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Showing "LXRX Announces Positive Topline Clinical Data LX9211 https" PubMed Articles 1–25 of 55,000+

A clinical and histopathological analysis of the anti-centromere antibody positive subset of primary Sjögren's syndrome.

ACA-positive/primary Sjögren's syndrome (pSS) represents a distinct overlapping entity with intermediate features in between limited systemic sclerosis (lSSc) and pSS. Few data are available on their general risk for lymphoproliferative complications, specifically regarding adverse predictors at the level of minor salivary gland (MSG) histology. The objectives of this work are: a) to characterise, through a detailed immunohistochemistry study, the organisation of the lymphomonocitic infiltrates in ACA-posi...

Clinical registries in ophthalmology.

Clinical registries in Ophthalmology CLINICAL RELEVANCE: In recent years advancements in digital technology and increasing use of the electronic medical record in health systems have led to the dramatic growth in large clinical data sets. Clinical data registries are organised systems which collect data on patients diagnosed with a disease or condition, or who undergo a certain procedure.

Arterio-venous blood gas Δvalues for validation of umbilical cord blood samples at birth are biased not only by sample mix ups but also affected by clinical factors.

Traditional validation of umbilical cord blood samples with positive veno-arterial (V-A) ΔpH and A-V ΔpCO values confirms the source of samples, where negative Δvalues represent mix-up of samples. To investigate whether this is true, the distributions of V-A ΔpO and A-V Δlactate were also explored and related to clinical characteristics. In addition, different cord blood sampling techniques were evaluated MATERIAL AND METHODS: Register study with cord blood acid-base and clinical data from 27 233 newbo...

The number of positive confirmatory tests is associated with the clinical presentation and incidence of cardiovascular and cerebrovascular events in primary aldosteronism.

Primary aldosteronism (PA) is a major cause of secondary hypertension and presents a higher risk for cardio-cerebrovascular (CCV) events compared with essential hypertension. To diagnose PA after a positive screening test, at least one of three available confirmatory tests [the saline infusion test (SIT), the captopril challenge test (CCT) or the furosemide upright test (FUT)] should be performed. The aim of our study was to investigate the relationship between the number of positive confirmatory tests usin...

Multicenter clinical experience of real life Dalbavancin use in gram-positive infections.

Dalbavancin, a lipoglycopeptide with prolonged half-life approved for the treatment of acute bacterial skin-and-soft-tissue-infections, can be used for the treatment of infections caused by gram-positive bacteria requiring long term treatment such as endocarditis, prosthetic joint infections (PJI) or osteomyelitis. Clinical data is limited in these settings.

Prototype of running clinical trials in an untrustworthy environment using blockchain.

Monitoring and ensuring the integrity of data within the clinical trial process is currently not always feasible with the current research system. We propose a blockchain-based system to make data collected in the clinical trial process immutable, traceable, and potentially more trustworthy. We use raw data from a real completed clinical trial, simulate the trial onto a proof of concept web portal service, and test its resilience to data tampering. We also assess its prospects to provide a traceable and us...

Presenting and Sharing Clinical Data using the eTRIKS Standards Master Tree for tranSMART.

Standardization and semantic alignment have been considered one of the major challenges for data integration in clinical research. The inclusion of the CDISC SDTM clinical data standard into the tranSMART i2b2 via a guiding master ontology tree positively impacts and supports the efficacy of data sharing, visualization and exploration across datasets.

Clinical features of patients with male breast cancer in Shanxi province of China from 2007 to 2016.

This study aims to understand the clinical features, treatment, and prognosis of patients with male breast cancer (MBC) in Shanxi province of China from 2007 to 2016. Data for 77 patients with MBC were collected for analysis. Immunohistochemistry, pathological results, and other data such as demographic characteristics (age, marital status, smoking history, drinking history, and family history of cancer) as well as clinical data were investigated by retrieving information from the patients' medical records....

The radiation oncology ontology (ROO): Publishing linked data in radiation oncology using semantic web and ontology techniques.

Personalized medicine is expected to yield improved health outcomes. Data mining over massive volumes of patients' clinical data is an appealing, low-cost and noninvasive approach toward personalization. Machine learning algorithms could be trained over clinical "big data" to build prediction models for personalized therapy. To reach this goal, a scalable "big data" architecture for the medical domain becomes essential, based on data standardization to transform clinical data into FAIR (Findable, Accessible...

Indicators of positive youth development can be maladaptive: The example case of caring.

Research on positive youth development typically takes a more-is-better approach in which higher scores on measures of positive youth development indicate better outcomes. We question the validity of this assumption and describe how an imbalance among the Five Cs of Positive Youth Development can lead to a situation where "more" is actually "less." We then provide an empirical illustration using crosssectional data.

Clinical and Laboratory Findings of MERS-CoV infection.

There is a paucity of data regarding the differentiating characteristics of patients with laboratory confirmed and those negative for Middle East respiratory syndrome coronavirus (MERS-CoV) in South Korea. This is a hospital-based retrospective study comparing MERS-CoV-positive patients with MERS-CoV-negative patients. A total of 7 positive patients and 55 negative patients with a median age of 43 (P = 0.833) were included. No statistical differences were observed in relation to sex and the presence of como...

To challenge or not to challenge: literature data on the positive predictive value of skin tests to beta-lactams.

Evolution of Firearm Violence over 20 Years: Integrating Law Enforcement and Clinical Data.

Data linking ballistics to injury is lacking. To address this data chasm, a partnership with law enforcement was developed to describe clinical outcomes from specific firearms.

Validation of abdominal aortic aneurysm repair codes in Ontario administrative data.

To determine the positive predictive values (PPV) of Ontario administrative data codes for the identification of open (OSR) and endovascular (EVAR) repairs of elective (eAAA) and ruptured (rAAA) abdominal aortic aneurysms.

Weighing of evidence by health technology assessment bodies: retrospective study of reimbursement recommendations for conditionally approved drugs.

This study assessed whether five health technology assessment (HTA) bodies in Europe were more negative about drugs with a conditional marketing authorisation (CMA) that are approved without controlled studies compared to CMA drugs that are approved based on controlled studies. HTA recommendations were categorized into positive, restricted and negative. A total of 92 HTA recommendations were available for 27 drugs. 30/62 (48%) and 17/30 (57%) of recommendations were negative for drugs with and without contr...

Development and initial validation of the Positive Sexuality Scale for female adults.

To develop and initially validate the Positive Sexuality Scale (PSS) to assess adult female positive sexuality.

Occult Hepatitis B Virus Infection in Patients with Leprosy.

Leprosy patients may present with immune system impairment and have a higher HBV seroprevalence, justifying the investigation of occult HBV infection in these individuals. The aim of this study is to verify the frequency and the clinical factors associated with occult HBV infection in leprosy patients. Between 2015 and 2016, leprosy patients from a Reference Center in Brazil were interviewed to assess clinical data. Blood samples were collected for the screening of HBV serological markers by enzyme-linked i...

In-hospital and long-term outcomes of HIV-positive patients undergoing PCI according to kind of stent: a meta-analysis.

Pathogenesis of cardiovascular disease in HIV-positive patients is related to the interaction between traditional and HIV-specific factors. Limited data are available regarding the prognosis of HIV-positive patients undergoing percutaneous coronary intervention (PCI).

Healthy Post-Menarchal Adolescent Girls Demonstrate Multi-Level Reproductive Axis Immaturity.

Menstrual irregularity after menarche has been attributed to immature estrogen positive feedback activity (E+FB) but data are conflicting.

SNOMED CT Concept Hierarchies for Sharing Definitions of Clinical Conditions Using Electronic Health Record Data.

 Defining clinical conditions from electronic health record (EHR) data underpins population health activities, clinical decision support, and analytics. In an EHR, defining a condition commonly employs a diagnosis value set or "grouper." For constructing value sets, Systematized Nomenclature of Medicine-Clinical Terms (SNOMED CT) offers high clinical fidelity, a hierarchical ontology, and wide implementation in EHRs as the standard interoperability vocabulary for problems.

Haemoglobin-based oxygen carriers and myocardial infarction.

The incidence of investigator diagnosed myocardial infarction (MI) is greater in patients treated with haemoglobin-based oxygen carriers (HBOCs) than controls. Clinical trials and literature pertaining to possible HBOC toxicity mechanisms have been analyzed in order to identify possible reasons for this imbalance. MI diagnosis is hampered by potential interference of troponin assays by haemoglobin, haemolysis and bilirubin. Nevertheless, insofar as the reported incidence correlates with actual occurrence, t...

Experiences of self-conscious emotions in temporal lobe epilepsy.

Self-conscious emotions (SCEs) with a negative valence (such as shame and guilt) or a positive valence (such as pride) are moral emotions that emerge from self-reflection and self-evaluation processes in social contexts. In some neurologic and psychiatric disorders, experiences of SCEs are dysregulated. The objectives of the present study were to (i) evaluate whether patients with temporal lobe epilepsy (TLE) experience SCEs in the same way as nonclinical (control) participants and (ii) probe the relationsh...

Malaise with praise: A narrative review of 10 years of research on the concept of Fear of Positive Evaluation in social anxiety.

Social anxiety is characterized by a fear of being negatively evaluated by others (i.e., Fear of Negative Evaluation [FNE]). In 2008, Weeks, Heimberg, and Rodebaugh proposed Fear of Positive Evaluation (FPE) as a second cognitive component in social anxiety. The article presents an overview of FPE, its psycho-evolutionary theoretical foundation and assessment by the Fear of Positive Evaluation Scale as well as relevant psychometric research on demographic characteristics. The relationship of FPE with a wide...

Solid organ transplantation from Zika IgM positive donors: Not always a true positive.

What Should Oversight of Clinical Decision Support Systems Look Like?

A learning health system provides opportunities to leverage data generated in the course of standard clinical care to improve clinical practice. One such opportunity includes a clinical decision support structure that would allow clinicians to query electronic health records (EHRs) such that responses from the EHRs could inform treatment recommendations. We argue that though using a clinical decision support system does not necessarily constitute a research activity subject to the Common Rule, it requires m...

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