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PubMed Journals Articles About "Index Plays Chippy Action" RSS

17:17 EST 21st January 2019 | BioPortfolio

Index Plays Chippy Action PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Index Plays Chippy Action articles that have been published worldwide.

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Showing "Index Plays Chippy Action" PubMed Articles 1–25 of 11,000+

Examining associations between action game play and motor control.

The effects of playing action video games have been investigated across a wide range of attentional and cognitive abilities. However, few studies have examined the association between motor control and action gaming experience. We report data from two discrete pointing tasks, manipulating the index of difficulty (ID) by movement distance and target size, respectively. Participants' gaming experience ranged from non-players to individuals who played several hours a night. Our results indicated greater experi...


Amanitins and their development as a payload for antibody-drug conjugates.

Amanitin-based ADCs represent a new class of ADCs using a novel mode of action. This payload introduces a novel mode of action into oncology therapy, the inhibition of RNA Polymerase II. The high potency of the toxin leads to highly efficacious ADCs. The development of the technology around this toxin will be described. These developments support the clinical development of amanitin-based ADCs by using a toxin with a new mode of action and with a favorable therapeutic index. HDP-101 is an Amanitin based ADC...

Freely chosen and instructed actions are terminated by different neural mechanisms revealed by kinematics-informed EEG.

Neurophysiological accounts of human volition are dominated by debates on the origin of voluntary choices but the neural consequences that follow such choices remain poorly understood. For instance, could one predict whether or not an action was chosen voluntarily based only on how that action is motorically executed? We investigated this possibility by integrating scalp electroencephalograms and index-finger accelerometer recordings acquired while people chose between pressing a left or right button either...


Development of nanoparticulate systems with action in breast and ovarian cancer: nanotheragnostics.

The use of nanoparticulate systems with action in breast and ovarian cancer has been highlighted in recent years as an alternative to increasing the therapeutic index of conventional anticancer drugs. Thus, nanoparticles have advantageous characteristics in the treatment of cancer. Several nanocarriers of drugs and nanoparticles are described in the literature. The pharmacokinetics of the drugs can be modified by the use of nanocarriers, which in turn facilitate the specific delivery of the drug to the tumo...

When context modulates the influence of action observation on language processing.

Numerous studies in the field of embodied cognition have shown a crosstalk between language and sensorimotor processes. In particular, it has been demonstrated that perceiving an action influences subsequent language processing. However, when studying the effect of action observation on language processing it has not been considered whether the context of action presentation could modulate this influence. To test this assumption, the participants in our study observed a prime, specifically a cartoon picture...

Narcissism and Risky Decisions: A Neurophysiological Approach.

Narcissists are prone to risky decision-making, but why? This study tested-via behavioral and event-related potential (ERP) measures-two accounts: Deficiencies in error monitoring and deficiencies in action updating. High and low narcissists were engaged in a monetary gambling task by choosing between a high-risk and a low-risk option while the electroencephalogram (EEG) was being recorded. Two ERP components relevant to outcome evaluation-feedback-related negativity (FRN) and P3-were analyzed, with the FRN...

Construct validation of a Frailty Index, an HIV Index and a Protective Index from a clinical HIV database.

Standard care for HIV clinical practice has started focusing on age-related problems, but despite this recent change physicians involved in HIV care do not often screen HIV patients for frailty. Our aim was to construct three indexes from an HIV clinical database (i.e. Frailty Index, (FI), HIV Index, (HIVI), and Protective Index (PI)) and to assess levels of frailty, HIV severity and demographic and protective lifestyle factors among HIV patients.

Decreased use of active coping styles contributes to elevated allostatic load index in first-episode psychosis.

Accumulating evidence indicates that stress plays an important role in the development of psychotic disorders. Recent studies have revealed that patients with first-episode psychosis (FEP) present systemic biological dysregulations related to stress-exposure in terms of elevated allostatic load (AL) index. However, the mechanisms underlying this observation remain unknown. Therefore, in this study we aimed to investigate the AL index with respect to stress coping strategies in 36 FEP patients and 31 matched...

Vertico-horizontal atlantoaxial index (VHAI): A new craniovertebral radiographic index.

The purpose of this study was to develop a new index that can reliably quantify the reduction of basilar invagination with atlantoaxial dislocation.

Pesticide Detox by Design.

Detoxification (detox) plays a major role in pesticide action and resistance. The mechanisms involved are sometimes part of the discovery and development process in seeking new biochemical targets and metabolic pathways. Genetically- and chemical safener- modified crops are a marked exception and often involve herbicide detox by design to achieve the required crop tolerance. This perspective evaluates the role of detox by design or chance and target site-based selectivity in insecticide, herbicide, and fung...

Simon effects in action sequences.

Most actions we perform in daily life consist of multiple movement elements. In two Simon task experiments, we investigated the impact of stimulus-response compatibility on planning and execution of action sequences. A total of 38 participants were instructed to perform action sequences consisting of multiple key presses (two to four key presses) as response to a left- or right-presented colored stimulus. Within one block, the requested action sequences were of the same length but differed in their spatial ...

Causal learning from joint action: Collaboration helps first graders but hinders kindergartners.

This study investigated whether early school-aged children's causal learning from collaborative joint action differs from their learning from their own individual action or observation. Children in a joint condition performed causal interventions with an adult on two causal systems. Children in an independent condition took turns and observed an adult perform the same interventions on one system and performed the same interventions themselves on the other system. Joint action improved first graders' (n =...

Robustness of Light-Transport Processes to Bending Deformations in Graded-Index Multimode Waveguides.

Light transport through a multimode optical waveguide undergoes changes when subjected to bending deformations. We show that optical waveguides with a perfectly parabolic refractive index profile are almost immune to bending, conserving the structure of propagation-invariant modes. Moreover, we show that changes to the transmission matrix of parabolic-index fibers due to bending can be expressed with only two free parameters, regardless of how complex a particular deformation is. We provide detailed analysi...

Exposure-dependent refractive index of Nanoscribe IP-Dip photoresist layers.

The refractive indices of photoresists used for direct laser writing (DLW) have been determined after exposure to ultraviolet (UV) light. However, it was anticipated that the refractive index will differ when applying a two-photon polymerization (TPP) process. In this Letter, we demonstrate that this is indeed the case. Making use of a guided mode coupling approach, we measure the dispersive real part of the refractive index (n) of a commercial photoresist (IP-Dip, Nanoscribe) at very high accuracy. Additio...

A novel bibliometric index with a simple geometric interpretation.

We propose the χ-index as a bibliometric indicator that generalises the h-index. While the h-index is determined by the maximum square that fits under the citation curve of an author when plotting the number of citations in decreasing order, the χ-index is determined by the maximum area rectangle that fits under the curve. The height of the maximum rectangle is the number of citations ck to the kth most-cited publication, where k is the width of the rectangle. The χ-index is then defined as [Formula: see...

The Structural and Functional Signature of Action Control.

Individuals differ in their ability to initiate self- and emotional-control mechanisms. These differences have been explicitly described in Kuhl's action-control theory. Although interindividual differences in action control make a major contribution to our everyday life, their neural foundation remains unknown. Here, we measured action control in a sample of 264 healthy adults and related interindividual differences in action control to variations in brain structure and resting-state connectivity. Our resu...

Observation of an action with a congruent contextual background facilitates corticospinal excitability: A combined TMS and eye-tracking experiment.

Action observation produces activity in similar regions of the brain to those involved in action execution and can offer an effective intervention for motor (re)learning, although optimal viewing conditions for such interventions remain to be established. In this experiment, single-pulse transcranial magnetic stimulation (TMS) and eye-tracking were used simultaneously to investigate the effect of manipulating background context on both corticospinal excitability and visual attention during action observatio...

Assessment of Pain-related Disability in Pediatric Chronic Pain - A Comparison of the Functional Disability Inventory and the Paediatric Pain Disability Index.

The assessment of pain-related disability in pediatric chronic pain patients plays an important role in research on the effectiveness of pain treatment. The present study aimed to compare the two available measures of pain-related disability in German language, the Functional Disability Inventory (FDI) and Paediatric Pain Disability Index (PPDI), in terms of psychometric properties and convergent validity. Additionally, associations between FDI/PPDI scores and sex, age and pain locations were investigated.

Reduced Motor Interference in Preschoolers with Autism Spectrum Disorder and Williams Syndrome.

Motor interference occurs when action execution is hindered by the observation of an incongruent action. The present study used a novel eye-tracking paradigm to test the motor interference effect in 22 preschoolers with autism spectrum disorder (ASD), 14 preschoolers with Williams syndrome (WS), and 18 typically developing (TD) peers. In TD children, performance of a pre-determined action was slower after the observation of an incongruent motor action and faster following observation of a congruent motor ac...

Evaluation of the post-LA space index in the normal fetus.

We previously reported the post-LA space index (PLAS index), which is calculated as left atrial-descending aorta distance (LD) divided by the diameter of descending aorta (DA), could be useful for prenatal diagnosis of total anomalous pulmonary venous connection (TAPVC). In this study, we evaluated PLAS index in normal fetuses to assess its usefulness.

Emerging platinum(iv) prodrugs to combat cisplatin resistance: from isolated cancer cells to tumor microenvironment.

Cisplatin plays a pivotal role in the treatment of various malignant tumors, but its therapeutic effects are hampered by drug resistance. Pt(iv) prodrugs represent a promising class of "non-conventional" platinum-based anticancer agents to circumvent drug resistance, which can be easily functionalized with other bioactive ligands. One strategy is to build "dual-action" and "multi-action" Pt(iv) prodrugs that not only damage DNA but also perturb other pathways related to cisplatin resistance to achieve combi...

Author Index/Subject Index Vol. 89, No. 5, 2018.

The development of anticipatory action planning in children with unilateral cerebral palsy.

Background Previous studies suggest that compromised bimanual performance experienced by children with unilateral cerebral palsy (CP) is not only due to difficulties in action execution but may also be a result of impaired anticipatory action planning. Aims The effect of age and side of hemiplegia were examined and the relationship between anticipatory action planning, unimanual capacity and bimanual performance was explored. Methods and procedures Using a multi-centre, prospective, cross-sectional observat...

Chronological Review of Endoscopic Indices in Inflammatory Bowel Disease.

Inflammatory bowel disease (IBD) is considered a chronic condition characterized by mucosal or transmural inflammation in the gastrointestinal tract. Endoscopic diagnosis and surveillance in patients with IBD have become crucial. In addition, endoscopy is a useful modality in estimation and evaluation of the disease, treatment results, and efficacy of treatment delivery and surveillance. In relation to these aspects, endoscopic disease activity has been commonly estimated in clinical practices and trials. A...

The dominant role of functional action representation in object recognition.

Action representation of manipulable objects has been found to be involved in object recognition. Recently, studies have indicated the existence of two distinct action systems: functional action specifying how to use an object and structural action concerning how to grasp an object. Despite evidence revealing the systems' anatomical and functional differences, few preceding studies have dissociated their respective roles in object recognition. The present study aimed to tease apart their roles in the recogn...


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