PubMed Journals Articles About "Innovation Could Spur Faster Cheaper Nano Based Manufacturing" RSS

20:48 EST 15th November 2018 | BioPortfolio

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Showing "Innovation Could Spur Faster Cheaper Nano Based Manufacturing" PubMed Articles 1–25 of 34,000+

Effect of innovation capacity, production capacity and vertical specialization on innovation performance in China's electronic manufacturing: Analysis from the supply and demand sides.

Manufacturing in China has developed rapidly with the widening and deepening of globalization, but only innovation can industry keep upgrading and enhancing its international competitiveness. This paper combines Global Value Chains (GVCs) and National Value Chains (NVCs) in a unified theory framework, uses Structural Decomposition Analysis (SDA) to explore how innovation capacity, production capacity, and vertical specialization affect innovation performance from the supply and demand sides by examining the...

Bizarre calcaneal spur: A case report.

A calcaneal spur, also known as enthesophyte, is an abnormal bone outgrowth at the inferior part of the calcaneus, which is the most common site of bony spur occurrence. Although there is consensus that a calcaneal spur is a common cause of heel pain, approximately 20% of calcaneal spurs are asymptomatic and its pathology remains not fully understood.

Research on the sliding friction associated spur-face gear meshing efficiency based on the loaded tooth contact analysis.

In order to solve the problem of Meshing Efficiency of spur-face gear sliding friction, a method for calculating the Meshing Efficiency of Spur-Face gear is proposed based on Elastohydrodynamic lubrication (EHL) theory. Through the Tooth Contact Analysis (TCA) and Loaded Tooth Contact Analysis technique (LTCA) method, the meshing process of the Spur-Face gear was simulated. The calculation model of Sliding friction coefficient was established by using non Newtonian quasi steady thermal Elastohydrodynamic lu...

Compressed sensing FTIR nano-spectroscopy and nano-imaging.

Infrared scattering scanning near-field optical microscopy (IR s-SNOM) provides for spectroscopic imaging with nanometer spatial resolution, yet full spatio-spectral imaging is constrained by long measurement times. Here, we demonstrate the application of compressed sensing algorithms to achieve hyperspectral FTIR-based nano-imaging at an order of magnitude faster imaging speed to achieve the same spectral content compared to conventional approaches. At the example of the spectroscopy of a single vibrationa...

Comparison of high pressure homogenization and stirred bead milling for the production of nano-crystalline suspensions.

Currently, the two technologies primarily used for the manufacturing of nano-crystalline suspensions using top down process (i.e. wet milling) are high pressure homogenization (HPH) and stirred bead milling (SBM). These two technologies are based upon different mechanisms, i.e., cavitation forces for HPH and shear forces for stirred bead milling. In this article, the HPH and SBM technologies are compared in terms of the impact of the suspension composition the process parameters and the technological config...

Preliminary report of the characteristics of the upper thigh spur area of the femoral neck in Garden I and II subcapital fractures.

The "heart" of the calcar is the internal cortical septum called "femoral thigh spur". Nevertheless, the integrity of the femoral thigh spur and its extensions in Garden I and II  femoral neck fractures has not been examined in depth, in CT scan-based studies. The aim of this retrospective study is to analyze characteristics as integrity of upper thigh spur area of the intra-capsular femoral neck using precise CT scans, as well as features of the medial cortical bone interruption of orthopedic calcar, in f...

Considering the forms of released engineered nanomaterials in probabilistic material flow analysis.

Most existing models for assessing the releases of engineered nanomaterials (ENMs) into the environment are based on the assumption that ENMs remain in their pristine forms during their whole life cycle. It is known, however, that this is not always the case as ENMs are often embedded into solid matrices during manufacturing and can undergo physical or chemical transformations during their life cycle, e.g. upon release to wastewater. In this work, we present a method for systematically assessing the forms i...

Addressing the paradox of the team innovation process: A review and practical considerations.

Facilitating team innovation is paramount to promoting progress in the science, technology, engineering, and math fields, as well as advancing national health, safety, prosperity, and welfare. However, innovation teams face a unique set of challenges due to the novelty and uncertainty that is core to the definition of innovation, as well as the paradoxical nature of idea generation and idea implementation processes. These and other challenges must be overcome for innovation teams to realize their full poten...

Magnetic nano-nets for capture of microbes in solution based on physical contact.

Self-assembly of Au nanoparticles with Fe ions is used to develop magnetic nano-nets similar to fishing nets for capture and removal of microbes in aqueous medium. The nano-nets have a high aspect ratio, span microns in length with openings of 80-300 nm. This allows them to sample the liquid medium even at low volume fraction and also entrap the microbes in the solution. The nets and the trapped microbes can be effectively pulled from the solution by using an off the shelf magnet. Since the capture is bas...

High Mobility Indium Oxide Electron Transport Layer for Efficient Charge Extraction and Optimized Nano-Morphology in Organic Photovoltaics.

Electron transport layer (ETL) plays an important role in determining the device efficiency of organic solar cells (OSCs). A rational design of ETL for OSCs targets high charge extraction and induction of an optimized active layer morphology. In this manuscript, a high mobility In2O3 synthesized via a solution-processed combustion reaction is successfully used as a universal ETL in an organic photovoltaic device. With the modification of a thin layer of polyethylenimine ethoxylated (PEIE), device based on t...

Processing Lignocellulose-Based Composites into an Ultrastrong Structural Material.

Nature lignocellulose has been a significant renewable raw material due to high specific mechanical properties, in comparison to the values of traditional reinforcing fibres. However, the unsatisfactory mechanical performance of lignocellulose-based materials has limited applications in many advanced engineering domain. Herein, we demonstrate that layered bulk delignified nano-lignocellulose/brushite composites with a multifold increase in strength and toughness. Our procedure contains the partially removin...

A new method for measurement of the size of subacromial spurs of the shoulder by cassette tilt view.

Subacromial impingement syndrome is one of the most common causes of pain in the shoulder. To this date, there is no specific radiographic view that can be used to evaluate the size of a subacromial spur. This study aims to examine a cassette tilt view can be used to evaluate the size of a subacromial spur.

HitPickV2: a Web Server to predict targets of chemical compounds.

The identification of protein targets of novel compounds is essential to understand compounds' mechanisms of action leading to biological effects. Experimental methods to determine these protein targets are usually slow, costly and time consuming. Computational tools have recently emerged as cheaper and faster alternatives that allow the prediction of targets for a large number of compounds.

Dual-targeted nano-in-nano albumin carriers enhance the efficacy of combined chemo/herbal therapy of lung cancer.

A Nano-in-Nano approach was exploited to facilitate incorporation of the chemotherapeutic drug etoposide (ETP) as nanosuspension, synergistically with berberine (BER) into hydrophilic albumin nanoparticles (HSA NPs).

BIPSPI: a method for the prediction of Partner-Specific Protein-Protein Interfaces.

Protein-Protein Interactions (PPI) are essentials for most cellular processes and thus, unveiling how proteins interact is a crucial question that can be better understood by identifying which residues are responsible for the interaction. Computational approaches are orders of magnitude cheaper and faster than experimental ones, leading to proliferation of multiple methods aimed to predict which residues belong to the interface of an interaction.

RTD-based Material Tracking in a Fully-Continuous Dry Granulation Tableting Line.

Continuous manufacturing (CM) offers quality and cost-effectiveness benefits over currently dominating batch processing. One challenge that needs to be addressed when implementing CM is traceability of materials through the process, which is needed for the batch/lot definition and control strategy. In this work the residence time distributions (RTD) of single unit operations (blender, roller compactor and tablet press) of a continuous dry granulation tableting line were captured with NIR based methods at se...

Bioinspired, multiscale reinforced composites with exceptionally high strength and toughness.

Nature's multiscale reinforcing mechanisms in fabricating composite armors such as seashells provide lessons for engineering materials design and manufacturing. However, it is still a challenge to simultaneously add both micro- and nano-reinforcements in a matrix material since nano-fillers tend to agglomerate, decreasing their reinforcing effects. In this study, we report a new type of micro/nano hybrid filler, synthesized by an unconventional cotton aided method, which has B4C microplatelet as the core an...

One-pot solvent-free synthesis of 2,3-dihydro-2-substituted-1H-naphtho1,2-e1,3oxazine derivatives using FeO@nano-cellulose/TiCl as a bio-based and recyclable magnetic nano-catalyst.

The present study describes an efficient and environmentally benign protocol for the synthesis of 2,3-dihydro-2-substituted-1H-naphtho[1,2-e][1,3]oxazine derivatives. Synthesis is done by one-pot three-component condensation of 2-naphthol, formaldehyde, and primary amines in the presence of FeO@nano-cellulose/TiCl as a bio-based magnetic nano-catalyst under solvent-free conditions at room temperature grinding. This green procedure offers the advantages of high yield, short reaction time, environmental frien...

The Barrow Innovation Center case series: Early clinical experience with a novel surgical instrument used to prevent intraoperative spinal cord injuries.

The Barrow Innovation Center comprises an educational program in medical innovation that enables residents to identify problems in patient care and to rapidly develop and implement solutions to these problems. Residents involved in this program noted an elevated risk of iatrogenic spinal cord injury during posterior cervical and thoracic procedures. The objective of this study was to describe this complication and a novel solution developed through a new innovation training program.

CRISPR-Cas9: A Precise Approach to Genome Engineering.

In the last few decades, genomic manipulation has made significant progress as a result of the development of recombinant DNA technologies; however, more often than not, these techniques have been costly and labor intensive. In contrast, recently developed next-generation sequencing (NGS) technologies have provided a cheaper, faster, and easier process to study genomics. In particular, an NGS technique emerged from bacterial CRISPR-associated protein-9 nuclease (Cas9) as a revolutionary method to modify, re...

Nano-Structured Bi Grown on Epitaxial Graphene/SiC.

Controllable growth of metal nano-structures on epitaxial graphene (EG) is particularly interesting and important for the applications in electric devices. In this paper, Bi nanostructures on EG/SiC are fabricated through thermal decomposition of SiC and subsequent low-flux evaporation of Bi. The orientation, atomic structure and thickness dependent electronic states of Bi are investigated by scanning tunneling microscopy/spectroscopy (STM/S). It is found that metallic Bi nano-flakes and nano-rods prefer to...

Potential benefits and phytotoxicity of bulk and nano-chitosan on the growth, morphogenesis, physiology, and micropropagation of Capsicum annuum.

Concerning environmental issues of metal based-nanomaterials and increasing demand for nano-based products; various strategies have been employed to find eco-friendly natural nano-compounds, among which nano-polymer chitosan is mostly considered. Herein, the various aspects of the way in which bulk or nano-chitosan may modify growth, morphogenesis, micropropagation, and physiology of Capsicum annuum L. were considered. Culture medium was manipulated with different concentrations of bulk chitosan or synthesi...

A tutorial for developing a topical cream formulation based on the Quality by Design approach.

The pharmaceutical industry has entered in a new era, as there is a growing interest in increasing the quality standards of dosage forms, through the implementation of more structured development and manufacturing approaches. For many decades, the manufacturing of drug products was controlled by a regulatory framework to guarantee the quality of the final product through a fixed process and exhaustive testing. Limitations related to the Quality by Test (QbT) system have been widely acknowledged. The emergen...

Designing and testing an educational innovation.

Technology provides an opportunity to develop innovations to improve the way we teach. Developing educational innovations must be approached in a methodical and thorough manner to identify the educational gap and validate the innovation's success in filling the gap. A successful educational innovation requires a stepwise approach that includes needs assessment, design of intervention, testing and analysis, evaluation of intervention, and determination of learning retention.

Multi-Drug Delivery System Based on Lipid Membrane Mimetic Coated Nano-hydroxyapatite Formulations.

Local delivery systems from an osteoconductive biomaterial are suggested as a promising strategy to avoid simultaneously peri-implant traumas and to induce tissue regeneration. In this work, it is detailed the design and construction of a multi-drug delivery formulation based on lipid membrane mimetic coated nano-hydroxyapatite, LMm / nano-HA, as a bone-specific drug delivery approach. The optimal LMm / nano-HA formulation was selected after analysing the lipid/ nano-HA interaction by dynamic light scatteri...

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