PubMed Journals Articles About "Human Medicines European Public Assessment Report EPAR Kevzara∨derfield=score∨derval=DESC" RSS

02:44 EDT 19th July 2019 | BioPortfolio

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Showing "Human medicines European public assessment report EPAR Kevzara" PubMed Articles 1–25 of 44,000+

Broad-spectrum antibiotic use in Europe: more evidence of cultural influences on prescribing behaviour.

Sociocultural factors have been hypothesized as important drivers of inappropriate antibiotic prescribing in European ambulatory care. This study sought to assess whether they can also explain the reported variation in broad-spectrum antibiotic (Br-Ab) use among EU/European Economic Area (EEA) countries.

Assessment of Routine Esophagram for Detecting Anastomotic Leak After Esophagectomy.

Pharmacist Compliance With Therapeutic Guidelines on Diagnosis and Treatment Provision.

Misuse and overselling of over-the-counter pharmaceuticals poses a major burden on both private and public health expenditures.

Assessment of Medicaid Beneficiaries Included in Community Engagement Requirements in Kentucky.

States are pursuing Section 1115 Medicaid demonstration waiver authority to apply community engagement (CE) requirements (eg, participation in work, volunteer activities, or training) to beneficiaries deemed able-bodied as a condition of coverage. Understanding the size and characteristics of the populations included in these requirements can help inform policy initiatives and anticipate effects.

Infant bed sharing in Canada.

There is debate about the practice of bed sharing, which is defined as sharing a sleep surface with an infant. Most public health guidance in Canada, including the 2011 Joint Statement on Safe Sleep, advises parents against it because of an association with infant injury and death. However, proponents cite potential physical and psychological benefits, and evidence suggests that the risks associated with bed sharing are low in the absence of other risk factors. Until now, little has been known about the pre...

Risk of bleeding and thrombosis in inherited qualitative fibrinogen disorders.

Inherited dysfibrinogenemia is a rare disorder, for which clinical studies related to the risk of bleeding or thrombosis and the type of causative mutation are scanty.

Enzyme Mimic Basing on Self-assembled Chitosan/DNA Hybrid Exhibits Superior Activity and Tolerance.

Nature has evolved exquisite active sites with which enzymes catalyze biotransformations with high efficiency. However, the exploitation of natural enzymes is often hampered by poor stability and natural enzyme production and purification are costly. Supramolecular self-assembly allows one to construct biomimetic active sites, although it is challenging to produce such artificial enzymes with catalytic activity and stability that rivals those of natural enzymes. In this work, we report a modular strategy to...

Sunlight selectively modifies Maillard reaction products in a wide array of chemical reactions.

We report the photochemical transformation of Maillard reaction products (MRPs) under simulated sunlight into mostly unexplored photoproducts. Non-enzymatic glycation of amino acids leads to a heterogeneous class of intermediates with extreme chemical diversity, which is of particular relevance in processed and stored food products as well as in diabetic and age-related protein damage. We here reacted three amino acids (lysine, arginine, and histidine) with ribose at 100 °C for ten hours. Exposing these mo...

Does older adults' use of social care influence their healthcare utilisation? A systematic review of international evidence.

Improving our understanding of the complex relationship between health and social care utilisation is vital as populations age. This systematic review aimed to synthesise evidence on the relationship between older adults' use of social care and their healthcare utilisation. Ten databases were searched for international literature on social care (exposure), healthcare use (outcome) and older adults (population). Searches were carried out in October 2016, and updated May 2018. Studies were eligible if they we...

Developmental horizons in the pre-natal development of the Greater cane rat (Thryonomys swinderianus).

The Greater cane rat (GCR, Thyronomys swinderianus) is a precocial rodent predominantly found within Africa. Economic and scientific interests have led to several research efforts towards the domestication and better understanding of the biology and development of this rodent. Despite these efforts, information on the pre-natal development of this rodent is currently lacking. This study characterises distinct developmental milestones including skin pigmentation, emergence and distributions of hairs, calvari...

Occupational contact dermatitis due to rosewood in an indigenous Basque flute ("txistu").

Allergic contact dermatitis caused by trees of the genus Dalbergia is infrequent (1). We report the case of a young musician who suffered from occupational contact dermatitis caused by a wooden mouthpiece made of this genus. This article is protected by copyright. All rights reserved.

C7orf59/Lamtor4 phosphorylation and structural flexibility modulate Ragulator assembly.

Ragulator is a pentamer composed of p18, MP1, p14, C7orf59 and HBXIP (LAMTOR 1 - 5) which acts as a lysosomal scaffold of the Rag GTPases in the amino acid sensitive branch of TORC1 signaling. Here we present the crystal structure of human HBXIP-C7orf59 dimer (LAMTOR 4/5) at 2.9Å and identify a phosphorylation site on C7orf59 which modulates its interaction with p18. Additionally, we demonstrate the requirement of HBXIP-C7orf59 to stabilize p18 and allow further binding of MP1-p14. The structure of the dim...

The draft genome of a wild barley genotype reveals its enrichment in genes related to biotic and abiotic stresses compared to cultivated barley.

Wild barley (Hordeum spontaneum) is the progenitor of cultivated barley (H. vulgare) and provides a rich source of genetic variations for barley improvement. Currently, the genome sequences of wild barley and its differences with cultivated barley remain unclear. In this study, we report a high-quality draft assembly of wild barley accession (AWCS276; henceforth named as WB1), which consists of 4.28 Gb genome and 36,395 high-confidence protein coding genes. BUSCO analysis revealed that the assembly included...

Direct visualization of single nuclear pore complex proteins using genetically-encoded probes for DNA-PAINT.

The Nuclear Pore Complex (NPC) is one of the largest and most complex protein assemblies in the cell and - among other functions - serves as the gatekeeper of nucleocytoplasmic transport. Unraveling its molecular architecture and functioning has been an active research topic for decades with recent cryogenic electron microscopy and super-resolution studies advancing our understanding of the NPC's complex architecture. However, the specific and direct visualization of single copies of NPC proteins is thus fa...

Characterization of epidermal growth factor receptor (EGFR) P848L, an unusual EGFR variant present in lung cancer patients, in a murine Ba/F3 model.

Lung cancer patients with mutations in epidermal growth factor receptor (EGFR) benefit from treatments targeting tyrosine kinase inhibitors (TKIs). However, both intrinsic and acquired resistance of tumors to TKIs are common, and EGFR variants have been identified that are resistant to multiple TKIs. In the present study, we characterized selected EGFR variants previously observed in lung cancer patients and expressed in a murine bone marrow pro-B Ba/F3 cell model. Among these EGFR variants, we report that ...

All that fails to abduct may not be an abducens palsy.

The authors enjoyed the case report by Singh et al. of a low flow carotid cavernous fistula producing defective abduction in one eye..

Big data in nephrology: are we ready for the change?

Chronic kidney disease (CKD) is a major public health issue worldwide. However, the status of kidney health care needs to be strengthened globally and research evidence in nephrology is relatively limited. The unmet needs in nephrology leave ample space for imagination regarding leveraging big data and artificial intelligence (AI). Big data has potential to drive medical innovation, reduce medical costs and improve health care quality. Compared with other specialties such as cardiology, the scopes of utiliz...

Research paradigms and the politics of nursing knowledge: A reflective discussion.

A standard view would suggest that research is a neutral apolitical activity. It neutralizes external pressures by its fidelity to robust scientific methods. However, politics is an inevitable part of human knowledge. Our knowledge of the world is always mediated by human priorities. What matters is therefore a contested and political debate rather a neutral accumulation of factual data. How researchers manage this varies. Research paradigms are one way in which research engages with knowledge. They frame k...

Adverse effects of bevacizumab in metastatic colorectal cancer : a case report and literature review.

Colorectal cancer is one of the most frequently diagnosed malignancies worldwide. One of the most important developments in the management of metastatic colorectal cancer is targeted therapy. Bevacizumab, a monoclonal antibody inhibiting VEGF induced angiogenesis, has been accepted as safe and efficient in the treatment of metastatic colorectal cancer for more than a decade. Addition of bevacizumab to fluorouracil-based chemotherapy is also associated with severe adverse events. We present a case of bevaciz...

Cheilitis granulomatosa and Crohn's disease : a case report.

In this case report we describe the evolution of Cheilitis granulomatosa (GC) in a young patient with Crohn's disease during treatment with anti-TNF-alfa therapy.

Colorectal cribriform comedo-type adenocarcinoma: a distinct subtype with poor prognosis?

Colorectal cancer is one of the most commonly diagnosed cancers in the world. It is a heterogeneous disease with several histologic subtypes, and some of them are associated with adverse prognostic factors. Cribriform comedo-type adenocarcinoma (CCA) has been included as a colorectal adenocarcinoma subtype in the last World Health Organization (WHO) classification of gastrointestinal system tumors. Some authors have linked this subtype to an adverse prognosis, but to the best of our knowledge there is only ...

Correlates of secondhand smoke exposure in public and private settings in Mexico. Encodat 2016.

To assess the correlates of secondhand smoke exposure (SHS) in public and private settings.

Health innovation in Mexico: important challenges and a long road to walk.

The transfer of technology from health research institutions to businesses that develop new medical treatments has generated great benefits for public health at a global level. Mexico however, is lagging in innovation indicators. There are important cultural, regulatory, and financial barriers that limit innovation in Mexico. However recent years have seen the appearance of several useful initiatives that constitute progress in the right direction. This work provides a brief overview of the current situatio...

Molecular Design Strategies for Color Tuning of Blue TADF Emitters.

New thermally activated delayed fluorescence (TADF) blue emitter molecules based on the known donor-acceptor-donor (D-A-D)-type TADF molecule, 2,7-bis(9,9-dimethylacridin-10-yl)-9,9-dimethylthioxanthene-,-dioxide (DDMA-TXO2), are reported. The motivation for the present investigation is via the use of rational molecular design, based on DDMA-TXO2, to elevate the organic light emitting diode (OLED) performance and obtain deeper blue color coordinates. To achieve this goal, the strength of the donor (D) unit ...

Quantification of Opioids in Urine using an Aptamer-based Free-solution Assay.

The opioid epidemic continues in the United States. Many have been impacted by this epidemic including neonates who exhibit Neonatal Abstinence Syndrome (NAS). Opioid diagnosis and NAS can be negatively impacted by limited testing options outside the hospital, due to poor assay performance, false-negatives, rapid drug clearance rates, and difficulty in obtaining enough specimen for testing. Here we report a small volume urine assay for oxycodone, hydrocodone, fentanyl, noroxycodone, norhydrocodone, and norf...

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