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PubMed Journals Articles About "Hemogenyx Pharmaceuticals Announces Research Agreement With Global Pharma" RSS

16:58 EST 10th December 2019 | BioPortfolio

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Showing "Hemogenyx Pharmaceuticals Announces Research Agreement with Global Pharma" PubMed Articles 1–25 of 30,000+

III. THE ROLE OF THE RESEARCH ETHICS COMMITTEES IN THE REGULATION OF PHARMA-SPONSORED STUDIES.

Participants of Pharma-sponsored research are exposed to risks, benefits, and uncertainties that do not occur in other forms of clinical studies. Ethics committees represent the subjects' first line of protection. This responsibility begins with the study review and ends after all study subjects finish the intervention. The objective of this paper is to review the most common controversial issues found in Pharma-sponsored studies. Potential solutions are proposed to prevent or resolve the polemical aspects....


Mytilidae as model organisms in the marine ecotoxicology of pharmaceuticals - A review.

Growing production and consumption of pharmaceuticals is a global problem. Due to insufficient data on the concentration and distribution of pharmaceuticals in the marine environment, there are no appropriate legal regulations concerning their emission. In order to understand all aspects of the fate of pharmaceuticals in the marine environment and their effect on marine biota, it is necessary to find the most appropriate model organism for this purpose. This paper presents an overview of the ecotoxicologica...

Data science tools and applications on the way to Pharma 4.0.

Multiple obstacles are driving the digital transformation of the biopharmaceutical industry. Novel digital techniques, often marketed as 'Pharma 4.0', are thought to solve some long-existing obstacles in the biopharma life cycle. Pharma 4.0 concepts, such as cyberphysical systems and dark factories, require data science tools as technological core components. Here, we review current data science applications at various stages of the bioprocess life cycle, including their scopes and data sources. We are conv...


Coopetitive solutions of environmental agreements for the global economy after COP21 in Paris.

The decision of the 45th US president on June 1, 2017, to withdraw the United States of America from the COP21 Paris agreement caused a deep change in the environmental scenarios of the global economy, which risks moving away from the virtuous path of a green economy. The major conclusion of our model is to prove the existence of infinitely many economic scenarios in which a strong commitment towards the global green economy will allow gains for each country participating in a green deal project and guarant...

Systematic analysis of global health research funding in Canada, 2000-2016.

Considering recent shifts in global funding landscapes, this study analyzes Canada's long-term global health research funding trends in the hope of informing a new Canadian global health research strategy. Examining past investments can help prioritize limited future resources to either build on Canada's existing strengths or fill gaps where needed, while simultaneously informing the investments of research funders in other countries.

The Paris Agreement objectives will likely halt future declines of emperor penguins.

The Paris Agreement is a multinational initiative to combat climate change by keeping a global temperature increase in this century to 2°C above preindustrial levels while pursuing efforts to limit the increase to 1.5°C. Until recently, ensembles of coupled climate simulations producing temporal dynamics of climate en route to stable global mean temperature at 1.5 and 2°C above preindustrial levels were not available. Hence, the few studies that have assessed the ecological impact of the Paris Agreement ...

Sharing the costs and benefits of climate change mitigation via Shapley value.

This paper examines the free rider problem that exists in the joint effort to mitigate climate change. There is a need to develop a model that is stable and that provides evidence of an objective burden sharing rule so that the environmental agreement is more acceptable. This study approaches this problem via a cooperative game at the global level to make International Environmental Agreements (IEA) more stable. For this purpose, we apply the Shapley value transfer mechanism and find that under the commitme...

Occurrence and ranking of pharmaceuticals in the major rivers of China.

Residual pharmaceuticals have received widespread attention worldwide due to their continuous release and potential hazard to the environment. As a result of rapid development and a large population, China has become a country with high production and consumption of pharmaceuticals. This may be the main reason for the high detection frequencies and concentrations of pharmaceuticals in the aquatic environment in China. Rivers represent an important water resource and play an important role in the sustainable...

Analysis, occurrence and removal of pharmaceuticals in African water resources: A current status.

Pharmaceuticals are organic compounds used in medicines for alleviation of pain. Since 2017, there has been a steady increase on the availability of information on contamination of water resources caused by pharmaceuticals in some African countries. Thus far, most environmental monitoring studies of pharmaceuticals are conducted in South Africa while there is still no available data in majority of the African countries. Therefore, the knowledge on the presence of pharmaceuticals in African water resources i...

Landscape of Global Oncology Research and Training at National Cancer Institute-Designated Cancer Centers: Results of the 2018 to 2019 Global Oncology Survey.

The National Cancer Institute (NCI)-Designated Cancer Centers (NDCCs) are active in global oncology research and training, leading collaborations to support global cancer control. To better understand global oncology activities led by NDCCs, the NCI Center for Global Health collaborated with ASCO to conduct the 2018/2019 NCI/ASCO Global Oncology Survey of NDCCs.

Can real-world evidence save pharma US$1 billion per year? A framework for an integrated evidence generation strategy.

Sorption of ionic and neutral species of pharmaceuticals to loessial soil amended with biochars.

To clarify the impact of biochar amendment on soil sorption for coexisting pharmaceuticals, wheat straw-derived biochars pyrolyzed at 300 and 700 °C (labeled as WS300 and WS700, respectively) were prepared. Batch experiments on ketoprofen (KTP), atenolol (ATL) and carbamazepine (CBZ) sorption to biochars, loessial soil and biochar-amended soils were conducted. The results indicated that sorption affinity of different species of pharmaceuticals to WS300 and WS700 was in the order of cationic ATL > neutral C...

Prioritization of pharmaceuticals in water environment in China based on environmental criteria and risk analysis of top-priority pharmaceuticals.

Numerous studies have shown that a wide range of pharmaceuticals are present in the environment and many of their adverse biological effects on the aquatic ecosystem and human health are unknown. Due to the high population density and large number of pharmaceuticals produced and consumed in China, a systematic approach is needed to identify pharmaceuticals that require greater attention. The present study provides a ranking of pharmaceuticals in China in terms of their occurrence (O), persistence, bioaccumu...

Advances and limits of two model species for ecotoxicological assessment of carbamazepine, two by-products and their mixture at environmental level in freshwater.

In order to evaluate the environmental impacts associated with the presence of low-level of pharmaceuticals in waters, chronic ecotoxicity of carbamazepine (CBZ), oxcarbazepine (OxCBZ) and acridine 9-carboxylic acid (9-CAA) and their mixture was investigated using two species from different trophic levels. Innovative approaches were developed by monitoring: (i) phytometabolites in the duckweed Lemna minor L. and, (ii) alterations at the population, cellular and molecular levels on the cnidarian Hydra circum...

Occurrence and distribution of pharmaceuticals in raw, finished, and drinking water from seven large river basins in China.

The occurrence of pharmaceuticals in the drinking water is a growing concern in China. In this study, we determined the concentration and distribution of 59 selected pharmaceuticals in raw, finished, and tap water samples from 79 drinking water treatment plants (DWTPs) in 15 cities, encompassing seven large river basins in China, using solid-phase extraction pretreatment and ultra-high-performance liquid chromatography-tandem mass spectrometry analysis. Forty-seven pharmaceuticals were detected in raw water...

Global knowledge gaps in acute febrile illness etiologic investigations: A scoping review.

Acute febrile illness (AFI), a common reason for people seeking medical care globally, represents a spectrum of infectious disease etiologies with important variations geographically and by population. There is no standardized approach to conducting AFI etiologic investigations, limiting interpretation of data in a global context. We conducted a scoping review to characterize current AFI research methodologies, identify global research gaps, and provide methodological research standardization recommendation...

A cross-sectional study assessing agreement between self-reported and general practice-recorded health conditions among community dwelling older adults.

self-reported data regarding health conditions are utilised in both clinical practice and research, but their agreement with general practice records is variable. The extent of this variability is poorly studied amongst older adults, particularly amongst those with multiple health conditions, cognitive impairment or frailty. This study investigates the agreement between self-reported and general practice-recorded data amongst such patients and the impact of participant factors on this agreement.

Agreement and predictive power of six fall risk assessment methods in community-dwelling older adults.

A large number of fall risk assessment methods are available with a variety of performances for screening the risk of falling in older adults, but their agreement for assessing the risk of falling remains unknown. This observational prospective cohort study describes the agreement and predictive power of methods to classify the risk of falling in older adults using prospective data and published cut-off values. Fifty-two participants aged 74 years (interquartile range 69-80) were assessed using the Berg Bal...

How Should Schools Respond to Learners' Demands for Global Health Training?

In the past decade, more students than ever entered medical school with the desire, if not the expectation, of participating in meaningful global health experiences. Schools must now weigh benefits to students of global experiences against burdens of students' learning experiences on institutions and individuals with whom schools partner. Most often, global health training is done as offsite immersion rotations in research or clinical settings. This article explores ethical dimensions of expanding global he...

How to evaluate agreement between quantitative measurements.

When a method comparison study is performed, the aim is to evaluate the agreement of measurements of different methods. We present the Bland-Altman plot with limits of agreement as the correct analysis methodology. We also discuss other scaled and unscaled indices of agreement and commonly used inappropriate approaches.

Collection of Anti-Rheumatic Medication Data from Both Patients and Rheumatologists Shows Strong Agreement in a Real World Clinical Cohort: The Ontario Best Practices Research Initiative (OBRI) a Rheumatoid Arthritis Cohort.

To examine the agreement between patient and rheumatologist reported Anti-Rheumatic Medication (ARM) use in the Ontario Best Practices Research Initiative (OBRI).

Dose-dependent effects of acetate on the biodegradation of pharmaceuticals in moving bed biofilm reactors.

Moving bed biofilm reactors (MBBR) are promising as a post-treatment for removing pharmaceuticals from wastewater. However, the effect of easily degradable carbon sources on the degradation of pharmaceuticals is unclear. This study shows the influence of acetate on the degradation of 26 pharmaceuticals in an MBBR was dose- and compound-dependent: while the degradation of venlafaxine, tramadol and ciprofloxacin was promoted (increase of reaction rate constant (k) by 133%, 212%, 55%) by acetate, its presence ...

The CCGHR Principles for Global Health Research: Centering equity in research, knowledge translation, and practice.

Medical geography and global health share a fundamental concern for health equity. Both fields operate within similar multiple intersecting funding, academic, health systems, and development landscapes to produce scholarship. Both reflect complex interactions and partnerships between people, communities and institutions of unequal power. The Canadian Coalition of Global Health Research Principles for Global Health Research evolved from deep concern about the absence of standards for how Canadians engage in ...

Effects of diclofenac and salicylic acid exposure on Lemna minor: Is time a factor?

The global occurrence of pharmaceuticals in the aquatic environment has been considered a particularly concerning problem with unknown consequences. Non-steroidal anti-inflammatory drugs (NSAIDs) including diclofenac (DCF) and salicylic acid (SA), are among the most frequently prescribed drugs in the world, being consequently commonly found in the aquatic environment. Prolonged experiments (with duration of exposure that surpass those recommended by already established testing guidelines) are important to o...

Rutgers Center of Alcohol Studies Announces New Name.


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