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PubMed Journals Articles About "Hedge Fund Takes Another Shot Biotech This Time" RSS

18:17 EDT 19th September 2018 | BioPortfolio

Hedge Fund Takes Another Shot Biotech This Time PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Hedge Fund Takes Another Shot Biotech This Time articles that have been published worldwide.

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Showing "Hedge Fund Takes Another Shot Biotech This Time" PubMed Articles 1–25 of 21,000+

Anomalous non-linear shot noise at high voltage bias.

Since the work of Walter Schottky, it is known that the shot-noise power for a completely uncorrelated set of electrons increases linearly with the time averaged current. At zero temperature and in the absence of inelastic scattering the linearity relation between noise power and average current is quite robust, in many cases even for correlated electrons. Through high-bias shot-noise measurements on single Au atom point contacts, we find that the noise power in the high-bias regime shows highly non-linear ...


Imaging and electron energy-loss spectroscopy using single nanosecond electron pulses.

We implement a parametric study with single electron pulses having a 7 ns duration to find the optimal conditions for imaging, diffraction, and electron energy-loss spectroscopy (EELS) in the single-shot approach. Photoelectron pulses are generated by illuminating a flat tantalum cathode with 213 nm nanosecond laser pulses in a 200 kV transmission electron microscope (TEM) with thermionic gun and Wehnelt electrode. For the first time, an EEL spectrometer is used to measure the energy distribution of si...

Single-shot submicrosecond mid-infrared spectroscopy on protein reactions with quantum cascade laser frequency combs.

The kinetic analysis of irreversible protein reactions requires an analytical technique that provides access to time-dependent infrared spectra in a single shot. Here, we present a spectrometer based on dual frequency comb spectroscopy using mid-infrared frequency combs generated by quantum cascade lasers. Attenuation of the intensity of the combs by molecular vibrational resonances results in absorption spectra covering 55 cm in the fingerprint region. The setup has a native resolution of 0.3 cm, noise lev...


Single-shot real-time detection technique for pulse-front tilt and curvature of femtosecond pulsed beams with multiple-slit spatiotemporal interferometry.

Spatiotemporal coupling (STC) of femtosecond pulsed beams could significantly reduce the focal-spot intensity of ultra-intense lasers. We theoretically present a very simple method for single-shot real-time detecting pulse-front tilt, curvature, or tilt and curvature (PFT, PFC or PFT&PFC) by using multiple-slit spatiotemporal interferometry (MSTI). An unknown input pulsed beam is spatially cut by a high-density multiple-slit and changed into a series of spatially separated sub-pulses. By only measuring the ...

Single-shot time-gated fluorescence lifetime imaging using three-frame images.

Qualitative and quantitative measurements of complex flows demand for fast single-shot fluorescence lifetime imaging (FLI) technology with high precision. A method, single-shot time-gated fluorescence lifetime imaging using three-frame images (TFI-TGFLI), is presented. To our knowledge, it is the first work to combine a three-gate rapid lifetime determination (RLD) scheme and a four-channel framing camera to achieve this goal. Different from previously proposed two-gate RLD schemes, TFI-TGFLI can provide a ...

Shot-noise-limited Doppler-broadened noise-immune cavity-enhanced optical heterodyne molecular spectrometry.

Shot-noise-limited Doppler-broadened (Db) noise-immune cavity-enhanced optical heterodyne molecular spectrometry (NICE-OHMS) has been realized by implementation of balanced detection. A characterization of the system based on Allan-Werle plots of the absorption coefficient, retrieved by fitting a model function to data, shows that the system has a white noise equivalent absorption per unit length per square root of bandwidth of 2.3×10  cm Hz, solely 44% above the shot noise limit, and a detection sen...

Spatial resolution improvement of single-shot digital optical frequency comb-based Brillouin optical time domain analysis utilizing multiple pump pulses.

A spatial resolution improvement scheme for the digital optical frequency comb (DOFC)-based single-shot Brillouin optical time domain analysis (BOTDA) by utilizing multiple pump pulses is demonstrated. Assisted by four pump pulses, the spatial resolution can be improved by four times without decreasing the detection resolution. The response time, and the spatial resolution of our scheme over 10 km fiber, are 0.1 ms and 12.5 m. Distributed temperature and strain measurements are carried out with detection...

Sub-shot-noise-limited phase estimation via SU(1,1) interferometer with thermal states.

We theoretically study the phase sensitivity of an SU(1,1) interferometer with a thermal state and a squeezed vacuum state as inputs and parity detection as the measurement. We find that the phase sensitivity can beat the shot-noise limit and approaches the Heisenberg limit, with increasing input photon number, in an ideal situation. We also consider the effect of various noises, including photon loss, dark counts, and thermal photon noise. Our results show that the phase sensitivity is below the shot-noise...

Rapid and Comprehensive Single Shot Proteomics with LC-FAIMS-MS/MS.

Liquid chromatography pre-fractionation is often implemented to increase proteomic coverage; however, while effective, this approach is laborious, requires considerable sample amount, and can be cumbersome. We describe how interfacing a recently described High Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) device between a nanoESI-emitter and an Orbitrap hybrid mass spectrometer enables the collection of single shot proteomic data with comparable depth to conventional two-dimensional LC approac...

Photoionization delays in xenon using single-shot referencing in the collinear back-focusing geometry.

Attosecond photoemission delays for all the valence (5p, 5p, 5s, 4d, 4d) subshells of xenon have been accessed using the interferometric RABBITT technique. The 4d subshell delays in Xe have been accessed for the first time, to the best of our knowledge, due to the high photon energy used. A novel technique of single-shot referencing in the collinear back-focusing geometry has been introduced. This enables us to distinguish the signal from principal photoelectron peaks due to ionization by extreme ultraviole...

Audio-based performance evaluation of squash players.

In competitive sports it is often very hard to quantify the performance. A player to score or overtake may depend on only millesimal of seconds or millimeters. In racquet sports like tennis, table tennis and squash many events will occur in a short time duration, whose recording and analysis can help reveal the differences in performance. In this paper we show that it is possible to architect a framework that utilizes the characteristic sound patterns to precisely classify the types of and localize the posi...

Signal-to-noise ratio of single-pixel cameras based on photodiodes.

Single-pixel cameras have been successfully used in different imaging applications in the last years. One of the key elements affecting the quality of these cameras is the photodetector. Here, we develop a numerical model of a single-pixel camera, which takes into account not only the characteristics of the incident light but also the physical properties of the detector. In particular, our model considers the photocurrent, the dark current, the photocurrent shot noise, the dark-current shot noise, and the J...

Comparing learning curves of two established "single-shot" devices for ablation of atrial fibrillation.

We compared the contour of learning curves of two "single-shot" devices used for pulmonary vein isolation (PVI) for safety and procedural data.

Second-quarter biotech job picture.

Research biotech patenting 2017.

Gates unveils biotech-within-a-charity.

Public biotech in 2017-the numbers.

New Nonprofit Biotech From Bill and Melinda Gates.

UK newspaper reporting of the NHS cancer drugs fund, 2010 to 2015: a retrospective media analysis.

Objective We wished to explore how UK national newspapers had covered the creation and operation of the Cancer Drugs Fund from 2010 to 2015. This was introduced to provide cancer patients in England with access to drugs not appraised or approved by the National Institute for health and Care Excellence. Design We sought stories in nine newspapers from the Factiva database, and copied their salient details to a spreadsheet. They were categorised by whether they were supportive or critical of the Cancer Drugs ...

Continuous every-single-shot carrier-envelope phase measurement and control at 100  kHz.

With the emergence of high-repetition-rate few-cycle laser pulse amplifiers aimed at investigating ultrafast dynamics in atomic, molecular, and solid-state science, the need for ever faster carrier-envelope phase (CEP) detection and control has arisen. Here we demonstrate a high-speed, continuous, every-single-shot measurement and fast feedback scheme based on a stereo above-threshold ionization time-of-flight spectrometer capable of detecting the CEP and pulse duration at a repetition rate of up to 400 kH...

Triple Verification Network for Generalised Zero-shot Learning.

Conventional Zero-shot Learning approaches often suffer from severe performance degradation in the Generalised Zero-shot Learning (GZSL) scenario, i.e. to recognise test images that are from both seen and unseen classes. This paper studies the Class-level Over-fitting (CO) and empirically shows its effects to GZSL. We then address ZSL as a Triple Verification problem and propose a unified optimisation of regression and compatibility functions, i.e. two main streams of existing ZSL approaches. The complement...

Optical thickness measurement with single-shot dual-wavelength in-line digital holography.

An algorithm for quantitative reconstruction of the optical thickness distribution of objects is proposed based on single-shot dual-wavelength in-line digital holography. Two single-wavelength holograms can be extracted from a single-shot recorded dual-wavelength in-line hologram. The quantitative optical thickness distribution of the specimen can be reconstructed directly without calculations of the phase images at every single wavelength. Thus, off-axis recording and phase-shifting operation are not requi...

Suicidal shot in the mouth with rubber bullets.

Rubber bullets weapons can have tragic consequences when used at short range and on vulnerable body areas. A man in his forties was found deceased at his house, covered in blood. A "non-lethal" firearm was found near the bed: the «SAPL GC27». This is a single shot handgun with mini Gomm Cogne ammunition: 12 rubber spherical pellets, 7.4 mm in diameter. The findings were consistent with an intra buccal shot, and an ingestion-inhalation of blood and projectiles. Cause of the death was linked to both the h...

Single-shot noninterferometric measurement of the phase transmission matrix in multicore fibers.

A simple technique for far-field single-shot noninterferometric determination of the phase transmission matrix of a multicore fiber with over 100 cores is presented. This phase retrieval technique relies on the aperiodic arrangement of the cores.

Hilbert-Huang single-shot spatially multiplexed interferometric microscopy.

Hilbert-Huang single-shot spatially multiplexed interferometric microscopy (H2S2MIM) is presented as the implementation of a robust, fast, and accurate single-shot phase estimation algorithm with an extremely simple, low-cost, and highly stable way to convert a bright field microscope into a holographic one using partially coherent illumination. Altogether, H2S2MIM adds high-speed (video frame rate) quantitative phase imaging capability to a commercially available nonholographic microscope with improved pha...


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