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Journal Club 2019 Breakers PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Journal Club 2019 Breakers articles that have been published worldwide.
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The traditional journal club (JC) format of reviewing an article followed by group discussion may be misaligned with millennial learners' needs and may not rely on best principles of adult learning. Our objective was to deliver an interactive JC allowing pediatric residents to critically engage with medical education research without prior preparation.
Obliterative bronchiolitis (OB) is a poorly understood airway disease characterized by the generation of fibrotic bronchiolar occlusions. In the lung transplant setting, OB is a pathological manifestation of bronchiolitis obliterans syndrome (BOS), which is a major impediment to long-term recipient survival. Club cells play a key role in bronchiolar epithelial repair, but whether they promote lung transplant tolerance through preventing OB remains unclear. We determined if OB occurs in mouse orthotopic lung...
The Lindsay Leg Club network is a research-based initiative that provides treatment, health guidance, education and ongoing care for people of all age groups who are experiencing lower limb-related problems. Leg Club clinicians work in a unique partnership with patients (known as 'members') and the local community. Working to current best-practice guidelines, they provide a high standard of care in a social and friendly setting that promotes understanding, peer support and informed choice. This article pres...
The purpose of this study was to compare the game movement demands between professional club and senior international rugby union players. Data were obtained from 188 players from 4 professional club teams (Rabo Direct Pro12) and the affiliated international team during the 2014-15 season. Players were tracked by global positioning system (GPS) sampled at 10 Hz and were categorized into 6 different positional groups (front row forwards, FRF; second row forwards, SRF; back row forwards, BRF; half backs, HB...
Lung cancer and chronic lung diseases impose major disease burdens worldwide and are caused by inhaled noxious agents including tobacco smoke. The cellular origins of environmental-induced lung tumors and of the dysfunctional airway and alveolar epithelial turnover observed with chronic lung diseases are unknown. To address this, we combined mouse models of genetic labeling and ablation of airway (club) and alveolar cells with exposure to environmental noxious and carcinogenic agents. Club cells are shown t...
Although empirical evidence suggests that the adherence club model is more effective in retaining people living with HIV in antiretroviral treatment care and sustaining medication adherence compared to standard clinic care, it is poorly understood exactly how and why this works. In this paper, we examined and made explicit how, why and for whom the adherence club model works at a public health facility in South Africa.
Many older community-living persons with schizophrenia report unmet psychological and social needs. The Amsterdam-based New Club is a novel facility that intends to foster self-reliance and social participation in this group. To explore participants' and staff perceptions, a naturalistic qualitative study combined participant observation with interviews. The results illustrate how the New Club contributes to the personal and social recovery of its participants. At the personal level, attending the facility,...
The HospitalitY (HY) intervention is a novel recovery oriented intervention for people with psychotic disorders in which peer support and home-based skill training are combined in an eating club. A feasibility study was conducted to inform a subsequent randomised trial.
Epithelial cells that line lung airways produce and secrete proteins with important roles in barrier function and host defense. Secretion of airway goblet cells is controlled by autophagy proteins during inflammatory conditions, resulting in accumulation of mucin proteins. We hypothesized that autophagy proteins would also be important in the function of club cells, a dominant secretory airway epithelial cell that is dysregulated in chronic lung disease. We found that in the absence of an inflammatory stimu...
With the evolution of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) technique and equipment, the success rate of CTO PCI has improved over the years. We examined the failed cases in this expert registry and looked at the mode of failure.
The unusual clubbed tails of glyptodonts among mammals and ankylosaurines among dinosaurs most likely functioned as weapons of intraspecific combat or interspecific defense and are characterized by stiffening of the distal tail and, in some taxa, expansion of the distal tail tip. Although similarities in tail weaponry have been noted as a potential example of convergent evolution, this hypothesis has not been tested quantitatively, particularly with metrics that can distinguish convergence from long-term st...