PubMed Journals Articles About "Goal-oriented Intervention In Parkinson's Disease" RSS

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Showing "Goal oriented Intervention Parkinson Disease" PubMed Articles 1–25 of 28,000+

Comparison of an Online-Only Parkinson's Disease Research Cohort to Cohorts Assessed In Person.

Online tools for data collection could be of value in self-reported patient-oriented research. The Fox Insight (FI) study collects data online from individuals with self-reported Parkinson's disease (PD). Comparing the FI cohort to other cohorts assessed through more traditional (in-person) observational research studies would inform the representativeness and utility of FI data.

Vascular, flow and perfusion abnormalities in Parkinson's disease.

Reduced flow into the brain or decreased jugular venous outflow from the brain may serve as a potential biomarker for Parkinson's disease (PD). Our goal was to compare the presence of vascular abnormalities, flow, and increases in midbrain iron content (a hallmark of the disease) in patients with PD.

intervention to promote physical activity in older adults with Parkinson's disease: Study design and methods.

The main motor impairments of gait and balance experienced by people with Parkinson's disease (PD) contribute to a sedentary lifestyle, resulting in poor physical conditioning, loss of functional independence, and reduced quality of life. Despite the known benefits of physical activity in PD, the majority of older adults with PD are insufficiently active. Few studies incorporate behavioral change approaches to promoting physical activity in PD. The main goal of this research is to foster community mobility ...

Individually Tailored Internet-Based Cognitive-Behavioral Therapy for Daily Functioning in Patients with Parkinson's Disease: A Randomized Controlled Trial.

Parkinson's disease (PD) is often associated with psychological distress and lowered daily functioning. The availability of psychological interventions tailored for people with Parkinson is very limited.

Parkinson's disease - heterogeneous and complex in its clinical presentation.

Parkinson's disease is the second most common neurodegenerative disease. Lewy bodies with alpha-synuclein as the major component and loss of dopaminergic nerve cells in substantia nigra are neuropathological features. The diagnosis of Parkinson's disease is based on the occurrence of bradykinesia, rigidity and resting tremor. The disease is also associated with several non-motor symptoms. The therapy is mainly based on pharmacological treatment to increase dopamine signaling and neurosurgical deep brain sti...

Augmented reality-based dance intervention for individuals with Parkinson's disease: A pilot study.

The effects of dance on improving the symptoms of individuals with Parkinson's disease (PD) is well documented. Augmented reality devices, such as Google Glass, may be used to implement dance interventions to improve mobility and balance.

Soluble TREM2 is elevated in Parkinson's disease subgroups with increased CSF tau.

Parkinson's disease is the second most common neurodegenerative disease after Alzheimer's disease and affects 1% of the population above 60 years old. Although Parkinson's disease commonly manifests with motor symptoms, a majority of patients with Parkinson's disease subsequently develop cognitive impairment, which often progresses to dementia, a major cause of morbidity and disability. Parkinson's disease is characterized by α-synuclein accumulation that frequently associates with amyloid-β and tau fibri...

Investigation of the roles of dysbindin-1 and SATB2 in the progression of Parkinson's disease.

Parkinson's disease is a neurodegenerative disease that typically results in the loss of dopaminergic neurons, especially in an area of the brain known as the substantia nigra. Here, we investigated the roles of two important neuronal development proteins, dysbindin-1 and SATB2, at different stages of Parkinson's disease.

Dyspnea Is a Specific Symptom in Parkinson's Disease.

Dyspnea is a multidimensional sensation that is reported in Parkinson's disease (PD). The multidimensional dyspnea profile (MDP) questionnaire can help to distinguish the perceptive dimension and the emotion response.

Reporting and methodological quality of clinical trials on exercise therapy for Parkinson's disease.

Exercise therapy is becoming extremely relevant as a new efficacious intervention in multiple medical fields. Although several clinical trials have reported benefits of exercise therapy for Parkinson's disease (PD), recommendations and prescriptions for its use in clinical practice remain limited.

Is Aquatic Therapy Optimally Prescribed for Parkinson's Disease? A Systematic Review and Meta-Analysis.

Aquatic therapy offers an alternative physiotherapy approach to managing the motor and non-motor symptoms associated with Parkinson's disease (PD).

Comparison of Awake and Asleep Deep Brain Stimulation for Parkinson's Disease: A Detailed Analysis Through Literature Review.

Deep brain stimulation (DBS) for Parkinson's disease (PD) has been applied to clinic for approximately 30 years. The goal of this review is to explore the similarities and differences between "awake" and "asleep" DBS techniques.

Social cognition impairments in Parkinson's disease.

Parkinson's disease is the second most common neurodegenerative disease of the elderly caused by the neurodegenerative process in different parts of the brain, which resulted in motor and non-motor symptoms. Investigation of non-motor symptoms of Parkinson's disease is increasingly rising for the last years. Social cognition is a special type of cognitive process, which provides people interaction in the society and their impairment also can be observed in Parkinson's disease. Social cognitive functions inc...

A New Prospective, Home-Based Monitoring of Motor Symptoms in Parkinson's Disease.

Subjective symptoms, which are retrospectively assessed during clinical interviews in the office, may be influenced by patient recall in Parkinson's disease (PD). Prospective collection of subjective data might be an effective tool to overcome this bias.

The genetic architecture of Parkinson's disease.

Parkinson's disease is a complex neurodegenerative disorder for which both rare and common genetic variants contribute to disease risk, onset, and progression. Mutations in more than 20 genes have been associated with the disease, most of which are highly penetrant and often cause early onset or atypical symptoms. Although our understanding of the genetic basis of Parkinson's disease has advanced considerably, much remains to be done. Further disease-related common genetic variability remains to be identifi...

Genomewide association study of Parkinson's disease clinical biomarkers in 12 longitudinal patients' cohorts.

Several reports have identified different patterns of Parkinson's disease progression in individuals carrying missense variants in GBA or LRRK2 genes. The overall contribution of genetic factors to the severity and progression of Parkinson's disease, however, has not been well studied.

Effect of repetitive transcranial magnetic stimulation on gait and freezing of gait in Parkinson's disease: a systematic review and meta-analysis.

The purpose of this review was to systematically assess the effectiveness of repetitive transcranial magnetic stimulation (rTMS) intervention on gait in individuals with Parkinson's disease (PD).

Delayed Clinical Manifestation of Parkinson's Disease Among Physically Active: Do Participants in a Long-Distance Ski Race Have a Motor Reserve?

Physical activity is associated with reduced risk of Parkinson's disease (PD). The explanations for this association are not completely elucidated. We use long-term PD-incidence data from long-distance skiers to study the relationship between exercise and PD.

Perspective of α-synuclein and Familial Parkinson's Disease.

To date, there have been several reports about the genes associated with familial Parkinson's disease. These genes are classified following the PARK nomenclature. The prevalence of these genes varies between countries. Moreover, each gene is associated with different symptoms during disease progression. In this review, we will summarize the clinical findings and molecular functions, with a focus on alpha-synuclein, along with recent discoveries and will try to associate them with sporadic Parkinson's diseas...

Plasma Cytokines Profile in Patients with Parkinson's Disease Associated with Mutations in GBA Gene.

Plasma cytokine concentration in patients with Parkinson's disease and mutation in GBA gene, in patients with sporadic Parkinson's disease, and in healthy volunteers were measured by ELISA and multiplex analysis. In patients with Parkinson's disease and mutation in GBA gene, elevated plasma concentrations of IL-1β and TNFα were revealed by ELISA in comparison with both controls and patients with sporadic form of Parkinson's disease. Multiplex analysis revealed enhanced secretion of IL-1β, IL-2, IFNγ and...

Subjective and objective subtypes of excessive daytime sleepiness in Parkinson's disease.

Excessive daytime sleepiness (DS) is a common symptom of Parkinson's disease (PD), which can occur at any stage of the disease and decrease the quality of life of patients. The relationship between excessive daytime sleepiness and Parkinson's disease is determined by neurodegenerative process in the brain structures. However, there are many other factors, which can contribute to this phenomenon.

Effects of rhythmic auditory cueing on stepping in place in patients with Parkinson's disease.

Stepping in place (SIP) is a useful locomotor training intervention. The purpose of this study was to investigate the effects of single auditory-cued SIP training on cortical excitability, rhythmic movements and walking ability in patients with Parkinson's disease(PD).

Synaptic changes in Parkinson's disease assessed with in-vivo imaging.

Parkinson's disease is characterized by motor and non-motor symptoms, reduced striatal dopamine signaling and loss of dopamine neurons in the substantia nigra. It is now known that the pathological process in Parkinson's disease may begin decades before the clinical diagnosis and include a variety of neuronal alterations in addition to the dopamine system.

Use of Goal Setting to Enhance Self-Efficacy After Sports-Related Injury: A Critically Appraised Topic.

Clinical Scenario: Patients after sports-related injury experience deficits in self-efficacy. Goal setting may be an appropriate psychoeducation technique to enhance self-efficacy after sports-related injury. Clinical Question: Does goal setting-enhanced rehabilitation improve self-efficacy compared with traditional rehabilitation alone in individuals with sports-related injury? Summary of Key Findings: Two randomized controlled trials were included. The two studies selected assessed changes in self-efficac...

Tau Tangles in Parkinson's Disease: A 2-Year Follow-Up Flortaucipir PET Study.

Flortaucipir PET, a marker of tau tangles, has shown lower than expected cortical uptake in Parkinson's disease (PD), than would be predicted from neuropathologic estimates of Alzheimer's disease co-pathology. Instead, the most characteristic finding of flortaucipir imaging in PD is decreased uptake in the substantia nigra, reflecting reduction in its "off-target" binding to neuromelanin. We have previously reported these observations in cross-sectional studies.

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