PubMed Journals Articles About "Global Bone Complication Treatment Market Research Report Forecast" RSS

02:58 EDT 22nd September 2018 | BioPortfolio

Global Bone Complication Treatment Market Research Report Forecast PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Global Bone Complication Treatment Market Research Report Forecast articles that have been published worldwide.

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Showing "Global Bone Complication Treatment Market Research Report Forecast" PubMed Articles 1–25 of 62,000+

Treatment of tibial nonunion with bone defect using a heterotopic ossification as autologous bone graft: literature overview and case report.

Nonunion after open fracture of the lower leg is a frequent complication with a prevalence of up to 40%. In cases with major bone defects, revision of the osteosynthesis with bone grafting is commonly performed. Until today, there is no report on treatment of a tibial nonunion with transplantation of a heterotopic ossification.

The mathematics of market timing.

Market timing is an investment technique that tries to continuously switch investment into assets forecast to have better returns. What is the likelihood of having a successful market timing strategy? With an emphasis on modeling simplicity, I calculate the feasible set of market timing portfolios using index mutual fund data for perfectly timed (by hindsight) all or nothing quarterly switching between two asset classes, US stocks and bonds over the time period 1993-2017. The historical optimal timing path ...

Analysis of global stock index data during crisis period via complex network approach.

Considerable research has been done on the complex stock market, however, there is very little systematic work on the impact of crisis on global stock markets. For filling in these gaps, we propose a complex network method, which analyzes the effects of the 2008 global financial crisis on global main stock index from 2005 to 2010. Firstly, we construct three weighted networks. The physics-derived technique of minimum spanning tree is utilized to investigate the networks of three stages. Regional clustering ...

Recent Advances in Drug Development and Regulatory Science in China.

As the second largest pharmaceutical market with a great potential for future growth, China has drawn much attention from the global pharmaceutical community. With an increasing government investment in biomedical research, the domestic biopharmaceutical (biotechnological) companies in China are turning their attention to the development of innovative medicines and targeting the global market. To introduce innovative products to Chinese patients sooner, to improve the efficiency of its review and approval p...

Hypomagnesemia During Teriparatide Treatment in Osteoporosis: Incidence and Determinants.

In our clinical experience, we have encountered patients who developed hypomagnesemia after the introduction of teriparatide. Some trials have reported hypomagnesemia as an adverse event during teriparatide treatment, but this issue had never been studied specifically.

Pituitary Diseases and Bone.

Neuroendocrinology of bone is a new area of research based on the evidence that pituitary hormones may directly modulate bone remodeling and metabolism. Skeletal fragility associated with high risk of fractures is a common complication of several pituitary diseases such as hypopituitarism, Cushing disease, acromegaly and hyperprolactinemia. As in other forms of secondary osteoporosis, pituitary diseases generally affect bone quality more than bone quantity and fractures may occur even in the presence of nor...

Effects of 24 months of treatment with romosozumab followed by 12 months of denosumab or placebo in postmenopausal women with low bone mineral density: A randomized, double-blind, phase 2, parallel group study.

Over 12 months, romosozumab increased bone formation and decreased bone resorption, resulting in increased BMD in postmenopausal women with low BMD (NCT00896532). Herein we report the study extension evaluating 24 months treatment with romosozumab, discontinuation of romosozumab, alendronate followed by romosozumab, and romosozumab followed by denosumab. Postmenopausal women age 55-85 years with a lumbar spine (LS), total hip (TH), or femoral neck T-score ≤-2.0 and ≥-3.5 were enrolled and randomly assig...

Bone transport for reconstruction of large bone defects after tibial tumor resection: a report of five cases.

This study was performed to explore the clinical efficacy of bone transport using external fixation for treatment of large bone defects after tibial tumor resection in five patients. Bone transport started 14 days postoperatively at 1 mm/day and was adjusted according to the callus-to-diameter ratio. The bone transport time, bone graft fusion, relapse, and metastasis were recorded. Clinical efficacy was evaluated using the Musculoskeletal Tumor Society (MSTS) scoring system. The tumors included osteosarcoma...

Late Reconstruction of the Interosseous Membrane with Bone-Patellar Tendon-Bone Graft for Chronic Essex-Lopresti Injuries: Outcomes with a Mean Follow-up of Over 10 Years.

The purpose of this study was to report our long-term outcomes following reconstruction of the forearm interosseous membrane (IOM) with bone-patellar tendon-bone (BPTB) graft for treatment of chronic Essex-Lopresti injuries.

Vertical 3D Bone Reconstruction with Simultaneous Implantation: A Case Series Report.

Tooth loss generally leads to a corresponding loss of supporting bone structures, jeopardizing correct implant placement. Bone augmentation procedures facilitate reconstruction of the alveolar contours but lengthen treatment time by about 4 to 9 months. The aim of this case series report is to describe the short-term results of the combination of three-dimensional bone augmentation using the shell technique in conjunction with simultaneous implantation. A total of 10 patients who underwent autologous bone a...

Expression of Concern Regarding "Effect of Deconditioning on Cortical and Cancellous Bone Growth in the Exercise Trained Young Rats".

Intra-articular migration of a tibial bone block after an anterior cruciate ligament reconstruction using a bone-tendon-bone graft.

We report the case of a patient that presented an intra-articular protrusion of the tibial bone block after an arthroscopically-assisted ACL reconstruction using a bone-patellar tendon-bone graft. The divergence between the tunnel and the screw was thought to be the reason of the migration. There are several animal-model studies that evidence a relationship between the decreased fixation of the graft and the tunnel-screw divergence. To the best of our knowledge, this is the first report of this complication...

Vertical bone augmentation in a single-tooth gap with an allogenic bone ring: Clinical considerations.

The main objective of this case report is to introduce a one-stage bone block augmentation with a cylindrical freeze-dried bone allograft (FDBA) and simultaneous implantation for the reconstruction of a single-tooth bone defect. Clinical Considerations: The report describes this method on the basis of radiographical and clinical images derived from a single patient.

NR4A1 regulates motility of osteoclast precursors and serves as target for the modulation of systemic bone turnover.

NR4A1 (Nur77 or NGFI-B), an orphan member of the nuclear receptor superfamily, has been identified as a key regulator of the differentiation and function of myeloid, lymphoid and mesenchymal cells. The detailed role of NR4A1 in bone biology is incompletely understood. Here we report a role for NR4A1 as novel factor controlling the migration and recruitment of osteoclast precursors during bone remodelling. Myeloid-, but not osteoblast- specific deletion of NR4A1 resulted in osteopenia due to an increase in t...

Bone health evaluation one year after aromatase inhibitors completion.

Breast cancer patients treated with aromatase inhibitors (AIs) experience increased bone loss during their treatment. However, there is little information about bone mineral density (BMD) after completing AI-treatment. The present study aimed to assess BMD changes one year after AI-therapy completion.

Substandard and falsified medical products are a global public health threat. A pilot survey of awareness among physicians in Sweden.

Substandard and falsified medical products are a public health threat, primarily associated with low- and middle-income countries. Today, the phenomenon also exists in high-income countries. Increased Internet access has opened a global market. Self-diagnosis and self-prescription have boosted the market for unregulated websites with access to falsified medicines.

LRP1 suppresses bone resorption in mice by inhibiting the RANKL-stimulated NFκB and p38 pathways during osteoclastogenesis.

Single nucleotide polymorphisms in the LRP1 gene coding sequence are associated with low bone mass, and cell culture studies suggest that LRP1 plays a role in osteoblast proliferation and osteoblast-mediated osteoclastogenesis. However, the in vivo function of LRP1 in bone homeostasis has not been explored. In this work, we studied the osteoclast-specific role of LRP1 in bone homeostasis using a Ctsk-Cre;Lrp1 mouse model on the C57BL/6J background. These mice had a dramatically decreased trabecular bone mas...

Radiotherapy of meningioma: a treatment in need of radiobiological research.

Meningiomas account for one third of primary intracranial tumors, nevertheless information on meningioma cell lines and in vivo models is scant. Although radiotherapy is one of the most relevant therapeutic options for the treatment patients with meningioma, radiobiological research to understand tumor responses to this treatment is far from being thoroughly understood. The aim of this report is to provide a comprehensive picture of the current literature on this field, so as to foster s research in this re...

Comparative Effect of rhPTH(1-84) on Bone Mineral Density and Trabecular Bone Score in Hypoparathyroidism and Postmenopausal Osteoporosis.

Parathyroid hormone (PTH) (1-84) improves lumbar spine (LS) areal bone mineral density (aBMD) and trabecular bone score (TBS) in hypoparathyroidism over a 2-year treatment period. Studies in osteoporosis have shown that with PTH(1-34) there is a significant increase in LS aBMD and TBS. In this article, we provide new data comparing the effects of the same form of PTH, namely recombinant human PTH, rhPTH(1-84), on aBMD and TBS in hypoparathyroid and osteoporotic patients over an 18-month treatment period. We...

Reconstruction of the Alveolar Bone Using Bone Augmentation With Selective Laser Melting Titanium Mesh Sheet: A Report of 2 Cases.

Bone augmentation is used to supplement bone defects during dental implant treatment. In this technique, the area filled with bone prosthetic material is covered with an artificial space-making device or titanium mesh sheet, which must be manually adapted to the bone defect during the procedure before being fixed in place. Selective laser melting (SLM) method can be used to preadapt the titanium mesh sheet based on preoperative CT data. This method enables shorter surgery times compared with conventional ti...

Denosumab: a potential treatment option for aneurysmal bone cyst of the atlas.

Aneurysmal bone cysts (ABCs) of spine are conventionally treated with en-bloc resection or intralesional excision/curettage and reconstruction or filling of defects with bone cement. For the treatment of upper cervical ABCs, en-bloc resections are often not desirable considering the risk/benefit ratio while the risk of recurrence after intralesional excision is high. Hence, alternative management options are often necessary. We describe our clinical experience with one such treatment alternative-denosumab f...

Bone tissue engineering: Adult stem cells in combination with electrospun nanofibrous scaffolds.

Since bone tissue lesions caused by several reasons and has global outbreak without any attentions to the modernity level of the countries. In the other hands treatment of patients with this problem faced to the several limitations, in this because the future of the bone lesions treatments is related to the future of the bone tissue engineering. This review tries to cover the most suitable stem cells and materials from either natural or synthetic sources for bone tissue engineering. These understanding poin...

BMP3 expression by osteoblast lineage cells is regulated by canonical Wnt signaling.

Bone morphogenetic protein (BMP) and canonical Wnt (cWnt) signaling factors are both known to regulate bone mass, fracture risk, fracture repair, and osteoblastogenesis. BMP3 is the most abundant BMP and negatively regulates osteoblastogenesis and bone mass. Thus, identifying the mechanism by which BMP3 acts to depress bone formation may allow for the development of new therapeutics useful in the treatment for osteopenia and osteoporosis. Here, we report that cWnt signaling stimulates BMP3 expression in ost...

Treatment of a bilaterally severely resorbed posterior mandible due to early tooth loss by Guided Bone Regeneration using customized allogeneic bone blocks: A case report with 24 months follow-up data.

The use of allogeneic bone grafts for alveolar ridge reconstruction has become an often-discussed alternative to augmentation procedures using autografts. Nevertheless, there still is a lack of literature concerning long-time experiences of allografts for alveolar ridge reconstruction. Especially the results of the use of allogeneic bone blocks for mandible reconstructions need to be further investigated.

To The Editor.

To The Editor We were pleased to read and are delighted to acknowledge the Editorial of Cummings and Eastell that reviewed the history of pivotal advances in clinical research into bone and mineral disease in connection with the 40 anniversary celebration of the ASBMR. The article provides a succinct review of several key epidemiological, technological, biochemical and therapeutic advances that, overall, have signalled landmark achievements in our field.

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