PubMed Journals Articles About "Liver Cancer Pipeline Review 2015" RSS

17:25 EST 21st January 2019 | BioPortfolio

Liver Cancer Pipeline Review 2015 PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Liver Cancer Pipeline Review 2015 articles that have been published worldwide.

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Showing "Liver Cancer Pipeline Review 2015" PubMed Articles 1–25 of 37,000+

Risk factors for developing liver cancer in people with and without liver disease.

The National Liver Cancer Surveillance Program (NLCSP) targets patients with liver diseases that lead to liver cancer in South Korea. This study aimed to investigate the risk of liver disease leading to liver cancer using nationally representative data to establish an efficient NLCSP.

Influence of the time interval from diagnosis to treatment on survival for early-stage liver cancer.

Liver cancer is the fifth most common cancer in men and the ninth most common cancer in women, and the WHO expects that there will be 1,341,344 cases in 2034 worldwide. Liver cancer also has the second-highest cancer death rate, accounting for 7% of all cancers. The study is going to explore the relationship between time interval from diagnosis to treatment and survival status of early-stage liver cancer patients.

miR-409 down-regulates Jak-Stat pathway to inhibit progression of liver cancer.

To elucidate the influence of microRNA-409 and the Jak-Stat pathway on the development of liver cancer.

The long noncoding RNA LncHDAC2 drives the self-renewal of liver cancer stem cells via activation of Hedgehog Signaling.

Liver cancer is the second leading cause of cancer death worldwide. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults. The aim of this study was to define the role of long non-coding RNA lncHDAC2 in the tumorigenesis of HCC.

miR‑498 inhibits the growth and metastasis of liver cancer by targeting ZEB2.

MicroRNAs (miRNAs) play critical roles in the growth, metastasis and therapeutic resistance of liver cancer. Accumulating evidence suggests that miR‑498 is aberrantly expressed in several human malignancies. However, the role and underlying mechanism of miR‑498 in liver cancer remain unclear. In the present study, we investigated the potential roles and clinical value of miR‑498 in liver cancer. We found that the miR‑498 expression level was significantly lower in liver cancer patient tissues than t...

Knockdown of FOXK1 suppresses liver cancer cell viability by inhibiting glycolysis.

Aerobic glycolysis is a unique characteristic of cancer cells, and this key signature provides a target for therapeutic intervention of cancers. Forkhead box protein K1 (FOXK1) is a transcriptional factor that plays an oncogenic role in several types of cancers, including liver cancer. However, whether FOXK1 could affect glycolysis in cancer cells remains unknown. The aim of the present study was to evaluate the effect of FOXK1 on glycolysis in liver cancer cells.

Functional Liver Imaging and Dosimetry to Predict Hepatotoxicity Risk in Cirrhotic Patients with Primary Liver Cancer.

Mitigating radiation-induced liver disease (RILD) is an ongoing need in hepatocellular carcinoma (HCC) patients. We hypothesize that [Tc]-sulfur colloid (SC) SPECT/CT scans can provide global functional liver metrics and functional liver dosimetric parameters that are predictive of hepatotoxicity risk in primary liver cancer patients with cirrhosis.

Evaluation of published assessment tools for comorbidity in liver transplantation: a systematic review protocol.

Liver transplantation is considered the best therapy option for end-stage liver disease. Different factors including recipient comorbidity at time of transplantation are supposed to have substantial impact on outcomes. Although several studies have focused on comorbidity assessment indices for liver transplant recipients, there is no systematic review available on the methodological details and prognostic accuracy of these instruments. The aim of this study is to systematically review recipient comorbidity ...

Organ procurement center allows for daytime liver transplantation with less resource utilization: may address burnout, pipeline and safety for field of transplantation.

Abdominal organ transplantation faces several challenges: burnout, limited pipeline of future surgeons, changes in liver allocation potentially impacting organ procurement travel, and travel safety. The organ procurement center (OPC) model may be one way to mitigate these issues. Liver transplants from 2009-2016 were reviewed. There were 755 liver transplants performed with 525 OPC and 230 in-hospital procurements. Majority of transplants (87.4%) were started during daytime hours (5 am - 7 pm). Transplants ...

Staging systems of hepatocellular carcinoma: A review.

Staging of hepatocellular carcinoma (HCC) is necessary for guiding prognostication, management, and research purposes that further aid in the improvement of existing clinical and epidemiological health services. Though there are some new staging systems for HCC developed in different parts of the world, there is no globally accepted staging system that allows for comparison of current management protocols among heterogeneous populations. In this review, we discuss the evolution and applicability in clinical...

Rewiring urea cycle metabolism in cancer to support anabolism.

Cancer cells reprogramme metabolism to maximize the use of nitrogen and carbon for the anabolic synthesis of macromolecules that are required during tumour proliferation and growth. To achieve this aim, one strategy is to reduce catabolism and nitrogen disposal. The urea cycle (UC) in the liver is the main metabolic pathway to convert excess nitrogen into disposable urea. Outside the liver, UC enzymes are differentially expressed, enabling the use of nitrogen for the synthesis of UC intermediates that are r...

Identifying Key Genes of Liver Cancer by Networking of Multiple Data Sets.

Liver cancer is one of the deadliest cancers in the world. To find effective therapies for this cancer, it is indispensable to identify key genes, which may play critical roles in the incidence of the liver cancer. To identify key genes of the liver cancer with high accuracy, we integrated multiple microarray gene expression data sets to compute common differentially expressed genes, which will result more accurate than those from individual data set. To find the main functions or pathways that these genes ...

Research progress on non-coding RNAs in the molecular pathogenesis of hepatocellular carcinoma.

Primary liver cancer arises from chronic liver disease, and cirrhotic liver gradually develops into dysplastic nodules that eventually form malignant tumors. In recent years, molecular biotechnology development has deepened people's understanding on the pathogenesis of liver cancer. Epigenetic modifications play a significant role in DNA methylation, non-coding RNAs, chromatin remodeling, and histone modification. This review focuses on the progress of currently implicated non-coding RNAs in the molecular p...

Research on values of GDF-15 level in the diagnosis of primary liver cancer and evaluation of chemotherapeutic effect.

To investigate the values of growth differentiation factor-15 (GDF-15) level in the diagnosis of primary liver cancer and evaluation of chemotherapeutic effect.

The rising incidence of testicular cancer among young men in Canada, data from 1971-2015.

Testicular cancer is the most common malignancy among young men aged 15-44 in Canada. The goal of this analysis was to examine age-period-cohort effects of testicular cancer incidence between 1971 and 2015.

Association of tooth loss with liver cancer incidence and chronic liver disease mortality in a rural Chinese population.

Tooth loss has been reported to be associated with the risk of liver cancer in several prior studies in economically advantaged countries. Whether this relationship is also evident in economically disadvantaged populations is not known.

Laparoscopic Liver Surgery - a Single Centre Series of 250 Consecutive Cases.

In spite of convincing results from internationally prominent liver centres, laparoscopic liver surgery is not widely used in Germany. A structured program to develop laparoscopic liver surgery was established in 2015 at the Department of Surgery, Charité Hospital, Berlin, in order to provide support for establishing this approach in German hospitals.

Homeobox containing 1 inhibits liver cancer progression by promoting autophagy as well as inhibiting stemness and immune escape.

Homeobox containing 1 (HMBOX1) is a novel transcription repressor that is significantly downregulated in human liver cancer tissues and cell lines, but the exact biological function of HMBOX1 in liver cancer is still unknown. We observed a negative association between HMBOX1 expression level and the clinical stages of liver cancer. HMBOX1 also increased the LC3 II/LC3 I ratio, the endogenous autophagy marker, and inhibited the p38/AKT/mTOR pathway. Furthermore, cancer stem cell specific genes, including C...

Incidence of primary liver cancer in American Indians and Alaska Natives, US, 1999-2009.

To evaluate liver cancer incidence rates and risk factor correlations in non-Hispanic AI/AN populations for the years 1999-2009.

Quantifying the effects of aging and urbanization on major gastrointestinal diseases to guide preventative strategies.

This study aimed to quantify the effects of aging and urbanization on major gastrointestinal disease (liver cirrhosis, hepatitis B, diarrhea, liver cancer, stomach cancer, pancreas cancer, hepatitis C, esophagus cancer, colon/rectum cancer, gastrointestinal ulcers, diabetes, and appendicitis).

The prognostic analysis of different metastatic patterns in advanced liver cancer patients: A population based analysis.

The prognostic impact of different distant metastases pattern in liver cancer is unexplored still now. The aim of this study is to analyze the metastasis patterns and prognosis differences for patients with stage IV liver cancers.

HGFAC expression decreased in liver cancer and its low expression correlated with DNA hypermethylation and poor prognosis.

As the activator of hepatocyte growth factor (HGF), hepatocyte growth factor activator (HGFAC) has been previously reported to involve in liver, kidney, and stomach regeneration in response to injury and several types of cancers. This study aimed to explore the expression of HGFAC and the correlation between decreased HGFAC and DNA methylation in liver cancer and its clinical significance. The molecular profiling of HGFAC in liver cancer was analyzed using genomic, transcriptomic, immunohistochemistry, and ...

The association of rs3787016 polymorphism and cancer risk: a Chinese case-control study and meta-analysis.

How single nucleotide polymorphisms (SNPs) in long non-coding RNAs (LncRNAs) are involved in cancer susceptibility remains poorly understood. We hypothesized that rs3787016 polymorphism, identified in a genome-wide association study of prostate cancer, might be a common genetic risk factor for cancer risk. To address this issue, we here conducted a case-control study to investigate the association of rs3787016 polymorphism with risk of liver and lung cancer (including 800 normal controls, 480 liver cancer...

PCAF fine-tunes hepatic metabolic syndrome, inflammatory disease, and cancer.

The P300/CBP-associating factor (PCAF), a histone acetyltransferase, is involved in metabolic and pathogenic diseases, particularly of the liver. The effects of PCAF on fine-tuning liver diseases are extremely complex and vary according to different pathological conditions. This enzyme has dichotomous functions, depending on differently modified sites, which regulate the activities of various enzymes, metabolic functions, and gene expression. Here, we summarize the most recent findings on the functions and ...

Testing for AFP in combination with ultrasound improves early liver cancer detection.

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