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PubMed Journals Articles About "FDAnews Announces Five Case Studies Using E2500 Approach" RSS

07:50 EDT 16th October 2018 | BioPortfolio

FDAnews Announces Five Case Studies Using E2500 Approach PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest FDAnews Announces Five Case Studies Using E2500 Approach articles that have been published worldwide.

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Showing "FDAnews Announces Five Case Studies Using E2500 Approach" PubMed Articles 1–25 of 43,000+

Multiple imputation of missing data in nested case-control and case-cohort studies.

The nested case-control and case-cohort designs are two main approaches for carrying out a substudy within a prospective cohort. This article adapts multiple imputation (MI) methods for handling missing covariates in full-cohort studies for nested case-control and case-cohort studies. We consider data missing by design and data missing by chance. MI analyses that make use of full-cohort data and MI analyses based on substudy data only are described, alongside an intermediate approach in which the imputation...


VA Announces Plan to Improve Worst-Performing Medical Centers.

Therapeutic gardening: A counseling approach for bereavement from suicide.

This article focuses on an innovative approach to treating people bereaved by the suicide of a loved one. Nature is powerful and restorative, and some research already supports the therapeutic use of nature to address grief. We outline a therapeutic gardening approach to use with survivors of suicide loss and present a case study. This approach can be used by counselors who work individually with people bereaved by suicide as a way of assisting and supporting them through their grief. Though we suggest that...


Utilization of injury care case studies: a systematic review of the World Health Organization's "Strengthening care for the injured: Success stories and lessons learned from around the world".

Translation of evidence to practice is a public health priority. Worldwide, injury is a leading cause of morbidity and mortality. Case study publications are common and provide potentially reproducible examples of successful interventions in healthcare from the patient to systems level. However, data on how well case study publications are utilized are limited. To our knowledge, the World Health Organization (WHO) published the only collection of international case studies on injury care at the policy level...

Modeling spatial distribution of population for environmental epidemiological studies: Comparing the exposure estimates using choropleth versus dasymetric mapping.

Precise population information is critical for identifying more accurate environmental exposures for air pollution impacts analysis. Basically, there are two methods for estimating spatial distribution of population, choropleth and dasymetric mapping. While the choropleth approach accounts for linear distribution of population over area based on census tract units, the dasymetric model accounts for a more heterogeneous population density by quantifying the association between the area-class map data categor...

Advantage of laparoscopic resection for pelvic Schwannoma: Case report and review of the literature.

Single pelvic schwannomas are rare tumor arising from the retrorectal, lateral or obturatory space. Laparoscopic approach to schwannoma located in lateral pelvic space has been previously described only in one case report. We present a case of a successful laparoscopic resection of pelvic schwannoma emphasizing the advantages of such a minimal invasive approach.

Case Studies in Exercise and Sport Sciences: A Powerful Tool to Bridge the Science-Practice Gap.

Despite the progress made by the scientific exercise community in collaborating and communicating with non-scientist coaches, there is room for improvement. Coaches find research difficult to understand, feel that their interests are not being addressed by exercise research, and rely on peer-discussion to further their coaching knowledge base while consuming little peer-reviewed articles. One useful strategy to bridge the science-practice gap is with case-studies. In addition to furthering our understanding...

Transoral endoscopic thyroidectomy vestibular approach (TOETVA): A case report as new technique in thyroid surgery in Vietnam.

Transoral endoscopic thyroidectomy via vestibular approach (TOETVA) is a promising procedure with many advantages such as truly scar free healing, minimally invasive dissection, and accessible approach to both thyroid lobes.

Correcting for batch effects in case-control microbiome studies.

High-throughput data generation platforms, like mass-spectrometry, microarrays, and second-generation sequencing are susceptible to batch effects due to run-to-run variation in reagents, equipment, protocols, or personnel. Currently, batch correction methods are not commonly applied to microbiome sequencing datasets. In this paper, we compare different batch-correction methods applied to microbiome case-control studies. We introduce a model-free normalization procedure where features (i.e. bacterial taxa) i...

Application of ensemble deep neural network to metabolomics studies.

Deep neural network (DNN) is a useful machine learning approach, although its applicability to metabolomics studies has rarely been explored. Here we describe the development of an ensemble DNN (EDNN) algorithm and its applicability to metabolomics studies. As a model case, the developed EDNN approach was applied to metabolomics data of various fish species collected from Japan coastal and estuarine environments for evaluation of a regression performance compared with conventional DNN, random forest, and su...

Surgical approach to a mycotic aneurysm of the pulmonary artery presenting with hemoptysis - A case report and a review of the literature.

Mycotic aneurysms of the pulmonary arteries are very rare and have high mortality. Risk groups are intravenous drug users and patients with congenital heart disorders. The surgical approach varies due to a limited number of reported cases.

Epidural approach to paravertebral thoracic sympathetic block as an alternative to stellate ganglion block: A case report.

Evidence from cadaveric studies note that the sympathetic nerves from the second and third thoracic ganglia bypass the stellate ganglion in 20% of the population. We present a novel alternative technique for sympathetic blockade of upper extremity via thoracic epidural approach.

Infraposition of Implant-Retained Maxillary Incisor Crown Placed in an Adult Patient: Case Report.

Several studies have clearly shown that osseointegrated implants, when inserted in growing bone, such as in adolescents, do not follow the eruptive path of adjacent teeth; instead, they act like ankylosed teeth, remaining in a stationary position for the lifetime, thus developing a progressive infraposition of the implant-supported crown. However, further studies have demonstrated that similar changes also occur in adult patients, although mostly in a small amount and over long time spans. Here the case of ...

John Charnley Award: Randomized Clinical Trial of Direct Anterior and Miniposterior Approach THA: Which Provides Better Functional Recovery?

The choice of surgical approach for THA remains controversial. Some studies suggest that the direct anterior approach (DAA) leads to less muscle damage than the miniposterior approach (MPA), but there is little high-quality evidence indicating whether this accelerates recovery, or whether this approach-which may be technically more demanding-is associated with component malposition or more complications.

Assessing Gaussian Process Regression and Permutationally Invariant Polynomial Approaches to Represent High-Dimensional Potential Energy Surfaces.

The mathematical representation of large data sets of electronic energies has seen substantial progress in the past ten or so years. The so-called Permutationally Invariant Polynomial (PIP) representation is one established approach. This approach dates from 2003, when a global potential energy surface (PES) for CH + 5 was reported using a basis of polynomials that are invariant with respect to the 120 permutations of the ve equivalent H atoms. More recently, several approaches from \machine learning" have ...

Novel Single-Needle Approach for Retrocrural Celiac Plexus Blockade Using Fluoroscopic Guidance: A Case Report.

Celiac plexus neurolysis has been shown to be an effective analgesic option for patients with visceral pain related to intraabdominal malignancies. In the setting of significant tumor burden, the celiac plexus may be inaccessible, limiting the efficacy of the transcrural approach. This case report describes a novel single-needle approach to retrocrural celiac plexus blockade, allowing for rapid blockade with a needle trajectory contralateral to the aorta in a 73-year-old woman with altered anatomy secondary...

Influence of Extraoral Apicoectomy on Revascularization of an Autotransplanted Tooth: A Case Report.

Autotransplantation is considered a standard procedure with a poorer prognosis for mature than for immature teeth. In this case report, the root tip of an almost fully developed tooth was resected during autotransplantation to fit into a deficient recipient site. As a positive side effect, the apical foramen was enlarged, with potential improvement of the probability of revascularization. Clinical and radiologic follow-up examinations up to 18 months indicated revascularization and uneventful periodontal r...

Decision rule approach applied to estimate occupational lead exposure in a case-control study of kidney cancer.

We developed a systematic, data-driven approach to estimate metrics of occupational exposure to lead to aid in epidemiologic analyses in a case-control study of kidney cancer.

Olfactory groove and tuberculum sellae meningioma resection by endoscopic endonasal approach versus transcranial approach: A systematic review and meta-analysis of comparative studies.

Intracranial meningiomas such as olfactory groove meningioma (OGM) and tuberculum sellae meningioma (TSM) arising at the anterior skull base are amenable to surgical resection. Traditionally, this has been achieved by transcranial approaches (TCAs), however, there has been an evolution in an endoscopic endonasal approach (EEA) within recent years. The aim of this systematic review and meta-analysis was to determine if the EEA was superior to the TCA in managing these anterior skull base meningioma based on ...

Estimating SNP-Based Heritability and Genetic Correlation in Case-Control Studies Directly and with Summary Statistics.

Methods that estimate SNP-based heritability and genetic correlations from genome-wide association studies have proven to be powerful tools for investigating the genetic architecture of common diseases and exposing unexpected relationships between disorders. Many relevant studies employ a case-control design, yet most methods are primarily geared toward analyzing quantitative traits. Here we investigate the validity of three common methods for estimating SNP-based heritability and genetic correlation betwee...

Dose-Finding Studies Among Orphan Drugs Approved in the EU: A Retrospective Analysis.

In the development process for new drugs, dose-finding studies are of major importance. Absence of these studies may lead to failed phase 3 trials and delayed marketing authorization. In our study we investigated to what extent dose-finding studies are performed in the case of orphan drugs for metabolic and oncologic indications. We identified all orphan drugs that were authorized until August 1, 2017. European Public Assessment Reports were used to extract the final dose used in the summary of product char...

Distributed Optimization for Multiagent Systems: An Edge-Based Fixed-Time Consensus Approach.

This paper deals with the problem of distributed optimization for multiagent systems by using an edge-based fixed-time consensus approach. In the case of time-invariant cost functions, a new distributed protocol is proposed to achieve the state agreement in a fixed time while the sum of local convex functions known to individual agents is minimized. In the case of time-varying cost functions, based on the new distributed protocol in the case of time-invariant cost functions, a distributed protocol is provid...

Airway Management of Near-Complete Tracheal Transection by Through-the-Wound Intubation: A Case Report.

We present an approach to airway management in a patient with machete injuries culminating in near-complete cricotracheal transection, in addition to a gunshot wound to the neck. Initial airway was established by direct intubation through the cricotracheal wound. Once the airway was secured, a bronchoscopy-guided orotracheal intubation was performed with simultaneous retraction of the cricotracheal airway to optimize the surgical field. This case offers insight into a rarely performed approach to airway man...

Benign tumours and tumour like lesions of bone.

Over the last century, there has been a remarkable development in the study of benign bone tumours. This is primarily due to the improved knowledge of the nature of these lesions and improved imaging technology. They present as a diverse group of clinical and pathological entities, which vary in their clinical behaviour and aggressiveness and, hence, multidisciplinary approach is necessary in their management. Combined opinion from an orthopaedic surgeon, radiologist and a pathologist is therefore required....

Leadership Presence: A "Must" Skill for Impactful Case Manager-Client Relationship.

Successful case manager-client relationships are those that demonstrate a humanistic, personal, empathetic, and empowering approach to health care provision. This editorial discusses leadership presence as an essential skill for professional case management practice and the impact of such relationships on the client/support system experience of care. It also presents a framework for building impactful and therapeutic relationships. In addition, it offers a list of key strategies that contribute to the succe...


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