PubMed Journals Articles About "Global Lymphoma Drugs Market 2017 2021 Regions Forecasts" RSS

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Showing "Global Lymphoma Drugs Market 2017 2021 Regions Forecasts" PubMed Articles 1–25 of 17,000+

2017 is Banner Year for Drug Approvals by the FDA.

In 2017, the US Food and Drug Administration approved 46 novel drugs and 29 drugs received newly approved indications. This record setting year was due in part to the new expedited review pathways. A review of these drugs were summarized.

Forensic drug intelligence and the rise of cryptomarkets. Part II: Combination of data from the physical and virtual markets.

Technology provides new ways to access customers and suppliers while enhancing the security of off-line criminal activity. Since the first cryptomarket, Silk Road, in 2011, cryptomarkets have transformed the traditional drug sale by facilitating the creation of a global network of vendors and buyers. Due to the fragmented nature of traces that result from illegal activities, combining the results of concurrent processes based on traces of different nature should provide supplementary benefit to understand t...

Proceedings of the 2017 International Forum on Gonococcal Infections and Resistance (2017 IFGIR) in Shenzhen, China.

The 2017 International Forum on Gonococcal Infections and Resistance (2017 IFGIR) was held at Shenzhen, China from 17 to 19 September 2017. The key objectives were to gather experts in the field to review and analyze the epidemiological profiles of gonococcal infections and antimicrobial resistance (AMR) at global, regional and national levels; to share and discuss findings from ongoing and completed research studies; and to identify research needs to respond to the spread of gonococcal infections and AMR. ...

Serum IL18 is associated with hemophagocytosis and poor survival in extranodal natural killer/T-cell lymphoma.

Extranodal natural killer/T-cell lymphoma (ENKTL) is associated with Epstein-Barr virus (EBV) infection, a common cause of hemophagocytosis. As interleukin-18 (IL18) is related with hemophagocytosis, we measured serum IL18 and IL18-related cytokines of newly diagnosed patients with ENKTL (N = 114) to investigate the role as a biomarker for hemophagocytosis and determine the prognosis of ENKTL. The median value of serum IL18 was 20.5 pg/mL (1.23-2021.81 pg/mL). The high IL18 group (≥20.5 pg/mL) w...

Challenges of bringing a new sedative to market!

The current review examines the success and failures of the development of new hypnotic compounds for the human market. One of the important aspects is that one of the key present agents, propofol, is considered by many anaesthesiologists as 'the ideal'. However, all drugs have adverse or side-effects.

Pre-exposure prophylaxis (PrEP) for MSM in low HIV incidence places: should high risk individuals be targeted?

Pre-exposure prophylaxis (PrEP) targeting high-risk men who have sex with men (MSM) has been shown to be a cost-effective HIV control measure. However, the approach could be a challenge in low HIV incidence places with a low proportion of high-risk MSM. To examine the impact of PrEP in such setting in Asia, we developed an epidemic model and conducted cost-effectiveness analysis using empirical multicentre clinical and HIV sequence data from HIV-infected MSM in Hong Kong, in conjunction with behavioural dat...

Orbital Lymphoma.

Orbital lymphomas constitute 50-60% of ocular adnexal lymphomas. A total of 2,211 cases of orbital lymphoma with a known subtype have been reported in the last 24 years (1994-2017). The vast majority of orbital lymphomas are of B-cell origin (97%), of which extranodal marginalzone B-cell lymphoma (EMZL) (59%) is the most common subtype, followed by diffuse large B-cell lymphoma (DLBCL) (23%), follicular lymphoma (FL) (9%), and mantle cell lymphoma (MCL) (5%). Orbital lymphoma is primarily a disease of the e...

The mathematics of market timing.

Market timing is an investment technique that tries to continuously switch investment into assets forecast to have better returns. What is the likelihood of having a successful market timing strategy? With an emphasis on modeling simplicity, I calculate the feasible set of market timing portfolios using index mutual fund data for perfectly timed (by hindsight) all or nothing quarterly switching between two asset classes, US stocks and bonds over the time period 1993-2017. The historical optimal timing path ...

The social issue in the BRICS Project.

BRICS, the acronym for Brazil, Russia, India, China and South Africa, is the first multilateral group created and run by non-western developed countries. The group aims to influence world geopolitics and market based on the right of developing and emerging countries to participate equitably in development. The social issue lies at the core of the group's justifications to achieve its goals. In this regard, this paper aims to analyze how the social issue has been addressed by BRICS. The methodology was based...

Presidential address 2017 William Harkness FRCS October 10th 2017 Denver, Co USA: 2017-annus mirabilis, a global view of neurosurgery for children.

The following presidential address was delivered at the 45th Annual Meeting of the ISPN held in Denver, CO, USA in October 2017.

Surveillance to Track Progress Toward Polio Eradication - Worldwide, 2016-2017.

Global efforts to eradicate polio began in 1988, and four of the six World Health Organization (WHO) regions currently have achieved poliofree certification. Within the remaining two regions with endemic poliomyelitis (African and Eastern Mediterranean), Afghanistan, Nigeria, and Pakistan have never interrupted transmission of wild poliovirus (WPV). The primary means of detecting poliovirus transmission is surveillance for acute flaccid paralysis (AFP) among children aged

Substandard and falsified medical products are a global public health threat. A pilot survey of awareness among physicians in Sweden.

Substandard and falsified medical products are a public health threat, primarily associated with low- and middle-income countries. Today, the phenomenon also exists in high-income countries. Increased Internet access has opened a global market. Self-diagnosis and self-prescription have boosted the market for unregulated websites with access to falsified medicines.

Analysis of global stock index data during crisis period via complex network approach.

Considerable research has been done on the complex stock market, however, there is very little systematic work on the impact of crisis on global stock markets. For filling in these gaps, we propose a complex network method, which analyzes the effects of the 2008 global financial crisis on global main stock index from 2005 to 2010. Firstly, we construct three weighted networks. The physics-derived technique of minimum spanning tree is utilized to investigate the networks of three stages. Regional clustering ...

Ensembles of radar nowcasts and COSMO-DE-EPS for urban flood management.

Sophisticated strategies are required for flood warning in urban areas regarding convective heavy rainfall events. An approach is presented to improve short-term precipitation forecasts by combining ensembles of radar nowcasts with the high-resolution numerical weather predictions COSMO-DE-EPS of the German Weather Service. The combined ensemble forecasts are evaluated and compared to deterministic precipitation forecasts of COSMO-DE. The results show a significantly improved quality of the short-term preci...

Characteristics and outcomes of non-Hodgkin's lymphoma patients with leptomeningeal metastases.

Leptomeningeal metastasis is an uncommon but devastating complication. The incidence of non-Hodgkin's lymphoma has been increasing in recent decades, due to the poor central nervous system penetration of drugs and the prolonged overall survival of patients, leptomeningeal metastases has gradually increased over time. Patients with leptomeningeal metastases have short survival durations and poor quality of life; there are few studies about non-Hodgkin's lymphoma with leptomeningeal metastases. We investigate...

Watershed microinfarct pathology and cognition in older persons.

Brain microinfarcts are common in aging and are associated with cognitive impairment. Anterior and posterior watershed border zones lie at the territories of the anterior, middle, and posterior cerebral arteries, and are more vulnerable to hypoperfusion than brain regions outside the watershed areas. However, little is known about microinfarcts in these regions and how they relate to cognition in aging. Participants from the Rush Memory and Aging Project, a community-based clinical-pathologic study of aging...

An update on the global prevalence of conduct disorder (2011-2017): Study protocol for a systematic review and meta-analysis.

The global burden of conduct disorder is considerable, particularly in males. Deaths were followed by conflict and terrorism increased 143·3% from 2006 to 2016. The objective of this study is to provide a protocol of systematic review and meta-analysis to update the global prevalence of conduct disorder during 2011-2017.

Forecasting future global food demand: A systematic review and meta-analysis of model complexity.

Predicting future food demand is a critical step for formulating the agricultural, economic and conservation policies required to feed over 9 billion people by 2050 while doing minimal harm to the environment. However, published future food demand estimates range substantially, making it difficult to determine optimal policies. Here we present a systematic review of the food demand literature-including a meta-analysis of papers reporting average global food demand predictions-and test the effect of model co...

Understanding resistance mechanisms to BTK and BCL2 inhibitors in mantle cell lymphoma: implications for design of clinical trials.

Novel targeted therapeutics has significantly improved the outlook of patients with relapsed/refractory mantle cell lymphoma (R/R MCL). Despite significant efficacy, one of the major limitations of these targeted agents is presence of primary or acquired resistance to these novel drugs. Patients who fail primary therapy especially with ibrutinib have poor outcomes and may respond poorly to subsequent therapies. Hence, it is important to understand resistance mechanisms a priori to identify patients who are ...

Effects of market type and time of purchase on oxidative status and descriptive off-odors and off-flavors of beef in Vietnam.

The objective of the current study was to determine the effects of market type (super market - SM, indoor market - IM, open market - OM) and sampling time (at the opening - T0 and 4 h after the opening - T4) on antioxidant capacity, lipid oxidation, and descriptive sensory attributes of beef in Vietnam. Values of FC and TEAC were greater in OM beef than IM and SM (P 

Opioid Deaths in Milwaukee County, Wisconsin 2013-2017: The Primacy of Heroin and Fentanyl.

Heroin and fentanyl are the overwhelming and increasing cause of opioid deaths in Milwaukee County, Wisconsin. We reviewed all drug and opioid deaths from 2013 to 2017 to delineate the specific opioid drugs involved and changes in their incidence. From 2013 to 2017, 980 deaths were due to opioids, rising from 184 in 2013 to 337 in 2017. In 2017, opioid deaths exceeded combined non-natural deaths from homicide and suicide. Illicit heroin and fentanyl/analogs caused 84% of opioid deaths and 80% of drug deaths...

Confirmatory versus explorative endpoint analysis: Decision-making on the basis of evidence available from market authorization and early benefit assessment for oncology drugs.

The early benefit assessment of pharmaceuticals in Germany and their preceding market authorization pursue different objectives. This is reflected by the inclusion of varying confirmatory endpoints within the evaluation of oncology drugs in early benefit assessment versus market authorization, with both relying on the same evidence. Data from assessments up to July 2015 are used to estimate the impact of explorative in comparison to confirmatory endpoints on market authorization and early benefit assessment...

HIV and AIDS among adolescents who use drugs: opportunities for drug policy reform within the sustainable development agenda.

The international community's commitment to halve by 2015 the HIV transmission among people who inject drugs has not only been largely missed, instead new HIV infections have increased by 30%. Moreover, drug injection remains one of the drivers of new HIV infections due to punitive responses and lack of harm reduction resourcing. In the midst of this situation, adolescents are a forgotten component of the global response to illegal drugs and their link with HIV infection. The Sustainable Development Goals (...

Skilful forecasting of global fire activity using seasonal climate predictions.

Societal exposure to large fires has been increasing in recent years. Estimating the expected fire activity a few months in advance would allow reducing environmental and socio-economic impacts through short-term adaptation and response to climate variability and change. However, seasonal prediction of climate-driven fires is still in its infancy. Here, we discuss a strategy for seasonally forecasting burned area anomalies linking seasonal climate predictions with parsimonious empirical climate-fire models ...

New perspectives in the therapeutic approach of peripheral T-cell lymphoma.

Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of mature T-cell and natural killer (NK)-cell neoplasms in the WHO 2016 classification. Patient prognosis is poor when treated with CHOP, and there is an unmet need for new drugs. Several agents have been developed for PTCL, and their use is the subject of this review.

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