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PubMed Journals Articles About "Hy-Vee, Inc." RSS

21:49 EDT 18th September 2018 | BioPortfolio

Hy-Vee, Inc. PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Hy-Vee, Inc. articles that have been published worldwide.

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Showing PubMed Articles 1–25 of 1,000,000+

Efficacy of an agonist of α-MSH, the palmitoyl tetrapeptide-20, in hair pigmentation.

Hair greying (i.e., canities) is a component of chronological aging and occurs regardless of gender or ethnicity. Canities is directly linked to the loss of melanin and increase in oxidative stress in the hair follicle and shaft. To promote hair pigmentation and reduce the hair greying process, an agonist of α-melanocyte-stimulating hormone (α-MSH), a biomimetic peptide (palmitoyl tetrapeptide-20; PTP20) was developed. The aim of this study was to describe the effects of the designed peptide on hair greyi...


Intra-strain Variability in the Effects of Temperature on UV-B Sensitivity of Cyanobacteria.

Stratospheric ozone depletion is mostly marked over the Antarctic and to a lesser extent over the Arctic, though recent reports have revealed that this also occurs at lower latitudes. Continued depletion of ozone in the lower stratosphere allows more UVR to reach the Earth's surface. Furthermore, it is projected that surface water temperatures will increase by between 0.2 and 2.0 °C by the year 2060 and this will directly or indirectly influence algal growth. The interactions between environmental factors ...

Activator-type R2R3-MYB genes induce a repressor-type R2R3-MYB gene to balance anthocyanin and proanthocyanidin accumulation.

Anthocyanin and proanthocyanidin (PA) accumulation is regulated by both MYB activators and repressors, but little information is available on hierarchical interactions between the positive and negative regulators. Here, we report on a R2R3-MYB repressor in peach, designated PpMYB18, which acts as a negative regulator of anthocyanin and PA accumulation. PpMYB18 can be activated by both anthocyanin- and PA-related MYB activators, and is expressed both at fruit ripening and juvenile stages when anthocyanins or...


Hydrogen peroxide metabolism and functions in plants.

H O is produced, via superoxide and superoxide dismutase, by electron transport in chloroplasts and mitochondria, plasma membrane NADPH oxidases, peroxisomal oxidases, type III peroxidases and other apoplastic oxidases. Intracellular transport is facilitated by aquaporins and H O is removed by catalase, peroxiredoxin, glutathione peroxidase-like enzymes and ascorbate peroxidase, all of which have cell compartment-specific isoforms. Apoplastic H O influences cell expansion, development and defence by its inv...

Size and Substitution Effect on Antimicrobial Activity of Polythiophene Polyelectrolyte Derivatives Under Photolysis and Dark Conditions.

Cationic polythiophenes have been shown to be potent antimicrobial compounds due to their ability to absorb visible light and sensitize the production of reactive oxygen species (ROS) as well as their ability to selectively associate with and damage negatively charged cell envelopes. This study demonstrates the ability of differentially sized imidazolium and tertiary amine functionalized poly(3-hexylthiophene) (P3HT) to inactivate Gram-negative Escherichia coli and Gram-positive Bacillus atrophaeus under ph...

Intestinal barrier integrity in patients with plaque psoriasis.

Psoriasis is a chronic inflammatory systemic disease. Growing evidence suggests that human homeostasis depends on a mutualistic relationship with gut bacteria that produce a number of biologically active compounds. Therefore, enteric microbiota dysbiosis with gut barrier disruption may be an important factor in the development of chronic inflammatory diseases. The aim of our study was to assess non-invasive markers of intestinal barrier integrity in patients with moderate to severe psoriasis. Concentrations...

Structure, stability and ecological significance of natural epigenetic variation: a large-scale survey in Plantago lanceolata.

Within-species diversity is an important driver of ecological and evolutionary processes. Recent research has found that plants can harbour significant epigenetic diversity, but its extent, stability and ecological significance in natural populations is largely unexplored. We analysed genetic, epigenetic and phenotypic variation in a large number of natural grassland populations of Plantago lanceolata, covering a broad geographic and environmental range. Within-population diversity and among-population diff...

Comparison of oxidative stress on DNA, protein and lipids in patients with actinic keratosis, Bowen's disease and squamous cell carcinoma.

Detailed mechanisms on the effect of oxidative stress (OS), an etiological factor involved in photocarcinogenesis, remain to be fully elucidated. We used immunohistochemical methods to study OS in the DNA, protein and lipids of patients with actinic keratosis (AK), Bowen's disease (BD) and squamous cell carcinoma (SCC). Between January 2009 and December 2014, we treated 230 patients; 79 had AK, 61 had (BD) and 90 had cutaneous SCC; 28 healthy subjects served as the normal controls. OS on DNA, protein and li...

Fetal exposure to mitotane/Op'DDD: post-natal study of four children.

Mitotane/o,p'DDD is used in the treatment of adrenocortical carcinoma and for other causes of hypercortisolism. Mitotane inhibits cortisol secretion and displays adrenolytic and antitumor actions. This compound is a metabolite of the pesticide and endocrine disruptor DDT (Dichlorodiphenyltrichloroethane) and is classified among teratogenic compounds worldwide. However, little is known about its effects on human development.

Acquisition of resistance to vemurafenib leads to interleukin-10 production through an aberrant activation of Akt in a melanoma cell line.

Serine/threonine-protein kinase B-Raf (BRAF) inhibitors are very effective in treating melanoma with BRAF mutations. BRAF inhibitors suppress aberrant growth of melanoma cells caused by BRAF mutations. BRAF mutations reportedly result in melanoma cells releasing immunosuppressive factors, and BRAF inhibitors elicit anti-melanoma immune responses by reducing such factors. However, immunological characteristics of tumor cells that acquire resistance to BRAF inhibitors remain unknown. Here, we compared immuno...

An observational study of environmental exposures, airway cytology, and performance in racing thoroughbreds.

Mild equine asthma is presumed to arise in response to environmental exposures but the relative impact of differing inflammatory phenotypes upon performance are largely unexplored.

Alopecia areata and overt thyroid diseases: A nationwide population-based study.

An association between alopecia areata (AA) and other autoimmune diseases has been reported. We investigated the associations between AA and overt autoimmune thyroid diseases. A nationwide, population-based, cross-sectional study was performed using the Korea National Health Insurance claims database. We defined patients with AA as those whose records showed at least four physician contacts in which AA, alopecia totalis (AT) or alopecia universalis (AU) was the principal diagnosis. We also established an ag...

Eccentric cycling is more efficient in reducing fat mass than concentric cycling in adolescents with obesity.

The benefits of eccentric (ECC) training on fat mass (FM) remain underexplored. We hypothesized that in obese adolescents, ECC cycling training is more efficient for decreasing whole-body FM percentage compared to concentric (CON) performed at the same oxygen consumption (VO ). Twenty-four adolescents aged 13.4±1.3 yrs. (BMI >90 percentile) were randomized to ECC or CON. They performed 3 cyclo-ergometer sessions per week (30 min per session) for 12 weeks: 2 habituation, 5 at 50% VO , and 5 at 70% VO . A...

Clinical utility of currently available biomarkers in inflammatory enteropathies of dogs.

Chronic inflammatory enteropathies (CIE) in dogs are a group of disorders that are characterized by chronic persistent or recurrent signs of gastrointestinal disease and histologic evidence of mucosal inflammation. These CIEs are classified as either food-responsive, antibiotic-responsive, or immunosuppressant-responsive enteropathy. Patients not clinically responding to immunomodulatory treatment are grouped as nonresponsive enteropathy and dogs with intestinal protein loss as protein-losing enteropathy. D...

Resolution of isoborneol and its isomers by GC/MS to identify "synthetic" and "semi-synthetic" borneol products.

Borneol is a plant terpene commonly used in traditional Chinese medicine. Optically pure (+)-borneol and (-)-borneol can be obtained by extraction from the plants Dipterocarpaceae and Blumea balsamifera, respectively. "Synthetic borneol" is obtained from the reduction of (±)-camphor to lead to four different stereoisomers: (+)-isoborneol, (-)-isoborneol, (+)-borneol, and (-)-borneol. In contrast, "semi-synthetic borneol" is produced from the reduction of natural camphor, (+)-camphor, to afford two isomers:...

The identification of autoantigens in mucous membrane pemphigoid using immortalized oral mucosal keratinocytes.

Mucous membrane pemphigoid (MMP) is a rare chronic autoimmune subepithelial blistering disorder, targeting multiple basement membrane zone (BMZ) proteins including collagen XVII (COL17). Circulating autoantibodies of MMP are often undetected due to their lower titers. The oral mucosa is a valuable substrate for the detection of autoantibodies in MMP patients. However, obtaining normal human oral mucosa is more difficult than obtaining normal human skin. We established immortalized normal human oral mucosal ...

Variations in maternal adenylate cyclase genes are associated with congenital Zika syndrome in a cohort from Northeast, Brazil.

Vertical transmission of Zika virus (ZIKV) is associated with congenital malformations but the mechanism of pathogenesis remains unclear. Although host genetics appear to play a role, no genetic association study has yet been performed to evaluate this question. In order to investigate if maternal genetic variation is associated with Congenital Zika Syndrome (CZS), we conducted a case-control study in a cohort of Brazilian women infected with ZIKV during pregnancy.

Stimuli-Responsive Properties of Aggregation-Induced-Emission Compounds Containing 9,10-Distyrylanthracene Moiety.

Two aggregation-induced-emission active luminophores based on 9,10-distyrylanthracene with stimuli-responsive properties are successfully synthesized. A distinct seven- or five-colour luminescence switching built upon a single organic molecule is firstly achieved. These phase transitions can be interconverted by physical stimuli such as grinding by mortar and pestle, heating and exposing to the vapor of organic solvents. Moreover, an applicable strategy for the design of new mechano-responsive materials wit...

Interactions of C-F bonds with hydridoboranes: Reduction, Borylation and Friedel-Crafts Alkylation.

The stoichiometric reactions of the alkylfluorides 1-fluoroadamantane (Ad-F), fluorocyclohexane (Cy-F), 1-fluoropentane (Pent-F) and benzyl fluorides with secondary boranes pinacolborane (HBpin), catecholborane (HBcat), 9-borabicyclo(3.3.1)nonane (9-BBN) and Pier's borane (HB(C6F5)2) are described. While HBcat, 9-BBN and HB(C6F5)2 reduce Ad-F to Ad-H, the latter borane was shown to react with secondary and primary fluoroalkanes, affording C-F borylation, while benzyl fluorides undergo Friedel-Crafts chemist...

Metallacarboranes on the road to anticancer therapies: cellular uptake, DNA interaction and biological evaluation of cobaltabisdicarbollide (COSAN-).

After uptake by U87 MG and A375 cancer cells, [COSAN]- distribute between membrane and nucleus, while presenting no relevant cytotoxicity against both cell lines even for long incubation times. As cell's nucleus contains DNA, the interaction between [COSAN]- and CT-dsDNA has been investigated showing a strong interaction between both molecules forming a nanohybrid CT-dsDNA-[COSAN] biomaterial, which was fully characterized. Moreover, Na[COSAN] shows characteristic redox peaks ascribed to the oxidation/reduc...

Entrapment of THF-stabilized Iridacyclic Ir(III)-"Silylenes" from Double H-Si Bond Activation and H2 Elimination.

The reaction of H₃SiR (R=Ph, nBu) with a cationic Cp*-and benzo[h]quinolinyl- based iridacycle [1b]+ gives rise to new [(Ir-H)→SiRH₂]+ adducts. In the presence of tetrahydrofuran (THF) the latter adducts readily convert by H₂ gas elimination at subambient temperature into new THF-stabilized metallacyclic Ir(III)-"silylene" complexes that were characterized in situ by NMR spectroscopic analyses, trapped in minute amount by reactive crystallization and their structures established by X-ray diffraction...

N-Type Organic Thermoelectrics of Donor-Acceptor Copolymers: Improved Power Factor by Molecular Tailoring of the Density of States.

It is demonstrated that the n-type thermoelectric performance of donor-acceptor (D-A) copolymers can be enhanced by a factor of >1000 by tailoring the density of states (DOS). The DOS distribution is tailored by embedding sp -nitrogen atoms into the donor moiety of the D-A backbone. Consequently, an electrical conductivity of 1.8 S cm and a power factor of 4.5 µW m K are achieved. Interestingly, an unusual sign switching (from negative to positive) of the Seebeck coefficient of the unmodified D-A copolymer...

From photoinduced to dark cytotoxicity via an octahedral cluster hydrolysis.

Octahedral molybdenum and tungsten clusters have the potential for biological applications such as photodynamic therapy and bioimaging. However, poor solubility and hydrolysis stability of these compounds hinder their application. The first water-soluble photoluminescent octahedral tungsten cluster [{W6I8}(DMSO)6](NO3)4 was synthesised and demonstrated to be at least one order of magnitude more stable towards hydrolysis than its molybdenum analogue. Biological studies of the compound on larynx carcinoma cel...

Interfacial Defect Vibrations Enhance Thermal Transport in Amorphous Multilayers with Ultrahigh Thermal Boundary Conductance.

The role of interfacial nonidealities and disorder on thermal transport across interfaces is traditionally assumed to add resistance to heat transfer, decreasing the thermal boundary conductance (TBC). However, recent computational studies have suggested that interfacial defects can enhance this thermal boundary conductance through the emergence of unique vibrational modes intrinsic to the material interface and defect atoms, a finding that contradicts traditional theory and conventional understanding. By m...

The Effects of Doping Density and Temperature on the Optoelectronic Properties of Formamidinium Tin Triiodide Thin Films.

Optoelectronic properties are unraveled for formamidinium tin triiodide (FASnI ) thin films, whose background hole doping density is varied through SnF addition during film fabrication. Monomolecular charge-carrier recombination exhibits both a dopant-mediated part that grows linearly with hole doping density and remnant contributions that remain under tin-enriched processing conditions. At hole densities near 10 cm , a strong Burstein-Moss effect increases absorption onset energies by ≈300 meV beyond the...


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