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PubMed Journals Articles About "Karolinska Development Publ Karolinska Development Portfolio Company Aprea" RSS

12:13 EST 20th November 2019 | BioPortfolio

Karolinska Development Publ Karolinska Development Portfolio Company Aprea PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Karolinska Development Publ Karolinska Development Portfolio Company Aprea articles that have been published worldwide.

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Showing "Karolinska Development publ Karolinska Development portfolio company Aprea" PubMed Articles 1–25 of 18,000+

Oxygen sensing decoded: a Nobel concept in biology.

Oxygen is essential to most organisms as it is a necessity for aerobic metabolism and energy production. Too much or too little oxygen can be deadly, such that mechanisms for fast and titrated response to changing oxygen levels are crucial. These mechanisms have evolved from the studies of Gregg L. Semenza, William G. Kaelin and Peter J. Ratcliffe. It is through the work of their three laboratories, performed in the 1990s, that the cellular oxygen sensing mechanisms have been decoded. Their discoveries have...


Funding global health product R&D: the Portfolio-To-Impact Model (P2I), a new tool for modelling the impact of different research portfolios.

The Portfolio-To-Impact (P2I) Model is a novel tool, developed to estimate minimum funding needs to accelerate health product development from late stage preclinical study to phase III clinical trials, and to visualize potential product launches over time. A mixed methods approach was used. Assumptions on development costs at each phase were based on clinical trial costs from Parexel's R&D cost sourcebook. These were further refined and validated by interviews, with a wide variety of stakeholders from Prod...

CEPI: Driving Progress Towards Epidemic Preparedness And Response.

The Coalition of Epidemic Preparedness Innovations (CEPI) was formed in the aftermath of the 2014-15 Ebola outbreak in west Africa to support the development of vaccines that could improve the world's preparedness against outbreaks of epidemic infectious diseases. Since its launch in 2017, CEPI has mobilised over US$ 750 million to support its mission to develop vaccines against agents such as Lassa Virus, Middle East Respiratory Syndrome coronavirus, and Nipah Virus, as well as several rapid response vacci...


Developing new health technologies for neglected diseases: a pipeline portfolio review and cost model.

:  Funding for product development for neglected diseases fell from 2009-2015, other than a short-term injection of Ebola funding. One impediment to mobilizing resources is a lack of information on product candidates, the estimated costs to move them through the pipeline, and the likelihood of specific launches. This study aimed to help fill these information gaps. : We conducted a pipeline portfolio review to identify current candidates for 35 neglected diseases. Using an adapted version of the Portfolio ...

Science and Art of Protein Formulation Development.

Protein pharmaceuticals have become a significant class of marketed drug products and are expected to grow steadily over the next decade. Development of a commercial protein product is, however, a rather complex process. A critical step in this process is formulation development, enabling the final product configuration. A number of challenges still exist in the formulation development process. This review is intended to discuss these challenges, to illustrate the basic formulation development processes, an...

Unlocking the Drug Potential of the Bryostatin Family: Recent Advances in Product Synthesis and Biomedical Applications.

Bryostatins are a class of naturally occurring macrocyclic lactones with a unique fast developing portfolio of clinical applications, including treatment of AIDS, Alzheimer's disease and cancer. This comprehensive account summarizes the recent progress (2014-present) in the development of bryostatins, including their total synthesis and biomedical applications. An emphasis is placed on the discussion of bryostatin 1, the most-studied analog to date. This review highlights the synthetic and biological challe...

A review of Lassa fever vaccine candidates.

Lassa fever is a zoonotic disease caused by the Lassa virus, a rodent-borne arenavirus endemic to West Africa. Recent steady increase in reported cases of the disease in Nigeria, where 123 deaths occurred in 546 confirmed cases in 2019 has further underlined the need to accelerate the development of vaccines for preventing the disease. Intensified research and development of Lassa fever medical countermeasures have yielded some vaccine candidates with preclinical scientific plausibility using predominantly ...

Associations between gross motor skills and cognitive development in toddlers.

The early years of life are critical for motor and cognitive development. A better understanding is needed on the associations between the control and development of motor and cognitive tasks.

The impact of anticipating a stressful task on sleep inertia when on-call.

Sleep inertia, the state of reduced alertness upon waking, can negatively impact on-call workers. Anticipation of a stressful task on sleep inertia, while on-call was investigated. Young, healthy males (n = 23) spent an adaptation, control and two counterbalanced on-call nights in the laboratory. When on-call, participants were told they would be woken to a high or low stress task. Participants were not woken during the night, instead were given a 2300-0700 sleep opportunity. Participants slept ∼7.5-h...

Identifying Milestones in Language Development for Young Children Ages 1-6 Years.

Language development is important for children's success in life. Therefore, language is monitored by child health care professionals and parents, but a uniform set of milestones in language development is lacking. Our aim was to identify a set of clear and distinctive milestones that empirically reflect language development in children aged one to six years of age.

Using Rasch Analyses To Inform the Revision of a Scale Measuring Students' Process-Oriented Writing Competence in Portfolios.

Thanks to the wide range of benefits it provides to teaching and learning, portfolio assessment has maintained widespread popularity in language education over the last few decades. However, the practical use of this assessment method is still subject to debates, particularly about the lack of clear definitions and empirical validations of the constructs underlying the assessment. This problem can be addressed by research into portfolio scale development and examination and this article reports on the proce...

sPortfolio: Stratified Visual Analysis of Stock Portfolios.

Quantitative Investment, built on the solid foundation of robust financial theories, is at the center stage in investment industry today. The essence of quantitative investment is the multi-factor model, which explains the relationship between the risk and return of equities. However, the multi-factor model generates enormous quantities of factor data, through which even experienced portfolio managers find it difficult to navigate. This has led to portfolio analysis and factor research being limited by a la...

Preparing Nurse Leaders in Nursing Professional Development: Quality Improvement in Nursing Professional Development.

The role of endothelial cilia in post-embryonic vascular development.

Cilia are essential for morphogenesis and maintenance of many tissues. Loss-of-function of cilia in early zebrafish development causes a range of vascular defects including cerebral haemorrhage and reduced arterial vascular mural cell coverage. In contrast, loss of endothelial cilia in mice has little effect on vascular development. We therefore used a conditional rescue approach to induce endothelial cilia ablation after early embryonic development and examined the effect on vascular development and mural ...

Role of epigenetics in zebrafish development.

The role of epigenetics in development has garnered attention in recent years due to their ability to modulate the embryonic developmental gene expression in response to the environmental cues. The epigenetic mechanisms - DNA methylation, histone modification, and non-coding RNAs have a unique impact on vertebrate development. Zebrafish, a model vertebrate organism is being used widely in developmental studies due to their high fecundability and rapid organogenesis. With increased studies on various aspects...

An insight into professional identity formation: Qualitative analyses of two reflection interventions during the dissection course.

The professional behavior of future doctors is increasingly important in medical education. One of the first subjects in the curriculum to address this issue is gross anatomy. The Tuebingen Medical Faculty implemented a learning portfolio and a seminar on medical professionalism during the dissection course. The aims of this research project are to get an overview of how students form a professional identity in the dissection course and to compare the content of both their oral and written reflections on th...

Voice dissatisfaction in individuals with a disorder of sex development.

Changes of sex hormone levels in disorders of sex development (DSD) can affect the body during and after foetal development. The vocal folds and thus the voice is a gender characteristic that may also be affected. There is a lack of knowledge on voice alteration in DSD. To explore this in different forms of DSD, we describe the prevalence of voice alterations and investigate patient satisfaction with voice.

Cord Leptin is Associated with Neuropsychomotor Development in Childhood.

Leptin is critical for central nervous system development and maturation. This study aimed to evaluate the potential regulatory role of cord leptin in the neuropsychomotor development of children ages 18 months to 6 years.

Dynamic transcriptome sequencing and analysis during early development in the bighead carp (Hypophthalmichthys nobilis).

Early development is a key process of the life history of fish. However, the relationship between the transcriptome and the dynamic regulation of early development is still uncharacterized in the bighead carp (Hypophthalmichthys nobilis). In the present study, we performed transcriptome analysis of six development stages in H. nobilis, aiming to understand the dynamic molecular regulation of early development in this fish.

Youth Sexual Development: A Primer for Social Workers.

Sexuality and sexual expression are core aspects of most clients' lives, yet most schools of social work fail to cover sexual development, leaving social workers uninformed about this essential area of human development. This is particularly the case when the sexual development of youths is concerned, as youth sexuality is often considered too controversial to explore. Considering a positive approach to youth sexuality that seeks to enhance youths' sexual development and promote their achievement of full se...

Universal Mechanisms and the Development of the Face Network: What You See Is What You Get.

Our assignment was to review the development of the face-processing network, an assignment that carries the presupposition that a face-specific developmental program exists. We hope to cast some doubt on this assumption and instead argue that the development of face processing is guided by the same ubiquitous rules that guide the development of cortex in general. Expected final online publication date for the Volume 5 is September 16, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for ...

Huntingtin confers fitness but is not embryonically essential in zebrafish development.

Attempts to constitutively knockout HTT in rodents resulted in embryonic lethality, curtailing efforts to study HTT function later in development. Here we show that HTT is dispensable for early zebrafish development, contrasting published zebrafish morpholino experiment results. Homozygous HTT knockouts were embryonically viable and appeared developmentally normal through juvenile stages. Comparison of adult fish revealed significant reduction in body size and fitness in knockouts compared to hemizygotes an...

Histone Demethylase UTX is an Essential Factor for Zygotic Genome Activation and Regulates Zscan4 Expression in Mouse Embryos.

Following fertilization, the zygotic genome is activated through a process termed zygotic genome activation (ZGA), which enables zygotic gene products to replace the maternal products and initiates early embryonic development. During the ZGA period, the embryonic epigenome experiences extensive recodifications. The H3K27me3 demethylase UTX is essential for post-implantation embryonic development. However, it remains unclear whether UTX participates in preimplantation development, especially during the ZGA p...

The race between drug introduction and appearance of microbial resistance. Current balance and alternative approaches.

As current levels of antimicrobial resistance are alarming, the World Health Organization urged the development of new antimicrobials to fight infections produced by multidrug resistant bacteria. Antibiotics impose severe selective pressure for the development of resistance, and currently bacteria resistant to all of them exist. In this review, we discuss the release and development of new antibacterial drugs and their properties as well as the current advances in the development of alternative approaches t...

Promoting Child Growth and Development in the Sustainable Development Goals Era: Is It Time for New Thinking?

Growth monitoring and promotion (GMP) programs have been implemented worldwide for decades. Consistent evidence of their effectiveness is lacking and complicated by design and operational differences. Nevertheless, tracking child growth and development is a fundamental component of routine preventive child health care, and governments in 178 countries implement some form of GMP. This article makes the point that despite implementation challenges, there is a compelling need for GMP. It enables a crucial dial...


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