Advertisement

Topics

PubMed Journals Articles About "Hutchison China Meditech Limited Positive Fruquintinib Pivotal Phase" RSS

19:55 EDT 20th September 2018 | BioPortfolio

Hutchison China Meditech Limited Positive Fruquintinib Pivotal Phase PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Hutchison China Meditech Limited Positive Fruquintinib Pivotal Phase articles that have been published worldwide.

More Information about "Hutchison China Meditech Limited Positive Fruquintinib Pivotal Phase" on BioPortfolio

We have published hundreds of Hutchison China Meditech Limited Positive Fruquintinib Pivotal Phase news stories on BioPortfolio along with dozens of Hutchison China Meditech Limited Positive Fruquintinib Pivotal Phase Clinical Trials and PubMed Articles about Hutchison China Meditech Limited Positive Fruquintinib Pivotal Phase for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Hutchison China Meditech Limited Positive Fruquintinib Pivotal Phase Companies in our database. You can also find out about relevant Hutchison China Meditech Limited Positive Fruquintinib Pivotal Phase Drugs and Medications on this site too.

Showing "Hutchison China Meditech Limited Positive Fruquintinib Pivotal Phase" PubMed Articles 1–25 of 18,000+

Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase II Study of Fruquintinib After Two Prior Chemotherapy Regimens in Chinese Patients With Advanced Nonsquamous Non‒Small-Cell Lung Cancer.

Purpose Patients with advanced non‒small-cell lung cancer (NSCLC) who fail two lines of chemotherapy have unmet medical needs. The kinase inhibitor fruquintinib selectively targets vascular endothelial growth factor receptors and, hence, tumor angiogenesis and lymphogenesis. This randomized, double-blind, placebo-controlled, multicenter phase II trial evaluated the efficacy and safety of fruquintinib in patients with advanced nonsquamous NSCLC who experienced disease progression after second-line chemothe...


Factors associated with disclosing men who have sex with men (MSM) sexual behaviors and HIV-positive status: A study based on a social network analysis in Nanjing, China.

We explored the factors associated with disclosure of men who have with sex with men (MSM) behaviors and HIV-positive status among HIV-positive MSM in Nanjing, China.

Interannual changes in zooplankton echo subtropical and high latitude climate effects in the southern East China Sea.

Climate variability plays a central role in the dynamics of marine pelagic ecosystems shaping the structure and abundance changes of plankton communities, thereby affecting energy pathways and biogeochemical fluxes in the ocean. Here we have investigated complex interactions driven a climate-hydrology-plankton system in the southern East China Sea over the period 2000 to 2012. In particular, we aimed at quantifying the influence of climate phenomena playing out in tropical (El Nino 3.4) and middle-high lati...


Epidemiology and ARIMA Model of Positive-Rate of Influenza Viruses among Children in Wuhan, China: A Nine-Year Retrospective Study.

Influenza is a common childhood disease and protecting children by predicting the positive rate of influenza virus is important as vaccines are not routinely administered in China. Our study aims to describe the epidemiology of influenza viruses among children in Wuhan, China during the past nine influenza seasons (2007-2015) and to predict the positive rate of different types of influenza virus in the future.

First detection and molecular identification of Borrelia species in Bactrian camel (Camelus bactrianus) from Northwest China.

Comprehensive epidemiological surveys for Lyme disease have not been conducted for the Bactrian camel in China. In this study, a total of 138 blood specimens collected from Bactrian camels from Zhangye City in Gansu Province and Yili and Aksu in Xinjiang Province, China, were examined for the presence of Borrelia spp. Species-specificity nested PCR based on the 5S-23S rRNA, OspA, flaB and 16S rRNA genes revealed that the total positive rate of Borrelia spp. was 3.6% (5/138, 95% CI = 0.2-17.9). These res...

A comparison between phase-III trials and a phase-IV study of nalmefene in alcohol use disorder patients. Is there a difference?

Concerns regarding the external validity of phase-III trials are common to many medical disciplines, with relevant discrepancies found between experimental and clinical samples in some diseases such as hypertension. The aim of this study was to compare the samples included in the pivotal, phase-III clinical trials of nalmefene with that of a recently conducted phase-IV trial. Baseline characteristics of the studies were compared through univariate analysis. Significant differences were found in the percenta...

The Detection of progressive and regressive phase and Line-1 retrotransposon in transfected dogs with transmissible venereal tumor during chemotherapy.

Canine transmissible venereal tumor (CTVT) is a tumor that commonly occurs in genital and extragenital sites of both genders. Long Interspersed Nuclear Elements (LINE-1) retrotransposon has the pivotal role in allogenic transfection amongst uncontrolled dog population. In the study, it is aimed to evaluate pathomorphological, immunohistochemical and in-situ-PCR (Polymerase Chain Reaction) of CTVT (n:18) in transfected dogs during chemotherapy. Immunohistochemically, the phases of the tumor were investigated...

Toxoplasma gondii and Neospora caninum in Tolai Hares (Lepus tolai) Intended for Human Consumption in China: Seroprevalence, DNA Detection, and Genotyping.

Currently, there is no information available on the detection of Toxoplasma gondii and Neospora caninum in the tissues of Tolai hares in China. This study aimed to investigate the prevalence of these protozoan parasites in Tolai hares obtained from Shandong province, eastern China, between January 2016 and June 2017. Serum and brain tissue samples of 358 Tolai hares were obtained and detected for the presence of antibody and parasite DNAs by serodiagnosis and polymerase chain reaction (PCR), respectively. T...

Molecular Identification of Rickettsia Species in Haemaphysalis Ticks Collected from Southwest China.

Rickettsia species are obligate intracellular Gram-negative bacteria that can infect a wide range of vertebrate hosts, including humans, through arthropod vectors such as Ixodid ticks. These ticks are a threat to humans and animals because they are the primary vectors or reservoirs for rickettsiae, which is of public health importance. In this study, we report the identification and percent of positive of Rickettsia spp. in ticks collected from Cangxi County, Southwest China. Haemaphysalis longicornis compr...

Detection of West Nile Virus Infection in Viral Encephalitis Cases, China.

This study detected West Nile virus (WNV) infection in serum samples of patients clinically diagnosed with viral encephalitis in the Japanese encephalitis virus (JEV) endemic area (seven provinces) and JEV nonendemic area (Xinjiang province) in China from 2011 to 2012. In JEV endemic areas, there were 22 positive cases of WNV immunoglobulin M (IgM) antibody in serum specimens of 65 JEV patients (JEV IgM antibody positive) in the acute phase, whereas WNV IgM antibodies were not detected in serum specimens of...

Faecal carriage of optrA-positive enterococci in asymptomatic healthy humans in Hangzhou, China.

To investigate the faecal carriage of optrA-positive enterococci among asymptomatic healthy humans in Hangzhou, China, and to characterize the genetic context of optrA.

Multidrug-resistant Shigella sonnei carrying plasmid-mediated mcr-1 gene in China.

Since the plasmid-mediated polymyxin resistance gene mcr-1 was first reported in Escherichia coli and Klebsiella pneumoniae in China, only one mcr-1-positive isolate of Shigella sonnei, containing inactivated mcr-1, has been reported worldwide. Here, we screened 1650 historical S. sonnei strains isolated from 2003 to 2015 in China for mcr-1. We determined the antimicrobial susceptibilities and resistance genes of mcr-1-positive isolates and investigated the transferability of polymyxin resistance by plasmid...

Characterization of the complete sequences and stability of plasmids carrying the genes aac(6')-Ib-cr or qnrS in Shigella flexneri in the Hangzhou area of China.

The aim of this study was to explore the fluoroquinolone resistance mechanism of aac (6')-Ib-cr and qnrS gene by comparing complete sequences and stability of the aac(6')-Ib-cr- and qnrS-positive plasmids from Shigella isolates in the Hangzhou area of China. The complete sequences of four newly acquired plasmids carrying aac(6')-Ib-cr or qnrS were compared with those of two plasmids obtained previously and two similar reference Escherichia coli plasmids. The results showed that the length, antibiotic resist...

Hepatitis B virus serosurvey and awareness of mother-to-child transmission among pregnant women in Shenyang, China: An observational study.

Preventing hepatitis B virus (HBV) mother-to-child transmission (MTCT) is the key to controlling the prevalence of chronic HBV infection. Adequate awareness of hepatitis B in hepatitis B s antigen (HBsAg) positive pregnant women may be helpful to reduce HBV MTCT.The aim of this study was to explore HBV seroprevalence among pregnant women and investigate the level of hepatitis B awareness among HBsAg positive pregnant women.HBV serum biomarkers were tested among pregnant women visiting Shengjing Hospital of ...

A systematic review and meta-analysis of the epidemiology of bovine viral diarrhea virus (BVDV) infection in dairy cattle in China.

Bovine viral diarrhea virus (BVDV) infection causes significantly economic losses to cattle industry worldwide, also including China. The epidemiological prevalence of infection associated with BVDV in dairy cattle has not been systematically assessed in China. Therefore, we undertook this study to evaluate prevalent of BVDV infection. We conducted a systematic review and meta-analysis of data from papers on the BVDV incidence and prevalence in dairy cattle in China by searching China Science and Technology...

Molecular detection and genetic diversity of Theileria orientalis in cattle in China.

The apicomplexan parasite Theileria orientalis is a tick-borne intracellular protozoan parasite that is widely distributed throughout China. It causes bovine theileriosis in infected cattle, which results in huge economic losses to the cattle industry. In this study, the infection status of T. orientalis was determined in 260 blood samples from cattle from seven provinces across China. Results of a major piroplasm surface protein (MPSP)-PCR assay revealed that an average of 36.5% (95/260) of cattle was posi...

China's science, technology, engineering, and mathematics (STEM) research environment: A snapshot.

In keeping with China's President Xi Jinping's "Chinese Dream," China has set a goal of becoming a world-class innovator by 2050. China's higher education Science, Technology, Engineering, and Math (STEM) research environment will play a pivotal role in influencing whether China is successful in transitioning from a manufacturing-based economy to an innovation-driven, knowledge-based economy. Past studies on China's research environment have been primarily qualitative in nature or based on anecdotal evidenc...

Spatiotemporal evolution of carbon sequestration vulnerability and its relationship with urbanization in China's coastal zone.

Carbon sequestration plays a vital role in maintaining the stability of global climate and the carbon cycle, but is undergoing significant changes due to urbanization. This study proposes the concept of carbon sequestration vulnerability (CSV), and explores the spatiotemporal evolution of CSV and its relationship between urbanization in China's coastal zone from 2000 to 2010. The study results provide a scientific basis for government management and policy-making. The results showed that the average amount ...

Prevalence of Neospora spp. in donkeys in China.

This study was conducted to detect specific anti-Neospora antibodies using a commercial competitive-inhibition ELISA kit, and to evaluate the risk factors for Neospora spp. infection. Out of a total of 2,228 donkey sera collected in three provinces in China, 211 (9.5%) were found to be positive for anti-Neospora antibodies. Statistical analysis revealed that age (p = 0.019, OR = 1.62, 95%CI: 1.08-2.44), feeding status (p 

Cyclosporine-insensitive mode of cell death after prolonged myocardial ischemia: Evidence for sarcolemmal permeabilization as the pivotal step.

A prominent theory of cell death in myocardial ischemia/reperfusion (I/R) posits that the primary and pivotal step of irreversible cell injury is the opening of the mitochondrial permeability transition (MPT) pore. However, the predominantly positive evidence of protection against infarct afforded by the MPT inhibitor, Cyclosporine A (CsA), in experimental studies is in stark contrast with the overall lack of benefit found in clinical trials of CsA. One reason for the discrepancy might be the fact that rela...

A world of difference? Domain-specific views on aging in China, the US, and Germany.

Research on cross-national differences in views on aging has often focused on a comparison between Asian and Western countries. However, the results are mixed showing either more positive views in Asia, no difference at all, or even more positive views in Western countries. A potential moderator of country differences that might explain some of the heterogeneity is the fact that views on aging differ in their content and valence depending on life domains such as health versus family relations. Therefore, ou...

Genetic characteristics of H9N2 avian influenza viruses isolated from free-range poultry in Eastern China, in 2014-2015.

Circulating H7N9 influenza viruses in live poultry markets continue to pose a threat to human health. Free-range poultry, one of the sources for these markets, are common in China as well as in many developing countries. Because the H9N2 virus could be a source of internal genes for the H7N9 virus, we conducted surveillance in free-range poultry and live poultry markets to study the evolution of H7N9 and H9N2 viruses in Eastern China. We found 28 samples positive for the H9N2 virus (a rate of 3.2%), but no ...

An Update on the Clinical Use of CDK4/6 Inhibitors in Breast Cancer.

Deregulated cell division, resulting in aberrant cell proliferation, is one of the key hallmarks of cancer. Cyclin-dependent kinases (CDKs) play a central role in cell cycle progression in cancer, and the clinical development of the CDK4/6 inhibitors palbociclib, ribociclib, and abemaciclib has changed clinical practice in the setting of endocrine-receptor positive breast cancer. Results of pivotal phase II and III trials investigating these CDK4/6 inhibitors in patients with endocrine receptor-positive, ad...

Changes in metabolic parameters and body weight in brexpiprazole-treated patients with acute schizophrenia: pooled analyses of phase 3 clinical studies.

To analyze the effect of brexpiprazole on metabolic parameters and body weight in adults with schizophrenia, including clinically relevant subgroups of patients, based on data from two pivotal phase 3 studies (NCT01393613; NCT01396421) and a long-term extension study (NCT01397786).

Deoxynivalenol in wheat from the Northwestern region in China.

Because of global warming and changes in farming systems, Fusarium head blight has gradually spread towards high-latitude regions such as Northwestern China. A survey was conducted to assess the prevalence and concentration of deoxynivalenol (DON) in wheat harvested during 2013 from the Shaanxi, Ningxia, Gansu, and Xinjiang provinces in China. DON concentration in 181 wheat samples was analysed by high-performance liquid chromatography combined with ultraviolet detection. Of the wheat samples, 82.9% were co...


Advertisement
Quick Search
Advertisement
Advertisement