PubMed Journals Articles About "Lexi-Comp, Inc." RSS

16:57 EDT 23rd March 2019 | BioPortfolio

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Showing "Lexi Comp" PubMed Articles, all 14

Serum COMP expression in individuals who sustained a youth sport-related intra-articular knee injury 3-10 years previously and uninjured matched controls.

This study investigates the relationship between a youth sport-related intra-articular knee injury and cartilage oligomeric matrix protein (COMP), a biomarker of cartilage turnover.

Solriamfetol for the treatment of daytime sleepiness in obstructive sleep apnea.

Obstructive sleep apnea (OSA) is highly prevalent and constitutes a major health hazard. Current pharmacotherapy is ineffective in correcting sleep-disordered breathing and is used adjunctively to address residual sleepiness. A new drug, solriamfetol, a selective norepinephrine-dopamine reuptake inhibitor, is the first drug of its class that is being considered by the US Food and Drug Administration (FDA) to treat excessive sleepiness in OSA and narcolepsy patients. Areas Covered: This review covers drug ch...

Long non-coding RNA transcriptome of uncharacterized samples can be accurately imputed using protein-coding genes.

Long non-coding RNAs (lncRNAs) play an important role in gene regulation and are increasingly being recognized as crucial mediators of disease pathogenesis. However, the vast majority of published transcriptome datasets lack high-quality lncRNA profiles compared to protein-coding genes (PCGs). Here we propose a framework to harnesses the correlative expression patterns between lncRNA and PCGs to impute unknown lncRNA profiles. The lncRNA expression imputation (LEXI) framework enables characterization of lnc...

Protective effect of a novel sigma-1 receptor agonist is associated with reduced endoplasmic reticulum stress in stroke male mice.

Sigma-1 receptor (Sig-1R) is expressed at endoplasmic reticulum (ER) membranes, where it regulates a variety of specific physiological functions. However, the profile and exact roles of ER stress-related molecules after Sig-1R agonist treatment in an in vivo stroke model are largely unknown. The aim of this study is to investigate the effect of a novel Sig-1R agonist, aniline derivative compound (Comp-AD), on the ER stress response following ischemic stroke. Male C57BL/6J mice received transient middle cere...

COMP-Angiopoietin-1 accelerates muscle regeneration through N-cadherin activation.

Angiopoietin-1 modulates vascular stability via Tie2 on endothelial cells. In our previous study, we also showed it acts as an inhibitor of cardiomyocyte death. However, it remains poorly understood how Ang1 regulates myogenesis during muscle regeneration. Here we found that COMP-Ang1 (cAng1) enhances muscle regeneration through N-cadherin activation. Muscle fiber regeneration after limb muscle damage by ischemic injury was enhanced with cAng1 treatment. Mechanistically cAng1 directly bound to N-cadherin on...

Effect of circadian rhythm, age, training, and acute lameness on serum concentrations of cartilage oligomeric matrix protein (COMP) neo-epitope in horses.

Molecular serum markers that can identify early reversible osteoarthritis (OA) in horses are lacking.

Dose-response relationship between ambulatory load magnitude and load-induced changes in COMP in young healthy adults.

To determine the dose-response relationship between ambulatory load magnitude during a walking stress test and load-induced changes in serum concentration of cartilage oligomeric matrix protein (sCOMP) in healthy subjects.

Paroxetine and rivastigmine mitigates adjuvant-induced rheumatoid arthritis in rats: Impact on oxidative stress, apoptosis and RANKL/OPG signals.

Rheumatoid arthritis (RA) is considered a form of inflammatory autoimmune disease with unknown etiology, but environmental and genetic causes are sharing. T-cells, B-cells, synovial cells, osteoclast, and chondrocytes are the main cell types in RA pathophysiology. The present study aimed to investigate the anti-rheumatic effects of paroxetine, a selective serotonin reuptake inhibitor (SSRI), and rivastigmine, acetyl choline esterase inhibitor (AChEI), in complete Freund's adjuvant (CFA)-induced RA. Adult fe...

Improving patient outcomes and radiotherapy systems: A pan-Canadian approach to patient-reported outcome use.

Standardized collection and use of clinical patient-reported outcomes (PRO) have potential to benefit the care of individual patients and improve radiotherapy system performance. Its centralized health-care system makes Canada a prime candidate to take a leader and collaborator role in international endeavors to promote expansion of patient-reported outcome collection and use in radiotherapy. The current review discusses the development of a pan-Canadian approach to PRO use, through a quality improvement in...

Multinomial Extension of Propensity Score Trimming Methods: A Simulation Study.

Crump et al. (Biometrika 2009;96:187), Stürmer et al. (Am J Epidemiol 2010;172:843), and Walker et al. (Comp Eff Res 2013;3:11) proposed propensity score (PS) trimming methods as measures to improve efficiency (Crump) or reduce confounding (Stürmer and Walker). We generalized the trimming definitions by considering multinomial PSs, one for each treatment and proved these proposed definitions reduce to the original binary definitions when we only have two treatment groups. We then examined the performance ...

Projections of the densocellular part of the hyperpallium in the rostral Wulst of pigeons (Columba livia).

The Wulst in birds shows a four-layered structure: apical part of the hyperpallium (HA), interstitial part of HA (IHA), intercalated part of hyperpallium (HI), and densocellular part of hyperpallium (HD). The Wulst consists of a small rostral somatosensory region and a larger caudal visual region. The visual HD relays visual information to IHA and HA in the Wulst and also transfers visual information to the hippocampal formation (Atoji et al., J Comp Neurol 526: 146-165, 2018). However, fiber pathways of th...

Fabrication of poly (methyl methacrylate)/Ce/Cu substituted apatite/Egg white (Ovalbumin) biocomposite owning adjustable properties: Towards bone tissue rejuvenation.

A new biocomposite including Poly (methyl methacrylate)/Ce-Cu substituted apatite/Egg white (Ovalbumin) (PMMA/MHAP/EW) has been effectively manufactured via lyophilization technique. The reason to plan such biocomposite is to investigate for a perfect simple which may bio-imitate the constitution of natural bone for hard tissue designing regarding appropriate biodegradability, biocompatibility, and bactericidal properties. The FTIR and XRD spectra of prepared biocomposite showed the considerable intermolecu...

Two Keggin-Based Isostructural POMOF Hybrids: Synthesis, Crystal Structure, and Catalytic Properties.

In this work we synthesized two novel isostructural twin hybrids Comp1: [H(CHN)Cu][PMoO] & Comp2: [H(CHN)Cu][PWO], based on the Keggin ions (PMoO & PWO), Cu(I) cation, and 4,4'-bipyridine, by in situ hydrothermal reduction of Cu, facilitated through extensive standardizations of synthetic pH conditions. Both compounds crystallized in monoclinic P2/ c space group with similar lattice parameters and crystal structures. The structural similarity prompted us to explore comparative catalytic properties of the hy...

Tenogenic differentiation protocol in xenogenic-free media enhances tendon-related marker expression in ASCs.

Adipose-derived stem cells (ASCs) are multipotent and immune-privileged mesenchymal cells, making them ideal candidates for therapeutic purposes to manage tendon disorders. Providing safe and regulated cell therapy products to patients requires adherence to good manufacturing practices. To this aim we investigated the in vitro tenogenic differentiation potential of ASCs using a chemically defined serum-free medium (SF) or a xenogenic-free human pooled platelet lysate medium (hPL) suitable for cell therapy a...

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