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PubMed Journals Articles About "Interim Data Shows Stelara Promise Crohn" RSS

16:21 EDT 3rd April 2020 | BioPortfolio

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Showing "Interim data shows Stelara promise Crohn" PubMed Articles 1–25 of 28,000+

IM-UNITI at Three Years: Stellar Stelara® or Stardust? The Efficacy, Safety, and Immunogenicity of Ustekinumab Treatment of Crohn's Disease.


Preservation of the mesorectum in proctectomy for Crohn's does not compromise outcome.

Interim monitoring in a treatment strategy trial with a composite primary endpoint.

When a clinical trial has a composite endpoint and a comparison of treatment strategies with multiple intervention components, interim data reviews by a data safety and monitoring board (DSMB) can be challenging as the data evolve on multiple fronts. We illustrate with a study in the treatment of Kaposi sarcoma (KS), an HIV-associated cancer with a multi-faceted disease presentation. The study, ACTG-A5264/AMC-067, was a 1:1 randomized trial to compare two strategies: immediate initiation of etoposide with a...


Small Bowel Adenocarcinoma: Is there a difference in survival for Crohn's versus Sporadic cases?

It is well known that Crohn's disease is a risk factor for the development of small bowel adenocarcinoma. However, the association between Crohn's disease-associated small bowel adenocarcinoma and survival is less understood. The goal of this study is to determine the impact of Crohn's disease on survival in small bowel adenocarcinoma.

Evaluating the cost-effectiveness of early compared to late or no biologic treatment to manage Crohn's disease using real world data.

We evaluated the cost-effectiveness of early (≤2 years after diagnosis) compared to late or no biologic initiation (starting biologics >2 years after diagnosis or no biologic use) for adults with Crohn's disease in Switzerland.

Diagnosis and outcome of oesophageal Crohn's disease.

Crohn's disease (CD) can involve any part of the gastrointestinal tract. We aimed to characterize clinical, endoscopic, histologic features and treatment outcomes of CD patients with oesophageal involvement.

Integrating phase 2 into phase 3 based on an intermediate endpoint while accounting for a cure proportion-With an application to the design of a clinical trial in acute myeloid leukemia.

For a trial with primary endpoint overall survival for a molecule with curative potential, statistical methods that rely on the proportional hazards assumption may underestimate the power and the time to final analysis. We show how a cure proportion model can be used to get the necessary number of events and appropriate timing via simulation. If phase 1 results for the new drug are exceptional and/or the medical need in the target population is high, a phase 3 trial might be initiated after phase 1. Buildin...

A completely digital workflow for an interim implant-supported crown: A clinical report.

This article describes a completely digital workflow for the diagnostic phase, surgical and prosthetic planning, extraction, immediate single implant placement by guided surgery, and interim implant-supported crown. From a virtual impression, zirconia abutments and a polymethylmethacrylate (PMMA) interim crown was planned in a computer-aided design (CAD) software program. This workflow shortened the time required for chairside placement of an interim restoration with enhanced function and esthetics while re...

MicroRNA23a Overexpression in Crohn's Disease Targets Tumour Necrosis Factor Alpha Inhibitor Protein 3, Increasing Sensitivity to TNF and Modifying the Epithelial Barrier.

Mucosal healing is important in Crohn's disease therapies. Epithelial homeostasis becomes dysregulated in Crohn's, with increased permeability, inflammation, and diarrhoea. MicroRNAs are small non-coding RNAs that regulate gene expression and show changes in inflammatory bowel disease. Tumour necrosis factor alpha [TNFα] inhibitor protein 3 is raised in Crohn's and regulates TNFα-mediated activation of NFκB. We investigated TNFα regulation by microRNA in Crohn's disease [CD], and studied effects on epit...

Historical upheavals and eponyms in Crohn's disease - is there any relation ?

ECCO Guidelines on Therapeutics in Crohn's Disease: medical treatment.

Causes and Prognosis of Intestinal Failure in Crohn's Disease: An 18-year Experience from a National Centre.

Intestinal failure (IF) is a feared complication of Crohn's disease (CD). Although cumulative loss of small bowel due to bowel resections is thought to be the dominant cause, the causes and outcomes have not been reported.

Two cases of successful ustekinumab treatment for non-infectious uveitis associated with Crohn's disease.

Metastatic cutaneous Crohn's disease of the face - a successful case treated with ustekinumab.

Ustekinumab is a safe and effective biologic agent for Crohn's disease in a Liver Transplant patient.

Increased Postoperative Use of Computed Tomography Following Emergency Surgery for Ileocaecal Crohn Disease.

Multiple imaging modalities are often required for the relapsing nature of Crohn disease (CD). Computed tomography (CT) offers a rapid acquisition of images and shows high specificity and sensitivity. However, CT imaging exposes to a higher dose of ionizing radiation than other abdominal imaging modalities. The aim of this study was to compare the use of preoperative and postoperative CT scan in patients undergoing emergency and elective surgery for CD.

Terminal ileitis due to Yersinia enterocolitica: differential diagnosis with Crohn´s disease in a 12-year-old male.

Yersinia enterocolitica is a gram-negative rod causing intestinal infection in humans. It shows different clinical pictures with many different etiologies to be ruled-out, which sometimes makes it difficult to reach a timely and correct diagnosis. We report the case of an adolescent boy presenting with right lower quadrant pain from terminal ileitis with endoscopic findings akin to Crohn´s disease finally diagnosed as Yersinia enterocolitica, highlighting the usefulness of the different ancillary methods e...

Successful treatment of hidradenitis suppurativa in the setting of Crohn disease with combination adalimumab and ustekinumab.

Herein we report the combination of adalimumab and ustekinumab to successfully treat a 39-year-old woman who presented for evaluation of hidradenitis suppurativa in the setting of Crohn disease of both the small and large intestine. The patient reported previous control of her hidradenitis when she was using adalimumab for her Crohn disease. She had recently been started on ustekinumab for Crohn disease and had flaring of her hidradenitis. The patient re-started on adalimumab weekly and ustekinumab every 8 ...

CD40 blockade shows promise in pSS trial.

Anti-PD-1 shows promise against advanced paediatric Hodgkin lymphoma.

A review of breath analysis techniques in head and neck cancer.

Cancers of the head and neck region are a severely disabling group of diseases with no method for early detection. Analysis of exhaled breath volatile organic compounds shows promise as biomarkers for early detection and disease monitoring. This article reviews breath analysis in the setting of head and neck cancer, with a practical focus on breath sampling techniques, detection technologies and valid data analysis methods. Title and abstract keyword searches were conducted on PubMed and Embase databases to...

Fragility index: how fragile is the data that support the American College of Gastroenterology guidelines for the management of Crohn's disease?

Randomized controlled trials (RCTs) are the cornerstone of evidence-based medicine. However, recent literature has drawn attention to the limitations of using P-value to report statistical significance of outcomes in the clinical trials. We performed this analysis to analyze the strength of the data that supported the American College of Gastroenterology (ACG) guidelines for 'Management of Crohn's disease in adults' using fragility index (FI). We screened all the RCTs referenced in the 2018 ACG guidelines '...

Anti-PD-1 shows promise against advanced paediatric Hodgkin lymphoma - Author's reply.

Microscopic inflammation at ileocaecal resection margins in Crohn's disease: prevent recurrence or treat residual disease?

Riboflavin supplementation in patients with Crohn's disease (RISE-UP study).

Crohn's disease (CD) is characterized by chronic intestinal inflammation and dysbiosis in the gut. Riboflavin (vitamin B2) has anti-inflammatory, anti-oxidant and microbiome-modulatory properties. Here, we analyzed the effect of riboflavin on oxidative stress, markers of inflammation, clinical symptoms and the faecal microbiome in patients with CD.


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