Advertisement

Topics

PubMed Journals Articles About "Innovating Trusted Class Antibiotics Attack Superbugs" RSS

02:16 EDT 23rd July 2018 | BioPortfolio

Innovating Trusted Class Antibiotics Attack Superbugs PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Innovating Trusted Class Antibiotics Attack Superbugs articles that have been published worldwide.

More Information about "Innovating Trusted Class Antibiotics Attack Superbugs" on BioPortfolio

We have published hundreds of Innovating Trusted Class Antibiotics Attack Superbugs news stories on BioPortfolio along with dozens of Innovating Trusted Class Antibiotics Attack Superbugs Clinical Trials and PubMed Articles about Innovating Trusted Class Antibiotics Attack Superbugs for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Innovating Trusted Class Antibiotics Attack Superbugs Companies in our database. You can also find out about relevant Innovating Trusted Class Antibiotics Attack Superbugs Drugs and Medications on this site too.

Showing "Innovating trusted class antibiotics attack superbugs" PubMed Articles 1–25 of 4,200+

Octapeptins: Lipopeptide Antibiotics against Multidrug-Resistant Superbugs.

Antimicrobial resistance is increasing at an alarming rate. Polymyxin, one of the few antibiotics of last resort, is heavily affected. In this issue of Cell Chemical Biology, Velkov et al. (2018) present a promising alternative: octapeptin lipopeptide antibiotics active against multidrug- and extensively drug-resistant Gram-negative bacteria, which might help overcoming resistance toward polymyxins.


Emerging Antimicrobial Research against Superbugs: Perspectives from a Polymer Laboratory.

Infectious diseases caused by drug-resistant microorganisms have become a major contributor for human morbidity and mortality. To overcome such threats, we have developed various antimicrobial agents using natural product derivatives and metallopolymers. Abundant biomass such as resin acids can be utilized to prepare cationic polymers for inhibiting a variety of bacteria. These polymers have been used in solution as well as surfaces as antimicrobial materials with low cytotoxicity. In addition, a class of c...

A New Mechanism for β-Lactamases: Class D Enzymes Degrade 1β-Methyl Carbapenems via Lactone Formation.

β-Lactamases threaten the clinical use of carbapenems, considered antibiotics of last resort. The classical mechanism of serine carbapenemase activity proceeds via hydrolysis of an acyl-enzyme intermediate. We show that class D β-lactamases also degrade clinically used 1β-methyl-substituted carbapenems via the unprecedented formation of a carbapenem-derived β-lactone. β-Lactone formation results from the nucleophilic attack of the carbapenem hydroxyethyl side chain onto the ester carbonyl of the acyl-e...


Therapeutic Drug Monitoring of Beta-Lactams and Other Antibiotics in the Intensive Care Unit: Which Agents, Which Patients and Which Infections?

Antibiotics are among the medications most frequently administered to the critically ill, a population with high levels of intra- and inter-individual pharmacokinetic variability. Our knowledge of the relationships among antibiotic dosing, exposure and clinical effect in this population has increased in recent decades. Therapeutic drug monitoring (TDM) of serum antibiotic concentrations is the most practical means of assessing adequate antibiotic exposure, though until recently, it has been underutilised fo...

Sequential cooperative spectrum sensing in the presence of dynamic Byzantine attack for mobile networks.

Cooperative spectrum sensing (CSS) is envisaged as a powerful approach to improve the utilization of scarce radio spectrum resources, but it is threatened by Byzantine attack. Byzantine attack has been becoming a popular research topic in both academia and industry due to the demanding requirements of security. Extensive research mainly aims at mitigating the negative effect of Byzantine attack on CSS, but with some strong assumptions, such as attackers are in minority or trusted node(s) exist for data fusi...

Stabbed while Sleeping: Synthetic Retinoid Antibiotics Kill Bacterial Persister Cells.

Antibiotic-tolerant persister cells are difficult to eradicate by conventional classes of antibiotics. Kim and colleagues have discovered a new class of synthetic retinoid antibiotics that kill Staphylococcus aureus persisters by disrupting their cytoplasmic membrane.

Claramines : A new class of broad-spectrum antimicrobial agents with bimodal activity.

The emergence of multidrug resistant bacteria/pathogens has highlighted the need for the development of new antibiotics. In this manuscript, we report herein our results dealing with the broad spectrum of antibacterial activity against both sensitive and resistant Gram-negative and Gram-positive bacterial strains of an easily prepared water soluble polyaminosterol compound namely claramine A1. We will also demonstrate its peculiar mechanism of action (different from all the well-known classes of antibiotics...

Trusted Operations on Sensor Data .

The widespread use of mobile devices has allowed the development of participatory sensing systems that capture various types of data using the existing or external sensors attached to mobile devices. Gathering data from such anonymous sources requires a mechanism to establish the integrity of sensor readings. In many cases, sensor data need to be preprocessed on the device itself before being uploaded to the target server while ensuring the chain of trust from capture to the delivery of the data. This can b...

VLSI Design of Trusted Virtual Sensors.

This work presents a Very Large Scale Integration (VLSI) design of trusted virtual sensors providing a minimum unitary cost and very good figures of size, speed and power consumption. The sensed variable is estimated by a virtual sensor based on a configurable and programmable PieceWise-Affine hyper-Rectangular (PWAR) model. An algorithm is presented to find the best values of the programmable parameters given a set of (empirical or simulated) input-output data. The VLSI design of the trusted virtual sensor...

Keeping Antibiotics at Home Promotes Self-Medication with Antibiotics among Chinese University Students.

Inappropriate use of antibiotics has caused antimicrobial resistance, presenting a major health challenge to the world population. Self-medication with antibiotics (SMA) is currently at an alarming level in China.

Efficacy of prophylactic probiotics in combination with antibiotics versus antibiotics alone for colorectal surgery: A meta-analysis of randomized controlled trials.

This meta-analysis aimed to determine whether prophylactic probiotics in combination with antibiotics are superior to antibiotics alone in the prevention of surgical site infection (SSI) after colorectal surgery. Fourteen trials involving 1524 participants were included. Compared with antibiotics alone, prophylactic probiotics in combination with antibiotics reduced the risk of SSI as well as other complications, shortened the cumulative duration of antibiotic therapy. Current evidence suggested that probio...

Electrocatalytic dechlorination of halogenated antibiotics via synergistic effect of chlorine-cobalt bond and atomic H.

Although noble metal electrocatalysts are highly efficient in the dehalogenation of halogenated antibiotics, the prohibitive cost hinders their practical applications. In this study, a cobalt-phosphorous/oxide (CoP/O) composite prepared via a one-step electrodeposition was for the first time applied in electroreductive dechlorination of halogenated antibiotics (HA), including chloramphenicol (CAP), florfenicol (FLO) and thiamphenicol (TAP). CoP/O had a higher FLO dechlorination efficiency (91%) than Pd/C (6...

Stand-by antibiotics encourage unwarranted use of antibiotics for travelers' diarrhea: A prospective study.

As antibiotics predispose travelers to acquiring multidrug-resistant intestinal bacteria, they should no longer be considered a mainstay for treating travelers' diarrhea. Stand-by antibiotics are justified as a means to avoid visits with local healthcare providers often causing polypharmacy.

Frequency of Treatment Switching for Spironolactone Compared to Oral Tetracycline-Class Antibiotics for Women With Acne: A Retrospective Cohort Study 2010-2016.

Long-term oral antibiotic use in acne may be associated with a variety of adverse effects including antibiotic resistance, pharyngitis, inflammatory bowel disease, and breast and colon cancer. Spironolactone may represent an effective and safe alternative to oral antibiotics for women with moderate to severe acne, however comparative studies are lacking.

Dental, Oral, and Craniofacial Regenerative Medicine: Transforming Biotechnologies for Innovating Patient Care.

Antibiotics in early life: dysbiosis and the damage done.

Antibiotics are the most common type of medication prescribed to children, including infants, in the Western world. While use of antibiotics has transformed previously lethal infections into relatively minor diseases, antibiotic treatments can have adverse effects, as well. It has been shown in children, adults and animal models that antibiotics dramatically alter the gut microbial composition. Since the gut microbiota plays crucial roles in immunity, metabolism, and endocrinology, the effects of antibiotic...

Oral versus inhaled antibiotics for bronchiectasis.

Bronchiectasis is a chronic inflammatory disease characterised by a recurrent cycle of respiratory bacterial infections associated with cough, sputum production and impaired quality of life. Antibiotics are the main therapeutic option for managing bronchiectasis exacerbations. Evidence suggests that inhaled antibiotics may be associated with more effective eradication of infective organisms and a lower risk of developing antibiotic resistance when compared with orally administered antibiotics. However, it i...

New views of head-to-middle and cis- head-to-tail prenyltransferases: Structure of isosesquilavandulyl diphosphate synthase.

We report the first X-ray crystallographic structure of the "head-to-middle" prenyltransferase, isosesquilavandulyl diphosphate synthase, involved in biosynthesis of the merochlorin class of antibiotics. The protein adopts the ζ or cis-prenyl transferase fold but remarkably, unlike tuberculosinol adenosine synthase and other cis-prenyl transferases (e.g. cis-farnesyl, decaprenyl, undecaprenyl diphosphate synthases), the large, hydrophobic side-chain does not occupy a central hydrophobic tunnel. Instead, it...

Antimicrobial peptide capsids of de novo design.

The spread of bacterial resistance to antibiotics poses the need for antimicrobial discovery. With traditional search paradigms being exhausted, approaches that are altogether different from antibiotics may offer promising and creative solutions. Here, we introduce a de novo peptide topology that-by emulating the virus architecture-assembles into discrete antimicrobial capsids. Using the combination of high-resolution and real-time imaging, we demonstrate that these artificial capsids assemble as 20-nm holl...

Serum apolipoprotein E may be a novel biomarker of migraine.

Migraine attacks alter various molecules that might be related to the pathophysiology of migraine, such as serotonin, calcitonin gene-related peptide, and nitric oxide. The underlying pathophysiology of migraine is as yet unclear. We explored key proteins related to the pathogenesis of migraine here. Serum was collected from two patients with migraine with aura (MA) and seven patients with migraine without aura (MO) during attack-free periods and migraine attacks. Samples were analyzed using 2-dimensional g...

Ciprofloxacin-mediated induction of S-phase cell cycle arrest and apoptosis in COLO829 melanoma cells.

Low effectiveness of anti-melanoma therapies makes it necessary to search for new drugs that could improve or replace the standard chemotherapy. Fluoroquinolones are a group of synthetic antibiotics, used in the treatment of wide range of bacterial infections. Moreover, this class of antibiotics has shown promising anti-tumor activity in several cancer cell lines. The aim of this study was to examine the effect of ciprofloxacin on cell viability, apoptosis and cell cycle distribution in COLO829 melanoma cel...

How Academic Health Systems Can Achieve Population Health in Vulnerable Populations Through Value-Based Care: The Critical Importance of Establishing Trusted Agency.

Improving population health may require health systems to proactively engage patient populations as partners in the implementation of healthy behaviors as a shared value using strategies that incentivize healthy outcomes for the population as a whole. The current reactive health care model, which focuses on restoring the health of individuals after it has been lost, will not achieve the goal of improved population health. To achieve this goal, health systems must proactively engage in partnerships with the ...

Antibiotic Use and Reduction in Veterinary Medicine.

After a short history of the development of antimicrobial substances and the initially underestimated resistance problem, the paper describes the method of monitoring the use of antibiotics in food animals at farm level. The resulting benchmarking led to a remarkable reduction of the amount of antibiotics used in animals. However, it is also explained that, apart from reducing the use of antibiotics, the rules for "prudent use" of antibiotics have to be complied with. Concluding, a critical analysis of the ...

Microbial interactions trigger the production of antibiotics.

Since the discovery of penicillin, antibiotics have been instrumental in treating infectious diseases. However, emerging antibiotic multi-resistance coinciding with a nearly exhausted drug pipeline is a major concern for the future of the therapy of infections. A novel approach for the discovery of antibiotics relies on the analysis of microbial consortia in their ecological context, taking into account the potential natural role of antibiotics. Co-cultivations of microorganisms have been successfully appli...

A new class of synthetic retinoid antibiotics effective against bacterial persisters.

A challenge in the treatment of Staphylococcus aureus infections is the high prevalence of methicillin-resistant S. aureus (MRSA) strains and the formation of non-growing, dormant 'persister' subpopulations that exhibit high levels of tolerance to antibiotics and have a role in chronic or recurrent infections. As conventional antibiotics are not effective in the treatment of infections caused by such bacteria, novel antibacterial therapeutics are urgently required. Here we used a Caenorhabditis elegans-MRSA...


Advertisement
Quick Search
Advertisement
Advertisement