distribution for the Popular Pharmacy Program.

To analyze the regional allocation of the resources from the Brazilian Popular Pharmacy Program, taking into account the relative availability of the program and the potential needs of the region.

Combination of ozonation and electrolysis process to enhance elimination of thirty structurally diverse pharmaceuticals in aqueous solution.

The increasing amounts of pharmaceuticals in aqueous environment are found to be structurally diverse. O has been demonstrated as a high effective agent in removing pharmaceuticals, however, O is a very selective oxidant which is ineffective for some ozone refractory structures. Recently, a novel electrochemistry-based oxidation process (E-peroxone) has been developed by a simple combination of electrolysis and conventional ozonation process, which can produce a large amount of aqueous OH in situ. E-peroxon...

Surface water pollution by pharmaceuticals and an alternative of removal by low-cost adsorbents: A review.

Micropollutants, also called emerging contaminants, consist of an extensive group of synthetic and natural substances, including pharmaceuticals, personal care products, steroid hormones, and agrochemicals. Currently, the monitoring of residual pharmaceuticals in the environment has been highlighted due to the fact that many of these substances are found in wastewater treatment plants effluents and surface waters, in concentrations ranging from ng L to μg L. Most of these compounds are discharged into the ...

Assessing the public landscape of clinical-stage pharmaceuticals through freely available online databases.

Several public databases have emerged over the past decade to enable chemo- and bio-informatics research in the field of drug development. To a naive observer, as well as many seasoned professionals, the differences among many drug databases are unclear. We assessed the availability of all pharmaceuticals with evidence of clinical testing (i.e., been in at least a Phase I clinical trial) and highlight the major differences and similarities between public databases containing clinically tested pharmaceutical...

Herpes simplex virus encephalitis update.

HSV is the most frequently identified cause of infectious encephalitis, in Western countries. This article is an update on the topic based on a review of recent studies from 2017 to 2018.

Dose-dependent effects of acetate on the biodegradation of pharmaceuticals in moving bed biofilm reactors.

Moving bed biofilm reactors (MBBR) are promising as a post-treatment for removing pharmaceuticals from wastewater. However, the effect of easily degradable carbon sources on the degradation of pharmaceuticals is unclear. This study shows the influence of acetate on the degradation of 26 pharmaceuticals in an MBBR was dose- and compound-dependent: while the degradation of venlafaxine, tramadol and ciprofloxacin was promoted (increase of reaction rate constant (k) by 133%, 212%, 55%) by acetate, its presence ...

Vascular malformations syndromes: an update.

To provide an update of vascular malformation syndromes by reviewing the most recent articles on the topic and following the new International Society for the Study of Vascular Anomalies (ISSVA) 2018 classification.


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