PubMed Journals Articles About "ICER Panel Votes Against Elagolix Endometriosis" RSS

02:57 EST 11th December 2018 | BioPortfolio

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Showing "ICER panel votes against elagolix endometriosis" PubMed Articles 1–25 of 1,200+

Long-Term Outcomes of Elagolix in Women With Endometriosis: Results From Two Extension Studies.

To evaluate the efficacy and safety of elagolix, an oral, nonpeptide gonadotropin-releasing hormone antagonist, over 12 months in women with endometriosis-associated pain.

Elagolix: First Global Approval.

Elagolix (ORILISSA™), an orally bioavailable, second-generation, non-peptide gonadotropin-releasing hormone (GnRH) receptor antagonist, is being developed AbbVie and Neurocrine Biosciences for the treatment of reproductive hormone-dependent disorders in women. In July 2018, the US FDA approved elagolix tablets for the management of moderate to severe pain associated with endometriosis. This approval was based on positive results in two replicate phase III trials; additional phase III trials in the USA, Ca...

Elagolix (Orilissa)--an oral GnRH antagonist for endometriosis pain.

Aberrant expression of genes associated with stemness and cancer in endometria and endometrioma in a subset of women with endometriosis.

Is there molecular evidence for a link between endometriosis and endometriosis-associated ovarian cancers (EAOC)?

Endometriosis of Diaphragm: A Case Report.

Endometriosis affects about 10% of women of reproductive age. Its main feature is the presence of stroma and endometrial glands in sites other than the uterus, mainly in pelvis. Pelvic peritoneum, ovaries, uterine ligaments, bladder, intestines, andcul-de-sac are among the affected areas. Sometimes endometriosis can be found outside of the pelvis and even above abdominal cavity, like indiaphragm.Herein, we present a case of an asymptomatic diaphragmatic endometriosis that was discovered incidentally during ...

Influence of hippocampal low-frequency stimulation on GABAR α1, ICER and BNDF expression level in brain tissues of Amygdala-Kindled drug-resistant temporal lobe epileptic rats.

This study investigated the therapeutic effect of hippocampal low-frequency stimulation (Hip-LFS) and its influence on the typeA γ-aminobutyricacidreceptor α1 subunit (GABAR α1 subunit), inducible cAMP early repressor (ICER) and brain-derived neurotrophic factors (BNDF). The model of epilepsy was induced by chronic electrical stimulation in amygdala. Drug-resistant and drug-sensitive epileptic rats were selected by testing their seizure response to phenytoin and phenobarbital. The changes of GABAR α1 su...

Presumption of pericardial endometriosis using MRI: Case report and review of the literature.

Endometriosis is a condition where hormonal-responsive endometrial tissue grows outside the uterus usually within the pelvic cavity. Extra-pelvic endometriosis is rare and may involve the pericardium. We report the first case of pericardial endometriosis suspected using cardiac magnetic resonance imaging.

Is endometriosis associated with irritable bowel syndrome? A cross-sectional study.

Previous studies have found a high prevalence of irritable bowel syndrome (IBS). However, data on this relation in women without bowel endometriosis is limited. The aim of this study was to compare the prevalence of IBS in women with endometriosis to the prevalence in women without endometriosis and to investigate if the prevalence of IBS was associated with bowel involved endometriosis.

3,6-dihydroxyflavone suppresses the epithelial-mesenchymal transition, migration and invasion in endometrial stromal cells by inhibiting the Notch signaling pathway.

Endometriosis is a common disease in women of reproductive age. Characteristics of endometriosis include invasion, metastasis, and recurrence, which are similar to those of malignant tumors. However, the etiology and pathogenesis of endometriosis are still not clear. This study aims to explore the mechanism of 3,6-dihydroxyflavone (3,6-DHF) in the development of endometriosis.

Endometriosis: Perspective, lights, and shadows of etiology.

Endometriosis refers to the growth of ectopic endometrial tissue outside the uterine cavity. About 10-15% of female in reproductive age suffer from endometriosis. Several etiologies - such as oxidative stress, inflammatory factors and cytokines, genetic etiology, and hormone role - have been reported for endometriosis. Indeed, oxidative stress leads to abnormalities by the production of ROS and RNS. The mechanism of endometriosis genesis is a complicated process that concerns the alterations in cellular imm...

Advanced Prostate Cancer Consensus Conference 2017 : Discussion of the recommendations for diagnosis and treatment of metastatic prostate cancer by a German panel of experts.

In March 2017 the 'Advanced Prostate Cancer Consensus Conference' (APCCC) took place in St. Gallen (Switzerland). The APCCC-panelists are internationally well known experts. With the actual data in mind they discussed treatment options for patients with advanced prostate cancer in order to update the international APCCC-recommendations from the previous meeting in 2015. Recently these consensus recommendations have been published in "European Urology".A group of German experts discussed this year APCCC-vot...

The Association between ABO and Rh Blood Groups and Risk of Endometriosis in Iranian Women.

Endometriosis is a common gynaecological disease that affects quality of life for women. Several studies have revealed that both environmental and genetic factors contribute to the development of endometriosis. The aim of this study was to investigate the distribution of ABO and Rh blood groups in Iranian women with endometriosis who presented to two referral infertility centers in Tehran, Iran.

Anatomic distribution of endometriosis: A reappraisal based on series of 1101 patients.

To reappraise the anatomic distribution of endometriosis lesions in cases with Superficial Implants (SI), Ovarian Endometrioma (OMA) and Deep Infiltrating Endometriosis (DIE).

The involvement of multifunctional TGF-β and related cytokines in pathogenesis of endometriosis.

Transforming growth factor β (TGF-β) is one of the major immune and inflammation factors responsible for regulating cell proliferation, differentiation, angiogenesis, and immune responses. Deregulated TGF-β activity, especially its influence in peritoneal cytokine cross-talk, has been implicated in pathologies of endometriosis. The aim of this study was to determine whether TGF-β could be involved in the pathogenesis of endometriosis. For this purpose, we evaluated concentrations of TGFβ1, TGF-β2, TGF...

Cost-Effectiveness Analysis of 13-Valent Pneumococcal Conjugate Vaccine versus 23-Valent Pneumococcal Polysaccharide Vaccine in an Adult Population in South Korea.

In South Korea, the National Immunization Program offers a 23-valent pneumococcal polysaccharide vaccine (PPSV23) for the elderly; however, the 13-valent pneumococcal conjugate vaccine (PCV13) is not included, and vaccination is not offered to younger, at-risk populations. This study offers a comparative analysis of PCV13 and PPSV23 in Korea's adults, stratified by age and risk group. A Markov model with a lifetime horizon was developed from the healthcare perspective. Data sources included the Health Insur...

Endometriosis and ART: A prior history of surgery for OMA is associated with a poor ovarian response to hyperstimulation.

Many women whose fertility may have been impaired by endometriosis require assisted reproductive technology (ART) in order to become pregnant. However, the influence of ovarian endometriosis (OMA) on ovarian responsiveness to hyperstimulation has not been clearly established.

Use of the Endometriosis Fertility Index to Predict Natural Pregnancy after Endometriosis Surgery: A Single-Center Study.

Our objective was to predict natural pregnancy after endometriosis surgery using the endometriosis fertility index (EFI).

Risk of Gynecologic Cancer According to the Type of Endometriosis.

To assess the risks of gynecologic cancer according to the type of endometriosis in women with surgically verified endometriosis.

A nationwide cohort study on the risk of non-gynaecological cancers in women with surgically verified endometriosis.

We assessed the association of surgically verified endometriosis and risk of non-gynaecological cancers according to the type of endometriosis (i.e. ovarian, peritoneal, and deep infiltrating endometriosis). All diagnoses of endometriosis combined with relevant procedural codes were identified from the Finnish Hospital Discharge Register 1987-2012. Non-gynaecological cancers diagnosed after the endometriosis diagnosis were obtained from the Finnish Cancer Registry. The cohort of 49,933 women with surgically...

Ureteral endometriosis: a systematic review of epidemiology, pathogenesis, diagnosis, treatment, risk of malignant transformation and fertility.

The ureter is the second most common site affected by urinary tract endometriosis, after the bladder. Optimal strategies in the diagnosis and treatment of ureteral endometriosis (UE) are not yet well defined.

Ultrasonographic findings in primary umbilical endometriosis.

Primary cutaneous endometriosis is a rare condition. It appears without a prior history of surgical procedure and the umbilicus is the most frequently involved area. Primary umbilical endometriosis, or Villar's nodule, usually presents as a painful nodule. Its differential diagnosis may be challenging. Although histopathological assessment represents the gold standard for diagnosis, cutaneous ultrasonography may be useful in guiding the surgical treatment. Ultrasonographic features of cutaneous endometriosi...

Potential benefits of pregnancy on endometriosis symptoms.

To explore the potential benefits of pregnancy on endometriosis symptoms. This is a retrospective study that has been conducted at Academic department and referral center for endometriosis.

Thoracic endometriosis syndrome: Comparison between catamenial pneumothorax or endometriosis-related pneumothorax and catamenial hemoptysis.

To evaluate the clinical features of thoracic endometriosis syndrome (TES) represented by catamenial pneumothorax (CP), endometriosis-related pneumothorax (ERP), and catamenial hemoptysis (CH).

Perforación de colon sigmoides secundaria a endometriosis. Reporte de un caso.

La endometriosis es la presencia de glándulas endometriales o estroma viable fuera de la cavidad uterina, que afecta aproximadamente al 2-10% de las mujeres en edad reproductiva. Es común la afección de estructuras pélvicas, incluyendo el intestino. La perforación del colon por endometriosis es muy rara y representa una urgencia quirúrgica.

Parametrial Endometriosis: the Occult Condition that Makes the Hard Harder.

Despite the enormous impact of lateral parametrial endometriosis (LPE), only a few studies have evaluated its diagnosis, prevalence and clinical features. Our aim is to estimate the intraoperative prevalence of LPE in patients affected by deep infiltrating endometriosis (DIE) and to analyse clinical and surgical data associated with LPE.

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