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PubMed Journals Articles About "Heavy Drinkers Consuming More Than Half Alcohol" RSS

05:32 EDT 19th May 2019 | BioPortfolio

Heavy Drinkers Consuming More Than Half Alcohol PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Heavy Drinkers Consuming More Than Half Alcohol articles that have been published worldwide.

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Showing "Heavy drinkers consuming more than half alcohol" PubMed Articles 1–25 of 5,800+

Exposure to Stigma Elicits Negative Affect and Alcohol Craving Among Young Adult Sexual Minority Heavy Drinkers.

Sexual orientation disparities in alcohol use disorder (AUD) are thought to be explained by stigma specific to sexual minorities. Despite the importance of negative affect and craving in addiction, research has yet to test the effects of stigma on affect and alcohol craving among sexual minorities. This laboratory study examined the effects of 3 novel mood inductions (stigma, general unpleasant, and neutral) on affect and alcohol craving among heavy-drinking sexual minority young adults. We also paired thes...


Associations of community structure and functions of benthic invertebrates with nickel concentrations: analyses from field surveys.

Field surveys provide valuable empirical information about the effects of heavy metals on the biological integrity of river ecosystems. To evaluate the effect of nickel (Ni) on aquatic organisms, we conducted field surveys of benthic invertebrates and Ni concentrations at 45 sites in 19 rivers in Japan. We examined the relationships between 11 structural or functional measures of benthic invertebrate communities and free Ni ion concentrations with a 90th quantile regression model. Among the measures, Epheme...

Fluorine-Containing Drugs Approved by the FDA in 2018.

Over the last two decades, fluorine substitution has become one of the essential structural traits in modern pharmaceuticals. Thus, about half of the most successful drugs (blockbuster drugs) contain fluorine atom. In this review, we profile 17 fluorine-containing drugs approved by the FDA in 2018. The newly approved pharmaceuticals feature several types of aromatic F- and CF3-, aliphatic (CF2) substitution, offering advances in treatment of various diseases, including cancer, HIV, malarial and smallpox inf...


Toward identification of the risk group of food products: Chemometric assessment of heavy metals content in confectionery products.

The main raw material for cookies production is wheat flour (white or wholemeal/integral) as a nutritionally highly valuable component. In addition to the benefits it brings, this raw material is also a potential source of contamination with residues of heavy metals originating from soil and plant protection agents. Therefore, it is necessary to analyze their concentrations in both wheat flour and final products, since the wheat flour is often present in cookies and related confectionery products in a propo...

Experimental study on the control form of fin stabilizer at zero speed.

The zero-speed fin stabilizer is used to stabilize the roll motion of the ship at full speed. It has two working modes, that is the lift-based normal anti-rolling mode and the drag-based zero-speed anti-rolling mode. Different force generation mechanisms cause different control methods, especially in the form of control. The zero-speed fin stabilizer works in a sinusoidal fashion in normal mode, the same as the conventional fin stabilizer. However, its control form at zero speed is not particularly clear. T...

Transmammary delivery of firocoxib to piglets reduces stress and improves average daily gain after castration, tail docking, and teeth clipping1.

Painful processing procedures in piglets such as tail docking, castration, and teeth clipping are an emerging animal welfare concern. We hypothesized that transmammary delivery of a nonsteroidal anti-inflammatory drug, firocoxib, would reduce pain associated with processing in piglets. This study compared the pharmacokinetics, efficacy, safety, and tissue residue concentrations of 4 doses of firocoxib (0.5, 1.0, 1.5, or 2.0 mg/kg) administered to sows and delivered to nursing piglets prior to processing. Si...

Perfluorodecalin Versus Densiron 68 Heavy Silicone Oil in the Management of Inferior Retinal Detachment Recurrence.

To assess the efficacy of perfluorodecalin (PFD) or Densiron 68 heavy silicone oil (HSO) in the management of inferior complex retinal detachment recurrence.

Effects of CYP2D6 activity on the efficacy and safety of mirtazapine in patients with depressive disorders and comorbid alcohol use disorder.

The objective of the study was to investigate the effects of CYP2D6 activity on the efficacy and safety of mirtazapine in patients with depressive disorders and comorbid alcohol use disorder who received mirtazapine. The study included 109 Russian patients who received mirtazapine at a dose of 30.0 [15.0; 45.0] mg per day. Genotyping of CYP2D6*4 (1846G>A, rs3892097) was performed using real-time polymerase chain reaction with allele-specific hybridization. The activity of CYP2D6 was evaluated by determining...

A Challenge is Brewing: false-positive urine alcohol in an elderly diabetic male.

Risky Drinking Decisions: The Influence of Party Music and Alcohol Abuse in Young Adult Women.

Music is a ubiquitous feature of young adults' social drinking environments, yet no studies have assessed whether and how it impacts risky decisions to drink alcohol. Previous research on the influence of music on risky decisions is largely based around decision tasks with monetary incentives.

Many Patients With Irritable Bowel Syndrome Have Atypical Food Allergies Not Associated With Immunoglobulin E.

Confocal laser endomicroscopy (CLE) is a technique that permits real-time detection and quantification of changes in intestinal tissues and cells, including increases in intraepithelial lymphocytes and fluid extravasation through epithelial leaks. Using CLE analysis of patients with irritable bowel syndrome (IBS), we found that more than half have responses to specific food components. Exclusion of the defined food led to long-term symptom relief. We used results of CLE to detect reactions to food in a larg...

Small molecule inhibitor agerafenib effectively suppresses neuroblastoma tumor growth in mouse models via inhibiting ERK MAPK signaling.

Neuroblastoma (NB) is the most common extracranial solid tumor in early childhood. Despite intensive multimodal therapy, nearly half of children with high-risk disease will relapse with therapy-resistant tumors. Dysregulation of MAPK pathway has been implicated in the pathogenesis of relapsed and refractory NB patients, which underscores the possibility of targeting MAPK signaling cascade as a novel therapeutic strategy. In this study, we found that high expressions of RAF family kinases correlated with adv...

Expression and characterization of albumin fusion protein canine IFNγ-CSA in baculovirus-insect cell expression system.

In this study, canine IFNγ was fused by a flexible linker with canine serum albumin to construct the fusion protein IFNγ-CSA for the purpose to design a long-acting canine IFNγ. The fusion protein was successfully expressed in baculovirus-infected Sf9 insect cells and was purified by salting-out and ion exchange chromatography. The IFNγ-CSA fusion possessed potent anti-viral assay against vesicular stomatitis virus in cultured cells. IFNγ-CSA was also stable at 37 °C up to 72 h compared with 8 h...

The role of the light chain in the structure and binding activity of two cattle antibodies that neutralize bovine respiratory syncytial virus.

Cattle antibodies have unusually long CDR3 loops in their heavy chains (HCs), and limited light chain (LC) diversity, raising the question of whether these mask the effect of LC variation on antigen recognition. We have investigated the role of the LC in the structure and activity of two neutralizing cattle antibodies (B4 and B13) that bind the F protein of bovine respiratory syncytial virus (bRSV). Recombinant Fab fragments of B4 and B13 bound bRSV infected cells and showed similar affinities for purified ...

Nano-sized architectural design of multi-activity graphene oxide (GO) by chemical post-decoration for efficient uranium(VI) extraction.

The introduction of organic groups onto graphene oxide (GO) platelets can supply additional active sites for adsorption of uranium(VI) (U(VI)) to improve the adsorption capacity. However, as a result of the existence of stabilizing π-conjugation system, a facile and effective modification method remains a challenge. Therefore, a novel strategy is exploited by nano-sized architectural design of multi-activity GO through post-decoration with amidoxime functionalized diaminomaleonitrile (DM-AO). The post-modi...

Molecular characteristics of dissolved organic matter transformed by O and O/HO treatments and the effects on formation of unknown disinfection by-products.

We investigated semiquantitative changes in almost 1000 dissolved organic matter (DOM) features during oxidation with 1 mg of O per liter (mg O/L), 4 mg O/L, or 4 mg O/L + 2.5 mg of HO per liter (advanced oxidation process, AOP) by unknown screening analysis with Orbitrap mass spectrometry. The consequential effects on formation of unknown disinfection by-products (DBPs) by chlorination were evaluated in laboratory-scale experiments. Several hundred unsaturated DOM features with positive oxygen-sub...

Phytotoxicity and oxidative stress of perfluorooctanesulfonate to two riparian plants: Acorus calamus and Phragmites communis.

Despite previous efforts and the rapid progress on elucidating the impact of perfluorooctanesulfonate (PFOS) on the environment, its effects on riparian plants, a key component of aquatic ecosystems, are still poorly understood. A 48-day hydroponic experiment was carried out on two typical riparian species (Acorus calamus and Phragmites communis) to examine the toxic effects of PFOS on these plants. The results showed that, at high concentration (more than 10 mg L), PFOS could prevent chlorophyll accumu...

Dissipation and safety evaluation of afidopyropen and its metabolite residues in supervised cotton field.

The novel insecticidal mechanism of afidopyropen can be substituted for traditional pesticides to control sap-sucking pests in cotton field. The data of residue amounts of afidopyropen and its metabolite M440I007 in cotton matrix and the environment soil are important to evaluate the safe use of the target compound and establish maximum residue limit (MRL). In this work, the dissipation and residue of afidopyropen and its metabolite M440I007 in cotton and field soils were investigated. The analytical method...

Vertical distribution of microbial communities in chromium-contaminated soil and isolation of Cr(Ⅵ)-Reducing strains.

Soil ecosystems surrounding chromium slag undergo continuous harsh physicochemical conditions due to multiple heavy metals contamination. Previous studies of soil microbial communities mainly focused on surface soil layer, while little was known about the depth-related distributions of the microbial communities in chromium (Cr)-contaminated soil. In this study, a comprehensive analysis of depth-related distributions of microbial communities in Cr-contaminated soil was carried out by Illumina sequencing of 1...

Dissipation of chlorantraniliprole in contrasting soils and its effect on soil microbes and enzymes.

An experiment was set up to determine the rate of dissipation of chlorantraniliprole (CTP) from two soils with contrasting properties. The other objective of the study was to find out the effect of CTP on soil microorganisms (population, microbial biomass carbon and soil enzymes) under controlled environment. CTP residues when applied at recommended dose ((RD) (at 40 g a.i./ha)) could not be recovered either from alluvial soil or red soil at 60 days post application of CTP in a microcosm study. Higher cla...

Study of the contamination rate and change in growth features of lettuce (Lactuca sativa Linn.) in response to cadmium and a survey of its phytochelatin synthase gene.

Crops can become contaminated when grown in soils containing heavy metals. Cadmium is a heavy metal that poses a significant health risk to humans. The purpose of this study was to evaluate the effect of cadmium on lettuce (Lactuca sativa Linn) and the contamination risk of lettuce grown in cadmium environments. The results showed that photosynthesis and growth parameters were significantly affected by cadmium. Lettuce has the ability to absorb large amounts of cadmium from the contaminated environment and ...

How do particle number, surface area, and mass correlate with toxicity of diesel particle emissions as measured in chemical and cellular assays?

Increasingly stringent particulate matter (PM) emission standards have brought forth engine design improvements, cleaner-burning fuels, and aftertreatment technologies. Reductions in tailpipe PM mass have concomitantly reduced accumulation-mode particle emissions. However, some strategies promote the emission of nucleation-mode particles, which are typically quantified on a number (PN) basis. We previously demonstrated that PN emissions from heavy-duty diesel vehicles equipped with various aftertreatment sy...

Sociodemographic factors and social determinants associated with toxicology confirmed polysubstance opioid-related deaths.

While prescribed and illicit opioid use are primary drivers of the national surges in overdose deaths, opioid overdose deaths in which stimulants are also present are increasing in the U.S. We determined the social determinants and sociodemographic factors associated with opioid-only versus polysubstance opioid overdose deaths in Massachusetts. Particular attention was focused on the role of stimulants in opioid overdose deaths.

Testing the reciprocal association between smoking and depressive symptoms from adolescence to adulthood: A longitudinal twin study.

Longitudinal studies enhance understanding of the complex reciprocal relationship between smoking and depression from adolescence to young adulthood. Examining bi-directional associations between cigarette smoking and depressive symptoms in a genetically informative twin design can help to understand whether the associations are independent of shared genetic and environmental factors.

Therapeutic effect of angelica and its compound formulas for hypertension and the complications: Evidence mapping.

Hypertension is one of the common diseases, which brings heavy burden to human race. Currently, western medication is in absolutely dominant position in the treatment of hypertension, but it maintains for a short time and there are various side effects and drug tolerance. Therefore, Chinese medicine has attracted great attention in the treatment field of hypertension, and angelica is one of the most frequently used herbs.


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