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PubMed Journals Articles About "Hemogenyx Pharmaceuticals Announces Total Voting Rights" RSS

15:46 EST 18th January 2020 | BioPortfolio

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Showing "Hemogenyx Pharmaceuticals Announces Total Voting Rights" PubMed Articles 1–25 of 16,000+

An Accurate and Efficient Voting Scheme for a Maximally All-Inlier 3D Correspondence Set.

We present a highly accurate and efficient, yet simple, two-stage voting scheme for distinguishing inlier 3D correspondences by densely assessing and ranking their local and global geometric consistencies. The strength of the proposed method stems from both the novel idea of post-validated voting set, as well as single-point superimposition transforms, which are computationally cheap and avoid rotational ambiguities. Using a well-known dataset consisting of various 3D models and numerous scenes that include...


Occurrence and ranking of pharmaceuticals in the major rivers of China.

Residual pharmaceuticals have received widespread attention worldwide due to their continuous release and potential hazard to the environment. As a result of rapid development and a large population, China has become a country with high production and consumption of pharmaceuticals. This may be the main reason for the high detection frequencies and concentrations of pharmaceuticals in the aquatic environment in China. Rivers represent an important water resource and play an important role in the sustainable...

Analyzing a networked social algorithm for collective selection of representative committees.

A recent work (Hernández, et al., 2018) introduced a networked voting rule supported by a trust-based social network, where indications of possible representatives were based on individuals opinions. Individual contributions went beyond a simple vote-counting and were based on proxy voting. This mechanism selects committees with high levels of representativeness, weakening the possibility of patronage relations. By incorporating the integrity of individuals and its perception, we here address the question ...


Prioritization of pharmaceuticals in water environment in China based on environmental criteria and risk analysis of top-priority pharmaceuticals.

Numerous studies have shown that a wide range of pharmaceuticals are present in the environment and many of their adverse biological effects on the aquatic ecosystem and human health are unknown. Due to the high population density and large number of pharmaceuticals produced and consumed in China, a systematic approach is needed to identify pharmaceuticals that require greater attention. The present study provides a ranking of pharmaceuticals in China in terms of their occurrence (O), persistence, bioaccumu...

An Approach for Using In Vitro and In Silico Data to Identify Pharmaceuticals with Potential (Anti-)Estrogenic Activity in Aquatic Vertebrates at Environmentally Relevant Concentrations.

Endocrine-active pharmaceuticals can cause adverse reproductive and developmental effects in non-target organisms. Aquatic vertebrates may be susceptible to the effects of such pharmaceuticals given that the structure of hormone receptors and the physiology of the endocrine system are highly conserved across vertebrates. To aid in the regulatory review of the environmental impact of drugs, we demonstrate an approach to screen and support the prioritization of pharmaceuticals based on their ability to intera...

Comparison of the regulatory outline of ecopharmacovigilance of pharmaceuticals in Europe, USA, Japan and Australia.

Pharmaceuticals are known to improve the quality of life by curing and preventing diseases. However, these pharmaceutical products, when it diffuses through the environment by various routes, can cause severe harmful effects to the living organisms. During the last several years, the coping with the impact of pharmaceuticals on the environment was one of the challenging tasks for the pharmaceutical industries. These concerns about the environmental health and safety risks paved the way in developing a prope...

Postmaterialism and referenda voting to legalize marijuana.

This analysis of county-level voting on 22 state referenda that sought to legalize marijuana for medical purposes or recreational use is driven by hypotheses from post-materialism theory. Separate regression models for each type of policy largely, though not entirely, support our expectations. Voting to legalize both medical and recreational marijuana was greater in counties with larger college-educated populations, a partisan preference for Democratic presidential candidates, and smaller percentages of Cat...

Mytilidae as model organisms in the marine ecotoxicology of pharmaceuticals - A review.

Growing production and consumption of pharmaceuticals is a global problem. Due to insufficient data on the concentration and distribution of pharmaceuticals in the marine environment, there are no appropriate legal regulations concerning their emission. In order to understand all aspects of the fate of pharmaceuticals in the marine environment and their effect on marine biota, it is necessary to find the most appropriate model organism for this purpose. This paper presents an overview of the ecotoxicologica...

Analysis, occurrence and removal of pharmaceuticals in African water resources: A current status.

Pharmaceuticals are organic compounds used in medicines for alleviation of pain. Since 2017, there has been a steady increase on the availability of information on contamination of water resources caused by pharmaceuticals in some African countries. Thus far, most environmental monitoring studies of pharmaceuticals are conducted in South Africa while there is still no available data in majority of the African countries. Therefore, the knowledge on the presence of pharmaceuticals in African water resources i...

Volumetric Histogram-Based Alzheimer's Disease Detection Using Support Vector Machine.

In this research work, machine learning techniques are used to classify magnetic resonance imaging brain scans of people with Alzheimer's disease. This work deals with binary classification between Alzheimer's disease and cognitively normal. Supervised learning algorithms were used to train classifiers in which the accuracies are being compared. The database used is from The Alzheimer's Disease Neuroimaging Initiative (ADNI). Histogram is used for all slices of all images. Based on the highest performance, ...

Biological-activity-based prioritization of pharmaceuticals in wastewater for environmental monitoring: G protein-coupled receptor inhibitors.

Pharmaceuticals raise concerns for aquatic species owing to their biological activities. It is estimated that nearly 40% of marketed pharmaceuticals target G protein-coupled receptors (GPCRs). Using an in vitro transforming growth factor-α (TGFα) shedding assay, we previously detected antagonistic activities of GPCR-acting pharmaceuticals against angiotensin (AT1), dopamine (D2), acetylcholine (M1), adrenergic family members (β1), and histamine (H1) receptors at up to μg-antagonist-equivalent quantities...

Voting for Distortion Points in Geometric Processing.

Low isometric distortion is often required for mesh parameterizations. A configuration of some vertices, where the distortion is concentrated, provides a way to mitigate isometric distortion, but determining the number and placement of these vertices is non-trivial. We call these vertices distortion points. We present a novel and automatic method to detect distortion points using a voting strategy. Our method integrates two components: candidate generation and candidate voting. Given a closed triangular mes...

Selecting Essential MicroRNAs Using a Novel Voting Method.

Among the large number of known microRNAs (miRNAs), some miRNAs play negligible roles in cell regulation. Therefore, selecting essential miRNAs is an important initial step for a deeper understanding of miRNAs and their functions. In this study, we generated 60 classification models by combining 12 representative feature extraction methods and 5 commonly used classification algorithms. The optimal model for essential miRNA classification that we obtained is based on the Mismatch feature extraction method co...

Biological removal of pharmaceuticals by Navicula sp. and biotransformation of bezafibrate.

Pharmaceutically active compounds are of great concern due to their detection frequency in the environment and the unexpected risks. In this study, the simultaneous removal of mixed pharmaceuticals by microalgae was explored using a typical freshwater diatom Navicula sp. Results showed that Navicula sp. could efficiently remove atenolol, carbamazepine, ibuprofen and naproxen with the efficiencies of >90% after 21 d of exposure. As compared to the removal efficiencies of each pharmaceutical in the individu...

Identifying targets of potential concern by a screening level ecological risk assessment of human use pharmaceuticals in China.

The pollution of pharmaceuticals has attracted a lot of concerns during recent years. The goal of this study was to identify targets of ecological concern considering human use pharmaceuticals marketed in China. We constructed a database for 593 active pharmaceutical ingredients (APIs) by collecting their information on use and emission (e.g. production, human excretion, and removal by wastewater treatment) to calculated predicted environmental concentrations (PECs) by using an adapted European Medicines Ag...

Low concentrations of the benzodiazepine drug oxazepam induce anxiolytic effects in wild-caught but not in laboratory zebrafish.

Pollution by psychoactive pharmaceuticals has been found to disrupt anti-predator behaviors of wild fish. The challenge is now to identify which of the many psychoactive drugs pose the greatest threat. One strategy is to screen for behavioral effects of selected pharmaceuticals using a single, widely available fish species such as zebrafish. Here, we show that although such high-throughput behavioral screening might facilitate comparisons between pharmaceuticals, the choice of strain is essential. While wil...

Sorption of ionic and neutral species of pharmaceuticals to loessial soil amended with biochars.

To clarify the impact of biochar amendment on soil sorption for coexisting pharmaceuticals, wheat straw-derived biochars pyrolyzed at 300 and 700 °C (labeled as WS300 and WS700, respectively) were prepared. Batch experiments on ketoprofen (KTP), atenolol (ATL) and carbamazepine (CBZ) sorption to biochars, loessial soil and biochar-amended soils were conducted. The results indicated that sorption affinity of different species of pharmaceuticals to WS300 and WS700 was in the order of cationic ATL > neutral C...

Distribution and ecological risk of pharmaceuticals in surface water of the Yeongsan river, Republic of Korea.

This study examined the distribution of pharmaceuticals in Yeongsan River and at point sources (PSs) in the associated water system, and performed a risk assessment based on our findings. The samples included effluents collected from three sewage treatment plants (PS1, PS2, and PS3) and two industrial complexes (PS4 and PS5) as well as surface water collected from seven mainstreams and 11 tributaries of the river. The target pharmaceuticals were acetylsalicylic acid, carbamazepine, clarithromycin, naproxen,...

Single and mixture toxicity of four pharmaceuticals of environmental concern to aquatic organisms, including a behavioral assessment.

Pharmaceuticals are frequently detected in aquatic environments as mixtures and can cause toxic effects to non-target organisms. We aimed to evaluate the single and mixture effects of the pharmaceuticals metformin, bisoprolol, ranitidine and sotalol using Daphnia similis and Danio rerio. In addition, we aimed to test the predictive accuracy of the mathematical models concentration addition and independent action and to evaluate the nature of the possible toxicological interactions among these pharmaceutical...

VAMP (Voting Agent Model of Preferences): A computational model of individual multi-attribute choice.

This paper proposes an original account of decision anomalies and a computational alternative to existing dynamic models of multi-attribute choice. To date, most models attempting to account for the "Big Three" decision anomalies (similarity, attraction, and compromise effects) are variants of evidence accumulation models, or rational Bayesian analysis. This paper provides an existence proof of a new approach in the form of a multi-agent system based on the principles of voting geometry. Assuming there are ...

Rutgers Center of Alcohol Studies Announces New Name.

Insights into the isotherm and kinetic models for the coadsorption of pharmaceuticals in the absence and presence of metal ions: A review.

Pharmaceuticals are a wide class of emerging pollutants due to their continuous and the increasing consumption of users. These pollutants are usually found in the real environment as mixtures alone or with metal ions. Thus, the migration risk increases, which complicates the removal of pharmaceuticals because of the combined and synergistic effects. The focus of treatment of pharmaceutical mixtures and their coexistence with metals is of considerable importance. For this purpose, adsorption has been efficie...

Firearm Policy: Physician Organizations' Role in Political Action Committee Funds, 2018.

To compare donations to individual politicians from physician organization political action committees (PACs) and from the National Rifle Association Political Victory Fund (NRA PVF) in 2018. We identified 7 organizations with published firearm injury prevention policy. We determined the difference in funds received from physician organization PACs and the NRA PVF for each congressmember. We examined their voting records on firearm-related legislation. A total of 141 congressmembers received funds from both...

The American Association for Bronchology and Interventional Pulmonology Announces the First Certificate of Added Qualification in Advanced Diagnostic Bronchoscopy.

The people have spoken: Post-materialism and ballot measure voting on physician aid in dying (PAD).

For decades, public opinion polls have shown that most Americans favor physician aid in dying (PAD) but little is known about those who support PAD ballot measures. With its emphasis on self-fulfillment, personal choice, and civic and political engagement, post-materialists would argue that adopting states tend to have younger, educated, and more secular populations. County-level votes on all nine ballot measures to legalize death with dignity were subjected to multiple regression analysis. The results larg...


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