PubMed Journals Articles About "Innovating Trusted Class Antibiotics Attack Superbugs" RSS

13:06 EST 16th January 2019 | BioPortfolio

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Showing "Innovating trusted class antibiotics attack superbugs" PubMed Articles 1–25 of 4,300+

Mercaptopyrimidine-Conjugated Gold Nanoclusters as Nanoantibiotics for Combating Multidrug-Resistant Superbugs.

Widespread bacterial resistance induced by the abuse of antibiotics eagerly needs the exploitation of novel antimicrobial agents and strategies. Gold nanoclusters (Au NCs) have recently emerged as an innovative nanomedicine, but study on their antibacterial properties especially towards multidrug resistant (MDR) bacteria is scarce. Herein, we demonstrate that a novel class of Au NCs, mercaptopyrimidine conjugated Au NCs, can act as potent nanoantibiotics targeting these intractable superbugs in vitro and in...

Perspective: Pharmacokinetics of Beta lactam antibiotics: Clues from the past to help discover long acting oral drugs in the future.

Beta lactams represent perhaps the most important class of antibiotics yet discovered. However, despite many years of active research none of the currently approved drugs in this class combine oral activity with long duration of action. Recent devel-opments suggest that new beta lactam antibiotics with such a profile would have utility in the treatment of tuberculosis. Consequently the historical beta lactam pharmacokinetic data has been compiled and analysed to identify possible directions and drug discove...

Sequential cooperative spectrum sensing in the presence of dynamic Byzantine attack for mobile networks.

Cooperative spectrum sensing (CSS) is envisaged as a powerful approach to improve the utilization of scarce radio spectrum resources, but it is threatened by Byzantine attack. Byzantine attack has been becoming a popular research topic in both academia and industry due to the demanding requirements of security. Extensive research mainly aims at mitigating the negative effect of Byzantine attack on CSS, but with some strong assumptions, such as attackers are in minority or trusted node(s) exist for data fusi...

Stabbed while Sleeping: Synthetic Retinoid Antibiotics Kill Bacterial Persister Cells.

Antibiotic-tolerant persister cells are difficult to eradicate by conventional classes of antibiotics. Kim and colleagues have discovered a new class of synthetic retinoid antibiotics that kill Staphylococcus aureus persisters by disrupting their cytoplasmic membrane.

Determination of 18 antibiotics in urine using LC-QqQ-MS/MS.

A determination method to identify and quantify 18 multi-class antibiotics in urine was developed using liquid chromatography triple quadrupole tandem mass spectrometry (LC-QqQ-MS/MS). Targeted antibiotics were extracted using preliminary dilution followed by d-SPE extraction. Specificity and selectivity, linearity, LOD and LOQ, accuracy, and precision were validated. LOQ of the majority of targeted compounds ranged from 0.3-7.5 μg/L. Excellent recovery in the range of 73-136% was achieved for most antib...

Inhaled antibiotics for pulmonary exacerbations in cystic fibrosis.

Cystic fibrosis is a genetic disorder in which abnormal mucus in the lungs is associated with susceptibility to persistent infection. Pulmonary exacerbations are when symptoms of infection become more severe. Antibiotics are an essential part of treatment for exacerbations and inhaled antibiotics may be used alone or in conjunction with oral antibiotics for milder exacerbations or with intravenous antibiotics for more severe infections. Inhaled antibiotics do not cause the same adverse effects as intravenou...

Electrocatalytic dechlorination of halogenated antibiotics via synergistic effect of chlorine-cobalt bond and atomic H.

Although noble metal electrocatalysts are highly efficient in the dehalogenation of halogenated antibiotics, the prohibitive cost hinders their practical applications. In this study, a cobalt-phosphorous/oxide (CoP/O) composite prepared via a one-step electrodeposition was for the first time applied in electroreductive dechlorination of halogenated antibiotics (HA), including chloramphenicol (CAP), florfenicol (FLO) and thiamphenicol (TAP). CoP/O had a higher FLO dechlorination efficiency (91%) than Pd/C (6...

New antibiotics for community-acquired pneumonia.

This review provides the rationale for the development of new antibiotics to treat community-acquired pneumonia (CAP). It also provides an overview of the new antibiotics targeting CAP that have recently received approval by the regulatory agencies, and those antibiotics that are in the development pipeline.

Law of Food Labelling and Advertising: Chile innovating in public nutrition once again.

Biochar-mediated sorption of antibiotics in pig manure.

Using manure contaminated with antibiotics as fertilizer is a primary source of soil pollution with antibiotics and concomitantly with antibiotic resistance genes (ARG). Bioavailable antibiotics trigger further ARG amplification during manure storage. Consequently it is aimed to facilitate the immobilization of antibiotics in manure. To this end, five biochars derived from pine cone (BCP), rice husk, sewage sludge, digestate and Miscanthus were tested as additional sorbents in liquid pig manure for sulfamet...

Stand-by antibiotics encourage unwarranted use of antibiotics for travelers' diarrhea: A prospective study.

As antibiotics predispose travelers to acquiring multidrug-resistant intestinal bacteria, they should no longer be considered a mainstay for treating travelers' diarrhea. Stand-by antibiotics are justified as a means to avoid visits with local healthcare providers often causing polypharmacy.

Nomogram for predicting diabetes mellitus after the first attack of acute pancreatitis.

Diabetes mellitus can occur after acute pancreatitis (AP), but there are currently no tools for evaluating the risk of developing diabetes after an attack of AP. The aim of the study was to develop a nomogram for prediction of new-onset diabetes mellitus after the first attack of AP.

Adolescents trust physicians for vaccine information more than their parents or religious leaders.

Although, evidence clearly supports vaccination as the most cost effective approach to controlling infectious diseases there are many individuals questioning, delaying and refusing vaccines. The main purpose of this study was to find out what source of information adolescents trust the most on vaccines. We conducted a cross-sectional survey of public high school students using a paper-based questionnaire in a region with a high rate of vaccine acceptance to assess sources they trusted most for vaccine infor...

False Data Injection Attack for Cyber-Physical Systems With Resource Constraint.

Cyber-security is of the fundamental importance for cyber-physical systems (CPSs), since CPSs are vulnerable to cyber attack. In order to make the defensive measures better, one needs to understand the behavior from the view of an attacker. In this paper, the problem of false data injection attack on remote state estimation with resource constraints is studied in two cases, where the first case is that the attacker adds a Gaussian noise to the innovation, while the other is that the attacker employs a Gauss...

Security and efficiency enhancement of an anonymous three-party password-authenticated key agreement using extended chaotic maps.

Recently, Lu et al. claimed that Xie et al.'s three-party password-authenticated key agreement protocol (3PAKA) using chaotic maps has three security vulnerabilities; in particular, it cannot resist offline password guessing attack, Bergamo et al.'s attack and impersonation attack, and then they proposed an improved protocol. However, we demonstrate that Lu et al.'s attacks on Xie et al.'s scheme are unworkable, and their improved protocol is insecure against stolen-verifier attack and off-line password gue...

Frequency of Treatment Switching for Spironolactone Compared to Oral Tetracycline-Class Antibiotics for Women With Acne: A Retrospective Cohort Study 2010-2016.

Long-term oral antibiotic use in acne may be associated with a variety of adverse effects including antibiotic resistance, pharyngitis, inflammatory bowel disease, and breast and colon cancer. Spironolactone may represent an effective and safe alternative to oral antibiotics for women with moderate to severe acne, however comparative studies are lacking.

Antibiotics in early life: dysbiosis and the damage done.

Antibiotics are the most common type of medication prescribed to children, including infants, in the Western world. While use of antibiotics has transformed previously lethal infections into relatively minor diseases, antibiotic treatments can have adverse effects, as well. It has been shown in children, adults and animal models that antibiotics dramatically alter the gut microbial composition. Since the gut microbiota plays crucial roles in immunity, metabolism, and endocrinology, the effects of antibiotic...

BlaPred: predicting and classifying β-lactamase using a 3-tier prediction system via Chou's general PseAAC.

Antibiotics of β-lactam class account for nearly half of the global antibiotic use. The β-lactamase enzyme is a major element of the bacterial arsenals to escape the lethal effect of β-lactam antibiotics. Different variants of β-lactamases have evolved to counter the different types of β-lactam antibiotics. Extensive research has been done to isolate and characterize different variants of β-lactamases. Unfortunately, identification and classification of the β-lactamase enzyme are purely based on expe...

Antibiotics: a risk factor for irritable bowel syndrome in a population-based cohort.

Use of antibiotics affects the composition of the gut microbiome. The microbiome is thought to play a role in development of irritable bowel syndrome (IBS), but antibiotics as a possible risk factor for IBS has not been clarified. We aimed to explore if antibiotics is a risk factor for IBS by investigating use of antibiotics and development of IBS in a cohort from the Danish background population.

Introduction and geographic availability of new antibiotics approved between 1999 and 2014.

Despite the urgent need for new, effective antibiotics, few antibiotics of value have entered the market during the past decades. Therefore, incentives have been developed to stimulate antibiotic R&D. For these incentives to be effective, geographic availability for recently approved antibiotics needs to be better understood. In this study, we analyze geographic availability and market introduction of antibiotics approved between 1999 and 2014.

Influence of mixed antibiotics on Microcystis aeruginosa during the application of glyphosate and hydrogen peroxide algaecides.

Antibiotics regulate various physiological functions in cyanobacteria and may interfere with the control of cyanobacterial blooms during the application of algaecides. In this study, Microcystis aeruginosa was exposed to H O and glyphosate for seven days in the presence of coexisting mixed antibiotics (amoxicillin, spiramycin, tetracycline, ciprofloxacin and sulfamethoxazole) at an environmentally relevant concentration of 100 ng · L . The mixed antibiotics significantly (p

Exposure of adults to antibiotics in a Shanghai suburban area and health risk assessment: A biomonitoring-based study.

An extensive exposure to antibiotics has been demonstrated in children and pregnant women by biomonitoring, but data from general adults remain limited. In the current study, we studied 822 adults aged 21-75 years in Shanghai in 2017 and analyzed 18 common antibiotics (five veterinary antibiotics (VAs), four human antibiotics (HAs), and nine human/veterinary antibiotics (H/VAs)) in spot urine by liquid chromatography coupled to high-resolution mass spectrometry. All 18 antibiotics were detected in urine wit...

Incorporating Antibiotics into Platelet Rich Fibrin (PRF): A Novel Antibiotics Slow Release Biological Device.

The aim of the present in vitro study was to explore the possibility of using Platelet-rich fibrin (PRF) as a local sustained released device for antibiotics.

Truck attack: Fear of ISIS and reminder of truck attacks in Europe as associated with psychological distress and PTSD symptoms.

Following an ISIS attack, the present study examined the association between psychological distress and severe stress symptoms with vulnerability variables: i.e. Physical proximity to the site of the terror attack, Associative memory of prior events, Danger perception and ISIS anxiety. Using an online survey, 397 adult participants were recruited, Seventy-two hours after an ISIS terror attack, and filled out Psychological distress Patient Health Questionnaire 4 and severe stress symptoms questionnaire as we...

Meeting the discovery challenge of drug-resistant infections: progress and focusing resources.

Following multiple warnings from governments and health organisations, there has been renewed investment, led by the public sector, in the discovery of novel antimicrobials to meet the challenge of rising levels of drug-resistant infection, particularly in the case of resistance to antibiotics. Initiatives have also been announced to support and enable the antibiotic discovery process. In January 2018, the Medicines Discovery Catapult, UK, hosted a symposium: Next Generation Antibiotics Discovery, to consid...

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