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PubMed Journals Articles About "Feed Mycotoxin Binders Modifiers Market Type Binders Modifiers" RSS

09:58 EDT 23rd September 2018 | BioPortfolio

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Showing "Feed Mycotoxin Binders Modifiers Market Type Binders Modifiers" PubMed Articles 1–25 of 14,000+

In vitro Model to assess the Adsorption of Oral Veterinary Drugs to Mycotoxin Binders in a Feed- and Aflatoxin B1-containing Buffered Matrix.

Mycotoxin binders are feed additives which are mixed in the feed to adsorb mycotoxins and thereby reducing their toxic effects on animals. Interactions with orally administered veterinary medicinal products, such as antimicrobials or coccidiostats, have been reported previously. This paper describes an in vitro model to screen the interaction between mycotoxin binders and veterinary drugs with respect to the non-specific binding of drugs. It is designed as a static setup using a single concentration of drug...


Phosphorus binders: The new and the old, and how to choose.

In caring for patients with chronic kidney disease, it is important to prevent and treat hyperphosphatemia with a combination of dietary restrictions and phosphorus binders. This review describes the pathophysiology and control of hyperphosphatemia and the different classes of phosphorus binders with respect to their availability, cost, side effects, and scenarios in which one class of binder may be more beneficial than another.

Epigenetic modifiers: activities in renal cell carcinoma.

Renal cell carcinomas (RCCs) are a diverse set of malignancies that have recently been shown to harbour mutations in a number of chromatin modifier genes - including PBRM1, SETD2, BAP1, KDM5C, KDM6A, and MLL2 - through high-throughput sequencing efforts. Current research focuses on understanding the biological activities that chromatin modifiers employ to suppress tumorigenesis and on developing clinical approaches that take advantage of this knowledge. Unsurprisingly, several common themes unify the functi...


Predicting efficiency of NECEEM-based partitioning of protein binders from nonbinders in DNA-encoded libraries.

Nonequilibrium capillary electrophoresis of equilibrium mixtures (NECEEM) is an affinity method for separating binder-target complexes from nonbinders by gel-free CE. NECEEM is a promising high-efficiency method for partitioning protein binders from nonbinders in DNA-encoded libraries (DEL), such binders are used as "hits" in drug development. It is important to be able to predict the efficiency of NECEEM-based partitioning, which is the efficiency of collecting binders while removing nonbinders for a speci...

A comparative study on high selectivities of human telomeric dimeric G-quadruplexes by dimeric G-quadruplex binders.

Three new polyether-tethered bisquinolinium dimers (3a~c) were synthesized and studied their binding affinities, selectivities and thermal stabilization towards dimeric G-quadruplex DNA (G2T1) in human telomeric regions. Bisquinolinium dimer with the medium polyether linker (3b) showed 30~425-fold higher binding affinity and selectivity towards antiparallel G2T1 over monomeric quadruplexes including human monomeric G-quadruplexes (G1), c-kit 1, c-kit 2 and c-myc, respectively. And compound 3b induced the fo...

The Effects of Fillers and Binders on the Accuracy of Tablet Subdivision.

The effects of excipients on the accuracy of tablet subdivision are severely underinvestigated. In this study, placebo tablets were prepared using a combined mixture design of fillers and binders to evaluate the effect of these excipients on subdivision accuracy. The responses assessed were mass loss, mass variation, tablet fragmentation, and increased friability. Dicalcium phosphate dihydrate (DCP) gave rise to more uniform and denser tablets than microcrystalline cellulose (MCC), thus resulting in greater...

A review of the mycotoxin adsorbing agents, with an emphasis on their multi-binding capacity, for animal feed decontamination.

Contamination of animal feed with mycotoxins still occurs very often, despite great efforts in preventing it. Animal feeds are contaminated, at low levels, with several mycotoxins, particularly with those produced by Aspergillus and Fusarium genera (Aflatoxin BOchratoxin A, Zearalenone, Deoxynivalenol and Fumonisina B). In animal feed, to date, only Aflatoxin Bis limited through EU regulation. Consequently, mycotoxins cause serious disorders and diseases in farm animals. In 2009, the European Union (386/200...

Use of hydraulic binders for reducing sulphate leaching: application to gypsiferous soil sampled in Ile-de-France region (France).

Polluted soils are a serious environmental risk worldwide and consist of millions of tons of mineral waste to be treated. In order to ensure their sustainable management, various remediation options must be considered. Hydraulic binder treatment is one option that may allow a stabilisation of pollution and thus offer a valorisation as secondary raw materials rather than considering them as waste. In this study, we focused on sulphate-polluted soil and tested the effectiveness of several experimental hydraul...

Exploring genetic modifiers of Gaucher disease: The next horizon.

Gaucher disease is an autosomal recessive lysosomal storage disorder resulting from mutations in the gene GBA1 that lead to a deficiency in the enzyme glucocerebrosidase. Accumulation of the enzyme's substrates, glucosylceramide and glucosylsphingosine, result in symptoms ranging from skeletal and visceral involvement to neurological manifestations. Nonetheless, there is significant variability in clinical presentations amongst patients, with limited correlation between genotype and phenotype. Contributing ...

Inherited or acquired modifiers of iron status may dramatically affect the phenotype in dehydrated hereditary stomatocytosis.

Severe iron overload is frequent in dehydrated hereditary stomatocytosis (DHSt) despite well compensated hemolysis and no or little transfusion requirement. We investigated 4 patients with proven DHSt, in whom the degree of hemolysis was closely related with iron status. Genetic modifiers increasing iron stores (HFE:pCys282Tyr, HAMP:c-153C>T mutations) were accompanied with high liver iron concentrations and increased hemolysis whereas therapeutic phlebotomies alleviated the hemolytic phenotype. There were ...

Comparative in silico profiling of epigenetic modifiers in human tissues.

The technology of tissue differentiation from human pluripotent stem cells has attracted attention as a useful resource for regenerative medicine, disease modeling and drug development. Recent studies have suggested various key factors and specific culture methods to improve the successful tissue differentiation and efficient generation of human induced pluripotent stem cells. Among these methods, epigenetic regulation and epigenetic signatures are regarded as an important hurdle to overcome during reprogra...

Clinical variability and onset age modifiers in an extended Belgian GRN founder family.

We previously reported a granulin (GRN) null mutation, originating from a common founder, in multiple Belgian families with frontotemporal dementia. Here, we used data of a 10-year follow-up study to describe in detail the clinical heterogeneity observed in this extended founder pedigree. We identified 85 patients and 40 unaffected mutation carriers, belonging to 29 branches of the founder pedigree. Most patients (74.4%) were diagnosed with frontotemporal dementia, while others had a clinical diagnosis of u...

Impact of Different Binders on the Roughness, Adhesion Strength, and Other Properties of Mortars with Expanded Cork.

The aim of the research that is presented in this paper was to evaluate the physical and mechanical properties of heat-insulating mortars with expanded cork aggregates and different binders. In this work, the measurements of surface roughness and adhesion strength, supported by determination of basic mechanical and physical parameters, such as density, bulk density, open porosity, total porosity, absorbability, thermal conductivity coefficient, compressive strength, flexural strength, and frost resistance o...

Effectiveness of phosphate binders in adult patients with end stage renal disease receiving hemodialysis: a systematic review.

The objective of the review was to evaluate the effectiveness of the use of phosphate binders on mortality and serum levels of phosphorus, calcium and parathyroid hormone in adult patients with end stage renal disease receiving hemodialysis compared to hemodialysis with no phosphate binder use.

Surface probing by fragment-based screening and computational methods identifies ligandable pockets on the von Hippel-Lindau (VHL) E3 ubiquitin ligase.

Beyond the targeting of E3 ubiquitin ligases to inhibit protein homeostasis, E3 ligase binders can be converted into targeted protein degraders. We sought to identify new binders of the VHL E3 ligase by biophysical fragment-based screening followed by X-ray crystallographic soaking. We identified fragments binding at the ElonginC:Cullin2 interface and a new cryptic pocket in VHL, along with other potential ligandable sites predicted computationally. The elucidated interactions provide starting points for fu...

Rapid Selection of High-Affinity Antibody scFv Fragments Using Ribosome Display.

Ribosome display has proven to be a powerful in vitro selection and evolution method for generating high-affinity binders from libraries of folded proteins. It works entirely in vitro, and this has two important consequences. First, since no transformation of any cells is required, libraries with much greater diversity can be handled than with most other techniques. Second, since a library does not have to be cloned and transformed, it is very convenient to introduce random errors in the library by PCR-base...

Molecular Dynamics simulations of the Strings and Binders Switch Model of chromatin.

In recent years interest has grown on the applications of polymer physics to model chromatin folding in order to try to make sense of the complexity of experimental data emerging from new technologies such as Hi-C or GAM, in a principled way. Here we review the methods employed to efficiently implement Molecular Dynamics computer simulations of polymer models, focusing in particular on the String&Binders Switch (SBS) model. The constant improvement of such methods and computer power is returning increasingl...

In-situ Click Reaction Coupled with Quantitative Proteomics for Identifying Protein Targets of Catechol Estrogens.

Catechol estrogens (CEs) are metabolic electrophiles that actively undergo covalent interaction with cellular proteins, influencing molecular function. There is no feasible method to identify their binders in a living system. Herein, we developed a click chemistry-based approach using ethinylestradiol (EE2) as the precursor probe coupled with quantitative proteomics to identify protein targets of CEs and classify their binding strengths. Using in-situ metabolic conversion and click reaction in liver microso...

Physio-Microstructural Properties of Aerated Cement Slurry for Lightweight Structures.

Cementitious composites, including ferrocement and continuous fiber reinforced cement, are increasingly considered for building construction and repair. One alternative in processing of these composites is to infiltrate the reinforcement (continuous fibers or chicken mesh) with a flowable cementitious slurry. The relatively high density of cementitious binders, when compared with polymeric binders, are a setback in efforts to introduce cementitious composites as lower-cost, fire-resistant, and durable alter...

The role of kidney transplantation and phosphate binder use in vitamin K status.

Cardiovascular disease is the leading cause of death in end-stage renal disease and is strongly associated with vascular calcification. Both kidney transplantation and phosphate binders may lower the risk of vascular calcification. Vascular calcification is actively inhibited by vitamin-K-dependent matrix γ-carboxyglutamic acid protein (MGP). Whether kidney transplantation or phosphate binders affect vitamin K status is unknown. Therefore, we studied the influence of kidney transplantation and phosphate bi...

Selective Small Molecule Recognition of RNA Base Pairs.

Many types of RNAs exist in the human transcriptome, yet only the bacterial ribosome has been exploited as a small molecule drug target. Aside from ribosomal RNA, other cellular RNAs such as non-coding RNAs have primarily secondary structure and limited tertiary structure. Within these secondary structures of non-canonically paired and unpaired regions, more than 50% are base paired, with most efforts to target these structures focused on looped regions. A void exists in the availability of small molecules ...

Selected phytoestrogens distinguish roles of ERα transactivation and ligand binding for anti-inflammatory activity.

Estrogen Receptor α is a ligand-activated transcriptional activator that is also involved in multiple ways in the process of vascular inflammation and atherosclerosis. However, whether different ligands may impact this activity have not been explored. In this study, we screened a panel of phytoestrogens for their ability in ERα binding and transcriptional transcription and correlated it to anti-inflammatory activities in vascular endothelial cells stably expressing either a wild-type or a mutant form of E...

Effects of market type and time of purchase on oxidative status and descriptive off-odors and off-flavors of beef in Vietnam.

The objective of the current study was to determine the effects of market type (super market - SM, indoor market - IM, open market - OM) and sampling time (at the opening - T0 and 4 h after the opening - T4) on antioxidant capacity, lipid oxidation, and descriptive sensory attributes of beef in Vietnam. Values of FC and TEAC were greater in OM beef than IM and SM (P 

Micronutrient Status: Potential Modifiers-Drugs and Chronic Disease.

Thermodynamics of DNA minor groove binders.

Understanding the thermodynamic and binding characteristics of DNA minor groove binders (MGBs) is important for the rational design and development of novel MGBs; however, there are contradicting results in the literature regarding the thermodynamic signature of MGBs. The expansion of the thermodynamic database for MGBs in the literature was encouraging to evaluate and critically test the previously reported hypothesis that MGB binding is mainly entropically driven. In this review, the thermodynamic data of...


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