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02:09 EDT 30th March 2020 | BioPortfolio

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Showing "Ionis Pharmaceuticals IONS Presents 17th Annual Morgan Stanley" PubMed Articles 1–25 of 5,700+

Mytilidae as model organisms in the marine ecotoxicology of pharmaceuticals - A review.

Growing production and consumption of pharmaceuticals is a global problem. Due to insufficient data on the concentration and distribution of pharmaceuticals in the marine environment, there are no appropriate legal regulations concerning their emission. In order to understand all aspects of the fate of pharmaceuticals in the marine environment and their effect on marine biota, it is necessary to find the most appropriate model organism for this purpose. This paper presents an overview of the ecotoxicologica...


Insights into the isotherm and kinetic models for the coadsorption of pharmaceuticals in the absence and presence of metal ions: A review.

Pharmaceuticals are a wide class of emerging pollutants due to their continuous and the increasing consumption of users. These pollutants are usually found in the real environment as mixtures alone or with metal ions. Thus, the migration risk increases, which complicates the removal of pharmaceuticals because of the combined and synergistic effects. The focus of treatment of pharmaceutical mixtures and their coexistence with metals is of considerable importance. For this purpose, adsorption has been efficie...

Prescribing and Research in Medicines Management - PRIMM (UK & Ireland) 31st Annual Scientific Meeting, Manchester, UK, January 17th, 2020: 'Medication Without Harm - WHO is Responsible?'


Spatial distribution and temporal trends of pharmaceuticals sorbed to suspended particulate matter of German rivers.

Although several studies confirmed a wide distribution of pharmaceuticals in rivers and streams, a limited knowledge is available about the partitioning of pharmaceuticals between the water phase and suspended particulate matter (SPM). To close this gap of knowledge, we developed and validated a sensitive and high throughput analytical method for the analysis of 57 pharmaceuticals, 42 metabolites and transformation products (TP) as well as the artificial sweetener acesulfame sorbed to SPM. The method was ba...

Occurrence and ranking of pharmaceuticals in the major rivers of China.

Residual pharmaceuticals have received widespread attention worldwide due to their continuous release and potential hazard to the environment. As a result of rapid development and a large population, China has become a country with high production and consumption of pharmaceuticals. This may be the main reason for the high detection frequencies and concentrations of pharmaceuticals in the aquatic environment in China. Rivers represent an important water resource and play an important role in the sustainable...

Analysis, occurrence and removal of pharmaceuticals in African water resources: A current status.

Pharmaceuticals are organic compounds used in medicines for alleviation of pain. Since 2017, there has been a steady increase on the availability of information on contamination of water resources caused by pharmaceuticals in some African countries. Thus far, most environmental monitoring studies of pharmaceuticals are conducted in South Africa while there is still no available data in majority of the African countries. Therefore, the knowledge on the presence of pharmaceuticals in African water resources i...

Contributions of Zn Ions to ZnO Nanoparticle Toxicity on Microcystis aeruginosa During Chronic Exposure.

In this work, we assessed the toxic effects of ZnO nanoparticles (NPs; 1, 10, and 50 mg L) and the corresponding dissoluble Zn ions (0.71, 8.66, and 35.59 mg L) on Microcystis aeruginosa. After chronic exposure (28 days), significantly higher growth inhibition was observed under ZnO NPs at 1 mg L (47%) than under Zn ions at 0.71 mg L (-15%). The opposite effect pattern was observed for ZnO NPs at 10 (71% vs. 80%) and 50 mg L (73% vs. 95%) compared to Zn ions at the corresponding concentrations. A...

Isotopic evidence for anthropogenic lead exposure on a 17th/18th century Barbadian plantation.

To identify and characterize anthropogenic lead sources on a 17th/18th century Barbadian plantation and to test if lead isotope analyses can be used to identify the geographic origins of first-generation African captives.

Prioritization of pharmaceuticals in water environment in China based on environmental criteria and risk analysis of top-priority pharmaceuticals.

Numerous studies have shown that a wide range of pharmaceuticals are present in the environment and many of their adverse biological effects on the aquatic ecosystem and human health are unknown. Due to the high population density and large number of pharmaceuticals produced and consumed in China, a systematic approach is needed to identify pharmaceuticals that require greater attention. The present study provides a ranking of pharmaceuticals in China in terms of their occurrence (O), persistence, bioaccumu...

Biological-activity-based prioritization of pharmaceuticals in wastewater for environmental monitoring: G protein-coupled receptor inhibitors.

Pharmaceuticals raise concerns for aquatic species owing to their biological activities. It is estimated that nearly 40% of marketed pharmaceuticals target G protein-coupled receptors (GPCRs). Using an in vitro transforming growth factor-α (TGFα) shedding assay, we previously detected antagonistic activities of GPCR-acting pharmaceuticals against angiotensin (AT1), dopamine (D2), acetylcholine (M1), adrenergic family members (β1), and histamine (H1) receptors at up to μg-antagonist-equivalent quantities...

Occurrence, distribution, and ecological risk of pharmaceuticals in a seasonally ice-sealed river: From ice formation to melting.

Occurrence, distribution, and ecological risk of 21 pharmaceuticals in the Jilin Songhua River were investigated during its freeze-thaw periods, including ice formation, sealed, and breakup. Florfenicol was the most abundant pharmaceutical, with mean concentrations of 123.4 ± 61.1 ng L in water and 73.8 ± 66.3 ng kg in ice. Sulfadiazine occurred at a higher mean concentration in downstream areas (45.6 ± 7.4 ng L) than in upstream areas (0.7 ± 0.7 ng L). Most pharmaceuticals appea...

Separation of trace pharmaceuticals individually and in combination via forward osmosis.

With a high rejection coefficient for trace pharmaceuticals and personal care products (PPCPs), forward osmosis (FO) membrane separation has become a cutting-edge technology in water treatment owing to its low energy consumption and low membrane fouling. Wastewater contains many types of PPCPs, and one pharmaceutical molecule affects the separation behaviors of other pharmaceuticals in FO. Therefore, simultaneous FO of multiple PPCPs needs to be investigated. In this study, the separation behaviors of four ...

Comparison of the regulatory outline of ecopharmacovigilance of pharmaceuticals in Europe, USA, Japan and Australia.

Pharmaceuticals are known to improve the quality of life by curing and preventing diseases. However, these pharmaceutical products, when it diffuses through the environment by various routes, can cause severe harmful effects to the living organisms. During the last several years, the coping with the impact of pharmaceuticals on the environment was one of the challenging tasks for the pharmaceutical industries. These concerns about the environmental health and safety risks paved the way in developing a prope...

Development of sulfur doped carbon quantum dots for highly selective and sensitive fluorescent detection of Fe and Fe ions in oral ferrous gluconate samples.

Sulfur-doped carbon quantum dots (S-CQDs) with stable blue fluorescence were synthesized through a facile one-step hydrothermal method by using ascorbic acid and thioglycolic acid as carbon and sulfur sources. The prepared S-CQDs exhibited a sensitive and selective response to Fe ions in comparison with Fe and other metal ions, In the presence of adequate HO, Fe was completely transformed to Fe that is the determinable form of iron ions, and the difference in the change of the fluorescence intensity of S-CQ...

Tributes to Our First President and Founding Father, Stanley J. Dudrick, MD, FACS, FASPEN.

Biological removal of pharmaceuticals by Navicula sp. and biotransformation of bezafibrate.

Pharmaceutically active compounds are of great concern due to their detection frequency in the environment and the unexpected risks. In this study, the simultaneous removal of mixed pharmaceuticals by microalgae was explored using a typical freshwater diatom Navicula sp. Results showed that Navicula sp. could efficiently remove atenolol, carbamazepine, ibuprofen and naproxen with the efficiencies of >90% after 21 d of exposure. As compared to the removal efficiencies of each pharmaceutical in the individu...

Network meta-analysis of randomized controlled trials comparing the procedure for prolapse and hemorrhoids, Milligan-Morgan hemorrhoidectomy and tissue-selecting therapy stapler in the treatment of grade III and IV internal hemorrhoids(Meta-analysis).

Hemorrhoids are one of the most common conditions in the world, and grade III and IV internal hemorrhoids are mainly treated with surgery. However, there are many different surgical methods, and many postoperative complications occur. Therefore, we aimed to update and expand our previous work to compare the safety and efficacy of the procedure for prolapse and hemorrhoids (PPH), Milligan-Morgan hemorrhoidectomy (MMH) and tissue-selecting therapy stapler (TST) in the treatment of grade III and IV internal he...

Degradation of pharmaceutical mixtures in aqueous solutions using UV/peracetic acid process: Kinetics, degradation pathways and comparison with UV/HO.

This paper presents an evaluation of UV/PAA process for degradation of four pharmaceuticals venlafaxine (VEN), sulfamethoxazole (SFX), fluoxetine (FLU) and carbamazepine (CBZ) with comparison to UV/HO process. The effectiveness of combining PAA and HO at various proportions while irradiating with UVC were also evaluated. UVC/PAA (λ = 254 nm) was effective in degrading all four pharmaceuticals and followed pseudo first-order kinetics. Increasing PAA dosage or UVC intensity resulted in a linear increase i...

Sorption of ionic and neutral species of pharmaceuticals to loessial soil amended with biochars.

To clarify the impact of biochar amendment on soil sorption for coexisting pharmaceuticals, wheat straw-derived biochars pyrolyzed at 300 and 700 °C (labeled as WS300 and WS700, respectively) were prepared. Batch experiments on ketoprofen (KTP), atenolol (ATL) and carbamazepine (CBZ) sorption to biochars, loessial soil and biochar-amended soils were conducted. The results indicated that sorption affinity of different species of pharmaceuticals to WS300 and WS700 was in the order of cationic ATL > neutral C...

Desorption of pharmaceuticals from pristine and aged polystyrene microplastics under simulated gastrointestinal conditions.

Microplastics (MPs) in the environment usually undergo extensive weathering and can transport pollutants to organisms once being ingested. However, the transportation mechanism and effect of aging process are poorly understood. This study systematically investigated the desorption mechanisms of pharmaceuticals from pristine and aged polystyrene (PS) MPs under simulated gastric and intestinal conditions of marine organisms. Results showed that the increased desorption in stomach mainly depended on the solubi...

Transhumanism: The cutting edge biology of the… 17th century.

Investigation of interaction behaviours of cesium and strontium ions with engineering barrier material to prevent leakage to environmental.

This study deals with performance of removal of cesium (Cs) and strontium (Sr) ions from synthetic aqueous solution using amino pyridine sulfone amid resin as a barrier material for nuclear waste storage areas to reduce environmental risk. The effects of adsorbate concentration, temperature and contact time on the efficiencies of the engineering barrier material for Cs and Sr ions were investigated and evaluated. It was found that total adsorption capacity was higher for cesium ions than strontium ions. Dub...

Abstracts of Poster Presentations Tuesday, 17th of September 2019.

Erratum to: Abstracts of Poster Presentations Tuesday, 17th of September 2019.

Sorption behavior of Arachis hypogaea shells against Ag ions and assessment of antimicrobial properties of the product.

The paper presents sorption behavior of Arachis hypogaea shells towards silver ions and possibility of their use as antimicrobial product. During the modification process of the natural sorbent, equilibrium tests were carried out. Moreover, the possibility of obtaining biocomposite Arachis hypogaea shells/nAg has been determined, and its antimicrobial properties have been evaluated. Additionally, sorption kinetics has been calculated. In the last step, silver ions were desorbed. The conducted equilibrium te...


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