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PubMed Journals Articles About "Flexion Therapeutics FLXN Mike Clayman 2017 Results Earnings" RSS

08:36 EDT 19th September 2018 | BioPortfolio

Flexion Therapeutics FLXN Mike Clayman 2017 Results Earnings PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Flexion Therapeutics FLXN Mike Clayman 2017 Results Earnings articles that have been published worldwide.

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Showing "Flexion Therapeutics FLXN Mike Clayman 2017 Results Earnings" PubMed Articles 1–25 of 41,000+

Blowing up money? The earnings penalty of smoking in the 1970s and the 21st century.

We analyze the earnings penalty of smoking among Swedish twins in two social contexts: the 1970s, when smoking was common and widely accepted and when there were relatively few tobacco laws aiming to reduce smoking; and the 2000s, when smoking had become more expensive, stigmatizing and less common, and when tobacco laws and regulations had intensified. The results show that the short-term earnings penalty of smoking was much higher in the 21st century than in the 1970s for men. For women, smokers had on av...


Horizon Meeting on Cardiovascular Physiology:Dedicated to Dr. Mike Sharratt.

This perspective document summarizes discussions held at the CSEP Annual Meeting in Winnipeg on October 27, 2017 when an expert panel was assembled to discuss the key questions and challenges for future research in cardiovascular exercise physiology. We were inspired by the example of the late Dr. Mike Sharratt, an accomplished and impactful Professor in the Faculty of Kinesiology at the University of Waterloo. Dr. Sharratt had a unique ability to bring experts together and translate theory into action, wit...

Intentionally Increased Flexion Angle of the Femoral Component in Mobile Bearing Unicompartmental Knee Arthroplasty.

The purpose of this study was to determine the results of mobile bearing unicompartmental knee arthroplasty (UKA) with an intentionally increased flexion angle of the femoral component in patients requiring high flexion.


Posterior Condyle Offset and Maximum Knee Flexion Following a Cruciate Retaining Total Knee Arthroplasty.

Inconsistent data has been reported on the effect of the femoral posterior condyle offset (PCO) on the maximal knee flexion after total knee arthroplasty (TKA). This study investigated the relationship between the postoperative changes of the PCO and the changes of maximal knee flexion after a cruciate retaining (CR) TKA. Nine patients with medial osteoarthritis (OA) in one knee were investigated. Before operation, each index knee was magnetic resonance imaging (MRI) scanned for construction of a three-dime...

The Economic Foundations of Cohabiting Couples' Union Transitions.

In recent decades, cohabitation has become an increasingly important relationship context for U.S. adults and their children, a union status characterized by high levels of instability. To understand why some cohabiting couples marry but others separate, researchers have drawn on theories emphasizing the benefits of specialization, the persistence of the male breadwinner norm, low income as a source of stress and conflict, and rising economic standards associated with marriage (the marriage bar). Because of...

For richer, for poorer: the relationship between adolescent obesity and future household economic prosperity.

Adolescent obesity not only has serious long-term health implications, but also the potential to lead to a socioeconomic trajectory of lower earnings and household income. However, the magnitude and mechanisms of such outcomes across the life course are poorly understood. Using birth cohort data from the British National Child Development Study (1958 to 2008), we examined the relationship between adolescent obesity (at age 16) and future household income, employment, wages, marriage and spousal earnings whe...

Anterior distal femoral hemiepiphysiodesis can reduce fixed flexion deformity of the knee: a retrospective study of 83 knees.

Background and purpose - Fixed knee flexion deformity in children is a common problem in various diseases including myelomeningocele and cerebral palsy. Until now, only a few studies focusing on the surgical procedure of anterior distal femoral hemiepiphysiodesis have been published. We analyzed outcome and correction rate in the largest case series to date of patients treated by staples or 8-plates. Patients and methods - We reviewed the medical records of all patients with fixed knee flexion deformity who...

Dose-Dependent Lowering of Mutant Huntingtin Using Antisense Oligonucleotides in Huntington Disease Patients.

On December 11 of 2017, Ionis Pharmaceuticals published a press release announcing dose-dependent reductions of mutant huntingtin protein in their HTTRx Phase 1/2a study in Huntington disease (HD) patients. The results from this Ionis trial have gained much attention from the patient community and the oligonucleotide therapeutics field, since it is the first trial targeting the cause of HD, namely the mutant huntingtin protein, using antisense oligonucleotides (ASOs). The press release also states that the ...

An Investigation of the Probability of Reciprocation in a Risk Reduction Model of Sharing.

A laboratory study investigated whether reductions in the probability of reciprocation would influence sharing in situations of shortfall risk. Choice in twelve adults was evaluated against the predictions of a risk-reduction model of sharing derived from a risk-sensitive foraging theory (the energy-budget rule). Participants responded on a computer task to earn hypothetical money which could be later exchanged for real money. If participants selected the sharing option, their earnings were pooled and split...

Tribute to my mentor, Mike Bedford.

Variability of plyometric and ballistic exercise technique maintains jump performance.

The aim of this study was to investigate changes in vertical jump technique over the course of a training session. Twelve plyometric and ballistic exercise trained male athletes (age = 23.4 ± 4.6 years, body mass = 78.7 ± 18.8 kg, height = 177.1 ± 9.0 cm) performed three sets of 10 repetitions of drop (DJ), rebound (RJ) and squat jumps (SJ). Each exercise was analysed from touch down to peak joint flexion and peak joint flexion to take-off. SJ where analysed from peak joint flexion to take-off only. Jump...

Farewell to Our Good Friend, Outstanding Mentor, and Colleague Darrell R. Abernethy (1949-2017).

Kinetic and kinematic variables affecting trunk flexion during level walking in patients with lumbar spinal stenosis.

Lumbar spinal stenosis causes cauda equina and nerve root compression, resulting in neurological symptoms. Although trunk flexion during level walking may alleviate these symptoms by enabling spinal canal decompression, some patients do not use this strategy. We aimed to identify the kinetic and kinematic variables that affect trunk flexion in patients during level walking. Gait was recorded in 111 patients using a three-dimensional motion capture system and six force plates. From the data recorded, walking...

Kinetic change of spinal cord compression on flexion-extension magnetic resonance imaging in cervical spine.

We aimed to determine the changes in cervical canal diameters and spinal cord compression at each level from C2-3 to C7-T1 in flexion and extension positions and to study the use of flexion-extension magnetic resonance imaging (MRI). We also aimed to assess the changes in the length of the spinal cord in flexion and extension positions of the cervical spine.

12th World Congress on Neurohypophysial Hormones Mangaratiba, Rio de Janeiro, Brazil - July 26th-29th, 2017.

This Special Issue of Journal of Neuroendocrinology comprises six reviews and eight original research articles describing recent advances in the field of Vasopressin and Oxytocin hormone research based on presentations given at the 12th World Congress on Neurohypophysial Hormones held in July 2017, in Brazil. We, the Chair of the Local Organising Committee and Guest Editor (Maria José A. Rocha) and Guest/Senior Editors for this issue (Celia Sladek and Mike Ludwig), would like to thank the contributors for ...

Effect of Combined Flexion and External Rotation on Measurements of the Proximal Femur from Anteroposterior Pelvic Radiographs.

Fixed flexion and external rotation contractures are common in patients with hip osteoarthritis and in particular before total hip replacement (THR). We aimed to answer the following question: how does combined flexion and external rotation of the femur influence the radiographic assessment of 1) femoral offset (FO) 2) neck-shaft angle (NSA) and 3) distance (parallel to the femoral axis) from greater trochanter to femoral head centre (GT-FHC)?

Predictors of dysfunction and health-related quality of life in the flexion pattern subgroup of patients with chronic lower back pain: The STROBE study.

Findings about predictors of chronic lower-back pain (CLBP) were inconsistent and inconclusive in previous studies because patients with CLBP are heterogeneous. Subgrouping patients with CLBP, according to a CLBP classification system, might thus clarify the research findings. CLBP in the direction of lumbar flexion movement, that is, the flexion pattern, is common in clinical situations. Therefore, the purpose of this study was to determine the predictors of dysfunction (pain, disability) and health-relate...

Kinematic and kinetic analysis of the goalkeeper's diving save in football.

Kinetics and full body kinematics were measured in ten elite goalkeepers diving to save high and low balls at both sides of the goal, aiming to investigate their starting position, linear and angular momentum, and legs' contribution to end-performance. Our results showed that goalkeepers adopted a starting position with a stance width of 33 ± 1% of leg length, knee flexion angle of 62 ± 18° and hip flexion angle of 63 ± 18°. The contralateral leg contributed more than the ipsilateral leg to COM v...

Can cultural consumption increase future earnings? Exploring the economic returns to cultural capital.

Cultural consumption is often viewed as a form of embodied cultural capital which can be converted into economic rewards (e.g., earnings) because such practices increase the likelihood of moving into more advantaged social positions. However, quantitative evidence supporting this theory remains uncertain because it is often unable to rule out alternative explanations. Cultural consumption appears to influence hiring decisions in some elite firms, in both the US and the UK, but it is unclear whether these pr...

Disturbance of neck proprioception and feed-forward motor control following static neck flexion in healthy young adults.

The highly complex proprioceptive system provides neuromuscular control of the mobile cervical spine. Static neck flexion can induce the elongation of posterior tissues and altered afferent input from the mechanoreceptors. The purpose of this study was to examine the effect of prolonged static neck flexion on neck proprioception and anticipatory postural adjustments. Thirty-eight healthy participants (20 females and 18 males) between the ages of 20-35 years with no history of neck, low back, and shoulder ...

Inter-rater reliability of Dartfishmovement analysis software for measuring maximum flexion and extension at the hip and knee in older adults with osteoporosis and osteopenia.

Various methods are used to measure hip and knee joint motion angles; however, their use is often limited by cost or inability to measure dynamic movements. The assessment of movement patterns is clinically useful in individuals with osteoporosis (OP) and osteopenia (OPe) through its potential to optimize fracture risk assessment. This study evaluates the inter-rater reliability of using Dartfish2-D Motion Analysis Software to measure maximum flexion and extension angles at the hip and knee in individuals w...

Tactile cues can change movement: An example using tape to redistribute flexion from the lumbar spine to the hips and knees during lifting.

Given the appropriate cues, kinematic factors associated with low back injury risk and pain, such as spine flexion, can be avoided. Recent research has demonstrated the potential for tactile sensory information to change movement. In this study an athletic strapping tape was applied bilaterally along the lumbar extensor muscles to provide continuous tactile feedback information during a repeated lifting and lowering task. The presence of the tape resulted in a statistically significant reduction in lumbar s...

Can Women Have Children and a Career? IV Evidence from IVF Treatments.

This paper introduces a new IV strategy based on IVF (in vitro fertilization) induced fertility variation among childless women to estimate the causal effect of having children on their career. For this purpose, we use administrative data on IVF treated women in Denmark. Because observed chances of IVF success do not depend on labor market histories, IVF treatment success provides a plausible instrument for childbearing. Our IV estimates indicate that fertility effects on earnings are: (i) negative, large, ...

Progressive recruitment of contralesional cortico-reticulospinal pathways drives motor impairment post stroke.

Activation of the shoulder abductor muscles in the arm opposite a unilateral brain injury causes involuntary increases in elbow, wrist and finger flexion in the same arm, a phenomenon referred to as the flexion synergy. It has been proposed that flexion synergy expression is related to reduced output from ipsilesional motor cortex and corticospinal pathways. In this human subjects study, we provide evidence that the magnitude of flexion synergy expression is instead related to a progressive, task-dependent ...

Influence of Elbow Flexion and Stimulation Site on Neuromuscular Electrical Stimulation of the Biceps Brachii.

Functional electrical stimulation (FES) can help individuals with physical disabilities by assisting limb movement; however, the change in muscle geometry associated with limb movement may affect the response to stimulation. The aim of this paper was to quantify the effects of elbow flexion and stimulation site on muscle torque production. Contraction torque about the elbow was measured in 12 healthy individuals using a custom elbow flexion testbed and a transcutaneous electrode array. Stimulation was deliv...


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