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03:00 EST 19th January 2019 | BioPortfolio

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Showing "FDAnews Announces Five Case Studies Using E2500 Approach" PubMed Articles 1–25 of 43,000+

The characteristics and reporting quality of research impact case studies: A systematic review.

Despite the growing expectation that researchers report the impact of their research using a case study approach, systematic reviews of research impact have focused on frameworks, indicators, methods of data collection and assessment rather than impact case studies. Our aim is to provide an overview of the characteristics of published research impact case studies, including translation activities, and their reporting quality. We searched for peer-reviewed impact studies published between 2000 and 2018 using...

Therapeutic gardening: A counseling approach for bereavement from suicide.

This article focuses on an innovative approach to treating people bereaved by the suicide of a loved one. Nature is powerful and restorative, and some research already supports the therapeutic use of nature to address grief. We outline a therapeutic gardening approach to use with survivors of suicide loss and present a case study. This approach can be used by counselors who work individually with people bereaved by suicide as a way of assisting and supporting them through their grief. Though we suggest that...

Utilization of injury care case studies: a systematic review of the World Health Organization's "Strengthening care for the injured: Success stories and lessons learned from around the world".

Translation of evidence to practice is a public health priority. Worldwide, injury is a leading cause of morbidity and mortality. Case study publications are common and provide potentially reproducible examples of successful interventions in healthcare from the patient to systems level. However, data on how well case study publications are utilized are limited. To our knowledge, the World Health Organization (WHO) published the only collection of international case studies on injury care at the policy level...

Modeling spatial distribution of population for environmental epidemiological studies: Comparing the exposure estimates using choropleth versus dasymetric mapping.

Precise population information is critical for identifying more accurate environmental exposures for air pollution impacts analysis. Basically, there are two methods for estimating spatial distribution of population, choropleth and dasymetric mapping. While the choropleth approach accounts for linear distribution of population over area based on census tract units, the dasymetric model accounts for a more heterogeneous population density by quantifying the association between the area-class map data categor...

Topical steroids: A non-surgical approach for recurrent macular holes.

Report a case of a recurrent macular hole which completely resolved with a non-surgical approach with steroid drops.

Transoral endoscopic thyroidectomy vestibular approach (TOETVA): A case report as new technique in thyroid surgery in Vietnam.

Transoral endoscopic thyroidectomy via vestibular approach (TOETVA) is a promising procedure with many advantages such as truly scar free healing, minimally invasive dissection, and accessible approach to both thyroid lobes.

Distinguishing case study as a research method from case reports as a publication type.

The purpose of this editorial is to distinguish between case reports and case studies. In health, case reports are familiar ways of sharing events or efforts of intervening with single patients with previously unreported features. As a qualitative methodology, case study research encompasses a great deal more complexity than a typical case report and often incorporates multiple streams of data combined in creative ways. The depth and richness of case study description helps readers understand the case and w...

Application of ensemble deep neural network to metabolomics studies.

Deep neural network (DNN) is a useful machine learning approach, although its applicability to metabolomics studies has rarely been explored. Here we describe the development of an ensemble DNN (EDNN) algorithm and its applicability to metabolomics studies. As a model case, the developed EDNN approach was applied to metabolomics data of various fish species collected from Japan coastal and estuarine environments for evaluation of a regression performance compared with conventional DNN, random forest, and su...

Treatment of Comorbid Adult Attention-deficit/Hyperactivity Disorder and Generalized Anxiety Disorder: 2 Case Reports.

Attention-deficit/hyperactivity disorder (ADHD) is often comorbid with anxiety disorders such as generalized anxiety disorder, but the best approach to treat this comorbidity in adults has yet to be determined, as current evidence on which disorder should be treated first is poor and conflicting. In this report, we present 1 case in which we treated adult ADHD first and 1 case in which we treated generalized anxiety disorder before prescribing any medication for ADHD. More studies are required on this topic...

Surgical approach to a mycotic aneurysm of the pulmonary artery presenting with hemoptysis - A case report and a review of the literature.

Mycotic aneurysms of the pulmonary arteries are very rare and have high mortality. Risk groups are intravenous drug users and patients with congenital heart disorders. The surgical approach varies due to a limited number of reported cases.

Epidural approach to paravertebral thoracic sympathetic block as an alternative to stellate ganglion block: A case report.

Evidence from cadaveric studies note that the sympathetic nerves from the second and third thoracic ganglia bypass the stellate ganglion in 20% of the population. We present a novel alternative technique for sympathetic blockade of upper extremity via thoracic epidural approach.

Infraposition of Implant-Retained Maxillary Incisor Crown Placed in an Adult Patient: Case Report.

Several studies have clearly shown that osseointegrated implants, when inserted in growing bone, such as in adolescents, do not follow the eruptive path of adjacent teeth; instead, they act like ankylosed teeth, remaining in a stationary position for the lifetime, thus developing a progressive infraposition of the implant-supported crown. However, further studies have demonstrated that similar changes also occur in adult patients, although mostly in a small amount and over long time spans. Here the case of ...

Conservative Management of Retroperitoneal Ectopic Pregnancy by Computed Tomography-Guided Methotrexate Injection in the Gestational Sac: Two Case Reports and Literature Review.

Retroperitoneal ectopic pregnancy (REP) is an extremely rare type of ectopic pregnancy. Currently, surgery is the most widely used treatment method, although it involves a high liklihood of intraoperative hemorrhage. In this case report, we describe a safe and effective alternative method for managing epigastric REP. We conducted a retrospective analysis of the clinical data of two patients with REP in the epigastrium who were treated at our hospital using our non-surgical method. The treatment involved con...

Laparoscopic management of appendicular mucinous cystadenoma, case report.

Appendectomy is the most common emergency surgical procedure performed worldwide. Mucinous cystadenoma is a rare benign tumor of the appendix. There is no agreement on the best surgical approach for its management. Recently, laparoscopic approach is being increasingly tried. Careful excision of the tumor is mandatory to avoid content spillage into peritoneum resulting in pseudomyxoma peritonei.

Novel Single-Needle Approach for Retrocrural Celiac Plexus Blockade Using Fluoroscopic Guidance: A Case Report.

Celiac plexus neurolysis has been shown to be an effective analgesic option for patients with visceral pain related to intraabdominal malignancies. In the setting of significant tumor burden, the celiac plexus may be inaccessible, limiting the efficacy of the transcrural approach. This case report describes a novel single-needle approach to retrocrural celiac plexus blockade, allowing for rapid blockade with a needle trajectory contralateral to the aorta in a 73-year-old woman with altered anatomy secondary...

Influence of Extraoral Apicoectomy on Revascularization of an Autotransplanted Tooth: A Case Report.

Autotransplantation is considered a standard procedure with a poorer prognosis for mature than for immature teeth. In this case report, the root tip of an almost fully developed tooth was resected during autotransplantation to fit into a deficient recipient site. As a positive side effect, the apical foramen was enlarged, with potential improvement of the probability of revascularization. Clinical and radiologic follow-up examinations up to 18 months indicated revascularization and uneventful periodontal r...

Decision rule approach applied to estimate occupational lead exposure in a case-control study of kidney cancer.

We developed a systematic, data-driven approach to estimate metrics of occupational exposure to lead to aid in epidemiologic analyses in a case-control study of kidney cancer.

Design of Experiments in metabolomics-related studies: An overview.

Nowadays, Design of Experiments (DoE) approach is a very popular methodology of planning and conducting experiments, where the effect of each tested factor on the studied responses is systematically examined and documented. The results obtained in such manner represent the design space more precisely than in the case of One-Variable-At-Time (OVAT) approach, leading to reliable and comprehensive results, while saving time and resources. Despite such a large increase of interest in this approach recently, its...

Olfactory groove and tuberculum sellae meningioma resection by endoscopic endonasal approach versus transcranial approach: A systematic review and meta-analysis of comparative studies.

Intracranial meningiomas such as olfactory groove meningioma (OGM) and tuberculum sellae meningioma (TSM) arising at the anterior skull base are amenable to surgical resection. Traditionally, this has been achieved by transcranial approaches (TCAs), however, there has been an evolution in an endoscopic endonasal approach (EEA) within recent years. The aim of this systematic review and meta-analysis was to determine if the EEA was superior to the TCA in managing these anterior skull base meningioma based on ...

Case report: Disseminated pulmonary mucormycosis involving spleen in diabetic patient with aggressive surgical approach.

Mucormycosis is a life threatening fungal infection that occurs in immunocompromised patients.

Estimating SNP-Based Heritability and Genetic Correlation in Case-Control Studies Directly and with Summary Statistics.

Methods that estimate SNP-based heritability and genetic correlations from genome-wide association studies have proven to be powerful tools for investigating the genetic architecture of common diseases and exposing unexpected relationships between disorders. Many relevant studies employ a case-control design, yet most methods are primarily geared toward analyzing quantitative traits. Here we investigate the validity of three common methods for estimating SNP-based heritability and genetic correlation betwee...

Dose-Finding Studies Among Orphan Drugs Approved in the EU: A Retrospective Analysis.

In the development process for new drugs, dose-finding studies are of major importance. Absence of these studies may lead to failed phase 3 trials and delayed marketing authorization. In our study we investigated to what extent dose-finding studies are performed in the case of orphan drugs for metabolic and oncologic indications. We identified all orphan drugs that were authorized until August 1, 2017. European Public Assessment Reports were used to extract the final dose used in the summary of product char...

Airway Management of Near-Complete Tracheal Transection by Through-the-Wound Intubation: A Case Report.

We present an approach to airway management in a patient with machete injuries culminating in near-complete cricotracheal transection, in addition to a gunshot wound to the neck. Initial airway was established by direct intubation through the cricotracheal wound. Once the airway was secured, a bronchoscopy-guided orotracheal intubation was performed with simultaneous retraction of the cricotracheal airway to optimize the surgical field. This case offers insight into a rarely performed approach to airway man...

Distributed Optimization for Multiagent Systems: An Edge-Based Fixed-Time Consensus Approach.

This paper deals with the problem of distributed optimization for multiagent systems by using an edge-based fixed-time consensus approach. In the case of time-invariant cost functions, a new distributed protocol is proposed to achieve the state agreement in a fixed time while the sum of local convex functions known to individual agents is minimized. In the case of time-varying cost functions, based on the new distributed protocol in the case of time-invariant cost functions, a distributed protocol is provid...

Benign tumours and tumour like lesions of bone.

Over the last century, there has been a remarkable development in the study of benign bone tumours. This is primarily due to the improved knowledge of the nature of these lesions and improved imaging technology. They present as a diverse group of clinical and pathological entities, which vary in their clinical behaviour and aggressiveness and, hence, multidisciplinary approach is necessary in their management. Combined opinion from an orthopaedic surgeon, radiologist and a pathologist is therefore required....

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