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PubMed Journals Articles About "Gene Taxi With Turbo Drive" RSS

13:08 EST 14th November 2018 | BioPortfolio

Gene Taxi With Turbo Drive PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Gene Taxi With Turbo Drive articles that have been published worldwide.

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Showing "Gene taxi with turbo drive" PubMed Articles 1–25 of 13,000+

Path optimization of taxi carpooling.

The problem that passengers are hard to take taxis while empty driving rate is high widely exists under the traditional taxi operation mode. The implementation of taxi carpooling mode can alleviate the problem in a certain extent. The objective of this study is to optimize the taxi carpooling path. Firstly, the taxi carpooling path optimization model with single objective and its extended model with multiple objectives are built respectively. Then, the single objective path optimization model of taxi carpoo...


The influence of bus and taxi drivers' public self-consciousness and social anxiety on aberrant driving behaviors.

The study examined how bus and taxi drivers' public self-consciousness interacted with social anxiety to influence their aberrant driving behaviors. Questionnaires were distributed to 331 male and female Taiwanese bus and taxi drivers whose working environment involves frequent and direct interaction with passengers. Questionnaire statements measured drivers' dispositional public self-consciousness and social anxiety, and their intentions and driving behaviors related to speeding, errors and violations. The...

The Little-known Freshwater Metopid Ciliate, Idiometopus turbo (Dragesco and Dragesco-Kernéis, 1986) nov. gen., nov. comb., Originally Discovered in Africa, Found on the Micronesian Island of Guam.

Class Armophorea Lynn, 2004 includes two orders of mainly free-living anaerobic ciliates, Armophorida Jankowski, 1980 and Metopida Jankowski, 1980 and, a third, the exclusively endosymbiotic Clevelandellida. Kahl described the majority of free-living metopid species early in the 20th century. Excepting Jankowski in the 1960's, little further interest was shown in this group. Metopus turbo Dragesco and Dragesco-Kernéis, 1986, from a West African pond, was more recently described. Although not explicitly des...


Considerations for the governance of gene drive organisms.

Governance is a broader and more flexible concept than statute-driven regulations as it incorporates components outside the latter's remit. Considerations of governance are critical in the development of emerging biotechnologies such as gene drive organisms. These have been proposed or are being developed to address public and environmental health issues not addressed easily by conventional means. Here, we consider how the concept of governance differs from statute-driven regulation with reference to the ro...

Understanding the unbalance of interest in taxi market based on drivers' service profit margins.

Nowadays, ride-hailing services have been established as a part of the urban transportation. Their arrival has remade the profit structure and resulted in the unbalance of interest in taxi market. Here, we establish the service models of taxis, carpooling, and car-hailing under "Internet +" from the perspective of profit margins, to perform a comparative analysis among the different services.

Pest demography critically determines the viability of synthetic gene drives for population control.

Synthetic gene drives offer a novel solution for the control of invasive alien species. CRISPR-based gene drives can positively bias their own inheritance, and comprise a DNA sequence that is replicated by homologous recombination. Since gene drives can be positioned to silence fertility or developmental genes, they could be used for population suppression. However, the production of resistant alleles following self-replication errors threatens the technology's viability for pest eradication in real-world a...

CAR-T in the clinic: drive with care.

Artifact-robust diffusion-weighted whole-body imaging with background suppression at 3 T using improved turbo spin-echo diffusion-weighted imaging.

To compare single-shot turbo spin-echo (TSE) diffusion-weighted whole-body imaging with background suppression (DWIBS) and echo-planar imaging (EPI) DWIBS to determine the feasibility of direct-coronal TSE-DWIBS.

Understanding the effects of trip patterns on spatially aggregated crashes with large-scale taxi GPS data.

The primary objective of this study was to investigate how trip pattern variables extracted from large-scale taxi GPS data contribute to the spatially aggregated crashes in urban areas. The following five types of data were collected: crash data, large-scale taxi GPS data, road network attributes, land use features and social-demographic data. A data-driven modeling approach based on Latent Dirichlet Allocation (LDA) was proposed for discovering hidden trip patterns from a taxi GPS dataset, and a total of f...

Ecological effects on underdominance threshold drives for vector control.

Underdominance gene drives are frequency-dependent drives that aim to spread a desired homozygote genotype within a population. When the desired homozygote is released above a threshold frequency, heterozygote fitness disadvantage acts to drive the desired trait to fixation. Underdominance drives have been proposed as a way to control vector-borne disease through population suppression and replacement in a spatially contained and reversible way-benefits that directly address potential safety concerns with g...

An empirical investigation of taxi driver response behavior to ride-hailing requests: A spatio-temporal perspective.

Using data provided by a ride-hailing platform, this paper examines the factors that affect taxi driver response behavior to ride-hailing requests. The empirical investigation from a driver's perspective is of great importance for ride-hailing service providers, given that approximately 40% of the hailing requests receive no response from any driver. To comprehensively understand taxi driver response behavior, we use a rich dataset to generate variables related to the spatio-temporal supply-demand intensiti...

SRSF2 mutations drive oncogenesis by activating a global program of aberrant alternative splicing in hematopoietic cells.

Recurrent mutations in the splicing factor SRSF2 are associated with poor clinical outcomes in myelodysplastic syndromes (MDS). Their high frequency suggests these mutations drive oncogenesis, yet the molecular explanation for this process is unclear. SRSF2 mutations could directly affect pre-mRNA splicing of a vital gene product; alternatively, a whole network of gene products could be affected. Here we determine how SRSF2 mutations globally affect RNA binding and splicing in vivo using HITS-CLIP. Remarkab...

Intrinsic Stabilization of the Drive Beam in Plasma-Wakefield Accelerators.

The hose instability of the drive beam constitutes a major challenge for the stable operation of plasma-wakefield accelerators. In this Letter, we show that drive beams with a transverse size comparable to the plasma blowout radius generate a wake with a varying focusing along the beam, which leads to a rapid detuning of the slice-betatron oscillations and suppresses the instability. This intrinsic stabilization principle provides an applicable and effective method for the suppression of the hosing of the d...

Altered driving performance of symptomatic Huntington's disease gene carriers in simulated road conditions.

In clinical practice, patients with Huntington's disease (HD) often decide to solely drive in their own familiar neighborhoods and not on a motorway or in an unknown area. The aim of the study was to identify differences in driving performance between HD gene carriers and healthy individuals in simulated urban and motorway environments.

A novel tetracycline-responsive transgenic mouse strain for skeletal muscle-specific gene expression.

The tetracycline-responsive system (Tet-ON/OFF) has proven to be a valuable tool for manipulating gene expression in an inducible, temporal, and tissue-specific manner. The purpose of this study was to create and characterize a new transgenic mouse strain utilizing the human skeletal muscle α-actin (HSA) promoter to drive skeletal muscle-specific expression of the reverse tetracycline transactivator (rtTA) gene which we have designated as the HSA-rtTA mouse.

Design and implementation of a parent guide for coaching teen drivers.

Teens beginning to drive independently are at significant increased risk of motor-vehicle crashes relative to their other life stages. There is, however, little guidance for parents as to how best to supervise learning to drive.

Stage-Specific Transcription Factors Drive Astrogliogenesis by Remodeling Gene Regulatory Landscapes.

A broad molecular framework of how neural stem cells are specified toward astrocyte fate during brain development has proven elusive. Here we perform comprehensive and integrated transcriptomic and epigenomic analyses to delineate gene regulatory programs that drive the developmental trajectory from mouse embryonic stem cells to astrocytes. We report molecularly distinct phases of astrogliogenesis that exhibit stage- and lineage-specific transcriptomic and epigenetic signatures with unique primed and active...

Fenton Reactions Drive Nucleotide and ATP Syntheses in Cancer.

We present a computational study of tissue transcriptomic data of 14 cancer types to address: what may drive cancer cell division? Our analyses point to that persistent disruption of the intracellular pH by Fenton reactions may be at the root of cancer development. Specifically, we have statistically demonstrated that Fenton reactions take place in cancer cytosol and mitochondria across all the 14 cancer types, based on cancer tissue gene-expression data integrated via the Michaelis-Menten equation. In addi...

10-Min 3D Turbo Spin Echo MRI of the Knee in Children: Arthroscopy-Validated Accuracy for the Diagnosis of Internal Derangement.

Ten-minute MRI of the pediatric knee can add value through increased cost-effectiveness and decreased sedation needs but requires validation of its clinical efficacy.

Improving adenoviral vectors and strategies for prostate cancer gene therapy.

Gene therapy has been evaluated for the treatment of prostate cancer and includes the application of adenoviral vectors encoding a suicide gene or oncolytic adenoviruses that may be armed with a functional transgene. In parallel, versions of adenoviral vector expressing the p53 gene (Ad-p53) have been tested as treatments for head and neck squamous cell carcinoma and non-small cell lung cancer. Although Ad-p53 gene therapy has yielded some interesting results when applied to prostate cancer, it has not been...

Driving next-generation autophagy researchers towards translation (DRIVE), an international PhD training program on autophagy.

The European Autophagy consortium Driving next-generation autophagy researchers towards translation (DRIVE) held its kick-off meeting in Groningen on the 14 and 15 of June 2018. This Marie Skłodowska-Curie Early Training Network was approved under the European Union's Horizon 2020 Research and Innovation Program and is funded for 4 years. Within DRIVE, 14 European research teams from academia and industry will train 15 PhD students through applied, cross-disciplinary and collaborative macroautophagy/autoph...

Distributed Cognition in Aviation Operations: A gate-to-gate study with implications for distributed crewing.

The network analysis method, Event Analysis of Systemic Teamwork (EAST), was used to examine routine aviation operations from multiple perspectives form six key areas (i.e., Dispatch, ATC, ATM, Maintenance, Loading, and the Cockpit). Data was collected over a five-day observational field trial at an international air cargo operator. Researchers recorded the activities of agents operating within the six key areas over three outbound and two inbound flights. Three networks (i.e., social, information and task)...

Adherence to guidelines when evaluating fitness-to-drive in the elderly: a practice review of Swiss physicians.

We aimed to explore the extent to which general practitioners (GPs) in Western Switzerland adhere to Swiss recommendations when assessing fitness-to-drive in the elderly.

MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis.

MYC is an oncogenic driver that regulates transcriptional activation and repression. Surprisingly, mechanisms by which MYC promotes malignant transformation remain unclear. We demonstrate that MYC interacts with the G9a H3K9-methyltransferase complex to control transcriptional repression. Inhibiting G9a hinders MYC chromatin binding at MYC-repressed genes and de-represses gene expression. By identifying the MYC box II region as essential for MYC-G9a interaction, a long-standing missing link between MYC tran...

GECO: gene expression correlation analysis after genetic algorithm-driven deconvolution.

Large-scale gene expression analysis is a valuable asset for data-driven hypothesis generation. However, the convoluted nature of large expression datasets often hinders extraction of meaningful biological information. Results: To this end, we developed GECO, a gene expression correlation analysis software that uses a genetic algorithm-driven approach to deconvolute complex expression datasets into two subpopulations that display positive and negative correlations between a pair of queried genes. GECO's mut...


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